Click here to switch to the map view.

The map label for this gene is gcvA [H]

Identifier: 15602432

GI number: 15602432

Start: 652303

End: 653184

Strand: Direct

Name: gcvA [H]

Synonym: PM0567

Alternate gene names: 15602432

Gene position: 652303-653184 (Clockwise)

Preceding gene: 15602430

Following gene: 15602433

Centisome position: 28.9

GC content: 36.28

Gene sequence:

>882_bases
ATGTATAAACGTTTGCCTCCCTTGAATTCATTGAAAGCATTTGAATCCGCTGCTAGGCATTTAAGTTTCACAAAAGCTGC
AGAAGAATTATTTGTGACACAAGCAGCAATCAGCCATCAAATAAAATTATTAGAAGATTTTTTAGGCATAACCTTATTCA
AACGTAAAAATCGATCGCTGGAATTAACCGAATTAGGCAAAGCTTACTTCACGGATGTGAATAAAATTTTACGGCGATTG
GTAGAAGCAACAGAGAAATTATTAGCCCAGAAAAATGATAAGCACTTAACGATTAGTGTCCCGCAGACCTTTGGTATGCA
ATGGTTAGTACCACATTTAAGTGAGTTTAATCAACGCTATCCGGAGATTGAAGTACGCTTAAAAGGGGTAGATCAGGATG
AAGGGGTTTTAAATAAAGATATTGATATTGCTATTTATTATGGGCAAGGAAACTGGGATAATCTGCAGGTTGAAAAGTTA
GTGGAAGAAAATCTTCTTATTCTCGCTTCACCAAAACTCTTAGCGCACAATCCTATTCACAGCAAAGAAGATTTGAAACA
TCATACCCTGATTCATATCCATACCCGTGATAATTGGCAGAACATGGCAAATTTTTTACAGTTAGAAGATTTAAATATTC
AGCAAGGTCCCTTGTTTAGTCATACTTTTATGGCATTGCAAGCCGCAATTCATGGTCAGGGGTTGGTTTTGGCGAATCGT
TTGTTAGCCCAACAGGAAATTGATCATGGTCACTTACAAATTGTGTTACCGACCAATTTACATGATCCTAAATCTTTTTA
TGTGGTGAATCATTTTGATGTAAATGATGAACGTATCCAAGCATTTCGCGCTTGGATCATTGAAACAATGAAACAAAAAT
AA

Upstream 100 bases:

>100_bases
GAGAGTGGACAATCGATATTTTTTTATATGAAGCATTAGAAAAACTAATGCGAAGAAACACGCTATATTATAGATCAAAA
AGTAAACATTGAGAAGAAAT

Downstream 100 bases:

>100_bases
TGAATAAATTAGCATTATATTGCCGTCCTGGCTTTGAAAAAGAACTTGCCGCTGAAATCAGTGAAAAAGCGGCTGAACTG
GGCATATTTGGTTTTGCCAG

Product: DNA-binding transcriptional activator GcvA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MYKRLPPLNSLKAFESAARHLSFTKAAEELFVTQAAISHQIKLLEDFLGITLFKRKNRSLELTELGKAYFTDVNKILRRL
VEATEKLLAQKNDKHLTISVPQTFGMQWLVPHLSEFNQRYPEIEVRLKGVDQDEGVLNKDIDIAIYYGQGNWDNLQVEKL
VEENLLILASPKLLAHNPIHSKEDLKHHTLIHIHTRDNWQNMANFLQLEDLNIQQGPLFSHTFMALQAAIHGQGLVLANR
LLAQQEIDHGHLQIVLPTNLHDPKSFYVVNHFDVNDERIQAFRAWIIETMKQK

Sequences:

>Translated_293_residues
MYKRLPPLNSLKAFESAARHLSFTKAAEELFVTQAAISHQIKLLEDFLGITLFKRKNRSLELTELGKAYFTDVNKILRRL
VEATEKLLAQKNDKHLTISVPQTFGMQWLVPHLSEFNQRYPEIEVRLKGVDQDEGVLNKDIDIAIYYGQGNWDNLQVEKL
VEENLLILASPKLLAHNPIHSKEDLKHHTLIHIHTRDNWQNMANFLQLEDLNIQQGPLFSHTFMALQAAIHGQGLVLANR
LLAQQEIDHGHLQIVLPTNLHDPKSFYVVNHFDVNDERIQAFRAWIIETMKQK
>Mature_293_residues
MYKRLPPLNSLKAFESAARHLSFTKAAEELFVTQAAISHQIKLLEDFLGITLFKRKNRSLELTELGKAYFTDVNKILRRL
VEATEKLLAQKNDKHLTISVPQTFGMQWLVPHLSEFNQRYPEIEVRLKGVDQDEGVLNKDIDIAIYYGQGNWDNLQVEKL
VEENLLILASPKLLAHNPIHSKEDLKHHTLIHIHTRDNWQNMANFLQLEDLNIQQGPLFSHTFMALQAAIHGQGLVLANR
LLAQQEIDHGHLQIVLPTNLHDPKSFYVVNHFDVNDERIQAFRAWIIETMKQK

Specific function: Not known, the gcv operon regulated by the E.coli homolog does not exist in H.influenzae, so it probably acts as a transcriptional regulator on some other operon [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789173, Length=292, Percent_Identity=54.7945205479452, Blast_Score=313, Evalue=6e-87,
Organism=Escherichia coli, GI1786448, Length=288, Percent_Identity=29.8611111111111, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1788706, Length=295, Percent_Identity=29.4915254237288, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786401, Length=294, Percent_Identity=27.5510204081633, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI87081978, Length=273, Percent_Identity=30.4029304029304, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI157672245, Length=162, Percent_Identity=31.4814814814815, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789639, Length=269, Percent_Identity=25.2788104089219, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI145693193, Length=298, Percent_Identity=25.503355704698, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787128, Length=261, Percent_Identity=25.6704980842912, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789440, Length=245, Percent_Identity=26.1224489795918, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788748, Length=172, Percent_Identity=26.7441860465116, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI87082132, Length=159, Percent_Identity=27.6729559748428, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786508, Length=68, Percent_Identity=50, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787601, Length=278, Percent_Identity=23.7410071942446, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790262, Length=188, Percent_Identity=28.7234042553192, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788887, Length=144, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790011, Length=255, Percent_Identity=24.3137254901961, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788481, Length=256, Percent_Identity=25, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI145693105, Length=166, Percent_Identity=28.9156626506024, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33882; Mature: 33882

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKRLPPLNSLKAFESAARHLSFTKAAEELFVTQAAISHQIKLLEDFLGITLFKRKNRSL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCE
ELTELGKAYFTDVNKILRRLVEATEKLLAQKNDKHLTISVPQTFGMQWLVPHLSEFNQRY
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHCCHHHHHHHHHHHHHCC
PEIEVRLKGVDQDEGVLNKDIDIAIYYGQGNWDNLQVEKLVEENLLILASPKLLAHNPIH
CEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCEEEEECCCHHCCCCCC
SKEDLKHHTLIHIHTRDNWQNMANFLQLEDLNIQQGPLFSHTFMALQAAIHGQGLVLANR
CHHCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHH
LLAQQEIDHGHLQIVLPTNLHDPKSFYVVNHFDVNDERIQAFRAWIIETMKQK
HHHHHCCCCCEEEEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYKRLPPLNSLKAFESAARHLSFTKAAEELFVTQAAISHQIKLLEDFLGITLFKRKNRSL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCE
ELTELGKAYFTDVNKILRRLVEATEKLLAQKNDKHLTISVPQTFGMQWLVPHLSEFNQRY
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHCCHHHHHHHHHHHHHCC
PEIEVRLKGVDQDEGVLNKDIDIAIYYGQGNWDNLQVEKLVEENLLILASPKLLAHNPIH
CEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCEEEEECCCHHCCCCCC
SKEDLKHHTLIHIHTRDNWQNMANFLQLEDLNIQQGPLFSHTFMALQAAIHGQGLVLANR
CHHCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHH
LLAQQEIDHGHLQIVLPTNLHDPKSFYVVNHFDVNDERIQAFRAWIIETMKQK
HHHHHCCCCCEEEEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]