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The map label for this gene is lonA [H]

Identifier: 154686956

GI number: 154686956

Start: 2645002

End: 2647326

Strand: Reverse

Name: lonA [H]

Synonym: RBAM_025260

Alternate gene names: 154686956

Gene position: 2647326-2645002 (Counterclockwise)

Preceding gene: 154686957

Following gene: 154686955

Centisome position: 67.56

GC content: 48.47

Gene sequence:

>2325_bases
ATGGCAGAAGATACAAAACGCAGCATCCCGCTCCTCCCTTTAAGAGGCTTATTGGTATACCCGACAATGGTTTTACATTT
AGATGTAGGCCGTGACAAGTCGGTTCAGGCTCTTGAACAGGCAATGATGCATGATCATATGATTTTTTTAGCCACTCAGC
AGGATATTTCGATAGACGAACCGGGTGAAGAGGATATTTTCGCCGTCGGCACTTATACAAAAATTAAACAGATGCTGAAG
CTGCCCAACGGTACGATCAGAGTGCTTGTAGAAGGAATTCAGCGGGCGCAGATCCTTGAATACACCGAGCTCGAAGATTA
TACTTCGGTCGATATACAGCTGATGCATGAGGATGATTCAAAAGACGTGGAAGACGAAGCGCTTATGCGGACGCTGCTGG
ACCATTTTGACCAGTACATAAAAATTTCTAAAAAAATCTCCGCAGAAACGTATGCGGCTGTGACTGATATTGAAGAGCCC
GGCAGAATGGCGGATATCGTTGCTTCTCATCTCCCGCTGAAATTAAAGGACAAGCAGGACATTTTAGAAACGGCGGATAT
TAAAGAACGTCTGAATAAGGTCATCCGTTCCATTCATAATGAAAAAGAAGTGCTGGAGATTGAGAAAAAAATCGGTCAGC
GCGTCAAACGTTCGATGGAACGCACTCAAAAGGAATACTACTTGCGTGAACAGATGAAAGCCATTCAGAAGGAGCTTGGC
GACAAAGAAGGAAAAACCGGCGAAGTTCAGTCGCTCACGGAAAAGATAGAAGAAGCAGGCATGCCTGAGCGTGTCAAAGA
AACGGCGCTTAAGGAATTAAGCCGTTACGAAAAAGTGCCGTCAAGCTCAGCGGAAAGCTCTGTTATCCGCAACTATATTG
ACTGGCTCATCGCCCTTCCGTGGTCGGATGAAACAGAAGATAAACTTGATATTAAAAAAGCCGGGGAAATCTTAGATAAA
GAGCACCACGGCTTAGAGAAAGTGAAAGAGCGGATTTTGGAGTATTTGGCCGTGAAACAGCTGACGAAAACGCTGAAAGG
GCCGATTCTTTGTCTGGCCGGACCTCCGGGAGTCGGTAAAACATCTCTTGCAAAATCAATCAGTACGAGCATGGGGCGCC
GTTTTGTGAGAATTTCACTGGGCGGAGTGCGCGATGAGTCTGAAATCCGCGGGCACCGGCGTACATACGTCGGAGCGATG
CCTGGCCGTATTATACAGGGGATGAAAAAAGCCGGCAAACAAAATCCGGTTTTTCTCCTGGATGAGATCGATAAAATGTC
GTCTGATTTCAGAGGCGATCCGTCTTCAGCGATGCTTGAGGTGCTGGATCCGGAACAAAACAGCACATTCAGCGACCACT
ATATTGAAGAGACATTCGATTTATCGAAAGTGCTGTTTATCGCGACTGCGAATAACCTTGCTTCCATACCGGGACCTCTC
AGAGACAGAATGGAGATTATCAGCCTGTCAGGCTACACTGAAAACGAAAAGCTGGAGATCGTGAAGGACCACCTGCTTCC
GAAACAAATCAAAGAGCACGGGCTCACAAAGAGCAACCTGCAGATTCGGGATCAGGCGATTACGGACATCATCCGCTACT
ACACGAGGGAAGCCGGCGTGAGAACGCTTGAACGCCAGATTGCCGCCATTTGCCGAAAGGCTGCAAAAGCCATTGTGTCT
GAGGAGAGAAAACGCATTACCGTTACAGAGAAAAATCTGGCCGACTATCTCGGAAAACGGATATTCAGATACGGACAGGC
GGAAACCGAAGATCAAATCGGGGTTGTCACGGGGCTCGCGTATACGACGGTCGGCGGAGATACGCTGTCAATCGAAGTGT
CATTGTCACCGGGAAAAGGAAAGCTGATTCTGACCGGGAAGCTTGGAGATGTCATGCGGGAATCAGCGCAGGCCGCTTTC
AGTTATGTCCGCTCGAAAGCGGAACAGTTCGGAATCGATCCGAAATTCCATGAGAAGTATGACATTCATATCCATGTCCC
TGAAGGAGCGGTGCCGAAAGACGGCCCTTCTGCCGGAATTACGATGGCCACGGCGCTCGTTTCAGCATTAACGGACCGTG
CGGTAAAACGCGAAGTCGGTATGACGGGAGAAATCACGCTGCGGGGCCGCGTGCTTCCGATCGGCGGACTGAAAGAAAAG
GCGCTCGGCGCGCACAGAGCGGGCCTGACCACTATTATTGCGCCTAAAGATAACGAAAAAGATATAGAGGATATTCCAGA
AAGCGTCAGAGAAGGACTGAAGTTTATATTCGTTTCTCACCTGGATGACGTTTTGGAACATGCCTTAGTAGGAGAGAAGA
AATGA

