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The map label for this gene is mro [H]

Identifier: 154244970

GI number: 154244970

Start: 1171527

End: 1172594

Strand: Reverse

Name: mro [H]

Synonym: Xaut_1020

Alternate gene names: 154244970

Gene position: 1172594-1171527 (Counterclockwise)

Preceding gene: 154244971

Following gene: 154244965

Centisome position: 22.09

GC content: 70.6

Gene sequence:

>1068_bases
ATGACGACCCCCATCCTGCGCGAGAATTTCGGCCTGCTGCCCCATGGCCCGGTGGTGGAGCGGGTGCGCCTCCTGGGCGC
CGGGGGCTTCGAGGCGTCGGTCATCACCTATGGCGCGGCGCTGCAGGCGCTGCATGTGCCCGACGCCCATGGCGTGCTCG
CCGACGTGGTGCTCGGCCATGACGATGCCGCCGGCTATGGGCGGACGCGCGATTTCTACGGCGTCACCGTGGGCCGCGTC
GCCAACCGCATCGCCGGGGCGGCCTTCGACCTCGACGGCGCCCGCTTCACCGTTGAGGCCAATGACGGCGCCAACATGCT
GCACGGCGGCTTCAACGGCTTCGACCGGGCGCTGTGGACCATTGAGGCGGTGGACGAGGACCCGGTCCCGGCCGTCACCC
TGCGCCACATCAGCCCGGACGGGGCCGGCGGCTTTCCCGGCACGCTGGATGCCCGCGTCACCTACAGCCTCTCGGGCCTC
GGCGAACTGACCATCGCCTTTTCAGCGATGAGCGACCGGCCCACCGTGGTGAACCTCACCAACCACGCCTTCTTCAACCT
GGACGGGGTGGAGACGGGCGGCGATATCCTGGGCCATCACCTCACGCTTGCCGCCGAGCGCTTCCTCGCCACCGATTCCG
CGGCGATCCCCCTGCCCGGCCCGCCCCGCACGGTGGATGGCACGCCGTTCGATTTCCGCGCCGGCGCGCTCATCGGAGCG
CGCATCCGGGACGACGACGAGCAGCTGCGCTTCGGGCGCGGCTATGATCACAATTACTGTCTTGAACCGACCGACACGCC
GCGCCTCGCCGCCCGCGTGCGGGCCGCCCGGTCCGGCCGGGTGATGGAGCTGCTGACCGACCAGCCGGGCGTGCAGTTCT
ATTCGGGCAATGTCATCGACGGGGCGGCGCAGGGCAAATTTGGCCGCCTGCACCGCCAGTCGGACGCCTTCTGCCTGGAG
CCGCAGGCCTGGCCCGACGCGCCGAACCGGCCGGATTTTCCCTCCGCCCGGCTCGACCCCGGCGCGACCTACCGGCACGT
CTCCATCTACCGCTTCTCGACGCTTTGA

Upstream 100 bases:

>100_bases
GAACCGGGCGCCGCGCGGGCTTGACCAATGGCCCACGAGCTAAGCTCATGGGCCATTGGCATATCCATGCCGGACCGTTG
CCGTTCGAAGGCGAGACGCG

Downstream 100 bases:

>100_bases
GACCGCGCGGCGCGGGGGCGAGGGGATCTCGCCCTCACCCCCGGGTGTCCGTCCTCAGGACTTGAGCGCTGCCGCCGCCC
GGCTCGCGGCCTCGATGGCC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MTTPILRENFGLLPHGPVVERVRLLGAGGFEASVITYGAALQALHVPDAHGVLADVVLGHDDAAGYGRTRDFYGVTVGRV
ANRIAGAAFDLDGARFTVEANDGANMLHGGFNGFDRALWTIEAVDEDPVPAVTLRHISPDGAGGFPGTLDARVTYSLSGL
GELTIAFSAMSDRPTVVNLTNHAFFNLDGVETGGDILGHHLTLAAERFLATDSAAIPLPGPPRTVDGTPFDFRAGALIGA
RIRDDDEQLRFGRGYDHNYCLEPTDTPRLAARVRAARSGRVMELLTDQPGVQFYSGNVIDGAAQGKFGRLHRQSDAFCLE
PQAWPDAPNRPDFPSARLDPGATYRHVSIYRFSTL

Sequences:

>Translated_355_residues
MTTPILRENFGLLPHGPVVERVRLLGAGGFEASVITYGAALQALHVPDAHGVLADVVLGHDDAAGYGRTRDFYGVTVGRV
ANRIAGAAFDLDGARFTVEANDGANMLHGGFNGFDRALWTIEAVDEDPVPAVTLRHISPDGAGGFPGTLDARVTYSLSGL
GELTIAFSAMSDRPTVVNLTNHAFFNLDGVETGGDILGHHLTLAAERFLATDSAAIPLPGPPRTVDGTPFDFRAGALIGA
RIRDDDEQLRFGRGYDHNYCLEPTDTPRLAARVRAARSGRVMELLTDQPGVQFYSGNVIDGAAQGKFGRLHRQSDAFCLE
PQAWPDAPNRPDFPSARLDPGATYRHVSIYRFSTL
>Mature_354_residues
TTPILRENFGLLPHGPVVERVRLLGAGGFEASVITYGAALQALHVPDAHGVLADVVLGHDDAAGYGRTRDFYGVTVGRVA
NRIAGAAFDLDGARFTVEANDGANMLHGGFNGFDRALWTIEAVDEDPVPAVTLRHISPDGAGGFPGTLDARVTYSLSGLG
ELTIAFSAMSDRPTVVNLTNHAFFNLDGVETGGDILGHHLTLAAERFLATDSAAIPLPGPPRTVDGTPFDFRAGALIGAR
IRDDDEQLRFGRGYDHNYCLEPTDTPRLAARVRAARSGRVMELLTDQPGVQFYSGNVIDGAAQGKFGRLHRQSDAFCLEP
QAWPDAPNRPDFPSARLDPGATYRHVSIYRFSTL

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=351, Percent_Identity=41.025641025641, Blast_Score=262, Evalue=3e-70,
Organism=Escherichia coli, GI1786971, Length=351, Percent_Identity=33.9031339031339, Blast_Score=194, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17557428, Length=335, Percent_Identity=32.5373134328358, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI115533334, Length=335, Percent_Identity=32.5373134328358, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319493, Length=345, Percent_Identity=25.7971014492754, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324399, Length=340, Percent_Identity=25.2941176470588, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322004, Length=353, Percent_Identity=24.6458923512748, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24659048, Length=346, Percent_Identity=40.1734104046243, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24668282, Length=347, Percent_Identity=40.0576368876081, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24583720, Length=364, Percent_Identity=36.8131868131868, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24668278, Length=366, Percent_Identity=35.792349726776, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24641876, Length=347, Percent_Identity=34.0057636887608, Blast_Score=197, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38047; Mature: 37916

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPILRENFGLLPHGPVVERVRLLGAGGFEASVITYGAALQALHVPDAHGVLADVVLGH
CCCCCCHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEHHHHEEEEECCCCCCHHHHEEECC
DDAAGYGRTRDFYGVTVGRVANRIAGAAFDLDGARFTVEANDGANMLHGGFNGFDRALWT
CCCCCCCCCCCCCCEEHHHHHHHHHCCEEECCCCEEEEECCCCCCEEECCCCCCCCEEEE
IEAVDEDPVPAVTLRHISPDGAGGFPGTLDARVTYSLSGLGELTIAFSAMSDRPTVVNLT
EEECCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCEEEEC
NHAFFNLDGVETGGDILGHHLTLAAERFLATDSAAIPLPGPPRTVDGTPFDFRAGALIGA
CCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCEEEEE
RIRDDDEQLRFGRGYDHNYCLEPTDTPRLAARVRAARSGRVMELLTDQPGVQFYSGNVID
EECCCHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEECCEEC
GAAQGKFGRLHRQSDAFCLEPQAWPDAPNRPDFPSARLDPGATYRHVSIYRFSTL
CCCCCCCHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure 
TTPILRENFGLLPHGPVVERVRLLGAGGFEASVITYGAALQALHVPDAHGVLADVVLGH
CCCCCHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEHHHHEEEEECCCCCCHHHHEEECC
DDAAGYGRTRDFYGVTVGRVANRIAGAAFDLDGARFTVEANDGANMLHGGFNGFDRALWT
CCCCCCCCCCCCCCEEHHHHHHHHHCCEEECCCCEEEEECCCCCCEEECCCCCCCCEEEE
IEAVDEDPVPAVTLRHISPDGAGGFPGTLDARVTYSLSGLGELTIAFSAMSDRPTVVNLT
EEECCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCEEEEC
NHAFFNLDGVETGGDILGHHLTLAAERFLATDSAAIPLPGPPRTVDGTPFDFRAGALIGA
CCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCEEEEE
RIRDDDEQLRFGRGYDHNYCLEPTDTPRLAARVRAARSGRVMELLTDQPGVQFYSGNVID
EECCCHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEECCEEC
GAAQGKFGRLHRQSDAFCLEPQAWPDAPNRPDFPSARLDPGATYRHVSIYRFSTL
CCCCCCCHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]