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The map label for this gene is hemD [H]

Identifier: 154686950

GI number: 154686950

Start: 2639749

End: 2640528

Strand: Reverse

Name: hemD [H]

Synonym: RBAM_025200

Alternate gene names: 154686950

Gene position: 2640528-2639749 (Counterclockwise)

Preceding gene: 154686951

Following gene: 154686949

Centisome position: 67.38

GC content: 52.05

Gene sequence:

>780_bases
ATGGCAAATGACCTTCCTTTACAAGGAAAGACCGTGCTCGTCACCCGGAACAAAAGACAGGCCGCACCGTTCCGAAAAAA
AGTGGAGGCGCTCGGCGGAACGGCTGTTTCCGCTTCGCTGATCGCTTTTCAGGAAGCGCTCCCGGATGAATGTGCGGACA
GTCTCCGGGAAGACCTTTCTGAGCCGGGATGGCTTGTGTTTACAAGCGTAAACGGTGTCCGGTTCTTTTTTTCCTATCTT
GATCGTCACGGTCTTGCGCTTTCGGGACGGAAAAAAATCGCAGCCGTCGGTGAAAAGACTGCGCGCGCCCTGAAAGAGCG
GGGAGCCCGGACGGATGCGATGCCTGACGAGTATGTGGCGGAATGTCTGGCTGATACTTTAAAACGGTACGCATCAGCTG
CCGAACCCATTTCAGTGATAAAGGGCAATTTATCACGCGATGTCATAAAAGCGGAGCTTGAGCCGCTTGGCTATCAAATA
AGGGAATGGGTGTTATACAATACCATTCAGGATGAAAAAGGCATGGACGAGCTGAGACGGGCTGCATCCCGCTCTCATTT
TGATTTTATTACGTTTACCAGCTCATCGGCGGTCCATACGTTTATGCACGCGGTCGGAGACGGAGAAAAAGCGTGGGAAA
ACAGCGGTGCGAGCTATATCAGCATCGGCCCTTTGACAGAGAAAGCGCTCTTGGAATACGGGATCTCATCCCATGTGCCT
GACACTTATACGATTGAAGGCATGCTGGACGTCATGTGCAGCATGTCGGGAAAGGATTGA

Upstream 100 bases:

>100_bases
GGACATGATCCGGAAGAAATCGGAAAACGCTGTGCGGCGATGATGTCTGAAAAAGGAGCCAAAGCATTAATCGACAGTGT
AAAACAGGAGCTCGATCAGG

Downstream 100 bases:

>100_bases
TAATGATGAATCAAACATTTAACAGACACCGCCGTTTGCGCGCGAACGCTGCGATGAGAGATTTAGTAAAAGAAACACGT
CTTCACCCCTCAGATTTTAT

Product: hypothetical protein

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MANDLPLQGKTVLVTRNKRQAAPFRKKVEALGGTAVSASLIAFQEALPDECADSLREDLSEPGWLVFTSVNGVRFFFSYL
DRHGLALSGRKKIAAVGEKTARALKERGARTDAMPDEYVAECLADTLKRYASAAEPISVIKGNLSRDVIKAELEPLGYQI
REWVLYNTIQDEKGMDELRRAASRSHFDFITFTSSSAVHTFMHAVGDGEKAWENSGASYISIGPLTEKALLEYGISSHVP
DTYTIEGMLDVMCSMSGKD

Sequences:

>Translated_259_residues
MANDLPLQGKTVLVTRNKRQAAPFRKKVEALGGTAVSASLIAFQEALPDECADSLREDLSEPGWLVFTSVNGVRFFFSYL
DRHGLALSGRKKIAAVGEKTARALKERGARTDAMPDEYVAECLADTLKRYASAAEPISVIKGNLSRDVIKAELEPLGYQI
REWVLYNTIQDEKGMDELRRAASRSHFDFITFTSSSAVHTFMHAVGDGEKAWENSGASYISIGPLTEKALLEYGISSHVP
DTYTIEGMLDVMCSMSGKD
>Mature_258_residues
ANDLPLQGKTVLVTRNKRQAAPFRKKVEALGGTAVSASLIAFQEALPDECADSLREDLSEPGWLVFTSVNGVRFFFSYLD
RHGLALSGRKKIAAVGEKTARALKERGARTDAMPDEYVAECLADTLKRYASAAEPISVIKGNLSRDVIKAELEPLGYQIR
EWVLYNTIQDEKGMDELRRAASRSHFDFITFTSSSAVHTFMHAVGDGEKAWENSGASYISIGPLTEKALLEYGISSHVPD
TYTIEGMLDVMCSMSGKD

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 28449; Mature: 28317

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANDLPLQGKTVLVTRNKRQAAPFRKKVEALGGTAVSASLIAFQEALPDECADSLREDLS
CCCCCCCCCCEEEEECCCHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHC
EPGWLVFTSVNGVRFFFSYLDRHGLALSGRKKIAAVGEKTARALKERGARTDAMPDEYVA
CCCEEEEEECCHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
ECLADTLKRYASAAEPISVIKGNLSRDVIKAELEPLGYQIREWVLYNTIQDEKGMDELRR
HHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AASRSHFDFITFTSSSAVHTFMHAVGDGEKAWENSGASYISIGPLTEKALLEYGISSHVP
HHCCCCCEEEEECCCHHHHHHHHHHCCCHHHHHCCCCCEEEECCCHHHHHHHHCHHCCCC
DTYTIEGMLDVMCSMSGKD
CCEEHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ANDLPLQGKTVLVTRNKRQAAPFRKKVEALGGTAVSASLIAFQEALPDECADSLREDLS
CCCCCCCCCEEEEECCCHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHC
EPGWLVFTSVNGVRFFFSYLDRHGLALSGRKKIAAVGEKTARALKERGARTDAMPDEYVA
CCCEEEEEECCHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
ECLADTLKRYASAAEPISVIKGNLSRDVIKAELEPLGYQIREWVLYNTIQDEKGMDELRR
HHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AASRSHFDFITFTSSSAVHTFMHAVGDGEKAWENSGASYISIGPLTEKALLEYGISSHVP
HHCCCCCEEEEECCCHHHHHHHHHHCCCHHHHHCCCCCEEEECCCHHHHHHHHCHHCCCC
DTYTIEGMLDVMCSMSGKD
CCEEHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1672867; 9384377; 2110138 [H]