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The map label for this gene is cysK [H]

Identifier: 154248596

GI number: 154248596

Start: 5181427

End: 5182455

Strand: Direct

Name: cysK [H]

Synonym: Xaut_4677

Alternate gene names: 154248596

Gene position: 5181427-5182455 (Clockwise)

Preceding gene: 154248595

Following gene: 154248597

Centisome position: 97.6

GC content: 66.76

Gene sequence:

>1029_bases
ATGATCCGTAACGGCCTTGTGGACTCCATCGGCAACACCCCCCTCATCCGCCTGAAGCGTGCCTCCGAAGAGACCGGCTG
CGAGATCCTCGGCAAGGCCGAGTTCCTCAATCCCGGCCAGTCGGTGAAGGACCGCGCGGCCCTCGGCATCATCAAGGACG
CTGTGGCGCGCGGGGCACTGAAGCCCGGTGGCGTCATCGTGGAAGGCACCGCCGGCAATACCGGCATCGGCCTCGCGCTG
GTGGCCGCTCCCCTCGGCTTCCGTACTGTCATCGTCATTCCCGAGACCCAGTCCCAGGAAAAGAAGGACATGCTGAAGCT
CGCCGGCGCCATCCTGGTGGAGGTGCCGGCCGTGGCCTATGCCAATCCGAATAATTACGTGAAGGTCTCCGGCCGCCTCG
CCGAGGCACTCGCCAAGACCGAGCCCAACGGCGCCATCTGGGCCAACCAGTTCGACAATGTGGCCAACCGGCAGGCCCAT
ATCGAAACCACCGGGCCCGAGATCTGGGAGCAGACCTGCGGCAAGCTGGACGGCTTCATCTGCGCGGTGGGCACCGGCGG
CACGCTGGCCGGCATCGCCATCGCGCTGAAGGCGCGCAACCCCAACATCCGCATCGGCCTCGCCGATCCCATGGGCGCGG
CGCTCTATTCCTACTACACCACCGGCGAGCTGAAGGCCGAGGGCTCCTCCATCACCGAGGGCATCGGCCAGGGGCGCATC
ACCGCCAACCTCGTGGACGCGCCCATCGACACCGCCTTCCAGATCCCGGACGAGGAAGCTTTGCCCGTGGTGTTCGACCT
GCTGCAGCACGAGGGCCTGTGCCTCGGCGGCTCGTCGGGGGTGAACGTGGCCGGCGCCATCCGCCTCGCGAAGGAGATGG
GGCCGGGCCACACCATCGTGACCATCCTGTGCGACTACGGCACCCGCTACCAGTCCAAGCTCTTCAACCCCGAGTTCCTG
CGCTCCAAGAACCTGCCGGTGCCGGAATGGCTGGAGCGCAAGGTCGAGGTGCCGAACGTCCTGGTCTGA

Upstream 100 bases:

>100_bases
GCATTTGAATCCACACGAAAATGATGGGGCTTGTCATATTGATACGGCGAGATGCGTTGAGTAACGTGCCACCACATTCA
TTGAAGGCTTTGATCCGCAC

Downstream 100 bases:

>100_bases
GCAGGCAGGGCTCCCTTCGCGGCGCGCCTTGCGCCGGCCGCTTGACGCGCGTGCCCATCCGCTCAATGAGGGGCCGCGCG
CCCTTGCCGGTGCCTGAACG

Product: pyridoxal-5'-phosphate-dependent protein subunit beta

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MIRNGLVDSIGNTPLIRLKRASEETGCEILGKAEFLNPGQSVKDRAALGIIKDAVARGALKPGGVIVEGTAGNTGIGLAL
VAAPLGFRTVIVIPETQSQEKKDMLKLAGAILVEVPAVAYANPNNYVKVSGRLAEALAKTEPNGAIWANQFDNVANRQAH
IETTGPEIWEQTCGKLDGFICAVGTGGTLAGIAIALKARNPNIRIGLADPMGAALYSYYTTGELKAEGSSITEGIGQGRI
TANLVDAPIDTAFQIPDEEALPVVFDLLQHEGLCLGGSSGVNVAGAIRLAKEMGPGHTIVTILCDYGTRYQSKLFNPEFL
RSKNLPVPEWLERKVEVPNVLV

Sequences:

>Translated_342_residues
MIRNGLVDSIGNTPLIRLKRASEETGCEILGKAEFLNPGQSVKDRAALGIIKDAVARGALKPGGVIVEGTAGNTGIGLAL
VAAPLGFRTVIVIPETQSQEKKDMLKLAGAILVEVPAVAYANPNNYVKVSGRLAEALAKTEPNGAIWANQFDNVANRQAH
IETTGPEIWEQTCGKLDGFICAVGTGGTLAGIAIALKARNPNIRIGLADPMGAALYSYYTTGELKAEGSSITEGIGQGRI
TANLVDAPIDTAFQIPDEEALPVVFDLLQHEGLCLGGSSGVNVAGAIRLAKEMGPGHTIVTILCDYGTRYQSKLFNPEFL
RSKNLPVPEWLERKVEVPNVLV
>Mature_342_residues
MIRNGLVDSIGNTPLIRLKRASEETGCEILGKAEFLNPGQSVKDRAALGIIKDAVARGALKPGGVIVEGTAGNTGIGLAL
VAAPLGFRTVIVIPETQSQEKKDMLKLAGAILVEVPAVAYANPNNYVKVSGRLAEALAKTEPNGAIWANQFDNVANRQAH
IETTGPEIWEQTCGKLDGFICAVGTGGTLAGIAIALKARNPNIRIGLADPMGAALYSYYTTGELKAEGSSITEGIGQGRI
TANLVDAPIDTAFQIPDEEALPVVFDLLQHEGLCLGGSSGVNVAGAIRLAKEMGPGHTIVTILCDYGTRYQSKLFNPEFL
RSKNLPVPEWLERKVEVPNVLV

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=342, Percent_Identity=39.766081871345, Blast_Score=215, Evalue=4e-56,
Organism=Homo sapiens, GI295821200, Length=342, Percent_Identity=39.766081871345, Blast_Score=215, Evalue=4e-56,
Organism=Homo sapiens, GI4557415, Length=342, Percent_Identity=39.766081871345, Blast_Score=215, Evalue=4e-56,
Organism=Homo sapiens, GI11345492, Length=293, Percent_Identity=26.6211604095563, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI2367138, Length=323, Percent_Identity=36.8421052631579, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1788754, Length=320, Percent_Identity=39.0625, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17535051, Length=312, Percent_Identity=35.5769230769231, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI32566674, Length=306, Percent_Identity=37.2549019607843, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17562970, Length=306, Percent_Identity=37.2549019607843, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17534315, Length=335, Percent_Identity=34.0298507462687, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17561720, Length=324, Percent_Identity=34.8765432098765, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI115535073, Length=326, Percent_Identity=35.5828220858896, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI25147552, Length=334, Percent_Identity=30.5389221556886, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32566672, Length=220, Percent_Identity=34.5454545454545, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71996324, Length=334, Percent_Identity=28.4431137724551, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321449, Length=331, Percent_Identity=38.9728096676737, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6321594, Length=343, Percent_Identity=33.8192419825073, Blast_Score=176, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24643623, Length=330, Percent_Identity=35.1515151515151, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI20129101, Length=330, Percent_Identity=35.1515151515151, Blast_Score=165, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 36075; Mature: 36075

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRNGLVDSIGNTPLIRLKRASEETGCEILGKAEFLNPGQSVKDRAALGIIKDAVARGAL
CCCCCCHHHCCCCCEEEEECCCCCCCCEEEECHHHCCCCCCHHHHHHHHHHHHHHHHCCC
KPGGVIVEGTAGNTGIGLALVAAPLGFRTVIVIPETQSQEKKDMLKLAGAILVEVPAVAY
CCCCEEEECCCCCCCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHEEECEEEE
ANPNNYVKVSGRLAEALAKTEPNGAIWANQFDNVANRQAHIETTGPEIWEQTCGKLDGFI
ECCCCEEEECCHHHHHHHHCCCCCCEECCHHHHHCCCEEEEECCCHHHHHHHHCCCCCEE
CAVGTGGTLAGIAIALKARNPNIRIGLADPMGAALYSYYTTGELKAEGSSITEGIGQGRI
EEECCCCCEEEEEEEEEECCCCEEEEECCCHHHHHHHHEECCEEEECCCHHHHHCCCCCE
TANLVDAPIDTAFQIPDEEALPVVFDLLQHEGLCLGGSSGVNVAGAIRLAKEMGPGHTIV
EEEEECCCCCCEEECCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCCEEE
TILCDYGTRYQSKLFNPEFLRSKNLPVPEWLERKVEVPNVLV
EEEECCCCHHHHHCCCHHHHHCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIRNGLVDSIGNTPLIRLKRASEETGCEILGKAEFLNPGQSVKDRAALGIIKDAVARGAL
CCCCCCHHHCCCCCEEEEECCCCCCCCEEEECHHHCCCCCCHHHHHHHHHHHHHHHHCCC
KPGGVIVEGTAGNTGIGLALVAAPLGFRTVIVIPETQSQEKKDMLKLAGAILVEVPAVAY
CCCCEEEECCCCCCCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHEEECEEEE
ANPNNYVKVSGRLAEALAKTEPNGAIWANQFDNVANRQAHIETTGPEIWEQTCGKLDGFI
ECCCCEEEECCHHHHHHHHCCCCCCEECCHHHHHCCCEEEEECCCHHHHHHHHCCCCCEE
CAVGTGGTLAGIAIALKARNPNIRIGLADPMGAALYSYYTTGELKAEGSSITEGIGQGRI
EEECCCCCEEEEEEEEEECCCCEEEEECCCHHHHHHHHEECCEEEECCCHHHHHCCCCCE
TANLVDAPIDTAFQIPDEEALPVVFDLLQHEGLCLGGSSGVNVAGAIRLAKEMGPGHTIV
EEEEECCCCCCEEECCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCCEEE
TILCDYGTRYQSKLFNPEFLRSKNLPVPEWLERKVEVPNVLV
EEEECCCCHHHHHCCCHHHHHCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA