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The map label for this gene is apt

Identifier: 154686902

GI number: 154686902

Start: 2593575

End: 2594087

Strand: Reverse

Name: apt

Synonym: RBAM_024720

Alternate gene names: 154686902

Gene position: 2594087-2593575 (Counterclockwise)

Preceding gene: 154686903

Following gene: 154686901

Centisome position: 66.2

GC content: 44.83

Gene sequence:

>513_bases
ATGGATCTTAAAAAATACGTAACAATTGTGCCCGATTACCCGAAAGAAGGCGTACAATTTAAAGATATTACGACATTGAT
GGACAAAGGCGACGTATACCGTTACGCCACTGACCAAATTGTTGAATATGCAAAAGAAAAAGAAATTGATTTAGTTGTCG
GGCCTGAAGCGCGCGGCTTTATTATCGGCTGTCCGGTTGCATACGCTCTCGGAGTGGGCTTTGCGCCGGTTCGGAAAGAA
GGAAAACTTCCGCGTGAGGTCATTAAAGTCGATTACGGTTTGGAGTACGGAAAAGACGTACTGACGATTCATAAAGATGC
GATTCTGCCGGGACAGCGCGTGCTGATTACTGATGACTTGCTTGCAACAGGCGGCACGATCGAAGCAACAATTAAGCTGG
TCGAAGAACTGGGCGGCGTTGTAGCCGGTATTGCGTTCTTAATCGAGCTTTCTTACCTTGACGGCAGAGACAAGCTTGAC
GATTACGATATTTTAACATTAATGAAATATTAA

Upstream 100 bases:

>100_bases
AGCTCAATTATTCCGCAGCCCATGAGCTGAAGGAATGGCTGAATAAGCTGATGAACCAAGGTTCAGAAGCTTATGAAAGT
ACGAGGAGGACATAGAACAG

Downstream 100 bases:

>100_bases
CCGCATATGGAAAAAAGCACTCGTGTCAGGGTGCTTTTTTCCTATTATTTCATCATCCTGACAGATTCTTTAGGTGTTTT
GAACTTCTGCCCTTTACATC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MDLKKYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYAKEKEIDLVVGPEARGFIIGCPVAYALGVGFAPVRKE
GKLPREVIKVDYGLEYGKDVLTIHKDAILPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRDKLD
DYDILTLMKY

Sequences:

>Translated_170_residues
MDLKKYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYAKEKEIDLVVGPEARGFIIGCPVAYALGVGFAPVRKE
GKLPREVIKVDYGLEYGKDVLTIHKDAILPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRDKLD
DYDILTLMKY
>Mature_170_residues
MDLKKYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYAKEKEIDLVVGPEARGFIIGCPVAYALGVGFAPVRKE
GKLPREVIKVDYGLEYGKDVLTIHKDAILPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRDKLD
DYDILTLMKY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=39.1812865497076, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=40.8, Blast_Score=98, Evalue=3e-21,
Organism=Escherichia coli, GI1786675, Length=164, Percent_Identity=54.2682926829268, Blast_Score=167, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=41.7647058823529, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323619, Length=172, Percent_Identity=40.6976744186046, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=155, Percent_Identity=36.7741935483871, Blast_Score=79, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136334, Length=162, Percent_Identity=42.5925925925926, Blast_Score=129, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_BACA2 (A7Z756)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001422063.1
- ProteinModelPortal:   A7Z756
- SMR:   A7Z756
- STRING:   A7Z756
- EnsemblBacteria:   EBBACT00000007217
- GeneID:   5460662
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_024720
- eggNOG:   COG0503
- GeneTree:   EBGT00050000001499
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   BAMY326423:RBAM_024720-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18848; Mature: 18848

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKKYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYAKEKEIDLVVGPEARGF
CCCCCEEEECCCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCEEEECCCCCCE
IIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLTIHKDAILPGQRVLITDDL
EEECHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEECCH
LATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRDKLDDYDILTLMKY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MDLKKYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYAKEKEIDLVVGPEARGF
CCCCCEEEECCCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCEEEECCCCCCE
IIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLTIHKDAILPGQRVLITDDL
EEECHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEECCH
LATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRDKLDDYDILTLMKY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA