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The map label for this gene is hsaA [H]

Identifier: 154244883

GI number: 154244883

Start: 1053238

End: 1054431

Strand: Direct

Name: hsaA [H]

Synonym: Xaut_0933

Alternate gene names: 154244883

Gene position: 1053238-1054431 (Clockwise)

Preceding gene: 154244882

Following gene: 154244884

Centisome position: 19.84

GC content: 65.75

Gene sequence:

>1194_bases
ATGTTGGACAGATCAAGCTGCACGCCCACCGAGGCCGAGATTGTCGCCCGCGCCGAGGCGATGGTGCCCTGGCTGCGGGA
GCAGGCCGACGCCGTCGAGAAGGCACGCATGGTGCCGGCCGCGACCATCCAGGCGTTCCAGGATGCGGGCTTTTTCCGCA
TCCTCCAGCCGCGCCGCTGGGGCGGCTACGAAATGAGCCCCAACGTGCTCAACAAGGTGCTGATGGAGCTTGCCCGCGGC
TGCCCGTCCAGCGCGTGGAACGTGATGGTTCTGGGTGTCCATCCGTTCGAGGTGGGCCTGCTCGACCAGCGCTGCGGCGA
CGAATTGTGGGGCGAGGACACGAGCCGGCTGGTCTCGTCTTCCTACGCCCCGTTCGGAACCGTGACGGCGGTGGATGGCG
GCTATGTCCTGAAGGGCGAGTGGCTCACCTCCAGCGGCTGCGACCATGCGGAGGGCGGCGCCTTCCTCGGCGGTCGCGTG
GCGGAGAATGGCGAGCAGGTGTTCCGCTCCTTCTGGGTGCAGAAGTCCGATTTCGAGATCGTCGATGACTGGTTCGTGGT
GGGCCTCGCCGGCACCGGCAGCAAGAAGCTGGTGGTGAAGGAAGCGTTCGTTCCGTCCTATCGCAGCCACGTCATCGCCG
CCTACGGCGAGGAGACCCACGGCCACGTGGATAATCTCTACAAAATGCCGTTCTTCTATGTGTTCTATGCGGCGGTGTCT
TCGGTCATCGTCGGCATGGCCCGCGGCATGGTGGACCTCTACGTCGAGCACATGAAGCCCCGGCAGAACCTGAACCAGGC
CGTCGGCGCGGCGGTGAACGACCCCTTCATCAAGGGCCGGCTGGGCGAGGCCTCCGCCAAGATCCTGGGCGCGGCCGCCC
GTATCCTGCACAACACCGACGAGGCCTGGAGCTTTGCCGAGCGCGGCGAACTGGTGCCCATCGACGTGCGCGTGCGCCAC
TTCGCCACCAACCAGTTCACCGGCGGCGAATGCTTCGACGCCGCGCACATGATCTTCAAGAAGACATCGACGCGCGGCGT
CTGGCTGAACAACCCCATGCAGCGCCAGTTGCGCGACATCCTCGTGGGGGCGAACCACATCACCCAGAACCAGGACAATA
TCGGCGATCTCCTCGGCGGACAGATGCTCGGCAATCCCATGCCGGCGGCGAACCCGTTCGGCGTTCGGCCGTGA

Upstream 100 bases:

>100_bases
GCCCGATCAATGAATGGATCGCCGGCTACGGCGTCATGAGCGCCGAGCCACGCTGACAGCGTGCATGCGAAGCCCAGCGA
GGAACGCCAGGAGAATCAGG

Downstream 100 bases:

>100_bases
GCAGGGGGGCTCCTTCAATGACACAGAACATCAACCAGCGCCTTGACTGGGCGTCGAACGAAGCCCTGCGCGAGCTGCCC
ACCGTCAGCGCGGATGACCA

Product: acyl-CoA dehydrogenase type 2

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MLDRSSCTPTEAEIVARAEAMVPWLREQADAVEKARMVPAATIQAFQDAGFFRILQPRRWGGYEMSPNVLNKVLMELARG
CPSSAWNVMVLGVHPFEVGLLDQRCGDELWGEDTSRLVSSSYAPFGTVTAVDGGYVLKGEWLTSSGCDHAEGGAFLGGRV
AENGEQVFRSFWVQKSDFEIVDDWFVVGLAGTGSKKLVVKEAFVPSYRSHVIAAYGEETHGHVDNLYKMPFFYVFYAAVS
SVIVGMARGMVDLYVEHMKPRQNLNQAVGAAVNDPFIKGRLGEASAKILGAAARILHNTDEAWSFAERGELVPIDVRVRH
FATNQFTGGECFDAAHMIFKKTSTRGVWLNNPMQRQLRDILVGANHITQNQDNIGDLLGGQMLGNPMPAANPFGVRP

Sequences:

>Translated_397_residues
MLDRSSCTPTEAEIVARAEAMVPWLREQADAVEKARMVPAATIQAFQDAGFFRILQPRRWGGYEMSPNVLNKVLMELARG
CPSSAWNVMVLGVHPFEVGLLDQRCGDELWGEDTSRLVSSSYAPFGTVTAVDGGYVLKGEWLTSSGCDHAEGGAFLGGRV
AENGEQVFRSFWVQKSDFEIVDDWFVVGLAGTGSKKLVVKEAFVPSYRSHVIAAYGEETHGHVDNLYKMPFFYVFYAAVS
SVIVGMARGMVDLYVEHMKPRQNLNQAVGAAVNDPFIKGRLGEASAKILGAAARILHNTDEAWSFAERGELVPIDVRVRH
FATNQFTGGECFDAAHMIFKKTSTRGVWLNNPMQRQLRDILVGANHITQNQDNIGDLLGGQMLGNPMPAANPFGVRP
>Mature_397_residues
MLDRSSCTPTEAEIVARAEAMVPWLREQADAVEKARMVPAATIQAFQDAGFFRILQPRRWGGYEMSPNVLNKVLMELARG
CPSSAWNVMVLGVHPFEVGLLDQRCGDELWGEDTSRLVSSSYAPFGTVTAVDGGYVLKGEWLTSSGCDHAEGGAFLGGRV
AENGEQVFRSFWVQKSDFEIVDDWFVVGLAGTGSKKLVVKEAFVPSYRSHVIAAYGEETHGHVDNLYKMPFFYVFYAAVS
SVIVGMARGMVDLYVEHMKPRQNLNQAVGAAVNDPFIKGRLGEASAKILGAAARILHNTDEAWSFAERGELVPIDVRVRH
FATNQFTGGECFDAAHMIFKKTSTRGVWLNNPMQRQLRDILVGANHITQNQDNIGDLLGGQMLGNPMPAANPFGVRP

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol. Also catalyzes the o-hydroxylation of a range of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 43619; Mature: 43619

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDRSSCTPTEAEIVARAEAMVPWLREQADAVEKARMVPAATIQAFQDAGFFRILQPRRW
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCCC
GGYEMSPNVLNKVLMELARGCPSSAWNVMVLGVHPFEVGLLDQRCGDELWGEDTSRLVSS
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHCCCHHHHCCHHHCCCHHHHHHHC
SYAPFGTVTAVDGGYVLKGEWLTSSGCDHAEGGAFLGGRVAENGEQVFRSFWVQKSDFEI
CCCCCCEEEEECCCEEEECCEECCCCCCCCCCCCEECCCHHCCHHHHHHHHHCCCCCCEE
VDDWFVVGLAGTGSKKLVVKEAFVPSYRSHVIAAYGEETHGHVDNLYKMPFFYVFYAAVS
EECEEEEEEECCCCCEEEEEHHHCCHHHHCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
SVIVGMARGMVDLYVEHMKPRQNLNQAVGAAVNDPFIKGRLGEASAKILGAAARILHNTD
HHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHCCCCCHHHHHHHHHHHHHHHCCH
EAWSFAERGELVPIDVRVRHFATNQFTGGECFDAAHMIFKKTSTRGVWLNNPMQRQLRDI
HHHHHHHCCCEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHH
LVGANHITQNQDNIGDLLGGQMLGNPMPAANPFGVRP
HHCCHHHCCCCCHHHHHHCCHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDRSSCTPTEAEIVARAEAMVPWLREQADAVEKARMVPAATIQAFQDAGFFRILQPRRW
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCCC
GGYEMSPNVLNKVLMELARGCPSSAWNVMVLGVHPFEVGLLDQRCGDELWGEDTSRLVSS
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHCCCHHHHCCHHHCCCHHHHHHHC
SYAPFGTVTAVDGGYVLKGEWLTSSGCDHAEGGAFLGGRVAENGEQVFRSFWVQKSDFEI
CCCCCCEEEEECCCEEEECCEECCCCCCCCCCCCEECCCHHCCHHHHHHHHHCCCCCCEE
VDDWFVVGLAGTGSKKLVVKEAFVPSYRSHVIAAYGEETHGHVDNLYKMPFFYVFYAAVS
EECEEEEEEECCCCCEEEEEHHHCCHHHHCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
SVIVGMARGMVDLYVEHMKPRQNLNQAVGAAVNDPFIKGRLGEASAKILGAAARILHNTD
HHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHCCCCCHHHHHHHHHHHHHHHCCH
EAWSFAERGELVPIDVRVRHFATNQFTGGECFDAAHMIFKKTSTRGVWLNNPMQRQLRDI
HHHHHHHCCCEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHH
LVGANHITQNQDNIGDLLGGQMLGNPMPAANPFGVRP
HHCCHHHCCCCCHHHHHHCCHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]