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The map label for this gene is hom [H]

Identifier: 154247449

GI number: 154247449

Start: 3925272

End: 3926558

Strand: Reverse

Name: hom [H]

Synonym: Xaut_3521

Alternate gene names: 154247449

Gene position: 3926558-3925272 (Counterclockwise)

Preceding gene: 154247450

Following gene: 154247448

Centisome position: 73.96

GC content: 70.01

Gene sequence:

>1287_bases
ATGAGCGAACTGAAAGTGGGCCTTGCCGGCCTCGGCACCGTCGGGGCGGCGGTGTTCCGCATGCTCGAACGCCGCAAGGC
CGAGCTTGAGGCCCGCACCGGCCGCACCCTCAGGGTGACGGCGGTGGCGGCCCGCGACCGCAGCCGCGACCGTGGGCTCG
ACCTTGGCGGCGTGATCTGGTTCGAGGATCCCGTGGCGCTGGCCCGCGACGGCGACATCGATGTGTTCGTAGAGCTGATG
GGCGGCGACGGCGACCCCGCCAAAGCCGCGGTGGCCGCAGCCCTCGACCGGGGCATCCCGGTGGTGACCGCCAACAAGGC
GCTGCTGGCCAAATGCGGCGTGGAACTCGCCCAACGGGCGGAAGCTTCCCGGGCCGGCCTGCATTTCGAGGCGGCGGTGG
CGGGCGGCATCCCTATCGTGAAGACCCTGCGCGAATCGCTGGCCGGCAACACCATCGAGCGGGTGTCGGGCATCCTCAAC
GGGACCTGCAACTACATCCTCACCCGCATGGCGGAGGAGAAACTCTCCTTCCACGTCTGCCTCGGCGAGGCGCAGCGGCT
GGGCTATGCGGAGGCGGACCCGACCTTCGACATCGACGGCTTCGACACCGCCCACAAGCTCGCCATCCTCACGTCGCTGG
CCTTCGGCACCCAGGTGGATGCGGATTCCATATACGTGGAGGGCATTCGCCAGCTGACCCTCGCCGACCTCGAGGCGGCG
GACGACCTCGGCTACCGGGTGAAGCTGCTGGGCGTCGCCGTGCGCACCGAGACCGGCATCGAGCAGCGAGTGCATCCCAC
CATGGTGCCCAAGCACTGGCCCATCGCCCAGGTGTCCGGCGTCACCAATGCTGTGGCGGTGGACGGCGATGCGGTGGCGC
TGACACTGGTCGGCCCCGGCGCCGGCGGCGCGGCCACAGCCTCCGCCGTGGTGGGCGACCTGTTCGACGTGGCTCGCGGC
GCCAGGGGCTACACCTTCGGCCTGCCCGTGGCCGAGCTGACCAAGGCCGAGCGCGCCGCCATGCAGCGCCACGAGGGCGG
CTACTACATCCGCCTCGCGGTGGTGAACAAGCCCGGCACCGCCGCCACCATCGCCCGCCGCATGGCGGACGAGCAGATCT
CGCTCGAATCCATCATGCAGCGCCGGCCCGACGGCGCCGAGACCGCGCGCGTCATCCTCATCACCTATGCGACCACGGAA
GAAGCCGTGCGCCGCGCCATTGCCGCCATCGAGGCCGACGGGGTCATCTCTGCATTGCCGCAGGTGATCCGAATCGAGAA
GGATTGA

Upstream 100 bases:

>100_bases
CACCGGTCGCAGACCGGGGCCGTCGGGAGGAGTGGTGCATCCGGGCGCCGCGCGCTAAAAGCGCGGCGCTTTCCAACAGG
CGAAGAACCGGTCCGATCCC

Downstream 100 bases:

>100_bases
CGGCCATGCGCGTTGCCCGGATGCCCCAGGTCCTCGACCGTCGCCTGTCCCTGGACATGGCTCAGGTGACCGAACGCTGC
GCGGTGGCCGCCGCCCGGCT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSELKVGLAGLGTVGAAVFRMLERRKAELEARTGRTLRVTAVAARDRSRDRGLDLGGVIWFEDPVALARDGDIDVFVELM
GGDGDPAKAAVAAALDRGIPVVTANKALLAKCGVELAQRAEASRAGLHFEAAVAGGIPIVKTLRESLAGNTIERVSGILN
GTCNYILTRMAEEKLSFHVCLGEAQRLGYAEADPTFDIDGFDTAHKLAILTSLAFGTQVDADSIYVEGIRQLTLADLEAA
DDLGYRVKLLGVAVRTETGIEQRVHPTMVPKHWPIAQVSGVTNAVAVDGDAVALTLVGPGAGGAATASAVVGDLFDVARG
ARGYTFGLPVAELTKAERAAMQRHEGGYYIRLAVVNKPGTAATIARRMADEQISLESIMQRRPDGAETARVILITYATTE
EAVRRAIAAIEADGVISALPQVIRIEKD

Sequences:

