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The map label for this gene is yqiQ [H]

Identifier: 154686671

GI number: 154686671

Start: 2377696

End: 2378601

Strand: Reverse

Name: yqiQ [H]

Synonym: RBAM_022400

Alternate gene names: 154686671

Gene position: 2378601-2377696 (Counterclockwise)

Preceding gene: 154686672

Following gene: 154686669

Centisome position: 60.7

GC content: 52.76

Gene sequence:

>906_bases
ATGACGTGGATCGTCAGCAAGCAGTCGTCTCAAGAGGAGCTTGCAGAGCGGTTCCGTACGCTGATGACAGCGCCGGATCT
ACTGCAGATCCCCGGCGCCCATGATGCGATGGCCGCTCTTATCGCCAAGAAAACGGGGTTTTCGGCTCTTTATTTATCAG
GCGCGGCTTACACGGCGAGCAGAGGGCTGCCCGATTTAGGGATCATCACGTCGGCGGAAATGGCTGAACGGGTTAAAGAT
CTGGTCCGCTCGTCTGATCTGCCCGTCCTTGTCGATATTGACACGGGTTTCGGAGGAGTGCTGAATGCCGCCCGGACGGC
GAAAGAAATGTATGAAGCGCGCGCGGCCGCCGTCCAGATGGAGGATCAGCGCCTGCCGAAAAAATGCGGACATCTGAATG
GGAAGCAGCTCGTGCCGATTGAAGAAATGGCGCAAAAAATCCAAGCGGTCAAGCGGGCCGCGCCGACTCTTCTTGTTGTT
GCGAGAACAGACGCCAGACAGCAGGAAGGATTGGAGGGGGCATTAAAAAGGGCGTCCGCTTATATAAAAGCGGGTGCTGA
CGCTGTTTTTCCGGAAGCGCTCCAATCCGAAAGTGAATTCAGAGCGTTTTCCAAACAAATCAGTGTGCCGATTCTCGCAA
ACATGACTGAATTCGGAAAAACGCCGTATTACAGTGCTGATGAATTTTCCGATATGGGCTGTCAGATGGTCATTTACCCG
GTCACGTCACTCAGAACGGCGGCCAAGGCTTTTGAGCGTATTTTCCGCCTTCTGAAAGAAGAAGGCTCGCAAAAAGAGGG
GCTTTCGGATATGCAGACGAGAAAAGAACTATATGAAACGATCGCTTACGATGACTATGAAGAACTGGATCAATCCATTG
CCAAAACAATACTGCCGGACGACTGA

Upstream 100 bases:

>100_bases
AAAAATCGAAGAGGCCTGCGAACATAGCGGCCGAATGCAGAAGCTCAGCGTCAGTGAATTTATGGACTTATTTCTCGTAT
AAAATAGGAGGGTGACAAAC

Downstream 100 bases:

>100_bases
AAAAGCCCTTTTTTTGCAAGGGCTTTTTTTACAGCTTTTTTTTCCTGAACCGCGGGCTGACTTGATTGCGTTTCCGATCT
CTGTACAGAATAAATCCGGC

Product: YqiQ

Products: NA

Alternate protein names: 2-methylisocitrate lyase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MTWIVSKQSSQEELAERFRTLMTAPDLLQIPGAHDAMAALIAKKTGFSALYLSGAAYTASRGLPDLGIITSAEMAERVKD
LVRSSDLPVLVDIDTGFGGVLNAARTAKEMYEARAAAVQMEDQRLPKKCGHLNGKQLVPIEEMAQKIQAVKRAAPTLLVV
ARTDARQQEGLEGALKRASAYIKAGADAVFPEALQSESEFRAFSKQISVPILANMTEFGKTPYYSADEFSDMGCQMVIYP
VTSLRTAAKAFERIFRLLKEEGSQKEGLSDMQTRKELYETIAYDDYEELDQSIAKTILPDD

Sequences:

