Click here to switch to the map view.

The map label for this gene is fdxH [H]

Identifier: 15602272

GI number: 15602272

Start: 475349

End: 476257

Strand: Reverse

Name: fdxH [H]

Synonym: PM0407

Alternate gene names: 15602272

Gene position: 476257-475349 (Counterclockwise)

Preceding gene: 15602273

Following gene: 15602271

Centisome position: 21.1

GC content: 45.87

Gene sequence:

>909_bases
ATGGGTGTAGTACAATCTCAAAACATTATTAAAGCCTCTGCAACATCAAGCTTAACGCCACCACCACAAGCGCGTGAGCA
TCAAGTTGAAGTGGCAAAACTGATCGATGTCACCACCTGTATCGGCTGTAAAGCCTGTCAGGTGGGGTGTTCAGAGTGGA
ACGATATCCGTGCTGAGCCTGAAGCCTGTGTCGGTGTTTACGATAATCCGACCGATTTAAATGCCAAAGCTTGGACGGTG
ATGAAATTCAACGAAGTGGAAGAAAACGACCGCTTAGAATGGCTAATCCGTAAAGATGGTTGTATGCATTGTGCCGAACC
GGGTTGTTTAAAATCCTGTCCAGCACCAGGTGCCATTATCCAGTATGCGAATGGTATTGTGGATTTCCAATCGGATAAAT
GTATCGGCTGTGGCTATTGCATTGCGGGTTGTCCATTTAACGTACCACGCATGAATCCAGACGATAATCGTGTCTATAAA
TGTACACTTTGTGTGGACCGTGTCACCGTGGGTCAAGAACCCGCTTGTGTGAAAACCTGCCCAACCGGTGCGATTCGTTT
TGGTAGCAAAGAAGAGATGAAAATTTATGCAGAGCAACGCATTGCTGACTTAAAATCTCGTGGCTATGAAAACGCTGGAC
TTTACGATCCGGAAGGTGTGGGTGGCACACACGTCATGTATGTGTTACATCATGCAGATAAACCGGAACTTTATTCTGGT
CTGCCGAAAGATCCATCAATTGATCTCAGCATCAAAGTTTGGAAAGATGTGTTAAAACCAGTGGCAGCGGTTGCAATGGG
CGGTATTATCCTCAGTGAAATTGCTCACTACATCACCATCGGTCCAAATACCGAAGAATTCGATGAACACGAGGAGCACG
AAGAGCATACAGGAGGCAATCATGAGTAA

Upstream 100 bases:

>100_bases
TTCTTCGCCAACAACTTAACTGTTCGTACTGGTGATGCGAATACACAAACACCAGAATCTAAATGTATGTTAGTCAATAT
TGAGAAAGTGGGGGCGTAAA

Downstream 100 bases:

>100_bases
GATTCAGATCAGTAACGATCGTAAAATCGTACGCCATAAATTGCCAGCTCGCCTTAGCCATTGGTTACTGGTTATCTGTT
TCTTTATTACCGGTTTATCG

Product: FdxH

Products: CO2; NADH

Alternate protein names: Formate dehydrogenase subunit beta; FDH subunit beta [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MGVVQSQNIIKASATSSLTPPPQAREHQVEVAKLIDVTTCIGCKACQVGCSEWNDIRAEPEACVGVYDNPTDLNAKAWTV
MKFNEVEENDRLEWLIRKDGCMHCAEPGCLKSCPAPGAIIQYANGIVDFQSDKCIGCGYCIAGCPFNVPRMNPDDNRVYK
CTLCVDRVTVGQEPACVKTCPTGAIRFGSKEEMKIYAEQRIADLKSRGYENAGLYDPEGVGGTHVMYVLHHADKPELYSG
LPKDPSIDLSIKVWKDVLKPVAAVAMGGIILSEIAHYITIGPNTEEFDEHEEHEEHTGGNHE

Sequences:

>Translated_302_residues
MGVVQSQNIIKASATSSLTPPPQAREHQVEVAKLIDVTTCIGCKACQVGCSEWNDIRAEPEACVGVYDNPTDLNAKAWTV
MKFNEVEENDRLEWLIRKDGCMHCAEPGCLKSCPAPGAIIQYANGIVDFQSDKCIGCGYCIAGCPFNVPRMNPDDNRVYK
CTLCVDRVTVGQEPACVKTCPTGAIRFGSKEEMKIYAEQRIADLKSRGYENAGLYDPEGVGGTHVMYVLHHADKPELYSG
LPKDPSIDLSIKVWKDVLKPVAAVAMGGIILSEIAHYITIGPNTEEFDEHEEHEEHTGGNHE
>Mature_301_residues
GVVQSQNIIKASATSSLTPPPQAREHQVEVAKLIDVTTCIGCKACQVGCSEWNDIRAEPEACVGVYDNPTDLNAKAWTVM
KFNEVEENDRLEWLIRKDGCMHCAEPGCLKSCPAPGAIIQYANGIVDFQSDKCIGCGYCIAGCPFNVPRMNPDDNRVYKC
TLCVDRVTVGQEPACVKTCPTGAIRFGSKEEMKIYAEQRIADLKSRGYENAGLYDPEGVGGTHVMYVLHHADKPELYSGL
PKDPSIDLSIKVWKDVLKPVAAVAMGGIILSEIAHYITIGPNTEEFDEHEEHEEHTGGNHE

Specific function: Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron- sulfur centers. Electrons are transferred from the gamma chain to the m

COG id: COG0437

COG function: function code C; Fe-S-cluster-containing hydrogenase components 1

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Escherichia coli, GI1787749, Length=292, Percent_Identity=72.2602739726027, Blast_Score=460, Evalue=1e-131,
Organism=Escherichia coli, GI1790326, Length=291, Percent_Identity=71.8213058419244, Blast_Score=459, Evalue=1e-131,
Organism=Escherichia coli, GI1789370, Length=185, Percent_Identity=32.972972972973, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1787872, Length=161, Percent_Identity=32.2981366459627, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787122, Length=161, Percent_Identity=32.2981366459627, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI2367345, Length=158, Percent_Identity=32.2784810126582, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI226510944, Length=190, Percent_Identity=28.4210526315789, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082179, Length=172, Percent_Identity=30.2325581395349, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787478, Length=100, Percent_Identity=36, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1787740, Length=100, Percent_Identity=36, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1787963, Length=148, Percent_Identity=25, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR006470
- InterPro:   IPR014603
- InterPro:   IPR015246 [H]

Pfam domain/function: PF09163 Form-deh_trans [H]

EC number: 1.2.1.2

Molecular weight: Translated: 33086; Mature: 32955

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
5.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVVQSQNIIKASATSSLTPPPQAREHQVEVAKLIDVTTCIGCKACQVGCSEWNDIRAEP
CCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCC
EACVGVYDNPTDLNAKAWTVMKFNEVEENDRLEWLIRKDGCMHCAEPGCLKSCPAPGAII
CCEEECCCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCHHCCCCCCHHH
QYANGIVDFQSDKCIGCGYCIAGCPFNVPRMNPDDNRVYKCTLCVDRVTVGQEPACVKTC
HHHCCEEEECCCCEEECCCEECCCCCCCCCCCCCCCCEEEEEEEEEEHCCCCCCCEEEEC
PTGAIRFGSKEEMKIYAEQRIADLKSRGYENAGLYDPEGVGGTHVMYVLHHADKPELYSG
CCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHCC
LPKDPSIDLSIKVWKDVLKPVAAVAMGGIILSEIAHYITIGPNTEEFDEHEEHEEHTGGN
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHCCCCC
HE
CC
>Mature Secondary Structure 
GVVQSQNIIKASATSSLTPPPQAREHQVEVAKLIDVTTCIGCKACQVGCSEWNDIRAEP
CCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCC
EACVGVYDNPTDLNAKAWTVMKFNEVEENDRLEWLIRKDGCMHCAEPGCLKSCPAPGAII
CCEEECCCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCHHCCCCCCHHH
QYANGIVDFQSDKCIGCGYCIAGCPFNVPRMNPDDNRVYKCTLCVDRVTVGQEPACVKTC
HHHCCEEEECCCCEEECCCEECCCCCCCCCCCCCCCCEEEEEEEEEEHCCCCCCCEEEEC
PTGAIRFGSKEEMKIYAEQRIADLKSRGYENAGLYDPEGVGGTHVMYVLHHADKPELYSG
CCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHCC
LPKDPSIDLSIKVWKDVLKPVAAVAMGGIILSEIAHYITIGPNTEEFDEHEEHEEHTGGN
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHCCCCC
HE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formate; NAD+

Specific reaction: formate + NAD+ = CO2 + NADH

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]