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The map label for this gene is acxA

Identifier: 154247437

GI number: 154247437

Start: 3906138

End: 3908291

Strand: Direct

Name: acxA

Synonym: Xaut_3509

Alternate gene names: 154247437

Gene position: 3906138-3908291 (Clockwise)

Preceding gene: 154247434

Following gene: 154247438

Centisome position: 73.58

GC content: 65.88

Gene sequence:

>2154_bases
GTGAACGTTCCCGTGGGACACCTGCGCAACGTCCAGGTGCTTGGCATCGATGCCGGCGGCACCATGACGGACACTTTCTT
CGTGGACCAGGACGGCGACTTCGTCGTCGGCAAGGCCCAGTCCACGCCCCAGAACGAGGCTTTGGGCCTCATCGCCTCGT
CTGAAGACGGGCTCGCCAACTGGGGCATGTCGCTCCACGAGGCGCTGGCCCAGCTTCAGACCGGTGTCTATTCCGGCACC
GCGATGCTCAATCGCGTGGTCCAGCGCAAGGGGCTGAAATGCGGCCTCATCGTCAATCGCGGCATGGAGGATTTCCACCG
CATGGGCCGCGCGGTGCAGAGCCACCTCGGCTACGCCTATGAGGACCGCATCCACCTCAACACCCACCGCTACGATCCCC
CGCTCGTCCCGCGCCACCTCACCCGCGGCGTGGTGGAGCGCACCGACATGATCGGCACGCAGGTGATCCCGCTGCGCGAG
GACACGGCGCGGGACGCCGCCCGCGACCTGATCGCGGCCGACGCGGAAGGCATCGTCATCTCGCTGCTGCATTCCTACAA
GAACCCGGAGAACGAGCGCCGCGTGCGCGACATCGTGCTGGAGGAAGTGGAGAAGAGCGGCAAGAAGATCCCGGTCTTCG
CCTCCGCCGATTATTATCCGGTGCGCAAGGAAACCCACCGCACCAACACCACCATCCTCGAAGGCTACGCCGCCGAGCCC
TCGCGGCAGACCCTGTCCAAGATTTCCAACGCCTTCAAGGAGCGTGGCACCAAGTTCGACTTCCGCGTGATGGCGACCCA
TGGCGGCACCATCTCCTGGAAGGCGAAGGAGCTGGCGCGCACCATCGTGTCTGGCCCCATCGGCGGGGTGATCGGCGCGA
AATATCTCGGCGAGGTGCTGGGCTACAAGAACATCGCCTGCTCGGACATCGGCGGCACCTCGTTCGACGTGGCGCTGATC
ACCCAGGGCGAGATGACCATCAAGAACGATCCGGACATGGCGCGCCTCGTCCTGTCGCTGCCGCTGGTGGCCATGGATTC
GGTGGGCGCCGGCGCCGGCTCCTTCATTCGGCTCGATCCCTATACCCGGGCCATCAAGCTGGGGCCGGATTCGGCCGGCT
ACCGGGTGGGCGTGTGCTGGAAGGAGAGCGGCATCGAGACGGTGACCATCTCCGACTGTCACATGGTGCTCGGCTATCTC
AACCCCGACAACTTCCTCGGCGGGGCGGTGAAGCTCGATCGCCAGCGCTCGGTGGATGCCATCAAGGCGCAGATTGCCGA
TCCGCTCGGCCTGTCGGTCGAGGATGCCGCCGCCGGCGTTATCGAACTGCTCGACAGCGACCTGCGCGACTACCTGCGCT
CCATGATCTCCGGCAAGGGCTATTCGCCGGCGAGCTTCGTGTGCTTCTCCTATGGCGGCGCCGGCCCGGTGCACACCTAT
GGCTACACCGAGGGCCTTGGCTTCGAGGATGTGATCGTTCCGGCCTGGGCGGCGGGCTTCTCCGCCTTCGGCTGCGCGGC
GGCGGATTTCGAGTATCGCTACGACAAGTCCCTCGACATCAACATGCCGACGGAGACCCCTGACACCGACAAGGAGAAGG
CCGCCGCCACCCTCCAGGCGGCATGGGAGGAACTCACCAAGAACGTGCTCGAAGAGTTCAAGCTGAACGGCTATTCGGCC
GACCAGGTGACGCTCCAGCCCGGCTACCGCATGCAGTATCGCGGGCAGCTCAACGACCTGGAGATAGAGAGCCCGCTGGC
GCAGGCCCACACCGCGGCTGACTGGGACCAGCTGACGGACGCCTTCAACGCCACCTATGGCCGGGTCTATGCCGCCTCCG
CCCGCTCGCCGGAGCTGGGCTATTCGGTTACCGGCGCCATCATGCGCGGCATGGTGCCGATCCCCAAGCCCAAGATCCCC
AAGGAGCCGGAGGAGGGCGAGACCCCGCCGGAGAGCGCCAAGATCGGCACCCGCAAGTTCTATCGCAAGAAGCGGTGGGT
GGATGCGCAGCTCTATCACATGGAGTCGCTGCGCCCCGGCAACCGGGTGATGGGCCCTGCCGTGATCGAATCCGACGCCA
CCACCTTCGTGGTGCCCGACGGCTTCGAGACCTGGCTCGACGGCCACCGCCTGTTCCACCTGCGCGAGGTGTGA

