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The map label for this gene is pepB

Identifier: 15602894

GI number: 15602894

Start: 1211028

End: 1212332

Strand: Reverse

Name: pepB

Synonym: PM1029

Alternate gene names: 15602894

Gene position: 1212332-1211028 (Counterclockwise)

Preceding gene: 15602895

Following gene: 15602893

Centisome position: 53.7

GC content: 43.6

Gene sequence:

>1305_bases
ATGCCAATGCAAATTATGTTATCGACTCAAGTGGCAGATGAAGCTTGGGGAAAAAATGCACTATTAAGTTTTCATCAGGC
GCAAGCCACTATTCATGTTACTGACTATTCCGCGCGTAATACTGTACAAAAAGCAGCGCGTAAATTACGTGGTCAGGGGA
TTAAAGATGTGGTACTTGCTGGCGAAAATTGGGATTTAGAAACCTGCTGGGCATTTTATCAAGGTTTTTATAGCGCAAAA
CAAGATTATGCGGTGGAATTTCCAACTTTAGACGATGCACCGCAAGCGGAATTATTAGCACGCATTCAATGTGGTGATTT
TGTACGTGAAATGATTAATTTGCCCGCGGAAGTGATTACCCCTGTGGAATTGGCGCGCCGTGCAGCCCACTTTATCGAAG
AACAAGCAGAAGAATATGGGGATAAAAGTGCGGTCAGTTTTAACATTATTTCGGGCGAAGAATTAAAAGCACAGAATTAT
CAAGGTATTTGGAATGTGGGACGTGGTTCTGCTAACCCGCCAGCGATGTTGCAATTAGATTTCAACCCAACAGGCAATCC
TGATGCGCCGGTATTAGCCTGTTTAGTGGGGAAAGGCATTACTTTTGACAGTGGCGGTTATAGCATTAAACCAAGTGATA
ATATGAGCACGATGCGTACAGATATGGGCGGCGCGGCATTGTTAACAGGCTCATTAGGGTTAGCCATCGCCCGTGGTTTA
ACACAACGTGTGAAACTCTATTTATGCTGTGCAGAAAATCTGGTGAGCAGCAATGCGTTTAAATTGGGTGATATTATCAC
TTACAGCAACGGCGTGACTGCTGAAATTTTAAATACGGATGCGGAAGGGCGTTTGGTACTTGCAGATGGATTAATTGAAG
CCGATAAACAACAGCCAAAAATGATCATTGATTGTGCAACGTTAACTGGAGCTGCAAAAATGGCGGTAGGCAATGATTAC
CACTCAGTATTGTCTATGGATGATGCATTGGTAGCTGCGCTCTTTAAGTCTGCGGAAACCGAACAAGAACCTTTCTGGCG
TTTACCGTTTGCGGAATTACATCGTTCACAAATAAGCACGGCATTTGCCGATATTGCGAATACAGGGACGGTGCCAGTAG
GGGCGGGTGCAAGTACAGCCACAGCTTTTTTATCTTACTTTGTGAAAAATTATCAACAACATTGGTTACATATTGATTGT
TCAGCCACTTATCGTAAAACAGCAAGCGATTTATGGGCTGTGGGCGCAACGGGGATTGGTGTGCAAACGCTCGCCAACTT
ATTATTAAATCCAGTCAAGGGATAA

Upstream 100 bases:

>100_bases
AAAGATATTTTGTGGAAAAGGTACTAAAGTGCGGAAAAACTGGTATAGTGAATCGCACTTTATTTTTATTTAGATAATAC
AAAAAATAAAAGGATCGTTT

Downstream 100 bases:

