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The map label for this gene is fabB [H]

Identifier: 154244011

GI number: 154244011

Start: 56652

End: 57875

Strand: Reverse

Name: fabB [H]

Synonym: Xaut_0053

Alternate gene names: 154244011

Gene position: 57875-56652 (Counterclockwise)

Preceding gene: 154244012

Following gene: 154244010

Centisome position: 1.09

GC content: 67.65

Gene sequence:

>1224_bases
ATGCGGCGCGTCGTCGTCACCGGGATGGGCATCGTCTCGTCTATCGGCAACTCCACGCAAGAGGTGCTCGCCAGCCTGCG
CGAGGCCAAGAGCGGCATCTCCTTCGCGGAGGACCAGGCCAAGCTCGGCTTCCGCTGCCAGGTGCAGGGCGCGCCGACGC
TGAACGCCGAAGAGGTGGTGGATCGCCGCGCCATGCGCTTCCACGGCGGCGGCACCGCCTGGAACCATGTCGCCATGGAC
CAGGCCATCCGCGATTCGGGGCTGGAGCCGTCCGAGGTTTCCAACCCGCGCACCGGCATCGTCATGGGCTCCGGCGGCCC
GTCCACCCGCACCATCGTGGAAGCGGCGGACATCGCCCGCACCAAGGGCCCCAAGCGCATCGGCCCGTTCGCCGTGCCCA
AGGCCATGAGCTCGACCGCGTCGGCGACGCTCGCCACCTGGTTCAAGATCAAGGGCGTCAACTATTCCATCTCGTCGGCC
TGCGCCACGTCGAACCACTGCATCGGCAACGCCTACGAGCAGATCCAGTACGGCAAGCAGGACGTGGTCTTCGCCGGCGG
CTGCGAGGAGCTGGACTGGACCCTCTCCAGCCTGTTCGACGCCATGGGCGCCATGTCCTCCAAATTCAACGCCACGCCCC
ACAAGGCCTCCCGCGCCTATGATGTGAACCGCGACGGCTTCGTCATCGCCGGCGGCGCGGGCGTGCTGGTGCTGGAAGAG
CTGGAGCACGCCAAGGCCCGCGGCGCCAAGATCTATGGTGAGGTCGCCGGCTACGGCGCCACCTCCGACGGCTACGACAT
GGTCGCCCCCTCGGGCGAGGGCGCCGAGCGCTGCATGCGCATGGCCCTGTCCACCGTGAACCTGCCCATCGACTACATCA
ACCCGCACGCCACCTCGACCCCGGCCGGCGATCCGCCGGAAATCGAGGCCATCCGCAAGGTGTTTGGCGTCGGCGAGAAG
TGCCCGCCCATCTCGGCGACCAAGTCGCTGACCGGCCACTCGCTGGGCGCCACCGGAGTGCAGGAAGCCATCTACTGCCT
CCTCATGATGCAGAACGGCTTCATCTGCGAGAGCGCCAACATCGAGGAGCTGGACCCGGTGTTCGCCGACATGCCCATCG
TCCGCGCGCGGCAGGACAATGTGAAGCTCGGCGCGGTGCTGTCCAATTCGTTCGGCTTCGGCGGCACCAATGCGTCGCTG
GTCTTCAAGCACGTGGATGCGTGA

Upstream 100 bases:

>100_bases
GTTCCAGGCCGATGCGGCACCCGCCGCGGGAGCGGCGAGCGCCTGACAAGGCGCCGCCACGATCCGCGGCCATACTGCTG
CTTTCCAATGGGGATTTGAC

Downstream 100 bases:

>100_bases
TTGCACGACGGAGGCCTGAGCCCCGCCGGGCGGATGTCCGCCGTGCAGCCCCTGCAGGCCAGGCCAGCGGGGGCAATACC
GGCTTGAGGCAGGGCCATCC

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MRRVVVTGMGIVSSIGNSTQEVLASLREAKSGISFAEDQAKLGFRCQVQGAPTLNAEEVVDRRAMRFHGGGTAWNHVAMD
QAIRDSGLEPSEVSNPRTGIVMGSGGPSTRTIVEAADIARTKGPKRIGPFAVPKAMSSTASATLATWFKIKGVNYSISSA
CATSNHCIGNAYEQIQYGKQDVVFAGGCEELDWTLSSLFDAMGAMSSKFNATPHKASRAYDVNRDGFVIAGGAGVLVLEE
LEHAKARGAKIYGEVAGYGATSDGYDMVAPSGEGAERCMRMALSTVNLPIDYINPHATSTPAGDPPEIEAIRKVFGVGEK
CPPISATKSLTGHSLGATGVQEAIYCLLMMQNGFICESANIEELDPVFADMPIVRARQDNVKLGAVLSNSFGFGGTNASL
VFKHVDA

Sequences:

>Translated_407_residues
MRRVVVTGMGIVSSIGNSTQEVLASLREAKSGISFAEDQAKLGFRCQVQGAPTLNAEEVVDRRAMRFHGGGTAWNHVAMD
QAIRDSGLEPSEVSNPRTGIVMGSGGPSTRTIVEAADIARTKGPKRIGPFAVPKAMSSTASATLATWFKIKGVNYSISSA
CATSNHCIGNAYEQIQYGKQDVVFAGGCEELDWTLSSLFDAMGAMSSKFNATPHKASRAYDVNRDGFVIAGGAGVLVLEE
LEHAKARGAKIYGEVAGYGATSDGYDMVAPSGEGAERCMRMALSTVNLPIDYINPHATSTPAGDPPEIEAIRKVFGVGEK
CPPISATKSLTGHSLGATGVQEAIYCLLMMQNGFICESANIEELDPVFADMPIVRARQDNVKLGAVLSNSFGFGGTNASL
VFKHVDA
>Mature_407_residues
MRRVVVTGMGIVSSIGNSTQEVLASLREAKSGISFAEDQAKLGFRCQVQGAPTLNAEEVVDRRAMRFHGGGTAWNHVAMD
QAIRDSGLEPSEVSNPRTGIVMGSGGPSTRTIVEAADIARTKGPKRIGPFAVPKAMSSTASATLATWFKIKGVNYSISSA
CATSNHCIGNAYEQIQYGKQDVVFAGGCEELDWTLSSLFDAMGAMSSKFNATPHKASRAYDVNRDGFVIAGGAGVLVLEE
LEHAKARGAKIYGEVAGYGATSDGYDMVAPSGEGAERCMRMALSTVNLPIDYINPHATSTPAGDPPEIEAIRKVFGVGEK
CPPISATKSLTGHSLGATGVQEAIYCLLMMQNGFICESANIEELDPVFADMPIVRARQDNVKLGAVLSNSFGFGGTNASL
VFKHVDA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=415, Percent_Identity=36.8674698795181, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI41872631, Length=335, Percent_Identity=24.1791044776119, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI223972627, Length=160, Percent_Identity=38.75, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1788663, Length=407, Percent_Identity=60.6879606879607, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=38.9830508474576, Blast_Score=243, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=33.4939759036145, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=39.4736842105263, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17550940, Length=278, Percent_Identity=26.2589928057554, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI212642053, Length=338, Percent_Identity=23.6686390532544, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=454, Percent_Identity=31.4977973568282, Blast_Score=188, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24644341, Length=414, Percent_Identity=36.9565217391304, Blast_Score=224, Evalue=8e-59,
Organism=Drosophila melanogaster, GI221330659, Length=336, Percent_Identity=27.6785714285714, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI19920632, Length=336, Percent_Identity=27.6785714285714, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24581345, Length=337, Percent_Identity=23.7388724035608, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42911; Mature: 42911

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGMGIVSSIGNSTQEVLASLREAKSGISFAEDQAKLGFRCQVQGAPTLNAEEVV
CCEEEEECCHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHCCCEEEEECCCCCCCHHHHH
DRRAMRFHGGGTAWNHVAMDQAIRDSGLEPSEVSNPRTGIVMGSGGPSTRTIVEAADIAR
HHHHHEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHH
TKGPKRIGPFAVPKAMSSTASATLATWFKIKGVNYSISSACATSNHCIGNAYEQIQYGKQ
CCCCCCCCCCCCCHHHHHHHHHHEEEEEEEECCCEEHHHHHCCCCCCCCHHHHHHHCCCC
DVVFAGGCEELDWTLSSLFDAMGAMSSKFNATPHKASRAYDVNRDGFVIAGGAGVLVLEE
CEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCEEEECCCCEEEHHH
LEHAKARGAKIYGEVAGYGATSDGYDMVAPSGEGAERCMRMALSTVNLPIDYINPHATST
HHHHHHCCCEEEEHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
PAGDPPEIEAIRKVFGVGEKCPPISATKSLTGHSLGATGVQEAIYCLLMMQNGFICESAN
CCCCCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCC
IEELDPVFADMPIVRARQDNVKLGAVLSNSFGFGGTNASLVFKHVDA
CHHHCHHHHCCCCEEECCCCCEEEEEEECCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MRRVVVTGMGIVSSIGNSTQEVLASLREAKSGISFAEDQAKLGFRCQVQGAPTLNAEEVV
CCEEEEECCHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHCCCEEEEECCCCCCCHHHHH
DRRAMRFHGGGTAWNHVAMDQAIRDSGLEPSEVSNPRTGIVMGSGGPSTRTIVEAADIAR
HHHHHEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHH
TKGPKRIGPFAVPKAMSSTASATLATWFKIKGVNYSISSACATSNHCIGNAYEQIQYGKQ
CCCCCCCCCCCCCHHHHHHHHHHEEEEEEEECCCEEHHHHHCCCCCCCCHHHHHHHCCCC
DVVFAGGCEELDWTLSSLFDAMGAMSSKFNATPHKASRAYDVNRDGFVIAGGAGVLVLEE
CEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCEEEECCCCEEEHHH
LEHAKARGAKIYGEVAGYGATSDGYDMVAPSGEGAERCMRMALSTVNLPIDYINPHATST
HHHHHHCCCEEEEHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
PAGDPPEIEAIRKVFGVGEKCPPISATKSLTGHSLGATGVQEAIYCLLMMQNGFICESAN
CCCCCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCC
IEELDPVFADMPIVRARQDNVKLGAVLSNSFGFGGTNASLVFKHVDA
CHHHCHHHHCCCCEEECCCCCEEEEEEECCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]