Upstream 100 bases:

>100_bases
CGTGATTTTCTACAGTCGAACGCCTCTGGCACGCATCCTGCCACTCCCATGGCGAGCCGGCACCGAAAAGTGAGGCCGGC
ATTAATGGGAGGACAACGGC

Downstream 100 bases:

>100_bases
GGGCAGGTCAGGACGGGCCGTCATGCCCGGGCTTGTCCCGGGCATCCACACCGTGCCGCTCGCGCAACGCTCTGAATGCT
GCTCCCAGCCGCGAGGCGTG

Product: 5-oxoprolinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 717; Mature: 717

Protein sequence:

>717_residues
MNVPVGHLRNVQVLGIDAGGTMTDTFFVDQDGDFVVGKAQSTPQNEALGLIASSEDGLANWGMSLHEALAQLQTGVYSGT
AMLNRVVQRKGLKCGLIVNRGMEDFHRMGRAVQSHLGYAYEDRIHLNTHRYDPPLVPRHLTRGVVERTDMIGTQVIPLRE
DTARDAARDLIAADAEGIVISLLHSYKNPENERRVRDIVLEEVEKSGKKIPVFASADYYPVRKETHRTNTTILEGYAAEP
SRQTLSKISNAFKERGTKFDFRVMATHGGTISWKAKELARTIVSGPIGGVIGAKYLGEVLGYKNIACSDIGGTSFDVALI
TQGEMTIKNDPDMARLVLSLPLVAMDSVGAGAGSFIRLDPYTRAIKLGPDSAGYRVGVCWKESGIETVTISDCHMVLGYL
NPDNFLGGAVKLDRQRSVDAIKAQIADPLGLSVEDAAAGVIELLDSDLRDYLRSMISGKGYSPASFVCFSYGGAGPVHTY
GYTEGLGFEDVIVPAWAAGFSAFGCAAADFEYRYDKSLDINMPTETPDTDKEKAAATLQAAWEELTKNVLEEFKLNGYSA
DQVTLQPGYRMQYRGQLNDLEIESPLAQAHTAADWDQLTDAFNATYGRVYAASARSPELGYSVTGAIMRGMVPIPKPKIP
KEPEEGETPPESAKIGTRKFYRKKRWVDAQLYHMESLRPGNRVMGPAVIESDATTFVVPDGFETWLDGHRLFHLREV

Sequences:

