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The map label for this gene is galM [H]

Identifier: 15602899

GI number: 15602899

Start: 1216498

End: 1217529

Strand: Reverse

Name: galM [H]

Synonym: PM1034

Alternate gene names: 15602899

Gene position: 1217529-1216498 (Counterclockwise)

Preceding gene: 15602900

Following gene: 15602898

Centisome position: 53.93

GC content: 42.83

Gene sequence:

>1032_bases
ATGCTGAGCAAGTGTACACTGGGTGTCGCACCAGATGGACAACCATTTCAATTAGTCACTTTATCCAATGCAAAAGGGAT
GTCTATCCAAGTGATGGATTGGGGGGCGACATGGTTGTCTTGTAAGGTGCCTGTGCAAAATCAATTACGTGAAGTGTTAT
TAGGCTGTCAGCTTGAGGATTACCCTAAGCAACAGGTTTATTTAGGTGCGACTATCGGGCGTTATGCGAATCGTATTGCG
AATGGACGTTTTGTATTAAATGGGGTGCCTATTCAGTTACAGACGAATCAAGGACAACATCAGTTACATGGTGGCGAAAA
TGGTTTTGATTGCCAACGTTGGCAATTGGAAAAGTGCGGTGAAAATTTTGTGTGTTTTTCACTTTCTTCGCCAGACGGTG
ATCAAGGTTTTCCCGGTCATGTGAAAGTATGTGTAACGTACTTACTGAACGAGCAAAATTGTGTAGAAATTCAATTTGAG
GCGGAAAGTGATCAAGATACCCCGCTAAATTTGACCAATCATGCTTATTTTAATCTCAATAACGCGGAGCTTGGTGAGGA
CATTCGAGAACATTATTTGCAAGTCAATGCTGACCATTACTTACCTGTGAATCCAGAGGGGATCCCTTGTGCAGCGTTGA
AATCCGTACAGGGCACCAGTTTTGATTTTCGTGAGATGAAGTCTATTGAGAAAGACTTTTTACAAGATGAACAAGCCCTA
GTAAAAGGGTATGATCATGCCTTTCTATTAAATCAAGACAAAGAAAAACTCAGTGCGGTTCTTACGGCAGCAGACGGTTC
TTTACGTTTACAGGTCTCCACCTCTCAACCTGCCTTACAAATATATACTGGGAATTTTCTAGCCGGTACGCCGAATCGTT
TCGGCTCATACTATCAGGATTACGTCGGGATTGCGTTAGAAACACAAGCCTTACCTGATACCCCTAATCATCCTGAGTGG
TGGACATTGGGCGGCATGAGCCAAGCCGGAGAAAAATATCAACATTGGACCCGTTTTAACTTTTCATCATAA

Upstream 100 bases:

>100_bases
AAGTGGAAGCCGTTCGTCAGATTATTGCTGATAATTACGCCCAACAAACGGGTTTAAAAGAAGATTTTTATGTGTGTACT
GCCTCACAAGGAGTAAGCGT

Downstream 100 bases:

>100_bases
CAATAAATGCGAATTGTCGTTTTTTGCCCCACTGTCTAGGGGCTTTTTTTTGCTATTAAGCAGGAAATATGTTACTTTTC
AACGGTCAATGTTGACGGAA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MLSKCTLGVAPDGQPFQLVTLSNAKGMSIQVMDWGATWLSCKVPVQNQLREVLLGCQLEDYPKQQVYLGATIGRYANRIA
NGRFVLNGVPIQLQTNQGQHQLHGGENGFDCQRWQLEKCGENFVCFSLSSPDGDQGFPGHVKVCVTYLLNEQNCVEIQFE
AESDQDTPLNLTNHAYFNLNNAELGEDIREHYLQVNADHYLPVNPEGIPCAALKSVQGTSFDFREMKSIEKDFLQDEQAL
VKGYDHAFLLNQDKEKLSAVLTAADGSLRLQVSTSQPALQIYTGNFLAGTPNRFGSYYQDYVGIALETQALPDTPNHPEW
WTLGGMSQAGEKYQHWTRFNFSS

Sequences:

>Translated_343_residues
MLSKCTLGVAPDGQPFQLVTLSNAKGMSIQVMDWGATWLSCKVPVQNQLREVLLGCQLEDYPKQQVYLGATIGRYANRIA
NGRFVLNGVPIQLQTNQGQHQLHGGENGFDCQRWQLEKCGENFVCFSLSSPDGDQGFPGHVKVCVTYLLNEQNCVEIQFE
AESDQDTPLNLTNHAYFNLNNAELGEDIREHYLQVNADHYLPVNPEGIPCAALKSVQGTSFDFREMKSIEKDFLQDEQAL
VKGYDHAFLLNQDKEKLSAVLTAADGSLRLQVSTSQPALQIYTGNFLAGTPNRFGSYYQDYVGIALETQALPDTPNHPEW
WTLGGMSQAGEKYQHWTRFNFSS
>Mature_343_residues
MLSKCTLGVAPDGQPFQLVTLSNAKGMSIQVMDWGATWLSCKVPVQNQLREVLLGCQLEDYPKQQVYLGATIGRYANRIA
NGRFVLNGVPIQLQTNQGQHQLHGGENGFDCQRWQLEKCGENFVCFSLSSPDGDQGFPGHVKVCVTYLLNEQNCVEIQFE
AESDQDTPLNLTNHAYFNLNNAELGEDIREHYLQVNADHYLPVNPEGIPCAALKSVQGTSFDFREMKSIEKDFLQDEQAL
VKGYDHAFLLNQDKEKLSAVLTAADGSLRLQVSTSQPALQIYTGNFLAGTPNRFGSYYQDYVGIALETQALPDTPNHPEW
WTLGGMSQAGEKYQHWTRFNFSS

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=350, Percent_Identity=39.4285714285714, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI1786971, Length=341, Percent_Identity=50.4398826979472, Blast_Score=335, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI17557428, Length=303, Percent_Identity=29.7029702970297, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI115533334, Length=303, Percent_Identity=29.7029702970297, Blast_Score=153, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322004, Length=359, Percent_Identity=29.2479108635098, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324399, Length=353, Percent_Identity=26.628895184136, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319493, Length=345, Percent_Identity=26.3768115942029, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24659048, Length=340, Percent_Identity=35.5882352941176, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24668278, Length=341, Percent_Identity=33.1378299120235, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24583720, Length=348, Percent_Identity=30.7471264367816, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24668282, Length=340, Percent_Identity=32.0588235294118, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24641876, Length=346, Percent_Identity=30.635838150289, Blast_Score=152, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38340; Mature: 38340

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSKCTLGVAPDGQPFQLVTLSNAKGMSIQVMDWGATWLSCKVPVQNQLREVLLGCQLED
CCCCEEEECCCCCCCEEEEEECCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHCCCCCC
YPKQQVYLGATIGRYANRIANGRFVLNGVPIQLQTNQGQHQLHGGENGFDCQRWQLEKCG
CCCCEEEEEHHHHHHHHHHCCCEEEEECEEEEEECCCCCEEECCCCCCCCCHHHHHHHCC
ENFVCFSLSSPDGDQGFPGHVKVCVTYLLNEQNCVEIQFEAESDQDTPLNLTNHAYFNLN
CCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEECCEEEEECC
NAELGEDIREHYLQVNADHYLPVNPEGIPCAALKSVQGTSFDFREMKSIEKDFLQDEQAL
CHHHHHHHHHHHEEECCCCEECCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHH
VKGYDHAFLLNQDKEKLSAVLTAADGSLRLQVSTSQPALQIYTGNFLAGTPNRFGSYYQD
HCCCCEEEEECCCHHHHEEEEEECCCEEEEEEECCCCEEEEEECCEECCCCHHHHHHHHH
YVGIALETQALPDTPNHPEWWTLGGMSQAGEKYQHWTRFNFSS
HHCEEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHEEECCCC
>Mature Secondary Structure
MLSKCTLGVAPDGQPFQLVTLSNAKGMSIQVMDWGATWLSCKVPVQNQLREVLLGCQLED
CCCCEEEECCCCCCCEEEEEECCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHCCCCCC
YPKQQVYLGATIGRYANRIANGRFVLNGVPIQLQTNQGQHQLHGGENGFDCQRWQLEKCG
CCCCEEEEEHHHHHHHHHHCCCEEEEECEEEEEECCCCCEEECCCCCCCCCHHHHHHHCC
ENFVCFSLSSPDGDQGFPGHVKVCVTYLLNEQNCVEIQFEAESDQDTPLNLTNHAYFNLN
CCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEECCEEEEECC
NAELGEDIREHYLQVNADHYLPVNPEGIPCAALKSVQGTSFDFREMKSIEKDFLQDEQAL
CHHHHHHHHHHHEEECCCCEECCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHH
VKGYDHAFLLNQDKEKLSAVLTAADGSLRLQVSTSQPALQIYTGNFLAGTPNRFGSYYQD
HCCCCEEEEECCCHHHHEEEEEECCCEEEEEEECCCCEEEEEECCEECCCCHHHHHHHHH
YVGIALETQALPDTPNHPEWWTLGGMSQAGEKYQHWTRFNFSS
HHCEEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 1282642 [H]