Click here to switch to the map view.

The map label for this gene is galK

Identifier: 15602900

GI number: 15602900

Start: 1217523

End: 1218680

Strand: Reverse

Name: galK

Synonym: PM1035

Alternate gene names: 15602900

Gene position: 1218680-1217523 (Counterclockwise)

Preceding gene: 15602901

Following gene: 15602899

Centisome position: 53.98

GC content: 43.52

Gene sequence:

>1158_bases
ATGACTCCACAGCAATCTGCTCAACGCTTATTTCAAGAAAAATTTAATTGTACACCGACCTTAAATGTTTATGCACCAGG
TCGAGTCAATATTATTGGTGAACATACGGATTATAATGATGGTTTTGTGATGCCTTGTGCAATTAATTATGGCACCGCCA
TCAGTGGTCGAAAACGGGATGATAGCCGATTTAAAGTCTATGCTGGTGATTTGCAGCAATGGGATGAATTTGATTTAGCA
CAAGAGATCACTCCAGATTCAAGCAAAAAATGGACAGGTTATGTACGTGGCGTGGTGAAATTTGTGCAGACCCATTGTCC
AGACTTTAAGTGCGGTGCGGATTTAGTGATTTCTGGTAATGTGCCGTTATCTGCGGGCTTGAGTTCTTCTGCCTCTTTAG
AAGTGGCGGTTGGCAAATTTTGCCAACAATTAGGTAATTTACCTTTAACTAATACGGAAATTGCGCTTATTGGTCAGAAA
GCTGAGAACCAGTTTGTCGGTTGCCAATGTGGCAATATGGATCAATTGATTTCAGCATTAGGACAGAAAGATCATTTACT
GATGATCGATTGTCGTTCGTTAGAAACGATTCCAACCCCTATTCCCGCTAATGTGGCGGTGATGATTGTGAATTCTCATG
TGAAACACGATTTGGTGGCGGGGGAGTACAACACTCGTCGTCAGCAATGTGAAGTCGCCGCGAAATTCTTTGGCGTGAAA
GCATTACGTGATGTGTCTCTTGCTCAATTTAAACAAAGAGAAGCAGAGTTGACGGCATTGGATCCCGAAGTGGCGAAACG
TGCACGTCATGTAGTGACGGAAAACCAACGTGTTTTAGATGCGGTTAAAGCCTTACAAAGTGGCAATCTTGCGCTACTGG
GAGAACTTATGGCGCAATCGCATGAGTCAATGCGTGATGATTTTGAGATTACGGTACCGCAAATTGACTATTTAGTGGAA
CTGGCACAGATTGCAATTGGTAAAACCGGTGGCGCTAGAATGACTGGTGGTGGCTTTGGTGGGTGTATTGTGGCGGTTGC
ACCGGTGGAAAAAGTGGAAGCCGTTCGTCAGATTATTGCTGATAATTACGCCCAACAAACGGGTTTAAAAGAAGATTTTT
ATGTGTGTACTGCCTCACAAGGAGTAAGCGTATGCTGA

Upstream 100 bases:

>100_bases
AGTGCATTATAAGCAAAGATAACCTAAGTGAGATACAACGCGATTTCTATTTGTCATTTGATAAGACGCATATTGTTTGC
GATAAGGAAAGGGATATAAC

Downstream 100 bases:

>100_bases
GCAAGTGTACACTGGGTGTCGCACCAGATGGACAACCATTTCAATTAGTCACTTTATCCAATGCAAAAGGGATGTCTATC
CAAGTGATGGATTGGGGGGC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTPQQSAQRLFQEKFNCTPTLNVYAPGRVNIIGEHTDYNDGFVMPCAINYGTAISGRKRDDSRFKVYAGDLQQWDEFDLA
QEITPDSSKKWTGYVRGVVKFVQTHCPDFKCGADLVISGNVPLSAGLSSSASLEVAVGKFCQQLGNLPLTNTEIALIGQK
AENQFVGCQCGNMDQLISALGQKDHLLMIDCRSLETIPTPIPANVAVMIVNSHVKHDLVAGEYNTRRQQCEVAAKFFGVK
ALRDVSLAQFKQREAELTALDPEVAKRARHVVTENQRVLDAVKALQSGNLALLGELMAQSHESMRDDFEITVPQIDYLVE
LAQIAIGKTGGARMTGGGFGGCIVAVAPVEKVEAVRQIIADNYAQQTGLKEDFYVCTASQGVSVC

Sequences:

>Translated_385_residues
MTPQQSAQRLFQEKFNCTPTLNVYAPGRVNIIGEHTDYNDGFVMPCAINYGTAISGRKRDDSRFKVYAGDLQQWDEFDLA
QEITPDSSKKWTGYVRGVVKFVQTHCPDFKCGADLVISGNVPLSAGLSSSASLEVAVGKFCQQLGNLPLTNTEIALIGQK
AENQFVGCQCGNMDQLISALGQKDHLLMIDCRSLETIPTPIPANVAVMIVNSHVKHDLVAGEYNTRRQQCEVAAKFFGVK
ALRDVSLAQFKQREAELTALDPEVAKRARHVVTENQRVLDAVKALQSGNLALLGELMAQSHESMRDDFEITVPQIDYLVE
LAQIAIGKTGGARMTGGGFGGCIVAVAPVEKVEAVRQIIADNYAQQTGLKEDFYVCTASQGVSVC
>Mature_384_residues
TPQQSAQRLFQEKFNCTPTLNVYAPGRVNIIGEHTDYNDGFVMPCAINYGTAISGRKRDDSRFKVYAGDLQQWDEFDLAQ
EITPDSSKKWTGYVRGVVKFVQTHCPDFKCGADLVISGNVPLSAGLSSSASLEVAVGKFCQQLGNLPLTNTEIALIGQKA
ENQFVGCQCGNMDQLISALGQKDHLLMIDCRSLETIPTPIPANVAVMIVNSHVKHDLVAGEYNTRRQQCEVAAKFFGVKA
LRDVSLAQFKQREAELTALDPEVAKRARHVVTENQRVLDAVKALQSGNLALLGELMAQSHESMRDDFEITVPQIDYLVEL
AQIAIGKTGGARMTGGGFGGCIVAVAPVEKVEAVRQIIADNYAQQTGLKEDFYVCTASQGVSVC

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily

Homologues:

Organism=Homo sapiens, GI4503895, Length=386, Percent_Identity=42.2279792746114, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI48527957, Length=420, Percent_Identity=29.7619047619048, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4503897, Length=420, Percent_Identity=29.7619047619048, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1786972, Length=386, Percent_Identity=58.5492227979275, Blast_Score=445, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI71989053, Length=409, Percent_Identity=26.161369193154, Blast_Score=98, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6319494, Length=253, Percent_Identity=27.6679841897233, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24661292, Length=435, Percent_Identity=27.5862068965517, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI21355577, Length=435, Percent_Identity=27.5862068965517, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24661285, Length=435, Percent_Identity=27.5862068965517, Blast_Score=118, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GAL1_PASMU (P57899)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245972.1
- ProteinModelPortal:   P57899
- GeneID:   1244382
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1035
- NMPDR:   fig|272843.1.peg.1035
- HOGENOM:   HBG725121
- OMA:   YNDGFVM
- ProtClustDB:   PRK05101
- BioCyc:   PMUL272843:PM1035-MONOMER
- BRENDA:   2.7.1.6
- GO:   GO:0005737
- HAMAP:   MF_00246
- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000530
- PRINTS:   PR00473
- PRINTS:   PR00959
- TIGRFAMs:   TIGR00131

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.6

Molecular weight: Translated: 41923; Mature: 41792

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00106 GALACTOKINASE; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPQQSAQRLFQEKFNCTPTLNVYAPGRVNIIGEHTDYNDGFVMPCAINYGTAISGRKRD
CCCHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCC
DSRFKVYAGDLQQWDEFDLAQEITPDSSKKWTGYVRGVVKFVQTHCPDFKCGADLVISGN
CCEEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECC
VPLSAGLSSSASLEVAVGKFCQQLGNLPLTNTEIALIGQKAENQFVGCQCGNMDQLISAL
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEECCCCCCHHHHHHHH
GQKDHLLMIDCRSLETIPTPIPANVAVMIVNSHVKHDLVAGEYNTRRQQCEVAAKFFGVK
CCCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHH
ALRDVSLAQFKQREAELTALDPEVAKRARHVVTENQRVLDAVKALQSGNLALLGELMAQS
HHHHHHHHHHHHHHCHHEECCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHH
HESMRDDFEITVPQIDYLVELAQIAIGKTGGARMTGGGFGGCIVAVAPVEKVEAVRQIIA
HHHHCCCCEEECCHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEECCHHHHHHHHHHHH
DNYAQQTGLKEDFYVCTASQGVSVC
HHHHHHCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
TPQQSAQRLFQEKFNCTPTLNVYAPGRVNIIGEHTDYNDGFVMPCAINYGTAISGRKRD
CCHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCC
DSRFKVYAGDLQQWDEFDLAQEITPDSSKKWTGYVRGVVKFVQTHCPDFKCGADLVISGN
CCEEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECC
VPLSAGLSSSASLEVAVGKFCQQLGNLPLTNTEIALIGQKAENQFVGCQCGNMDQLISAL
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEECCCCCCHHHHHHHH
GQKDHLLMIDCRSLETIPTPIPANVAVMIVNSHVKHDLVAGEYNTRRQQCEVAAKFFGVK
CCCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHH
ALRDVSLAQFKQREAELTALDPEVAKRARHVVTENQRVLDAVKALQSGNLALLGELMAQS
HHHHHHHHHHHHHHCHHEECCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHH
HESMRDDFEITVPQIDYLVELAQIAIGKTGGARMTGGGFGGCIVAVAPVEKVEAVRQIIA
HHHHCCCCEEECCHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEECCHHHHHHHHHHHH
DNYAQQTGLKEDFYVCTASQGVSVC
HHHHHHCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100