>Translated_717_residues
MNVPVGHLRNVQVLGIDAGGTMTDTFFVDQDGDFVVGKAQSTPQNEALGLIASSEDGLANWGMSLHEALAQLQTGVYSGT
AMLNRVVQRKGLKCGLIVNRGMEDFHRMGRAVQSHLGYAYEDRIHLNTHRYDPPLVPRHLTRGVVERTDMIGTQVIPLRE
DTARDAARDLIAADAEGIVISLLHSYKNPENERRVRDIVLEEVEKSGKKIPVFASADYYPVRKETHRTNTTILEGYAAEP
SRQTLSKISNAFKERGTKFDFRVMATHGGTISWKAKELARTIVSGPIGGVIGAKYLGEVLGYKNIACSDIGGTSFDVALI
TQGEMTIKNDPDMARLVLSLPLVAMDSVGAGAGSFIRLDPYTRAIKLGPDSAGYRVGVCWKESGIETVTISDCHMVLGYL
NPDNFLGGAVKLDRQRSVDAIKAQIADPLGLSVEDAAAGVIELLDSDLRDYLRSMISGKGYSPASFVCFSYGGAGPVHTY
GYTEGLGFEDVIVPAWAAGFSAFGCAAADFEYRYDKSLDINMPTETPDTDKEKAAATLQAAWEELTKNVLEEFKLNGYSA
DQVTLQPGYRMQYRGQLNDLEIESPLAQAHTAADWDQLTDAFNATYGRVYAASARSPELGYSVTGAIMRGMVPIPKPKIP
KEPEEGETPPESAKIGTRKFYRKKRWVDAQLYHMESLRPGNRVMGPAVIESDATTFVVPDGFETWLDGHRLFHLREV
>Mature_717_residues
MNVPVGHLRNVQVLGIDAGGTMTDTFFVDQDGDFVVGKAQSTPQNEALGLIASSEDGLANWGMSLHEALAQLQTGVYSGT
AMLNRVVQRKGLKCGLIVNRGMEDFHRMGRAVQSHLGYAYEDRIHLNTHRYDPPLVPRHLTRGVVERTDMIGTQVIPLRE
DTARDAARDLIAADAEGIVISLLHSYKNPENERRVRDIVLEEVEKSGKKIPVFASADYYPVRKETHRTNTTILEGYAAEP
SRQTLSKISNAFKERGTKFDFRVMATHGGTISWKAKELARTIVSGPIGGVIGAKYLGEVLGYKNIACSDIGGTSFDVALI
TQGEMTIKNDPDMARLVLSLPLVAMDSVGAGAGSFIRLDPYTRAIKLGPDSAGYRVGVCWKESGIETVTISDCHMVLGYL
NPDNFLGGAVKLDRQRSVDAIKAQIADPLGLSVEDAAAGVIELLDSDLRDYLRSMISGKGYSPASFVCFSYGGAGPVHTY
GYTEGLGFEDVIVPAWAAGFSAFGCAAADFEYRYDKSLDINMPTETPDTDKEKAAATLQAAWEELTKNVLEEFKLNGYSA
DQVTLQPGYRMQYRGQLNDLEIESPLAQAHTAADWDQLTDAFNATYGRVYAASARSPELGYSVTGAIMRGMVPIPKPKIP
KEPEEGETPPESAKIGTRKFYRKKRWVDAQLYHMESLRPGNRVMGPAVIESDATTFVVPDGFETWLDGHRLFHLREV

Specific function: Catalyzes the carboxylation of acetone to form acetoacetate. Has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxide

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family

Homologues:

Organism=Homo sapiens, GI48314820, Length=745, Percent_Identity=23.3557046979866, Blast_Score=107, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI133901900, Length=707, Percent_Identity=21.3578500707214, Blast_Score=94, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322634, Length=756, Percent_Identity=22.2222222222222, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45550492, Length=742, Percent_Identity=24.5283018867925, Blast_Score=148, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACXA_XANP2 (Q8RM04)

Other databases:

- EMBL:   AF251789
- EMBL:   AY055852
- EMBL:   CP000781
- RefSeq:   YP_001418395.1
- STRING:   Q8RM04
- GeneID:   5423702
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_3509
- HOGENOM:   HBG303072
- OMA:   GFSAFGC
- ProtClustDB:   CLSK864233
- BioCyc:   XAUT78245:XAUT_3509-MONOMER
- InterPro:   IPR008040
- InterPro:   IPR002821