Upstream 100 bases:

>100_bases
GCAGACGGATAAGCCGATTAAAGCCCGATCCCGGAATTGTACAACGATGAAAAAGTTGTATTATAATGGTTCATACTAAA
GTCACGGAGGTGTCAGTCAC

Downstream 100 bases:

>100_bases
AAGTCACAAAGTCAGAAATCGTGATCAGCGCGGTCAAACCCGAACAGTACCCTGATGGGGGGCTTCCGGAAATCGCGCTG
GCGGGAAGATCAAATGTAGG

Product: LonA

Products: NA

Alternate protein names: ATP-dependent protease La 1 [H]

Number of amino acids: Translated: 774; Mature: 773

Protein sequence:

>774_residues
MAEDTKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMHDHMIFLATQQDISIDEPGEEDIFAVGTYTKIKQMLK
LPNGTIRVLVEGIQRAQILEYTELEDYTSVDIQLMHEDDSKDVEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP
GRMADIVASHLPLKLKDKQDILETADIKERLNKVIRSIHNEKEVLEIEKKIGQRVKRSMERTQKEYYLREQMKAIQKELG
DKEGKTGEVQSLTEKIEEAGMPERVKETALKELSRYEKVPSSSAESSVIRNYIDWLIALPWSDETEDKLDIKKAGEILDK
EHHGLEKVKERILEYLAVKQLTKTLKGPILCLAGPPGVGKTSLAKSISTSMGRRFVRISLGGVRDESEIRGHRRTYVGAM
PGRIIQGMKKAGKQNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSTFSDHYIEETFDLSKVLFIATANNLASIPGPL
RDRMEIISLSGYTENEKLEIVKDHLLPKQIKEHGLTKSNLQIRDQAITDIIRYYTREAGVRTLERQIAAICRKAAKAIVS
EERKRITVTEKNLADYLGKRIFRYGQAETEDQIGVVTGLAYTTVGGDTLSIEVSLSPGKGKLILTGKLGDVMRESAQAAF
SYVRSKAEQFGIDPKFHEKYDIHIHVPEGAVPKDGPSAGITMATALVSALTDRAVKREVGMTGEITLRGRVLPIGGLKEK
ALGAHRAGLTTIIAPKDNEKDIEDIPESVREGLKFIFVSHLDDVLEHALVGEKK

Sequences:

>Translated_774_residues
MAEDTKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMHDHMIFLATQQDISIDEPGEEDIFAVGTYTKIKQMLK
LPNGTIRVLVEGIQRAQILEYTELEDYTSVDIQLMHEDDSKDVEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP
GRMADIVASHLPLKLKDKQDILETADIKERLNKVIRSIHNEKEVLEIEKKIGQRVKRSMERTQKEYYLREQMKAIQKELG
DKEGKTGEVQSLTEKIEEAGMPERVKETALKELSRYEKVPSSSAESSVIRNYIDWLIALPWSDETEDKLDIKKAGEILDK
EHHGLEKVKERILEYLAVKQLTKTLKGPILCLAGPPGVGKTSLAKSISTSMGRRFVRISLGGVRDESEIRGHRRTYVGAM
PGRIIQGMKKAGKQNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSTFSDHYIEETFDLSKVLFIATANNLASIPGPL
RDRMEIISLSGYTENEKLEIVKDHLLPKQIKEHGLTKSNLQIRDQAITDIIRYYTREAGVRTLERQIAAICRKAAKAIVS
EERKRITVTEKNLADYLGKRIFRYGQAETEDQIGVVTGLAYTTVGGDTLSIEVSLSPGKGKLILTGKLGDVMRESAQAAF
SYVRSKAEQFGIDPKFHEKYDIHIHVPEGAVPKDGPSAGITMATALVSALTDRAVKREVGMTGEITLRGRVLPIGGLKEK
ALGAHRAGLTTIIAPKDNEKDIEDIPESVREGLKFIFVSHLDDVLEHALVGEKK
>Mature_773_residues
AEDTKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMHDHMIFLATQQDISIDEPGEEDIFAVGTYTKIKQMLKL
PNGTIRVLVEGIQRAQILEYTELEDYTSVDIQLMHEDDSKDVEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEPG
RMADIVASHLPLKLKDKQDILETADIKERLNKVIRSIHNEKEVLEIEKKIGQRVKRSMERTQKEYYLREQMKAIQKELGD
KEGKTGEVQSLTEKIEEAGMPERVKETALKELSRYEKVPSSSAESSVIRNYIDWLIALPWSDETEDKLDIKKAGEILDKE
HHGLEKVKERILEYLAVKQLTKTLKGPILCLAGPPGVGKTSLAKSISTSMGRRFVRISLGGVRDESEIRGHRRTYVGAMP
GRIIQGMKKAGKQNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSTFSDHYIEETFDLSKVLFIATANNLASIPGPLR
DRMEIISLSGYTENEKLEIVKDHLLPKQIKEHGLTKSNLQIRDQAITDIIRYYTREAGVRTLERQIAAICRKAAKAIVSE
ERKRITVTEKNLADYLGKRIFRYGQAETEDQIGVVTGLAYTTVGGDTLSIEVSLSPGKGKLILTGKLGDVMRESAQAAFS
YVRSKAEQFGIDPKFHEKYDIHIHVPEGAVPKDGPSAGITMATALVSALTDRAVKREVGMTGEITLRGRVLPIGGLKEKA
LGAHRAGLTTIIAPKDNEKDIEDIPESVREGLKFIFVSHLDDVLEHALVGEKK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=750, Percent_Identity=41.2, Blast_Score=566, Evalue=1e-161,
Organism=Homo sapiens, GI21396489, Length=627, Percent_Identity=43.0622009569378, Blast_Score=545, Evalue=1e-155,
Organism=Escherichia coli, GI1786643, Length=765, Percent_Identity=55.4248366013072, Blast_Score=870, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=688, Percent_Identity=39.9709302325581, Blast_Score=513, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17556486, Length=640, Percent_Identity=39.53125, Blast_Score=466, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319449, Length=682, Percent_Identity=40.3225806451613, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI221513036, Length=625, Percent_Identity=44.16, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24666867, Length=625, Percent_Identity=44.16, Blast_Score=545, Evalue=1e-155,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 86726; Mature: 86595

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEDTKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMHDHMIFLATQQDISIDE
CCCCCCCCCCCCCCCHHHHHCEEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCCCCC
PGEEDIFAVGTYTKIKQMLKLPNGTIRVLVEGIQRAQILEYTELEDYTSVDIQLMHEDDS
CCCCCEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCC
KDVEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEPGRMADIVASHLPLKLKDKQD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEECCHHH
ILETADIKERLNKVIRSIHNEKEVLEIEKKIGQRVKRSMERTQKEYYLREQMKAIQKELG
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DKEGKTGEVQSLTEKIEEAGMPERVKETALKELSRYEKVPSSSAESSVIRNYIDWLIALP
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEECC
WSDETEDKLDIKKAGEILDKEHHGLEKVKERILEYLAVKQLTKTLKGPILCLAGPPGVGK
CCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCH
TSLAKSISTSMGRRFVRISLGGVRDESEIRGHRRTYVGAMPGRIIQGMKKAGKQNPVFLL
HHHHHHHHHHHCCEEEEEEECCCCCHHHHCCCHHHEECCCCHHHHHHHHHCCCCCCEEEH
DEIDKMSSDFRGDPSSAMLEVLDPEQNSTFSDHYIEETFDLSKVLFIATANNLASIPGPL
HHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCH
RDRMEIISLSGYTENEKLEIVKDHLLPKQIKEHGLTKSNLQIRDQAITDIIRYYTREAGV
HHHHHHHEECCCCCCCHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RTLERQIAAICRKAAKAIVSEERKRITVTEKNLADYLGKRIFRYGQAETEDQIGVVTGLA
HHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
YTTVGGDTLSIEVSLSPGKGKLILTGKLGDVMRESAQAAFSYVRSKAEQFGIDPKFHEKY
EEEECCCEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
DIHIHVPEGAVPKDGPSAGITMATALVSALTDRAVKREVGMTGEITLRGRVLPIGGLKEK
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCHHH
ALGAHRAGLTTIIAPKDNEKDIEDIPESVREGLKFIFVSHLDDVLEHALVGEKK
HHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AEDTKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMHDHMIFLATQQDISIDE
CCCCCCCCCCCCCCHHHHHCEEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCCCCC
PGEEDIFAVGTYTKIKQMLKLPNGTIRVLVEGIQRAQILEYTELEDYTSVDIQLMHEDDS
CCCCCEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCC
KDVEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEPGRMADIVASHLPLKLKDKQD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEECCHHH
ILETADIKERLNKVIRSIHNEKEVLEIEKKIGQRVKRSMERTQKEYYLREQMKAIQKELG
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DKEGKTGEVQSLTEKIEEAGMPERVKETALKELSRYEKVPSSSAESSVIRNYIDWLIALP
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEECC
WSDETEDKLDIKKAGEILDKEHHGLEKVKERILEYLAVKQLTKTLKGPILCLAGPPGVGK
CCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCH
TSLAKSISTSMGRRFVRISLGGVRDESEIRGHRRTYVGAMPGRIIQGMKKAGKQNPVFLL
HHHHHHHHHHHCCEEEEEEECCCCCHHHHCCCHHHEECCCCHHHHHHHHHCCCCCCEEEH
DEIDKMSSDFRGDPSSAMLEVLDPEQNSTFSDHYIEETFDLSKVLFIATANNLASIPGPL
HHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCH
RDRMEIISLSGYTENEKLEIVKDHLLPKQIKEHGLTKSNLQIRDQAITDIIRYYTREAGV
HHHHHHHEECCCCCCCHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RTLERQIAAICRKAAKAIVSEERKRITVTEKNLADYLGKRIFRYGQAETEDQIGVVTGLA
HHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
YTTVGGDTLSIEVSLSPGKGKLILTGKLGDVMRESAQAAFSYVRSKAEQFGIDPKFHEKY
EEEECCCEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
DIHIHVPEGAVPKDGPSAGITMATALVSALTDRAVKREVGMTGEITLRGRVLPIGGLKEK
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCHHH
ALGAHRAGLTTIIAPKDNEKDIEDIPESVREGLKFIFVSHLDDVLEHALVGEKK
HHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961402; 8969504; 9384377 [H]