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The map label for this gene is thrA [H]

Identifier: 15601978

GI number: 15601978

Start: 137444

End: 139891

Strand: Direct

Name: thrA [H]

Synonym: PM0113

Alternate gene names: 15601978

Gene position: 137444-139891 (Clockwise)

Preceding gene: 15601972

Following gene: 15601979

Centisome position: 6.09

GC content: 42.57

Gene sequence:

>2448_bases
ATGCGTGTACTAAAATTCGGGGGGACGTCTTTAGCCAATCCAGAGCGTTTTTCGCAGGCGGCACAGCTTATCGAAAAAGC
CCATTTTGAAGAACAAGCCGCTGGCGTGTTATCAGCCCCTGCAAAAATTACCAACCATCTTGTCGCCCTTTCTGAAAAAG
CCAGTTTAAATCAACCTACCGATGCCAATTTCAATGAAGCTATTGAGATTTTTTATCACATTATTCATGGTTTACACGCA
GAAAATAATCGTTTTGATCTAGAAGGGACAAAAGCTTTAATTGATACCGAGTTTGCACAAATCAGCCAGTTGTTGGAAGA
AATTCGTCAACAAGGTTTTGTGTCGGATGCGGTTAAAGCCACGATTGATTGTCGTGGTGAAAAACTGTCTATTGCGATGA
TGAAGGCATGGTTTGAAGCTCGCGGTTATGACGTGACTGTGATTGATCCAGTCGAAAAATTATTAGCACACGGGAGCTAT
TTAGAGTCTTCAGTGGATATTGAAGAATCGACAAAACGCGTAGATGCCAAGTCAATTCCAACCAAAAATGTAGTGTTAAT
GGCAGGCTTTACCGCAGGTAATGAAAAAGGTGAGCTCGTTTTACTCGGGCGTAATGGTTCCGATTATTCTGCTGCTTGTT
TAGCCGCTTGTTTGGGCGCAAGTGCTTGTGAAATTTGGACCGATGTAGATGGGGTCTTTACCTGTGATCCGCGTTTGGTA
CCAGATGCTCGCTTATTGCCAAGCTTGTCTTATCGCGAAGCGATGGAATTGTCTTATTTCGGTGCAAAAGTGATTCATCC
ACGCACGATTGGACCATTAGTACAAACTAATATTCCTTGCTTAATTAAAAATACGGGCAATCCTTCTGCACCGGGTTCGA
TTATTGATGGCAACATTCAATCTGAACAGTTGCAAGTAAAAGGGATTACTAATTTAGATAATGTGGCGATGTTTAACGTG
TCTGGTCCTGGGATGCAGGGGATGGTGGGCATGGCGTCACGTGTTTTCTCTGCCATGTCAAATGCAGGCGTTTCGGTGAT
TTTAATTACGCAATCTTCCTCGGAATACAGTATCAGTTTCTGTGTACCAGCCAAATCAGTTGAGGTAGCAAAACAGGCGT
TAGAGAAAGAATTTGAGCAAGAATTAAAAGCTAATGATCTTGAACCAATTGATGTAATTCGTGACTTATCCATTATTTCG
GTAGTGGGTGATGGCATGAAACAAGCCAAAGGGATTGCCGCACGTTTCTTCTCAGCCCTTGCCCAAGCGAACATCAGTAT
TGTTGCTATTGCACAGGGTTCCTCTGAGCGTTCAATTTCTGCCGTGGTTGCACTGAATAAAGCAATTGAAGCCGTGAAAG
CCACACACCAAGCTCTCTTTAATAATAAAAAGGTCGTTGATGTTTTTTTAGTTGGGGTAGGGGGTGTCGGTGGCGAGTTG
ATTGAGCAAATTAAACATCAGAAAAGTTATCTAGCCAAGAAAGATATTGAAATTCGGGTGTGTGCGATTGCCAATTCAAA
CAAAATGTTATTAAAAGCAGATGGCTTAAATTTAGAAAATTGGCAAGCAGATTTGGAAACCGCGACTCAACCTTCTGATT
TTGATGTGTTACTGTCCTTTATTAAATTGCACCATGTCGTGAATCCGGTATTTGTGGATTGTACGTCAGCGGATTCTGTA
GCTGGTTTATATGTGCGTGCACTGGGAGAAGGGTTCCATGTTGTGACACCAAATAAAAAAGCCAATACGCGTGAACTGGC
GTATTATAATGCACTGCGTGAAAGTGCCCGTAATAACCAACGTAAATTCTTGTATGATACAAACGTTGGCGCAGGGTTAC
CCGTCATTGAAAACTTGCAGAATTTATTGGCTGCGGGTGATGAAGTCGTCAAGTTTAGTGGCGTACTCTCGGGGTCGTTG
TCCTTTATCTTTGGCGAGTTAGAAAACGGACTCACGTTATCTGAAGCGACTGCTCTTGCGCGTGAAAAAGGGTTTACTGA
ACCTGATCCAAGAGATGATCTTTCTGGACAAGATGTTGCCAGGAAACTGTTGATTTTAGCGCGTGAAACCGGTGCACAAT
TGGAATTAACAGATATTGAGGTAGAAAGTGTGCTCCCAGCGGGATTTGCTGAAGGGAAGACCACACAGGAATTTATGGCG
ATGTTACCACAATTAGACGCAGAATTTAGCCAACGTGTTGCTAACGCGAAAGCAGAAGGGAAAGTATTGCGTTATGTGGG
ACAAATTGAAAACAACAGTTGTAAAGTCTCTGTGTTGGAAGTCGATGCAGATGATCCATTATATAAAGTAAAAAATGGTG
AAAATGCGTTAGCCTTCTATACTCGTTATTATCAACCGATTCCGTTACTTTTACGTGGTTATGGCGCGGGAAATTCCGTA
ACTGCAGCGGGGATTTTTGCCGATATATTGAGAACGCTACAACATTAA