>100_bases
GGACCAGATATGGCAGTAGAAAGAACACTCTCATTGATTAAACCTGACGCGGTAAAACGACATTTAATTGGCGCTATTCT
AAGCCGTTTTGAACAAGCGG

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MPMQIMLSTQVADEAWGKNALLSFHQAQATIHVTDYSARNTVQKAARKLRGQGIKDVVLAGENWDLETCWAFYQGFYSAK
QDYAVEFPTLDDAPQAELLARIQCGDFVREMINLPAEVITPVELARRAAHFIEEQAEEYGDKSAVSFNIISGEELKAQNY
QGIWNVGRGSANPPAMLQLDFNPTGNPDAPVLACLVGKGITFDSGGYSIKPSDNMSTMRTDMGGAALLTGSLGLAIARGL
TQRVKLYLCCAENLVSSNAFKLGDIITYSNGVTAEILNTDAEGRLVLADGLIEADKQQPKMIIDCATLTGAAKMAVGNDY
HSVLSMDDALVAALFKSAETEQEPFWRLPFAELHRSQISTAFADIANTGTVPVGAGASTATAFLSYFVKNYQQHWLHIDC
SATYRKTASDLWAVGATGIGVQTLANLLLNPVKG

Sequences:

>Translated_434_residues
MPMQIMLSTQVADEAWGKNALLSFHQAQATIHVTDYSARNTVQKAARKLRGQGIKDVVLAGENWDLETCWAFYQGFYSAK
QDYAVEFPTLDDAPQAELLARIQCGDFVREMINLPAEVITPVELARRAAHFIEEQAEEYGDKSAVSFNIISGEELKAQNY
QGIWNVGRGSANPPAMLQLDFNPTGNPDAPVLACLVGKGITFDSGGYSIKPSDNMSTMRTDMGGAALLTGSLGLAIARGL
TQRVKLYLCCAENLVSSNAFKLGDIITYSNGVTAEILNTDAEGRLVLADGLIEADKQQPKMIIDCATLTGAAKMAVGNDY
HSVLSMDDALVAALFKSAETEQEPFWRLPFAELHRSQISTAFADIANTGTVPVGAGASTATAFLSYFVKNYQQHWLHIDC
SATYRKTASDLWAVGATGIGVQTLANLLLNPVKG
>Mature_433_residues
PMQIMLSTQVADEAWGKNALLSFHQAQATIHVTDYSARNTVQKAARKLRGQGIKDVVLAGENWDLETCWAFYQGFYSAKQ
DYAVEFPTLDDAPQAELLARIQCGDFVREMINLPAEVITPVELARRAAHFIEEQAEEYGDKSAVSFNIISGEELKAQNYQ
GIWNVGRGSANPPAMLQLDFNPTGNPDAPVLACLVGKGITFDSGGYSIKPSDNMSTMRTDMGGAALLTGSLGLAIARGLT
QRVKLYLCCAENLVSSNAFKLGDIITYSNGVTAEILNTDAEGRLVLADGLIEADKQQPKMIIDCATLTGAAKMAVGNDYH
SVLSMDDALVAALFKSAETEQEPFWRLPFAELHRSQISTAFADIANTGTVPVGAGASTATAFLSYFVKNYQQHWLHIDCS
ATYRKTASDLWAVGATGIGVQTLANLLLNPVKG

Specific function: Probably plays an important role in intracellular peptide degradation

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=326, Percent_Identity=35.8895705521472, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI47155554, Length=354, Percent_Identity=33.8983050847458, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI87082123, Length=426, Percent_Identity=57.981220657277, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1790710, Length=305, Percent_Identity=37.7049180327869, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=302, Percent_Identity=32.4503311258278, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17565172, Length=128, Percent_Identity=32.8125, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221379063, Length=304, Percent_Identity=36.8421052631579, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI221379062, Length=304, Percent_Identity=36.8421052631579, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI21357381, Length=304, Percent_Identity=36.8421052631579, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI21355725, Length=295, Percent_Identity=28.4745762711864, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24661038, Length=295, Percent_Identity=27.7966101694915, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI20129969, Length=374, Percent_Identity=26.4705882352941, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI161077148, Length=307, Percent_Identity=28.6644951140065, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI20130057, Length=307, Percent_Identity=28.6644951140065, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24662227, Length=329, Percent_Identity=26.7477203647416, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI20129963, Length=375, Percent_Identity=25.6, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21355645, Length=300, Percent_Identity=24.3333333333333, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24662223, Length=300, Percent_Identity=24.3333333333333, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19922386, Length=300, Percent_Identity=26.6666666666667, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24646701, Length=245, Percent_Identity=27.7551020408163, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646703, Length=245, Percent_Identity=27.7551020408163, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21358201, Length=245, Percent_Identity=27.7551020408163, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PEPB_PASMU (Q9CM16)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245966.1
- ProteinModelPortal:   Q9CM16
- SMR:   Q9CM16
- MEROPS:   M17.004
- GeneID:   1244376
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1029
- NMPDR:   fig|272843.1.peg.1029
- HOGENOM:   HBG742580
- OMA:   NDDILRM
- ProtClustDB:   PRK05015
- BioCyc:   PMUL272843:PM1029-MONOMER
- BRENDA:   3.4.11.23
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00504
- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819
- PANTHER:   PTHR11963:SF3
- PIRSF:   PIRSF036388
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17