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A

EC number: =6.4.1.6

Molecular weight: Translated: 78510; Mature: 78510

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVPVGHLRNVQVLGIDAGGTMTDTFFVDQDGDFVVGKAQSTPQNEALGLIASSEDGLAN
CCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCEEEECCCCCCCCCCEEEEECCCCCHHH
WGMSLHEALAQLQTGVYSGTAMLNRVVQRKGLKCGLIVNRGMEDFHRMGRAVQSHLGYAY
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCEE
EDRIHLNTHRYDPPLVPRHLTRGVVERTDMIGTQVIPLREDTARDAARDLIAADAEGIVI
ECEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCHHH
SLLHSYKNPENERRVRDIVLEEVEKSGKKIPVFASADYYPVRKETHRTNTTILEGYAAEP
HHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHCCCCCEEEECCCCCC
SRQTLSKISNAFKERGTKFDFRVMATHGGTISWKAKELARTIVSGPIGGVIGAKYLGEVL
HHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHH
GYKNIACSDIGGTSFDVALITQGEMTIKNDPDMARLVLSLPLVAMDSVGAGAGSFIRLDP
CCCCCEEECCCCCEEEEEEEECCCEEECCCCHHHHHHHHCCHHHHHCCCCCCCCEEEECC
YTRAIKLGPDSAGYRVGVCWKESGIETVTISDCHMVLGYLNPDNFLGGAVKLDRQRSVDA
CCEEEEECCCCCCCEEEEEEECCCCCEEEECCCEEEEEECCCCCCCCCCEEECCHHHHHH
IKAQIADPLGLSVEDAAAGVIELLDSDLRDYLRSMISGKGYSPASFVCFSYGGAGPVHTY
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCC
GYTEGLGFEDVIVPAWAAGFSAFGCAAADFEYRYDKSLDINMPTETPDTDKEKAAATLQA
CCCCCCCCCHHHHHHHHHHHHHHCCEECCCCEECCCEEEECCCCCCCCCCHHHHHHHHHH
AWEELTKNVLEEFKLNGYSADQVTLQPGYRMQYRGQLNDLEIESPLAQAHTAADWDQLTD
HHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCCCCCCCCCCHHHHHCCCCHHHHHH
AFNATYGRVYAASARSPELGYSVTGAIMRGMVPIPKPKIPKEPEEGETPPESAKIGTRKF
HHCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
YRKKRWVDAQLYHMESLRPGNRVMGPAVIESDATTFVVPDGFETWLDGHRLFHLREV
HHHHHCCCHHHHHHHHCCCCCCCCCCEEEECCCCEEEECCCHHHHHCCCEEEEEECC
>Mature Secondary Structure
MNVPVGHLRNVQVLGIDAGGTMTDTFFVDQDGDFVVGKAQSTPQNEALGLIASSEDGLAN
CCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCEEEECCCCCCCCCCEEEEECCCCCHHH
WGMSLHEALAQLQTGVYSGTAMLNRVVQRKGLKCGLIVNRGMEDFHRMGRAVQSHLGYAY
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCEE
EDRIHLNTHRYDPPLVPRHLTRGVVERTDMIGTQVIPLREDTARDAARDLIAADAEGIVI
ECEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCHHH
SLLHSYKNPENERRVRDIVLEEVEKSGKKIPVFASADYYPVRKETHRTNTTILEGYAAEP
HHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHCCCCCEEEECCCCCC
SRQTLSKISNAFKERGTKFDFRVMATHGGTISWKAKELARTIVSGPIGGVIGAKYLGEVL
HHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHH
GYKNIACSDIGGTSFDVALITQGEMTIKNDPDMARLVLSLPLVAMDSVGAGAGSFIRLDP
CCCCCEEECCCCCEEEEEEEECCCEEECCCCHHHHHHHHCCHHHHHCCCCCCCCEEEECC
YTRAIKLGPDSAGYRVGVCWKESGIETVTISDCHMVLGYLNPDNFLGGAVKLDRQRSVDA
CCEEEEECCCCCCCEEEEEEECCCCCEEEECCCEEEEEECCCCCCCCCCEEECCHHHHHH
IKAQIADPLGLSVEDAAAGVIELLDSDLRDYLRSMISGKGYSPASFVCFSYGGAGPVHTY
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCC
GYTEGLGFEDVIVPAWAAGFSAFGCAAADFEYRYDKSLDINMPTETPDTDKEKAAATLQA
CCCCCCCCCHHHHHHHHHHHHHHCCEECCCCEECCCEEEECCCCCCCCCCHHHHHHHHHH
AWEELTKNVLEEFKLNGYSADQVTLQPGYRMQYRGQLNDLEIESPLAQAHTAADWDQLTD
HHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCCCCCCCCCCHHHHHCCCCHHHHHH
AFNATYGRVYAASARSPELGYSVTGAIMRGMVPIPKPKIPKEPEEGETPPESAKIGTRKF
HHCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
YRKKRWVDAQLYHMESLRPGNRVMGPAVIESDATTFVVPDGFETWLDGHRLFHLREV
HHHHHCCCHHHHHHHHCCCCCCCCCCEEEECCCCEEEECCCHHHHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12003937