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The map label for this gene is pcm

Identifier: 154248334

GI number: 154248334

Start: 4894620

End: 4895279

Strand: Reverse

Name: pcm

Synonym: Xaut_4414

Alternate gene names: 154248334

Gene position: 4895279-4894620 (Counterclockwise)

Preceding gene: 154248337

Following gene: 154248333

Centisome position: 92.21

GC content: 67.58

Gene sequence:

>660_bases
ATGAGCACTGGCGAAAGCGAAGGCGAACAGGCGGAACGCATGGCCTTCATCCTTGGCCTGCGGCAGCGGGGGATTCGCGA
TGTAGGCGTATTGCGCGCCATGGAACTGGTGCCGCGCCCGCTGTTCGTCGATCCCGCGCTGCGCCGGCATGCCTATGACG
ACGTGGCCCTGCCCATCGCCTGCGGCCAGACCATGTCCCAGCCCAGCCTCGTCGCCGCCATGACGGAGGCGCTGTCGCTG
ACCGCCGACCATTCGGTGCTGGAGGTGGGGACGGGATCAGGTTACCACGCCGCCGTGCTCTCCCACCTCGCCGCGCGGGT
GGTGACGGTGGATCGCTACCGGTCTCTGGTGGCGGAGGCGCAGGCACGCTTCGAGGTGCTGGGTCTGCGCAATGTCACCG
CCTATGTGGGCGACGGTACCTTGGGCATGCCGGCCCGCGCCCCTTTCGATCGCATTCTGGTGACGGCGGCGGCGCCCGAC
ATTCCCTTTGCCCTGATCGACCAGCTCAAGTTCGGCGGCGTCATCGTGATGCCGTTGGGGGCGCCGGAGGAGATCCAGAC
CCTCGTGCGCTACGTGAAGGAGCAGTCCGGGCGCACCCGCACCGAACTCATGAAGGTGCGGTTCGTACCGCTGATTCCGG
GCGCTGCGGCCACACTTTGA

Upstream 100 bases:

>100_bases
CGCCTGCGCCGTGCAAGCCGCTCCTGTTCCGCTTCAACTGGAGGTCACAGGCGATCTCCTATATCTATCAACATTCAACC
CTCAGCGATGAGTGTCCCGC

Downstream 100 bases:

>100_bases
TGGAAAGCGCCACGCCGGCGCCCCATTGGTCCCATCTTACGCTGCGCTGCGGTTGCCGCCGGAGGGTGGGTCCGCTATCG
AACCTTTACGTTTGGTTTCG

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MSTGESEGEQAERMAFILGLRQRGIRDVGVLRAMELVPRPLFVDPALRRHAYDDVALPIACGQTMSQPSLVAAMTEALSL
TADHSVLEVGTGSGYHAAVLSHLAARVVTVDRYRSLVAEAQARFEVLGLRNVTAYVGDGTLGMPARAPFDRILVTAAAPD
IPFALIDQLKFGGVIVMPLGAPEEIQTLVRYVKEQSGRTRTELMKVRFVPLIPGAAATL

Sequences:

>Translated_219_residues
MSTGESEGEQAERMAFILGLRQRGIRDVGVLRAMELVPRPLFVDPALRRHAYDDVALPIACGQTMSQPSLVAAMTEALSL
TADHSVLEVGTGSGYHAAVLSHLAARVVTVDRYRSLVAEAQARFEVLGLRNVTAYVGDGTLGMPARAPFDRILVTAAAPD
IPFALIDQLKFGGVIVMPLGAPEEIQTLVRYVKEQSGRTRTELMKVRFVPLIPGAAATL
>Mature_218_residues
STGESEGEQAERMAFILGLRQRGIRDVGVLRAMELVPRPLFVDPALRRHAYDDVALPIACGQTMSQPSLVAAMTEALSLT
ADHSVLEVGTGSGYHAAVLSHLAARVVTVDRYRSLVAEAQARFEVLGLRNVTAYVGDGTLGMPARAPFDRILVTAAAPDI
PFALIDQLKFGGVIVMPLGAPEEIQTLVRYVKEQSGRTRTELMKVRFVPLIPGAAATL

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family

Homologues:

Organism=Homo sapiens, GI226530908, Length=213, Percent_Identity=32.8638497652582, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1789100, Length=204, Percent_Identity=49.5098039215686, Blast_Score=180, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI71983477, Length=190, Percent_Identity=30.5263157894737, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17981723, Length=211, Percent_Identity=32.2274881516588, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PIMT_XANP2 (A7INP1)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001419292.1
- ProteinModelPortal:   A7INP1
- SMR:   A7INP1
- STRING:   A7INP1
- GeneID:   5424488
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_4414
- eggNOG:   COG2518
- HOGENOM:   HBG699907
- OMA:   MEEVPRE
- ProtClustDB:   CLSK980295
- BioCyc:   XAUT78245:XAUT_4414-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00090
- InterPro:   IPR000682
- PANTHER:   PTHR11579
- TIGRFAMs:   TIGR00080

Pfam domain/function: PF01135 PCMT

EC number: =2.1.1.77

Molecular weight: Translated: 23550; Mature: 23419

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS01279 PCMT

Important sites: ACT_SITE 66-66

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGESEGEQAERMAFILGLRQRGIRDVGVLRAMELVPRPLFVDPALRRHAYDDVALPIA
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEECHHHHHHCCCCCEEEEE
CGQTMSQPSLVAAMTEALSLTADHSVLEVGTGSGYHAAVLSHLAARVVTVDRYRSLVAEA
CCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QARFEVLGLRNVTAYVGDGTLGMPARAPFDRILVTAAAPDIPFALIDQLKFGGVIVMPLG
HHHHHHHCCCCEEEEECCCCCCCCCCCCHHHEEEEECCCCCCHHHHHHHCCCCEEEEECC
APEEIQTLVRYVKEQSGRTRTELMKVRFVPLIPGAAATL
CCHHHHHHHHHHHHHCCCHHHHHHHHHEEEECCCHHCCC
>Mature Secondary Structure 
STGESEGEQAERMAFILGLRQRGIRDVGVLRAMELVPRPLFVDPALRRHAYDDVALPIA
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEECHHHHHHCCCCCEEEEE
CGQTMSQPSLVAAMTEALSLTADHSVLEVGTGSGYHAAVLSHLAARVVTVDRYRSLVAEA
CCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QARFEVLGLRNVTAYVGDGTLGMPARAPFDRILVTAAAPDIPFALIDQLKFGGVIVMPLG
HHHHHHHCCCCEEEEECCCCCCCCCCCCHHHEEEEECCCCCCHHHHHHHCCCCEEEEECC
APEEIQTLVRYVKEQSGRTRTELMKVRFVPLIPGAAATL
CCHHHHHHHHHHHHHCCCHHHHHHHHHEEEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA