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The map label for this gene is bioA [H]

Identifier: 154246855

GI number: 154246855

Start: 3243035

End: 3244300

Strand: Direct

Name: bioA [H]

Synonym: Xaut_2920

Alternate gene names: 154246855

Gene position: 3243035-3244300 (Clockwise)

Preceding gene: 154246854

Following gene: 154246856

Centisome position: 61.09

GC content: 69.67

Gene sequence:

>1266_bases
ATGACCGCAAGCCCTTCTCCCGTCTGGCATCCCTTCACCCAGCACGCGCTTGCGCCTGAGCCGCCGGTGGTGGTGCGGGG
GAATGGCGCGTGGCTGGAGACCGCCAGCGGCGGGCGCATTCTGGACGCTATTTCCTCGTGGTGGGTCATCACCCATGGCC
ATTGCCATCCGCGCATCGTCGCCGCCATCGCGGAGCAGGCCGGGCAGCTCGACCAGGTGATCTTCGCCGGCCACACCCAT
CCCGCCGCCGAGGCGCTGGCGCGCGGCCTCGTGGCCATGACGCCGGAGGGGCTCGATCACGTCTTCTTCTCGGACAGCGG
CTCCACCGCGGTCGAGGTCGCGCTCAAGATGGCGGCGGGCTACTGGCGCCACACCGGCGAGCAGCGCACCCGCATCCTGG
CGCTGGAGCACGGCTATCACGGCGATACCATCGGCACCATGTCGGTGGGCGCGCGGGGCGTCTACAACGCGGCCTACGAG
CCGTTCCTGTTCGAGGTGACGCGGCTGCCGTTTCCTGAGAAGGGCCGCGAGCAGGCGACCCTGGACGCGCTGGAAGCCGC
CTGCCGGGAGGCGCCGGCCGCGCTGTTGGTGGAGCCACTGATCCTCGGTGCCGGCGGCATGTACATCTATGGGCCCGGGG
TGCTGGCCGAAATGGCGGCGATCTGTGCCCGCCACGGTGTACTCTTCATCGCCGACGAGGTGATGACCGGATTCGGACGC
ACCGGCACCCTGTTTGCCTGTGAGCAGGCGGGTGTGGTTCCGGATATCGCCTGCTACGCCAAGGGCCTCACCGGCGGCTC
GCTGCCGCTGGCCGTCACCCTGTGCCGGAGCGCCATCTTCGATGCCCATTATTCCACCGATCGGGCGCGCACCTTCTTCC
ATTCCAGCTCGTTCACGGCCAATCCCATCGCCTGCGCGGCGGCGGTCGCCAACCTGAAGATCTGGGCGGAGGAGCCGGTT
CGCGGGCGCATCACCGCGCTTGGGGACGCGCAGGAGGAGCGCCTCGCGAACTTCCGCGACGACCGGCGCTTTGCCAACGT
GCGCCGCATCGGGACTATCGCTGCGCTGGACCTCGTGGCGCCCGATCCCGGCTATCTCGCGGATGTGGGGCCGCGGCTCG
CCGCCTTCTTCCGGGACGAGGGGCTGCTCATCCGCCCGCTGGGCAACACGCTGTATGTGATGCCGCCCTATTGCACCACG
GCCGAGGACCTCGACCTCGTCTACGGGGCCATCGCCACCGCCGCCGACCGCTTCGGGCGGGCTTGA

Upstream 100 bases:

>100_bases
GGCGCCTGCCGCACCTGCCCGAGGTGACGCCCGTCGCGCTCAAGGCCGCCTTCGCGGCGGCCTTCACCCTTGATGATTTC
CGCCGAGAGGACCTCCGGCC

Downstream 100 bases:

>100_bases
GCATGACACGGACACCCGTGGCGGGAACCCGCATCGCCGGCTTCGGCCACTACGCACCAGAGCAGGTGGTGACGAGCGTT
GAGATCGAGCGTGGGCTGGG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MTASPSPVWHPFTQHALAPEPPVVVRGNGAWLETASGGRILDAISSWWVITHGHCHPRIVAAIAEQAGQLDQVIFAGHTH
PAAEALARGLVAMTPEGLDHVFFSDSGSTAVEVALKMAAGYWRHTGEQRTRILALEHGYHGDTIGTMSVGARGVYNAAYE
PFLFEVTRLPFPEKGREQATLDALEAACREAPAALLVEPLILGAGGMYIYGPGVLAEMAAICARHGVLFIADEVMTGFGR
TGTLFACEQAGVVPDIACYAKGLTGGSLPLAVTLCRSAIFDAHYSTDRARTFFHSSSFTANPIACAAAVANLKIWAEEPV
RGRITALGDAQEERLANFRDDRRFANVRRIGTIAALDLVAPDPGYLADVGPRLAAFFRDEGLLIRPLGNTLYVMPPYCTT
AEDLDLVYGAIATAADRFGRA

Sequences:

>Translated_421_residues
MTASPSPVWHPFTQHALAPEPPVVVRGNGAWLETASGGRILDAISSWWVITHGHCHPRIVAAIAEQAGQLDQVIFAGHTH
PAAEALARGLVAMTPEGLDHVFFSDSGSTAVEVALKMAAGYWRHTGEQRTRILALEHGYHGDTIGTMSVGARGVYNAAYE
PFLFEVTRLPFPEKGREQATLDALEAACREAPAALLVEPLILGAGGMYIYGPGVLAEMAAICARHGVLFIADEVMTGFGR
TGTLFACEQAGVVPDIACYAKGLTGGSLPLAVTLCRSAIFDAHYSTDRARTFFHSSSFTANPIACAAAVANLKIWAEEPV
RGRITALGDAQEERLANFRDDRRFANVRRIGTIAALDLVAPDPGYLADVGPRLAAFFRDEGLLIRPLGNTLYVMPPYCTT
AEDLDLVYGAIATAADRFGRA
>Mature_420_residues
TASPSPVWHPFTQHALAPEPPVVVRGNGAWLETASGGRILDAISSWWVITHGHCHPRIVAAIAEQAGQLDQVIFAGHTHP
AAEALARGLVAMTPEGLDHVFFSDSGSTAVEVALKMAAGYWRHTGEQRTRILALEHGYHGDTIGTMSVGARGVYNAAYEP
FLFEVTRLPFPEKGREQATLDALEAACREAPAALLVEPLILGAGGMYIYGPGVLAEMAAICARHGVLFIADEVMTGFGRT
GTLFACEQAGVVPDIACYAKGLTGGSLPLAVTLCRSAIFDAHYSTDRARTFFHSSSFTANPIACAAAVANLKIWAEEPVR
GRITALGDAQEERLANFRDDRRFANVRRIGTIAALDLVAPDPGYLADVGPRLAAFFRDEGLLIRPLGNTLYVMPPYCTTA
EDLDLVYGAIATAADRFGRA

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=407, Percent_Identity=28.2555282555283, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI13994255, Length=438, Percent_Identity=26.9406392694064, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI37574042, Length=412, Percent_Identity=26.2135922330097, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI24119277, Length=410, Percent_Identity=26.3414634146341, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI284507298, Length=306, Percent_Identity=29.7385620915033, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI226442709, Length=376, Percent_Identity=26.5957446808511, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI226442705, Length=412, Percent_Identity=25.4854368932039, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1786991, Length=417, Percent_Identity=40.0479616306954, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI145693181, Length=395, Percent_Identity=31.3924050632911, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI1789016, Length=394, Percent_Identity=30.2030456852792, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1789759, Length=348, Percent_Identity=31.0344827586207, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788044, Length=408, Percent_Identity=29.1666666666667, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1787560, Length=350, Percent_Identity=31.7142857142857, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1786349, Length=317, Percent_Identity=29.0220820189274, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI32564660, Length=438, Percent_Identity=29.6803652968037, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25144271, Length=416, Percent_Identity=25.4807692307692, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71992977, Length=422, Percent_Identity=26.0663507109005, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=287, Percent_Identity=27.1777003484321, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17541228, Length=288, Percent_Identity=24.3055555555556, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324386, Length=451, Percent_Identity=31.2638580931264, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6323470, Length=419, Percent_Identity=28.8782816229117, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=416, Percent_Identity=26.4423076923077, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI21357415, Length=418, Percent_Identity=26.3157894736842, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI161085790, Length=438, Percent_Identity=29.6803652968037, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI28574759, Length=438, Percent_Identity=29.6803652968037, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI21356575, Length=417, Percent_Identity=28.0575539568345, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 44983; Mature: 44851

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASPSPVWHPFTQHALAPEPPVVVRGNGAWLETASGGRILDAISSWWVITHGHCHPRIV
CCCCCCCCCCCHHHCCCCCCCCEEEECCCCEEEECCCCHHHHHHHCCEEEEECCCCHHHH
AAIAEQAGQLDQVIFAGHTHPAAEALARGLVAMTPEGLDHVFFSDSGSTAVEVALKMAAG
HHHHHHCCCCCCEEEECCCCHHHHHHHCCCEEECCCCCCEEEECCCCCHHHHHHHHHHHH
YWRHTGEQRTRILALEHGYHGDTIGTMSVGARGVYNAAYEPFLFEVTRLPFPEKGREQAT
HHHCCCCCCEEEEEEECCCCCCCCEEHHCCCCCHHHCCCCCHHHHHHCCCCCCCCCHHHH
LDALEAACREAPAALLVEPLILGAGGMYIYGPGVLAEMAAICARHGVLFIADEVMTGFGR
HHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCEEEEEHHHHHCCCC
TGTLFACEQAGVVPDIACYAKGLTGGSLPLAVTLCRSAIFDAHYSTDRARTFFHSSSFTA
CCCEEEECCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHEEECCCCCC
NPIACAAAVANLKIWAEEPVRGRITALGDAQEERLANFRDDRRFANVRRIGTIAALDLVA
CHHHHHHHHHHEEEEECCCCCCEEEECCCCHHHHHHCCHHHHHHHHHHHHHHEEEEEEEC
PDPGYLADVGPRLAAFFRDEGLLIRPLGNTLYVMPPYCTTAEDLDLVYGAIATAADRFGR
CCCCCHHHCCHHHHHHHCCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
A
C
>Mature Secondary Structure 
TASPSPVWHPFTQHALAPEPPVVVRGNGAWLETASGGRILDAISSWWVITHGHCHPRIV
CCCCCCCCCCHHHCCCCCCCCEEEECCCCEEEECCCCHHHHHHHCCEEEEECCCCHHHH
AAIAEQAGQLDQVIFAGHTHPAAEALARGLVAMTPEGLDHVFFSDSGSTAVEVALKMAAG
HHHHHHCCCCCCEEEECCCCHHHHHHHCCCEEECCCCCCEEEECCCCCHHHHHHHHHHHH
YWRHTGEQRTRILALEHGYHGDTIGTMSVGARGVYNAAYEPFLFEVTRLPFPEKGREQAT
HHHCCCCCCEEEEEEECCCCCCCCEEHHCCCCCHHHCCCCCHHHHHHCCCCCCCCCHHHH
LDALEAACREAPAALLVEPLILGAGGMYIYGPGVLAEMAAICARHGVLFIADEVMTGFGR
HHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCEEEEEHHHHHCCCC
TGTLFACEQAGVVPDIACYAKGLTGGSLPLAVTLCRSAIFDAHYSTDRARTFFHSSSFTA
CCCEEEECCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHEEECCCCCC
NPIACAAAVANLKIWAEEPVRGRITALGDAQEERLANFRDDRRFANVRRIGTIAALDLVA
CHHHHHHHHHHEEEEECCCCCCEEEECCCCHHHHHHCCHHHHHHHHHHHHHHEEEEEEEC
PDPGYLADVGPRLAAFFRDEGLLIRPLGNTLYVMPPYCTTAEDLDLVYGAIATAADRFGR
CCCCCHHHCCHHHHHHHCCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]