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The map label for this gene is phr [H]

Identifier: 154248595

GI number: 154248595

Start: 5179848

End: 5181350

Strand: Direct

Name: phr [H]

Synonym: Xaut_4676

Alternate gene names: 154248595

Gene position: 5179848-5181350 (Clockwise)

Preceding gene: 154248594

Following gene: 154248596

Centisome position: 97.57

GC content: 71.52

Gene sequence:

>1503_bases
ATGAAAGCCGCCCGGTTGCCCACCTCCCAATTGCCGACGTCCGAGTCCCGTGCCTCCGGGTCACCCGCGTCCCCCTCCCT
GCTGTGGTTCCGCGACGACCTGCGGCTCTCCGACAACCCGGCGCTCGCCGCTTTGGCCGAAGCGCGCACGCCGCTCGCCG
CGCTCTATGTGCTCGACGAGGACAGCCCGGGCGTGCGTCCCCTCGGCGGGGCGGCGCGCTGGTGGCTCGCCCAGTCGCTG
CGGGCGTTGGCCGCCGACCTGAAGGACAGGGGGGTCCCCCTCATCCTGCGCCGGGGTCCGGCCAACCGGGTGGTGCCGGA
GGTTGCGGCGCTGCTGGGCGCCGCGACCGTCGCCTTCAATGACCGCGCCGGCGCGGCGGAGACCCGGGTGGACCACGCGG
TGGCCGCGCGGCTCCTGTCCGAAGACCGGCGCGTGCTCAGCTTCTGCGCCCATCTGCTGCACCCGCCCGGCAGCGTCGAA
GGGGCGTCCGGCGGCATGCCGCGCACCTTCTCCTCGTTCCACCGCGCAGCCCTCAAGGCCCGGCGGCTCGACACCCCCCT
GCCCGCGCCGAAGCATCTGGATGGTGTCGCCCATCCCCCGGAAGGCGAGACGCTGGAGAGCTTCGACCTTGAGCCCACCC
ATCCCGACTGGGCCGGCGGCCTGCGCTCCGCCTGGACCGCCGGCGAAGCGGCCGCCCAGGCGCGTCTCGCCGCCTTCATG
GACGCGGGGCTGGCCGGCTATGCGGAGGGCCGCGACCGGCCGGACCTCAACCACGTCTCCCGCCTGTCGCCCCACCTGCG
CTTCGGAGAAATCTCGCCGCGCCAGATCCTGAGCGCCGTGCGCCACGCCGCTGAGGCCGGCGCGGTGCCGCTGGTGGATG
CCGACAAGTTCGAGGCCGAGCTGTACTGGCGGGAATTCTCCTACCATCTCCTCGCCGAGATGCCGGACCTCGCCCGGAGC
AACATCCAGCACGGGTTCGACGCCTTCCCCTGGCGCGAATGCCCCGGCGAGCTGAAGGCCTGGCACAAGGGCCTGACCGG
CTATCCGCTGGTGGACGCCGGCCTGCGCCAGCTCTGGCAGACCGGATGGATGCACAACCGGGTCCGCATGGTGGTGGCCT
CCTTCCTCACCAAGCATCTGCTCATCGACTGGCGCTCCGGCGAGGACTGGTTCTGGGACACGCTGGTGGACGCGGACGGC
GCCAACAACGCCGCCTCCTGGCAATGGGTGGCGGGATCGGGGCTCGATGCAGCGCCGTATTTCCGCATCTTCAATCCGGT
GACCCAGGGCGAGAAATTCGACCCCGACGGCACCTATGTGCGCACCTTCGTGCCGGAGCTGGGCAAGCTGCCGGCGCCCC
TCATCCACAAGCCGTGGACGGCGGACGCGCATACGCTGGCCCATGCCGGCATCCGCCTCGGCCACACCTATCCGCGCCCC
CTGGTGGACCATGGTGCCGCGAGGGAGCGGGCCTTGCGGGCATTTGAATCCACACGAAAATGA