Upstream 100 bases:

>100_bases
GATCGAATTCCACAAAACCCGTACTGAATAAAAAGTGCGGGTTTTTTTATGAAAATTTTTATTCTATTTTTAAAATTCAC
AACATCGAGGAGATTTTATT

Downstream 100 bases:

>100_bases
TTGGAAATGACATGGAAAATAATATGCTCAGAATTTATGCACCAGCATCCAGTGCAAATTTAAGTGTTGGGTTTGATACC
TTGGGGACCGCGGTGTCCCC

Product: bifunctional aspartokinase I/homeserine dehydrogenase I

Products: NA

Alternate protein names: AK-HD; Aspartokinase; Homoserine dehydrogenase [H]

Number of amino acids: Translated: 815; Mature: 815

Protein sequence:

>815_residues
MRVLKFGGTSLANPERFSQAAQLIEKAHFEEQAAGVLSAPAKITNHLVALSEKASLNQPTDANFNEAIEIFYHIIHGLHA
ENNRFDLEGTKALIDTEFAQISQLLEEIRQQGFVSDAVKATIDCRGEKLSIAMMKAWFEARGYDVTVIDPVEKLLAHGSY
LESSVDIEESTKRVDAKSIPTKNVVLMAGFTAGNEKGELVLLGRNGSDYSAACLAACLGASACEIWTDVDGVFTCDPRLV
PDARLLPSLSYREAMELSYFGAKVIHPRTIGPLVQTNIPCLIKNTGNPSAPGSIIDGNIQSEQLQVKGITNLDNVAMFNV
SGPGMQGMVGMASRVFSAMSNAGVSVILITQSSSEYSISFCVPAKSVEVAKQALEKEFEQELKANDLEPIDVIRDLSIIS
VVGDGMKQAKGIAARFFSALAQANISIVAIAQGSSERSISAVVALNKAIEAVKATHQALFNNKKVVDVFLVGVGGVGGEL
IEQIKHQKSYLAKKDIEIRVCAIANSNKMLLKADGLNLENWQADLETATQPSDFDVLLSFIKLHHVVNPVFVDCTSADSV
AGLYVRALGEGFHVVTPNKKANTRELAYYNALRESARNNQRKFLYDTNVGAGLPVIENLQNLLAAGDEVVKFSGVLSGSL
SFIFGELENGLTLSEATALAREKGFTEPDPRDDLSGQDVARKLLILARETGAQLELTDIEVESVLPAGFAEGKTTQEFMA
MLPQLDAEFSQRVANAKAEGKVLRYVGQIENNSCKVSVLEVDADDPLYKVKNGENALAFYTRYYQPIPLLLRGYGAGNSV
TAAGIFADILRTLQH

Sequences:

>Translated_815_residues
MRVLKFGGTSLANPERFSQAAQLIEKAHFEEQAAGVLSAPAKITNHLVALSEKASLNQPTDANFNEAIEIFYHIIHGLHA
ENNRFDLEGTKALIDTEFAQISQLLEEIRQQGFVSDAVKATIDCRGEKLSIAMMKAWFEARGYDVTVIDPVEKLLAHGSY
LESSVDIEESTKRVDAKSIPTKNVVLMAGFTAGNEKGELVLLGRNGSDYSAACLAACLGASACEIWTDVDGVFTCDPRLV
PDARLLPSLSYREAMELSYFGAKVIHPRTIGPLVQTNIPCLIKNTGNPSAPGSIIDGNIQSEQLQVKGITNLDNVAMFNV
SGPGMQGMVGMASRVFSAMSNAGVSVILITQSSSEYSISFCVPAKSVEVAKQALEKEFEQELKANDLEPIDVIRDLSIIS
VVGDGMKQAKGIAARFFSALAQANISIVAIAQGSSERSISAVVALNKAIEAVKATHQALFNNKKVVDVFLVGVGGVGGEL
IEQIKHQKSYLAKKDIEIRVCAIANSNKMLLKADGLNLENWQADLETATQPSDFDVLLSFIKLHHVVNPVFVDCTSADSV
AGLYVRALGEGFHVVTPNKKANTRELAYYNALRESARNNQRKFLYDTNVGAGLPVIENLQNLLAAGDEVVKFSGVLSGSL
SFIFGELENGLTLSEATALAREKGFTEPDPRDDLSGQDVARKLLILARETGAQLELTDIEVESVLPAGFAEGKTTQEFMA
MLPQLDAEFSQRVANAKAEGKVLRYVGQIENNSCKVSVLEVDADDPLYKVKNGENALAFYTRYYQPIPLLLRGYGAGNSV
TAAGIFADILRTLQH
>Mature_815_residues
MRVLKFGGTSLANPERFSQAAQLIEKAHFEEQAAGVLSAPAKITNHLVALSEKASLNQPTDANFNEAIEIFYHIIHGLHA
ENNRFDLEGTKALIDTEFAQISQLLEEIRQQGFVSDAVKATIDCRGEKLSIAMMKAWFEARGYDVTVIDPVEKLLAHGSY
LESSVDIEESTKRVDAKSIPTKNVVLMAGFTAGNEKGELVLLGRNGSDYSAACLAACLGASACEIWTDVDGVFTCDPRLV
PDARLLPSLSYREAMELSYFGAKVIHPRTIGPLVQTNIPCLIKNTGNPSAPGSIIDGNIQSEQLQVKGITNLDNVAMFNV
SGPGMQGMVGMASRVFSAMSNAGVSVILITQSSSEYSISFCVPAKSVEVAKQALEKEFEQELKANDLEPIDVIRDLSIIS
VVGDGMKQAKGIAARFFSALAQANISIVAIAQGSSERSISAVVALNKAIEAVKATHQALFNNKKVVDVFLVGVGGVGGEL
IEQIKHQKSYLAKKDIEIRVCAIANSNKMLLKADGLNLENWQADLETATQPSDFDVLLSFIKLHHVVNPVFVDCTSADSV
AGLYVRALGEGFHVVTPNKKANTRELAYYNALRESARNNQRKFLYDTNVGAGLPVIENLQNLLAAGDEVVKFSGVLSGSL
SFIFGELENGLTLSEATALAREKGFTEPDPRDDLSGQDVARKLLILARETGAQLELTDIEVESVLPAGFAEGKTTQEFMA
MLPQLDAEFSQRVANAKAEGKVLRYVGQIENNSCKVSVLEVDADDPLYKVKNGENALAFYTRYYQPIPLLLRGYGAGNSV
TAAGIFADILRTLQH

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=814, Percent_Identity=64.004914004914, Blast_Score=1035, Evalue=0.0,
Organism=Escherichia coli, GI1790376, Length=815, Percent_Identity=29.9386503067485, Blast_Score=332, Evalue=7e-92,
Organism=Escherichia coli, GI1790455, Length=467, Percent_Identity=28.051391862955, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322599, Length=338, Percent_Identity=34.9112426035503, Blast_Score=184, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6320893, Length=515, Percent_Identity=29.7087378640777, Blast_Score=157, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005106
- InterPro:   IPR001341
- InterPro:   IPR018042
- InterPro:   IPR011147
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =2.7.2.4; =1.1.1.3 [H]

Molecular weight: Translated: 88058; Mature: 88058

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLKFGGTSLANPERFSQAAQLIEKAHFEEQAAGVLSAPAKITNHLVALSEKASLNQPT
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
DANFNEAIEIFYHIIHGLHAENNRFDLEGTKALIDTEFAQISQLLEEIRQQGFVSDAVKA
CCCHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
TIDCRGEKLSIAMMKAWFEARGYDVTVIDPVEKLLAHGSYLESSVDIEESTKRVDAKSIP
HHCCCCCEEHHHHHHHHHHHCCCEEEEECHHHHHHHCCCHHHCCCCHHHHHHHCCCCCCC
TKNVVLMAGFTAGNEKGELVLLGRNGSDYSAACLAACLGASACEIWTDVDGVFTCDPRLV
CCCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHCCCCCEEECCCCCC
PDARLLPSLSYREAMELSYFGAKVIHPRTIGPLVQTNIPCLIKNTGNPSAPGSIIDGNIQ
CCHHHCCCCCHHHHHHHHHCCCEEECCCCCCCHHHCCCCEEEECCCCCCCCCCEEECCCC
SEQLQVKGITNLDNVAMFNVSGPGMQGMVGMASRVFSAMSNAGVSVILITQSSSEYSISF
CCEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEE
CVPAKSVEVAKQALEKEFEQELKANDLEPIDVIRDLSIISVVGDGMKQAKGIAARFFSAL
ECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AQANISIVAIAQGSSERSISAVVALNKAIEAVKATHQALFNNKKVVDVFLVGVGGVGGEL
HHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHH
IEQIKHQKSYLAKKDIEIRVCAIANSNKMLLKADGLNLENWQADLETATQPSDFDVLLSF
HHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHH
IKLHHVVNPVFVDCTSADSVAGLYVRALGEGFHVVTPNKKANTRELAYYNALRESARNNQ
HHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCC
RKFLYDTNVGAGLPVIENLQNLLAAGDEVVKFSGVLSGSLSFIFGELENGLTLSEATALA
CEEEEECCCCCCCHHHHHHHHHHHCCCHHEEEHHHHHCCHHHHHHHHCCCCCHHHHHHHH
REKGFTEPDPRDDLSGQDVARKLLILARETGAQLELTDIEVESVLPAGFAEGKTTQEFMA
HHCCCCCCCCCCCCCHHHHHHHHHHHEECCCCEEEEEEEEHHHHCCCCCCCCCCHHHHHH
MLPQLDAEFSQRVANAKAEGKVLRYVGQIENNSCKVSVLEVDADDPLYKVKNGENALAFY
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCEEEECCCCCEEEEH
TRYYQPIPLLLRGYGAGNSVTAAGIFADILRTLQH
HHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVLKFGGTSLANPERFSQAAQLIEKAHFEEQAAGVLSAPAKITNHLVALSEKASLNQPT
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
DANFNEAIEIFYHIIHGLHAENNRFDLEGTKALIDTEFAQISQLLEEIRQQGFVSDAVKA
CCCHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
TIDCRGEKLSIAMMKAWFEARGYDVTVIDPVEKLLAHGSYLESSVDIEESTKRVDAKSIP
HHCCCCCEEHHHHHHHHHHHCCCEEEEECHHHHHHHCCCHHHCCCCHHHHHHHCCCCCCC
TKNVVLMAGFTAGNEKGELVLLGRNGSDYSAACLAACLGASACEIWTDVDGVFTCDPRLV
CCCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHCCCCCEEECCCCCC
PDARLLPSLSYREAMELSYFGAKVIHPRTIGPLVQTNIPCLIKNTGNPSAPGSIIDGNIQ
CCHHHCCCCCHHHHHHHHHCCCEEECCCCCCCHHHCCCCEEEECCCCCCCCCCEEECCCC
SEQLQVKGITNLDNVAMFNVSGPGMQGMVGMASRVFSAMSNAGVSVILITQSSSEYSISF
CCEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEE
CVPAKSVEVAKQALEKEFEQELKANDLEPIDVIRDLSIISVVGDGMKQAKGIAARFFSAL
ECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AQANISIVAIAQGSSERSISAVVALNKAIEAVKATHQALFNNKKVVDVFLVGVGGVGGEL
HHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHH
IEQIKHQKSYLAKKDIEIRVCAIANSNKMLLKADGLNLENWQADLETATQPSDFDVLLSF
HHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHH
IKLHHVVNPVFVDCTSADSVAGLYVRALGEGFHVVTPNKKANTRELAYYNALRESARNNQ
HHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCC
RKFLYDTNVGAGLPVIENLQNLLAAGDEVVKFSGVLSGSLSFIFGELENGLTLSEATALA
CEEEEECCCCCCCHHHHHHHHHHHCCCHHEEEHHHHHCCHHHHHHHHCCCCCHHHHHHHH
REKGFTEPDPRDDLSGQDVARKLLILARETGAQLELTDIEVESVLPAGFAEGKTTQEFMA
HHCCCCCCCCCCCCCHHHHHHHHHHHEECCCCEEEEEEEEHHHHCCCCCCCCCCHHHHHH
MLPQLDAEFSQRVANAKAEGKVLRYVGQIENNSCKVSVLEVDADDPLYKVKNGENALAFY
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCEEEECCCCCEEEEH
TRYYQPIPLLLRGYGAGNSVTAAGIFADILRTLQH
HHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]