>Translated_428_residues
MSELKVGLAGLGTVGAAVFRMLERRKAELEARTGRTLRVTAVAARDRSRDRGLDLGGVIWFEDPVALARDGDIDVFVELM
GGDGDPAKAAVAAALDRGIPVVTANKALLAKCGVELAQRAEASRAGLHFEAAVAGGIPIVKTLRESLAGNTIERVSGILN
GTCNYILTRMAEEKLSFHVCLGEAQRLGYAEADPTFDIDGFDTAHKLAILTSLAFGTQVDADSIYVEGIRQLTLADLEAA
DDLGYRVKLLGVAVRTETGIEQRVHPTMVPKHWPIAQVSGVTNAVAVDGDAVALTLVGPGAGGAATASAVVGDLFDVARG
ARGYTFGLPVAELTKAERAAMQRHEGGYYIRLAVVNKPGTAATIARRMADEQISLESIMQRRPDGAETARVILITYATTE
EAVRRAIAAIEADGVISALPQVIRIEKD
>Mature_427_residues
SELKVGLAGLGTVGAAVFRMLERRKAELEARTGRTLRVTAVAARDRSRDRGLDLGGVIWFEDPVALARDGDIDVFVELMG
GDGDPAKAAVAAALDRGIPVVTANKALLAKCGVELAQRAEASRAGLHFEAAVAGGIPIVKTLRESLAGNTIERVSGILNG
TCNYILTRMAEEKLSFHVCLGEAQRLGYAEADPTFDIDGFDTAHKLAILTSLAFGTQVDADSIYVEGIRQLTLADLEAAD
DLGYRVKLLGVAVRTETGIEQRVHPTMVPKHWPIAQVSGVTNAVAVDGDAVALTLVGPGAGGAATASAVVGDLFDVARGA
RGYTFGLPVAELTKAERAAMQRHEGGYYIRLAVVNKPGTAATIARRMADEQISLESIMQRRPDGAETARVILITYATTEE
AVRRAIAAIEADGVISALPQVIRIEKD

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=360, Percent_Identity=26.1111111111111, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786183, Length=246, Percent_Identity=29.6747967479675, Blast_Score=73, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322599, Length=156, Percent_Identity=28.8461538461538, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45204; Mature: 45073

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELKVGLAGLGTVGAAVFRMLERRKAELEARTGRTLRVTAVAARDRSRDRGLDLGGVIW
CCCCEECHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHCCCCCCCEEE
FEDPVALARDGDIDVFVELMGGDGDPAKAAVAAALDRGIPVVTANKALLAKCGVELAQRA
ECCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHH
EASRAGLHFEAAVAGGIPIVKTLRESLAGNTIERVSGILNGTCNYILTRMAEEKLSFHVC
HHHHCCCEEEEHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHEEEEE
LGEAQRLGYAEADPTFDIDGFDTAHKLAILTSLAFGTQVDADSIYVEGIRQLTLADLEAA
ECHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
DDLGYRVKLLGVAVRTETGIEQRVHPTMVPKHWPIAQVSGVTNAVAVDGDAVALTLVGPG
CCCCCEEEEEEEEEECCCCHHHCCCCCCCCCCCCCHHHCCCCCEEEECCCEEEEEEEECC
AGGAATASAVVGDLFDVARGARGYTFGLPVAELTKAERAAMQRHEGGYYIRLAVVNKPGT
CCCHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCCC
AATIARRMADEQISLESIMQRRPDGAETARVILITYATTEEAVRRAIAAIEADGVISALP
HHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEEEEECHHHHHHHHHHHHCCCCHHHHCH
QVIRIEKD
HHHEECCC
>Mature Secondary Structure 
SELKVGLAGLGTVGAAVFRMLERRKAELEARTGRTLRVTAVAARDRSRDRGLDLGGVIW
CCCEECHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHCCCCCCCEEE
FEDPVALARDGDIDVFVELMGGDGDPAKAAVAAALDRGIPVVTANKALLAKCGVELAQRA
ECCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHH
EASRAGLHFEAAVAGGIPIVKTLRESLAGNTIERVSGILNGTCNYILTRMAEEKLSFHVC
HHHHCCCEEEEHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHEEEEE
LGEAQRLGYAEADPTFDIDGFDTAHKLAILTSLAFGTQVDADSIYVEGIRQLTLADLEAA
ECHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
DDLGYRVKLLGVAVRTETGIEQRVHPTMVPKHWPIAQVSGVTNAVAVDGDAVALTLVGPG
CCCCCEEEEEEEEEECCCCHHHCCCCCCCCCCCCCHHHCCCCCEEEECCCEEEEEEEECC
AGGAATASAVVGDLFDVARGARGYTFGLPVAELTKAERAAMQRHEGGYYIRLAVVNKPGT
CCCHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCCC
AATIARRMADEQISLESIMQRRPDGAETARVILITYATTEEAVRRAIAAIEADGVISALP
HHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEEEEECHHHHHHHHHHHHCCCCHHHHCH
QVIRIEKD
HHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]