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The map label for this gene is ndk

Identifier: 15602893

GI number: 15602893

Start: 1210599

End: 1211018

Strand: Reverse

Name: ndk

Synonym: PM1028

Alternate gene names: 15602893

Gene position: 1211018-1210599 (Counterclockwise)

Preceding gene: 15602894

Following gene: 15602892

Centisome position: 53.64

GC content: 45.24

Gene sequence:

>420_bases
ATGGCAGTAGAAAGAACACTCTCATTGATTAAACCTGACGCGGTAAAACGACATTTAATTGGCGCTATTCTAAGCCGTTT
TGAACAAGCGGGGTTTCGCGTGGTGGCAGCGAAAATGTTACATCTGACACAAGCGCAAGCAGAAGGGTTTTACGCGGAGC
ATCAAGATAAAGCGTTTTTTCCTGAGCTTGTCGCGTATATGATCTCTGCACCGGTTTTAGCATTAGTGCTAGAAAAAGAA
AATGCGGTGAAAGATTATCGCACCTTAATTGGGGCAACGAACCCTGCCGTAGCCGCAGAGGGGACAATTCGTCGCGATTT
TGCGATTGATGGGCGACATAATTCAGTGCATGGGTCGGACAGTCTGGACAGTGCAAAACGCGAAATTGCTTATTTTTTCG
TGGAGAGTGAAATTTTTTAA

Upstream 100 bases:

>100_bases
TAAAACAGCAAGCGATTTATGGGCTGTGGGCGCAACGGGGATTGGTGTGCAAACGCTCGCCAACTTATTATTAAATCCAG
TCAAGGGATAAGGACCAGAT

Downstream 100 bases:

>100_bases
TCGTCTTTTCTTGCTTGTCTGAAAACGATTTCCCTTCGTGTGTTTTATCACGAAGGGAAATTTTTTTGCGATAAAGATTG
AATTTTCTCAATAAAAGCGT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 139; Mature: 138

Protein sequence:

>139_residues
MAVERTLSLIKPDAVKRHLIGAILSRFEQAGFRVVAAKMLHLTQAQAEGFYAEHQDKAFFPELVAYMISAPVLALVLEKE
NAVKDYRTLIGATNPAVAAEGTIRRDFAIDGRHNSVHGSDSLDSAKREIAYFFVESEIF

Sequences:

>Translated_139_residues
MAVERTLSLIKPDAVKRHLIGAILSRFEQAGFRVVAAKMLHLTQAQAEGFYAEHQDKAFFPELVAYMISAPVLALVLEKE
NAVKDYRTLIGATNPAVAAEGTIRRDFAIDGRHNSVHGSDSLDSAKREIAYFFVESEIF
>Mature_138_residues
AVERTLSLIKPDAVKRHLIGAILSRFEQAGFRVVAAKMLHLTQAQAEGFYAEHQDKAFFPELVAYMISAPVLALVLEKEN
AVKDYRTLIGATNPAVAAEGTIRRDFAIDGRHNSVHGSDSLDSAKREIAYFFVESEIF

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=48.5294117647059, Blast_Score=136, Evalue=6e-33,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=48.5294117647059, Blast_Score=136, Evalue=7e-33,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=48.5294117647059, Blast_Score=136, Evalue=7e-33,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=48.5294117647059, Blast_Score=136, Evalue=7e-33,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=48.5294117647059, Blast_Score=136, Evalue=7e-33,
Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=47.0588235294118, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=46.3235294117647, Blast_Score=130, Evalue=5e-31,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=46.3235294117647, Blast_Score=129, Evalue=7e-31,
Organism=Homo sapiens, GI4826862, Length=135, Percent_Identity=44.4444444444444, Blast_Score=123, Evalue=6e-29,
Organism=Homo sapiens, GI37574614, Length=136, Percent_Identity=37.5, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI7019465, Length=136, Percent_Identity=37.5, Blast_Score=102, Evalue=8e-23,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=38.6861313868613, Blast_Score=95, Evalue=2e-20,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=38.9705882352941, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=31.8518518518519, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=29.9270072992701, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788866, Length=138, Percent_Identity=58.695652173913, Blast_Score=169, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI17506807, Length=136, Percent_Identity=48.5294117647059, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=49.2647058823529, Blast_Score=141, Evalue=4e-35,
Organism=Drosophila melanogaster, GI45549037, Length=135, Percent_Identity=48.1481481481481, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI18860097, Length=140, Percent_Identity=36.4285714285714, Blast_Score=82, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_PASMU (Q9CM17)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245965.1
- ProteinModelPortal:   Q9CM17
- SMR:   Q9CM17
- GeneID:   1244375
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1028
- NMPDR:   fig|272843.1.peg.1028
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   PMUL272843:PM1028-MONOMER
- BRENDA:   2.7.4.6
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15408; Mature: 15277

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVERTLSLIKPDAVKRHLIGAILSRFEQAGFRVVAAKMLHLTQAQAEGFYAEHQDKAFF
CCHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHCCCCHHH
PELVAYMISAPVLALVLEKENAVKDYRTLIGATNPAVAAEGTIRRDFAIDGRHNSVHGSD
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCC
SLDSAKREIAYFFVESEIF
CHHHHHHHHHHHEEECCCC
>Mature Secondary Structure 
AVERTLSLIKPDAVKRHLIGAILSRFEQAGFRVVAAKMLHLTQAQAEGFYAEHQDKAFF
CHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHCCCCHHH
PELVAYMISAPVLALVLEKENAVKDYRTLIGATNPAVAAEGTIRRDFAIDGRHNSVHGSD
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCC
SLDSAKREIAYFFVESEIF
CHHHHHHHHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100