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The map label for this gene is lonB [H]

Identifier: 154686957

GI number: 154686957

Start: 2647526

End: 2649184

Strand: Reverse

Name: lonB [H]

Synonym: RBAM_025270

Alternate gene names: 154686957

Gene position: 2649184-2647526 (Counterclockwise)

Preceding gene: 154686958

Following gene: 154686956

Centisome position: 67.61

GC content: 47.86

Gene sequence:

>1659_bases
ATGAGTTGGACAGGGATCGCATTATTTGTACAGCTGTTTTTCGGGATAGTCATCGGATTATATTTTTGGAATCTGCTCAA
AAACCAGCGTACACAAAAAGTGACGATAGATAAAGAATCAAAAAAAGAAATGGAACAGCTGCGCAAAATGCGCGCCATCA
GTTTATCAGAACCTTTATCAGAAAAGGTGCGGCCGAAAAGCTTTCAGGACATTGTCGGCCAGGAAGACGGAATTAAAGCG
TTAAAAGCAGCGCTTTGCGGACCGAACCCGCAGCACGTCATTATTTACGGTCCTCCGGGAGTCGGTAAAACGGCTGCGGC
GCGGCTGGTATTGGAAGAAGCGAAAAAACATAAACAGTCACCGTTTCAAAAGCAGGCTGTTTTTGTTGAACTTGATGCGA
CGACCGCGCGGTTTGATGAACGGGGGATTGCCGATCCGCTTATCGGTTCAGTGCATGATCCGATTTATCAGGGAGCGGGT
GCGATGGGCCAAGCAGGCATTCCGCAGCCGAAACAGGGGGCTGTGACCCATGCTCACGGCGGGGTATTGTTTATTGATGA
AATCGGCGAGCTTCATCCGATTCAGATGAATAAAATGCTGAAGGTGCTTGAAGATCGAAAAGTATTTTTAGACAGTGCGT
ATTACAGTGAAGAAAATACGCAAATACCGAATCACATTCATGATATTTTTCAAAATGGGCTTCCGGCAGATTTCCGTTTG
ATCGGAGCGACAACGAGAATGCCGAATGAAATTCCGCCGGCCATCCGTTCGCGCTGTCTTGAAGTATTTTTCCGCGAGCT
GGAAAAGGATGAACTTAAAATCGTTGCGAAAAAAGCAGCCGACAAAATTCAGAAAGAGATTTCTGACGAAGCTCTCAGTG
TGCTGACCACATATACGAGAAACGGACGTGAAGCCGTCAATATGATCCAGATCGCCGCCGGCATGGCGGTGACTGAGGAC
AGAAAAGAAATTACGACAGAAGATATAGAATGGGTTGTTCATTCCAGTCAGCTTACACCTAAAAATGAGCAGAAAATCGC
CGATGAACCGCAAGTCGGCATCGTGAACGGACTTGCCGTCTACGGGCCGAACAGCGGCGCATTGCTGGAAATCGAAGTGA
ATGTCACACCTGCGCAGGACAAAGGAAGCCTGAATATCACGGGAATTGCAGAGGAAGAAAGCATCGGCAGCCAATCGAAG
TCGATCCGCCGCAAAAGTATGGCGAAGGGATCTGTAGAAAATGTTCTGACGGTTCTGCGCACAATGGGCATCAAACCTTC
AGACTATGACATTCACGTCAATTTTCCGGGCGGAGGCCCGATTGACGGACCTTCAGCAGGTATCGCGATGGCCGCGGGGA
TTTTTTCCGCGATTCACCGCATCCCGATCGACCATACGGTGGCGATGACGGGAGAAATCAGCCTGACGGGGCTTGTCAAA
CCGATCGGCGGCGTCATTCCGAAAATTAAAGCCGCAAAACAGGCCGGAGCAAAAACGGTCATTATCCCATATGAAAATCA
GCAGTCCATTCTGAAACGAATAGACGGAATCACCATTAAAGCGGTAAAAACGTTCCAGGAAGTGCTTGACGTCATATTGG
TTGATCCTCCTTCAGAACAAAAACCGTTTGATATCCAAATGAATAAAGAATCCGTATAA

Upstream 100 bases:

>100_bases
CTGACCCTTCTGAAAATGTTTATTCCGGGCTTTGCTGGGAGATACTAGCGGACAGAGGAATGAATTGGATACATAAATCG
TTTTTTCAGGAGGGACCAGC

Downstream 100 bases:

>100_bases
ACCCCATTTTTATAATGGGGTTTTTTTATGGAGGACATCTTTTCCTTTTTCAGAACAGAAAGAAAGGGTATACTACGAAG
AGACTGTTTTATATACAGGG

Product: hypothetical protein

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MSWTGIALFVQLFFGIVIGLYFWNLLKNQRTQKVTIDKESKKEMEQLRKMRAISLSEPLSEKVRPKSFQDIVGQEDGIKA
LKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKHKQSPFQKQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG
AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEENTQIPNHIHDIFQNGLPADFRL
IGATTRMPNEIPPAIRSRCLEVFFRELEKDELKIVAKKAADKIQKEISDEALSVLTTYTRNGREAVNMIQIAAGMAVTED
RKEITTEDIEWVVHSSQLTPKNEQKIADEPQVGIVNGLAVYGPNSGALLEIEVNVTPAQDKGSLNITGIAEEESIGSQSK
SIRRKSMAKGSVENVLTVLRTMGIKPSDYDIHVNFPGGGPIDGPSAGIAMAAGIFSAIHRIPIDHTVAMTGEISLTGLVK
PIGGVIPKIKAAKQAGAKTVIIPYENQQSILKRIDGITIKAVKTFQEVLDVILVDPPSEQKPFDIQMNKESV

Sequences:

>Translated_552_residues
MSWTGIALFVQLFFGIVIGLYFWNLLKNQRTQKVTIDKESKKEMEQLRKMRAISLSEPLSEKVRPKSFQDIVGQEDGIKA
LKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKHKQSPFQKQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG
AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEENTQIPNHIHDIFQNGLPADFRL
IGATTRMPNEIPPAIRSRCLEVFFRELEKDELKIVAKKAADKIQKEISDEALSVLTTYTRNGREAVNMIQIAAGMAVTED
RKEITTEDIEWVVHSSQLTPKNEQKIADEPQVGIVNGLAVYGPNSGALLEIEVNVTPAQDKGSLNITGIAEEESIGSQSK
SIRRKSMAKGSVENVLTVLRTMGIKPSDYDIHVNFPGGGPIDGPSAGIAMAAGIFSAIHRIPIDHTVAMTGEISLTGLVK
PIGGVIPKIKAAKQAGAKTVIIPYENQQSILKRIDGITIKAVKTFQEVLDVILVDPPSEQKPFDIQMNKESV
>Mature_551_residues
SWTGIALFVQLFFGIVIGLYFWNLLKNQRTQKVTIDKESKKEMEQLRKMRAISLSEPLSEKVRPKSFQDIVGQEDGIKAL
KAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKHKQSPFQKQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAGA
MGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEENTQIPNHIHDIFQNGLPADFRLI
GATTRMPNEIPPAIRSRCLEVFFRELEKDELKIVAKKAADKIQKEISDEALSVLTTYTRNGREAVNMIQIAAGMAVTEDR
KEITTEDIEWVVHSSQLTPKNEQKIADEPQVGIVNGLAVYGPNSGALLEIEVNVTPAQDKGSLNITGIAEEESIGSQSKS
IRRKSMAKGSVENVLTVLRTMGIKPSDYDIHVNFPGGGPIDGPSAGIAMAAGIFSAIHRIPIDHTVAMTGEISLTGLVKP
IGGVIPKIKAAKQAGAKTVIIPYENQQSILKRIDGITIKAVKTFQEVLDVILVDPPSEQKPFDIQMNKESV

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=491, Percent_Identity=25.4582484725051, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI31377667, Length=495, Percent_Identity=24.8484848484848, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786643, Length=482, Percent_Identity=27.1784232365145, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17505831, Length=476, Percent_Identity=26.890756302521, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17556486, Length=476, Percent_Identity=24.1596638655462, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319449, Length=77, Percent_Identity=53.2467532467532, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24666867, Length=502, Percent_Identity=24.3027888446215, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221513036, Length=502, Percent_Identity=24.3027888446215, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 60362; Mature: 60231

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWTGIALFVQLFFGIVIGLYFWNLLKNQRTQKVTIDKESKKEMEQLRKMRAISLSEPLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCHH
EKVRPKSFQDIVGQEDGIKALKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKHKQS
HHCCCCHHHHHHCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCC
PFQKQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAGAMGQAGIPQPKQGAVTHAHG
CCCCCEEEEEECCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCC
GVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEENTQIPNHIHDIFQNGLPADFRL
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEE
IGATTRMPNEIPPAIRSRCLEVFFRELEKDELKIVAKKAADKIQKEISDEALSVLTTYTR
EECCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NGREAVNMIQIAAGMAVTEDRKEITTEDIEWVVHSSQLTPKNEQKIADEPQVGIVNGLAV
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCCCCCCCCHHCCCCCCEEEECCEEE
YGPNSGALLEIEVNVTPAQDKGSLNITGIAEEESIGSQSKSIRRKSMAKGSVENVLTVLR
EECCCCCEEEEEEEEECCCCCCCEEEEEECCHHHCCHHHHHHHHHHHHCCCHHHHHHHHH
TMGIKPSDYDIHVNFPGGGPIDGPSAGIAMAAGIFSAIHRIPIDHTVAMTGEISLTGLVK
HHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCEEEHHHHH
PIGGVIPKIKAAKQAGAKTVIIPYENQQSILKRIDGITIKAVKTFQEVLDVILVDPPSEQ
HHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHEEEECCCCCC
KPFDIQMNKESV
CCEEEEECCCCC
>Mature Secondary Structure 
SWTGIALFVQLFFGIVIGLYFWNLLKNQRTQKVTIDKESKKEMEQLRKMRAISLSEPLS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCHH
EKVRPKSFQDIVGQEDGIKALKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKHKQS
HHCCCCHHHHHHCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCC
PFQKQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAGAMGQAGIPQPKQGAVTHAHG
CCCCCEEEEEECCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCC
GVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEENTQIPNHIHDIFQNGLPADFRL
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEE
IGATTRMPNEIPPAIRSRCLEVFFRELEKDELKIVAKKAADKIQKEISDEALSVLTTYTR
EECCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NGREAVNMIQIAAGMAVTEDRKEITTEDIEWVVHSSQLTPKNEQKIADEPQVGIVNGLAV
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCCCCCCCCHHCCCCCCEEEECCEEE
YGPNSGALLEIEVNVTPAQDKGSLNITGIAEEESIGSQSKSIRRKSMAKGSVENVLTVLR
EECCCCCEEEEEEEEECCCCCCCEEEEEECCHHHCCHHHHHHHHHHHHCCCHHHHHHHHH
TMGIKPSDYDIHVNFPGGGPIDGPSAGIAMAAGIFSAIHRIPIDHTVAMTGEISLTGLVK
HHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCEEEHHHHH
PIGGVIPKIKAAKQAGAKTVIIPYENQQSILKRIDGITIKAVKTFQEVLDVILVDPPSEQ
HHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHEEEECCCCCC
KPFDIQMNKESV
CCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]