EC number: =3.4.11.23

Molecular weight: Translated: 46878; Mature: 46746

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 210-210 ACT_SITE 284-284

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMQIMLSTQVADEAWGKNALLSFHQAQATIHVTDYSARNTVQKAARKLRGQGIKDVVLA
CCEEEEEECHHHHHHCCCHHHHEEEECCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEE
GENWDLETCWAFYQGFYSAKQDYAVEFPTLDDAPQAELLARIQCGDFVREMINLPAEVIT
CCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCC
PVELARRAAHFIEEQAEEYGDKSAVSFNIISGEELKAQNYQGIWNVGRGSANPPAMLQLD
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHCCCCCCCCEECCCCCCCCCEEEEEE
FNPTGNPDAPVLACLVGKGITFDSGGYSIKPSDNMSTMRTDMGGAALLTGSLGLAIARGL
CCCCCCCCHHHHHHHHCCCCEECCCCCEECCCCCHHHHHHCCCCCEEEHHHHHHHHHHHH
TQRVKLYLCCAENLVSSNAFKLGDIITYSNGVTAEILNTDAEGRLVLADGLIEADKQQPK
HHHHHEEEEEHHHHHCCCCEEECCEEEECCCCEEEEECCCCCCEEEEECCCHHCCCCCCC
MIIDCATLTGAAKMAVGNDYHSVLSMDDALVAALFKSAETEQEPFWRLPFAELHRSQIST
EEEEEEHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHH
AFADIANTGTVPVGAGASTATAFLSYFVKNYQQHWLHIDCSATYRKTASDLWAVGATGIG
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHCCCCCCC
VQTLANLLLNPVKG
HHHHHHHHHCCCCC
>Mature Secondary Structure 
PMQIMLSTQVADEAWGKNALLSFHQAQATIHVTDYSARNTVQKAARKLRGQGIKDVVLA
CEEEEEECHHHHHHCCCHHHHEEEECCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEE
GENWDLETCWAFYQGFYSAKQDYAVEFPTLDDAPQAELLARIQCGDFVREMINLPAEVIT
CCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCC
PVELARRAAHFIEEQAEEYGDKSAVSFNIISGEELKAQNYQGIWNVGRGSANPPAMLQLD
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHCCCCCCCCEECCCCCCCCCEEEEEE
FNPTGNPDAPVLACLVGKGITFDSGGYSIKPSDNMSTMRTDMGGAALLTGSLGLAIARGL
CCCCCCCCHHHHHHHHCCCCEECCCCCEECCCCCHHHHHHCCCCCEEEHHHHHHHHHHHH
TQRVKLYLCCAENLVSSNAFKLGDIITYSNGVTAEILNTDAEGRLVLADGLIEADKQQPK
HHHHHEEEEEHHHHHCCCCEEECCEEEECCCCEEEEECCCCCCEEEEECCCHHCCCCCCC
MIIDCATLTGAAKMAVGNDYHSVLSMDDALVAALFKSAETEQEPFWRLPFAELHRSQIST
EEEEEEHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHH
AFADIANTGTVPVGAGASTATAFLSYFVKNYQQHWLHIDCSATYRKTASDLWAVGATGIG
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHCCCCCCC
VQTLANLLLNPVKG
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100