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The map label for this gene is relA [H]

Identifier: 154686901

GI number: 154686901

Start: 2591213

End: 2593417

Strand: Reverse

Name: relA [H]

Synonym: RBAM_024710

Alternate gene names: 154686901

Gene position: 2593417-2591213 (Counterclockwise)

Preceding gene: 154686902

Following gene: 154686900

Centisome position: 66.18

GC content: 47.53

Gene sequence:

>2205_bases
ATGGCGAACGAACAAGTATTGACTGCCGAGCAAGTAATAGATAAAGCGCGCACTTATCTGCCGGAGGAGCAGATTGCGTT
TGTTGAGAAAGCTTACCTGTATGCGCAAAACGCGCATCGCGAACAGTACCGCAAATCGGGTGAGCCGTACATCATTCATC
CGATTCAGGTGGCGGGGATCCTCGTCGATCTGGAAATGGACCCTTCCACAATTGCGGGCGGATTTCTGCATGACGTGGTA
GAGGACACGGATGTCACCCTCGACGACCTGAAGGAAGCATTTTCTGAAGAAGTGGCGATGCTTGTCGACGGCGTGACGAA
GCTCGGTAAAATTAAGTATAAATCTCAAGAGGAGCAGCAGGCGGAAAACCATCGAAAAATGTTTGTCGCTATGGCTCAGG
ATATCAGAGTCATATTGATCAAGCTGGCGGATCGCCTTCACAATATGCGGACGTTAAAGCATCTTCCGCAGGAAAAGCAG
CGGAGAATTTCAAATGAGACGCTGGAAATTTTCGCTCCGCTGGCCCATCGGCTCGGGATTTCTAAAATCAAATGGGAGCT
GGAAGACACCGCTCTCCGTTATTTGAATCCTCAGCAATATTACAGAATCGTCAACCTCATGAAGAAAAAGCGCGCGGAAC
GCGAACTTTATGTCGAAGAGGTTGTCAATGAAGTGAAAAAACGCGTCGAAGAAGTGAATATCAAAGCGGACTTTTCAGGA
CGTCCGAAGCATATCTACAGCATTTACCGCAAGATGGCGCTGCAAAATAAACAGTTCAATGAAATATATGATCTGCTTGC
CGTCCGTATTCTTGTCGGAAGCATTAAAGACTGCTACGCCGTCCTCGGCATTATTCATACGTGCTGGAAGCCGATGCCGG
GCAGATTCAAAGATTATATTGCGATGCCTAAGCCGAATATGTATCAGTCGCTGCATACGACCGTAATCGGGCCTAAAGGC
GATCCGCTGGAAGTGCAGATCAGAACGTTTGAGATGCATGAGATCGCTGAATACGGGGTGGCCGCACACTGGGCATATAA
AGAAGGCAAGGCTGCAAACGAAGAAGCGACATTTGAGAAAAAACTGTCCTGGTTCCGTGAAATTCTGGAATTCCAAAACG
AGTCTACCGATGCGGAAGAATTTATGGAATCGCTGAAAATCGATCTGTTTTCTGACATGGTATACGTATTTACGCCAAAA
GGCGATGTCATTGAACTGCCATCAGGCTCTGTGCCGATTGATTTTTCCTACAGGATCCACTCGGAGATCGGCAACAAAAC
AATCGGGGCGAAAGTGAACGGAAAAATGGTGACGCTTGACCATAAGCTCCGGACGGGCGACATCGTCGAGATTCTGACGT
CCAAGCATTCTTACGGTCCGAGTCAAGACTGGGTCAAACTGGCGCAGACGTCCCAGGCGAAACACAAAATCCGCCAATTC
TTTAAGAAACAGCGCCGTGAAGAAAACGTCGAAAAAGGCCGTGAGCTTGTCGAGAAAGAAATTAAAAATCTTGATTTTGA
AGTGAAAGATGTTTTAACACTCGAAAATCTTCAAAAAGTTGCCGACAAGTTCAATTTCTCAAATGAAGAGGATATGTACG
CGGCGGTCGGATATAACGGCATTACCGCTCTTCAGGTGGCCAACAGGCTCACCGAAAAAGAACGGAAGCTCCGTGACCAG
GAAGAGCAGGAAAAAATCGTTCAGGAAGTCACTTCCGAGCCGAAACATTATCCGCAAGGGAGAAAACGGGAAGCGGGTGT
GCGCGTAAAAGGCATTGACAACCTTCTCGTCCGCTTGTCGAAATGCTGCAACCCGGTGCCTGGCGACCATATTGTCGGTT
TTATTACAAAAGGGCGCGGTGTATCTGTTCACCGGGATGACTGTCCGAACGTCAAAACGAATGAAGCGCAGGAACGTCTG
ATCCCCGTTGAATGGGAGCATGAATCACAGGTTCAAAGACGCAAAGAATATAACGTTGAGATTGAGATTTTGGGGTATGA
CCGTCTCGGGCTTTTAAATGAGGTGCTCCAAGCCGTAAATGAAACGAAAACCAACATCTCCTCTGTCTCCGGCAAATCCG
ACCGCAATAAAGTCGCTACGATTCATATGGCGATTTTTATTCAAAACATCAATCATCTGCACAAAGTGGTCGAGCGGATT
AAGCAGATCAGAGACATCTATTCAGTCCGCCGGGTAATGAACTAA

Upstream 100 bases:

>100_bases
CTGACAGATTCTTTAGGTGTTTTGAACTTCTGCCCTTTACATCTCTCGTTTTTTTCTTGATAATAAACTAATACAGTTTA
CATTTAAAAAAGGTGATTCC

Downstream 100 bases:

>100_bases
AAGGAGCTTGCTATGAAATTAGTTGTTCAGCGTGTAACAGAAGCGAGTGTGACGGTTGAGGGCGCTGTCGCCGGCCGGAT
CGGACCCGGTATTATGGCGC

Product: RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 734; Mature: 733

Protein sequence:

>734_residues
MANEQVLTAEQVIDKARTYLPEEQIAFVEKAYLYAQNAHREQYRKSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVV
EDTDVTLDDLKEAFSEEVAMLVDGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ
RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYVEEVVNEVKKRVEEVNIKADFSG
RPKHIYSIYRKMALQNKQFNEIYDLLAVRILVGSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKG
DPLEVQIRTFEMHEIAEYGVAAHWAYKEGKAANEEATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSDMVYVFTPK
GDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVEILTSKHSYGPSQDWVKLAQTSQAKHKIRQF
FKKQRREENVEKGRELVEKEIKNLDFEVKDVLTLENLQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKLRDQ
EEQEKIVQEVTSEPKHYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDHIVGFITKGRGVSVHRDDCPNVKTNEAQERL
IPVEWEHESQVQRRKEYNVEIEILGYDRLGLLNEVLQAVNETKTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERI
KQIRDIYSVRRVMN

Sequences:

>Translated_734_residues
MANEQVLTAEQVIDKARTYLPEEQIAFVEKAYLYAQNAHREQYRKSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVV
EDTDVTLDDLKEAFSEEVAMLVDGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ
RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYVEEVVNEVKKRVEEVNIKADFSG
RPKHIYSIYRKMALQNKQFNEIYDLLAVRILVGSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKG
DPLEVQIRTFEMHEIAEYGVAAHWAYKEGKAANEEATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSDMVYVFTPK
GDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVEILTSKHSYGPSQDWVKLAQTSQAKHKIRQF
FKKQRREENVEKGRELVEKEIKNLDFEVKDVLTLENLQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKLRDQ
EEQEKIVQEVTSEPKHYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDHIVGFITKGRGVSVHRDDCPNVKTNEAQERL
IPVEWEHESQVQRRKEYNVEIEILGYDRLGLLNEVLQAVNETKTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERI
KQIRDIYSVRRVMN
>Mature_733_residues
ANEQVLTAEQVIDKARTYLPEEQIAFVEKAYLYAQNAHREQYRKSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVE
DTDVTLDDLKEAFSEEVAMLVDGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQR
RISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYVEEVVNEVKKRVEEVNIKADFSGR
PKHIYSIYRKMALQNKQFNEIYDLLAVRILVGSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGD
PLEVQIRTFEMHEIAEYGVAAHWAYKEGKAANEEATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSDMVYVFTPKG
DVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVEILTSKHSYGPSQDWVKLAQTSQAKHKIRQFF
KKQRREENVEKGRELVEKEIKNLDFEVKDVLTLENLQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKLRDQE
EQEKIVQEVTSEPKHYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDHIVGFITKGRGVSVHRDDCPNVKTNEAQERLI
PVEWEHESQVQRRKEYNVEIEILGYDRLGLLNEVLQAVNETKTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIK
QIRDIYSVRRVMN

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=126, Percent_Identity=38.8888888888889, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790082, Length=719, Percent_Identity=40.0556328233658, Blast_Score=575, Evalue=1e-165,
Organism=Escherichia coli, GI1789147, Length=744, Percent_Identity=37.2311827956989, Blast_Score=531, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI25143118, Length=129, Percent_Identity=37.2093023255814, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24650996, Length=124, Percent_Identity=37.0967741935484, Blast_Score=70, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84903; Mature: 84772

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANEQVLTAEQVIDKARTYLPEEQIAFVEKAYLYAQNAHREQYRKSGEPYIIHPIQVAGI
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEE
LVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLVDGVTKLGKIKYKSQEEQQ
EEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
AENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQRRISNETLEIFAPLAHRLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHCCH
SKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYVEEVVNEVKKRVEEVNIKADFSG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCC
RPKHIYSIYRKMALQNKQFNEIYDLLAVRILVGSIKDCYAVLGIIHTCWKPMPGRFKDYI
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHC
AMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHEIAEYGVAAHWAYKEGKAANEEATFEK
CCCCCHHHHHHHHEEECCCCCCEEEEEEEEHHHHHHHHCHHHEEECCCCCCCCCHHHHHH
KLSWFREILEFQNESTDAEEFMESLKIDLFSDMVYVFTPKGDVIELPSGSVPIDFSYRIH
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCEEECCCCCCCEEEEEEEH
SEIGNKTIGAKVNGKMVTLDHKLRTGDIVEILTSKHSYGPSQDWVKLAQTSQAKHKIRQF
HHCCCCEECCEECCEEEEEECCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
FKKQRREENVEKGRELVEKEIKNLDFEVKDVLTLENLQKVADKFNFSNEEDMYAAVGYNG
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
ITALQVANRLTEKERKLRDQEEQEKIVQEVTSEPKHYPQGRKREAGVRVKGIDNLLVRLS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECHHHHHHHHH
KCCNPVPGDHIVGFITKGRGVSVHRDDCPNVKTNEAQERLIPVEWEHESQVQRRKEYNVE
HHCCCCCCCCEEEEEECCCCCEEECCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCE
IEILGYDRLGLLNEVLQAVNETKTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERI
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KQIRDIYSVRRVMN
HHHHHHHHHHHHCC
>Mature Secondary Structure 
ANEQVLTAEQVIDKARTYLPEEQIAFVEKAYLYAQNAHREQYRKSGEPYIIHPIQVAGI
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEE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HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]