Upstream 100 bases:

>100_bases
ACGCCCCGCCCTGAACCGTGTTGGGGGGCTTACGCCCCCCTTGCATCCCCGGTCGATTGGGAGTGAACCTCTTGCGCCCC
AAGGGCGTAGGAGGAGCGCC

Downstream 100 bases:

>100_bases
TGGGGCTTGTCATATTGATACGGCGAGATGCGTTGAGTAACGTGCCACCACATTCATTGAAGGCTTTGATCCGCACATGA
TCCGTAACGGCCTTGTGGAC

Product: deoxyribodipyrimidine photo-lyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MKAARLPTSQLPTSESRASGSPASPSLLWFRDDLRLSDNPALAALAEARTPLAALYVLDEDSPGVRPLGGAARWWLAQSL
RALAADLKDRGVPLILRRGPANRVVPEVAALLGAATVAFNDRAGAAETRVDHAVAARLLSEDRRVLSFCAHLLHPPGSVE
GASGGMPRTFSSFHRAALKARRLDTPLPAPKHLDGVAHPPEGETLESFDLEPTHPDWAGGLRSAWTAGEAAAQARLAAFM
DAGLAGYAEGRDRPDLNHVSRLSPHLRFGEISPRQILSAVRHAAEAGAVPLVDADKFEAELYWREFSYHLLAEMPDLARS
NIQHGFDAFPWRECPGELKAWHKGLTGYPLVDAGLRQLWQTGWMHNRVRMVVASFLTKHLLIDWRSGEDWFWDTLVDADG
ANNAASWQWVAGSGLDAAPYFRIFNPVTQGEKFDPDGTYVRTFVPELGKLPAPLIHKPWTADAHTLAHAGIRLGHTYPRP
LVDHGAARERALRAFESTRK

Sequences:

>Translated_500_residues
MKAARLPTSQLPTSESRASGSPASPSLLWFRDDLRLSDNPALAALAEARTPLAALYVLDEDSPGVRPLGGAARWWLAQSL
RALAADLKDRGVPLILRRGPANRVVPEVAALLGAATVAFNDRAGAAETRVDHAVAARLLSEDRRVLSFCAHLLHPPGSVE
GASGGMPRTFSSFHRAALKARRLDTPLPAPKHLDGVAHPPEGETLESFDLEPTHPDWAGGLRSAWTAGEAAAQARLAAFM
DAGLAGYAEGRDRPDLNHVSRLSPHLRFGEISPRQILSAVRHAAEAGAVPLVDADKFEAELYWREFSYHLLAEMPDLARS
NIQHGFDAFPWRECPGELKAWHKGLTGYPLVDAGLRQLWQTGWMHNRVRMVVASFLTKHLLIDWRSGEDWFWDTLVDADG
ANNAASWQWVAGSGLDAAPYFRIFNPVTQGEKFDPDGTYVRTFVPELGKLPAPLIHKPWTADAHTLAHAGIRLGHTYPRP
LVDHGAARERALRAFESTRK
>Mature_500_residues
MKAARLPTSQLPTSESRASGSPASPSLLWFRDDLRLSDNPALAALAEARTPLAALYVLDEDSPGVRPLGGAARWWLAQSL
RALAADLKDRGVPLILRRGPANRVVPEVAALLGAATVAFNDRAGAAETRVDHAVAARLLSEDRRVLSFCAHLLHPPGSVE
GASGGMPRTFSSFHRAALKARRLDTPLPAPKHLDGVAHPPEGETLESFDLEPTHPDWAGGLRSAWTAGEAAAQARLAAFM
DAGLAGYAEGRDRPDLNHVSRLSPHLRFGEISPRQILSAVRHAAEAGAVPLVDADKFEAELYWREFSYHLLAEMPDLARS
NIQHGFDAFPWRECPGELKAWHKGLTGYPLVDAGLRQLWQTGWMHNRVRMVVASFLTKHLLIDWRSGEDWFWDTLVDADG
ANNAASWQWVAGSGLDAAPYFRIFNPVTQGEKFDPDGTYVRTFVPELGKLPAPLIHKPWTADAHTLAHAGIRLGHTYPRP
LVDHGAARERALRAFESTRK

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI4758072, Length=477, Percent_Identity=29.1404612159329, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI188536100, Length=493, Percent_Identity=30.0202839756592, Blast_Score=179, Evalue=8e-45,
Organism=Homo sapiens, GI188536103, Length=446, Percent_Identity=29.372197309417, Blast_Score=159, Evalue=7e-39,
Organism=Escherichia coli, GI1786926, Length=489, Percent_Identity=37.4233128834356, Blast_Score=271, Evalue=7e-74,
Organism=Saccharomyces cerevisiae, GI6324962, Length=517, Percent_Identity=28.4332688588008, Blast_Score=190, Evalue=4e-49,
Organism=Drosophila melanogaster, GI17137248, Length=498, Percent_Identity=30.7228915662651, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24585455, Length=498, Percent_Identity=30.7228915662651, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24648152, Length=513, Percent_Identity=27.6803118908382, Blast_Score=162, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 54718; Mature: 54718

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAARLPTSQLPTSESRASGSPASPSLLWFRDDLRLSDNPALAALAEARTPLAALYVLDE
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCEEEEEEEEC
DSPGVRPLGGAARWWLAQSLRALAADLKDRGVPLILRRGPANRVVPEVAALLGAATVAFN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHEEC
DRAGAAETRVDHAVAARLLSEDRRVLSFCAHLLHPPGSVEGASGGMPRTFSSFHRAALKA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
RRLDTPLPAPKHLDGVAHPPEGETLESFDLEPTHPDWAGGLRSAWTAGEAAAQARLAAFM
HHCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DAGLAGYAEGRDRPDLNHVSRLSPHLRFGEISPRQILSAVRHAAEAGAVPLVDADKFEAE
HCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHH
LYWREFSYHLLAEMPDLARSNIQHGFDAFPWRECPGELKAWHKGLTGYPLVDAGLRQLWQ
HHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
TGWMHNRVRMVVASFLTKHLLIDWRSGEDWFWDTLVDADGANNAASWQWVAGSGLDAAPY
HCCHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHCCCCCCCCCCCEEEEECCCCCCCCH
FRIFNPVTQGEKFDPDGTYVRTFVPELGKLPAPLIHKPWTADAHTLAHAGIRLGHTYPRP
HHHHCHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCH
LVDHGAARERALRAFESTRK
HHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAARLPTSQLPTSESRASGSPASPSLLWFRDDLRLSDNPALAALAEARTPLAALYVLDE
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCEEEEEEEEC
DSPGVRPLGGAARWWLAQSLRALAADLKDRGVPLILRRGPANRVVPEVAALLGAATVAFN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHEEC
DRAGAAETRVDHAVAARLLSEDRRVLSFCAHLLHPPGSVEGASGGMPRTFSSFHRAALKA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
RRLDTPLPAPKHLDGVAHPPEGETLESFDLEPTHPDWAGGLRSAWTAGEAAAQARLAAFM
HHCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DAGLAGYAEGRDRPDLNHVSRLSPHLRFGEISPRQILSAVRHAAEAGAVPLVDADKFEAE
HCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHH
LYWREFSYHLLAEMPDLARSNIQHGFDAFPWRECPGELKAWHKGLTGYPLVDAGLRQLWQ
HHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
TGWMHNRVRMVVASFLTKHLLIDWRSGEDWFWDTLVDADGANNAASWQWVAGSGLDAAPY
HCCHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHCCCCCCCCCCCEEEEECCCCCCCCH
FRIFNPVTQGEKFDPDGTYVRTFVPELGKLPAPLIHKPWTADAHTLAHAGIRLGHTYPRP
HHHHCHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCH
LVDHGAARERALRAFESTRK
HHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]