>Translated_301_residues
MTWIVSKQSSQEELAERFRTLMTAPDLLQIPGAHDAMAALIAKKTGFSALYLSGAAYTASRGLPDLGIITSAEMAERVKD
LVRSSDLPVLVDIDTGFGGVLNAARTAKEMYEARAAAVQMEDQRLPKKCGHLNGKQLVPIEEMAQKIQAVKRAAPTLLVV
ARTDARQQEGLEGALKRASAYIKAGADAVFPEALQSESEFRAFSKQISVPILANMTEFGKTPYYSADEFSDMGCQMVIYP
VTSLRTAAKAFERIFRLLKEEGSQKEGLSDMQTRKELYETIAYDDYEELDQSIAKTILPDD
>Mature_300_residues
TWIVSKQSSQEELAERFRTLMTAPDLLQIPGAHDAMAALIAKKTGFSALYLSGAAYTASRGLPDLGIITSAEMAERVKDL
VRSSDLPVLVDIDTGFGGVLNAARTAKEMYEARAAAVQMEDQRLPKKCGHLNGKQLVPIEEMAQKIQAVKRAAPTLLVVA
RTDARQQEGLEGALKRASAYIKAGADAVFPEALQSESEFRAFSKQISVPILANMTEFGKTPYYSADEFSDMGCQMVIYPV
TSLRTAAKAFERIFRLLKEEGSQKEGLSDMQTRKELYETIAYDDYEELDQSIAKTILPDD

Specific function: Catalyzes the formation of pyruvate and succinate from 2-methylisocitrate [H]

COG id: COG2513

COG function: function code G; PEP phosphonomutase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1786525, Length=284, Percent_Identity=43.6619718309859, Blast_Score=234, Evalue=4e-63,
Organism=Escherichia coli, GI1790445, Length=256, Percent_Identity=32.421875, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17561814, Length=182, Percent_Identity=31.3186813186813, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71982926, Length=182, Percent_Identity=31.3186813186813, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR012695
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.30 [H]

Molecular weight: Translated: 33103; Mature: 32972

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWIVSKQSSQEELAERFRTLMTAPDLLQIPGAHDAMAALIAKKTGFSALYLSGAAYTAS
CCEEECCCCCHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHH
RGLPDLGIITSAEMAERVKDLVRSSDLPVLVDIDTGFGGVLNAARTAKEMYEARAAAVQM
CCCCCCCHHCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
EDQRLPKKCGHLNGKQLVPIEEMAQKIQAVKRAAPTLLVVARTDARQQEGLEGALKRASA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHH
YIKAGADAVFPEALQSESEFRAFSKQISVPILANMTEFGKTPYYSADEFSDMGCQMVIYP
HHHCCCCCCCHHHHHCHHHHHHHHHHCCCHHHHCHHHHCCCCCCCCCCHHHCCCEEEEEC
VTSLRTAAKAFERIFRLLKEEGSQKEGLSDMQTRKELYETIAYDDYEELDQSIAKTILPD
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
D
C
>Mature Secondary Structure 
TWIVSKQSSQEELAERFRTLMTAPDLLQIPGAHDAMAALIAKKTGFSALYLSGAAYTAS
CEEECCCCCHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHH
RGLPDLGIITSAEMAERVKDLVRSSDLPVLVDIDTGFGGVLNAARTAKEMYEARAAAVQM
CCCCCCCHHCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
EDQRLPKKCGHLNGKQLVPIEEMAQKIQAVKRAAPTLLVVARTDARQQEGLEGALKRASA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHH
YIKAGADAVFPEALQSESEFRAFSKQISVPILANMTEFGKTPYYSADEFSDMGCQMVIYP
HHHCCCCCCCHHHHHCHHHHHHHHHHCCCHHHHCHHHHCCCCCCCCCCHHHCCCEEEEEC
VTSLRTAAKAFERIFRLLKEEGSQKEGLSDMQTRKELYETIAYDDYEELDQSIAKTILPD
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]