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The map label for this gene is lpxB [H]

Identifier: 153952025

GI number: 153952025

Start: 1484379

End: 1485473

Strand: Direct

Name: lpxB [H]

Synonym: JJD26997_1683

Alternate gene names: 153952025

Gene position: 1484379-1485473 (Clockwise)

Preceding gene: 153952267

Following gene: 153951319

Centisome position: 80.45

GC content: 28.4

Gene sequence:

>1095_bases
ATGAAAACCTTTTTAGTTTGTGCTTTAGAGCCTTCAGCAAATTTGCATTTAAAAGAAGTTTTAAAAGCTTATAAAAAAGA
CTTTAGCAAATTTGAACTTCATGGGATTTATGATGAGAGTTTATGCAAAGAATTTGATTTAAATTCTAAACCACTTTATA
GCTCACATGAGTTTAGTGCTATGGGTTTTATAGAAGTTTTGCCTTTGATTTTTAAAGCAAAAAAAGCTATAAAAGAGCTT
GTAAATTTAAGTTTTACTCAAAAAATGGATGGGATTTTATGTATAGATTCGCCCGCTTTTAACATACCTTTTGCTAAGGC
TTTAAAAAAAGCAGGCAGTAAAATTCCACGCATTTATTATATCTTGCCTCAAGTTTGGGCGTGGAAAAAAGGTCGCATAC
CTATCATAGAAAGTCATTTTGATATTTTAGCTTCTATTTTGCCCTTTGATAATCAGTTTTTTAACAAAAGCACTTATGTG
GGTCATCCGCTTTTAGATGAACTAAAAGAATTTAAAAACCAAGAAGACATTAATAATACACTTTTAAAAAAAGATGATGA
AAAAACTATAGCCTTTTTACCGGGTTCAAGGCGTAGTGAAATTACGCGTTTAATGCCTATTTTTAAAGAACTCTCCCAAA
AATTTAAAGGTGAAAAAATTCTATGTGTTCCCCCGTTTAATCTTGAAAAATTAGAAATTTATGGTGATATTAGTGAATTT
AAGATAGAAAATAATACTCCAAAAGTGCTTAAAAAAGCTGATTTTGCCTTTATTTGTAGTGGAACGGCTACTTTAGAAGC
AGCTTTAGTGGGAACTCCTTTTGTTCTTGCTTATAAAGCAAAGGCTATTGATATTTTTATCGCAAAACTTTTTGTAAAAT
TAAAACACATAGGACTTGCAAATATTTTTTGTGATTTTGCTAAAAAAGAAGCTTTAAATCCTGAATTTTTACAAGATAAA
GTCAATGTTTTAAATTTATATGAAGCTTACAATAAATATGATTATAAGGCATTTTTTGCTAAAGTTGATTTTTTAAAAGA
ATATTTACAATTTGGAAGTGCTAAAAATTTAGCAAAAATATTGAGTGAAATTTAA

Upstream 100 bases:

>100_bases
AAAACATAAAAATAAATTTATTTTTTTATAACAAAAATATCAACAACGCTTCAGAAGAAATCAAAGATTTTGTTAGATCA
AATATAGAGGATATTTTCAG

Downstream 100 bases:

>100_bases
AAGGATAAATCATGCAAAAAGAACCAATGAGTCAATTTGGCTATGATAAATTAGCCGCAGAATTAAAAGATTTAAAAGAC
AATCAACGCCCTGCTGTTGT

Product: ipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKTFLVCALEPSANLHLKEVLKAYKKDFSKFELHGIYDESLCKEFDLNSKPLYSSHEFSAMGFIEVLPLIFKAKKAIKEL
VNLSFTQKMDGILCIDSPAFNIPFAKALKKAGSKIPRIYYILPQVWAWKKGRIPIIESHFDILASILPFDNQFFNKSTYV
GHPLLDELKEFKNQEDINNTLLKKDDEKTIAFLPGSRRSEITRLMPIFKELSQKFKGEKILCVPPFNLEKLEIYGDISEF
KIENNTPKVLKKADFAFICSGTATLEAALVGTPFVLAYKAKAIDIFIAKLFVKLKHIGLANIFCDFAKKEALNPEFLQDK
VNVLNLYEAYNKYDYKAFFAKVDFLKEYLQFGSAKNLAKILSEI

Sequences:

>Translated_364_residues
MKTFLVCALEPSANLHLKEVLKAYKKDFSKFELHGIYDESLCKEFDLNSKPLYSSHEFSAMGFIEVLPLIFKAKKAIKEL
VNLSFTQKMDGILCIDSPAFNIPFAKALKKAGSKIPRIYYILPQVWAWKKGRIPIIESHFDILASILPFDNQFFNKSTYV
GHPLLDELKEFKNQEDINNTLLKKDDEKTIAFLPGSRRSEITRLMPIFKELSQKFKGEKILCVPPFNLEKLEIYGDISEF
KIENNTPKVLKKADFAFICSGTATLEAALVGTPFVLAYKAKAIDIFIAKLFVKLKHIGLANIFCDFAKKEALNPEFLQDK
VNVLNLYEAYNKYDYKAFFAKVDFLKEYLQFGSAKNLAKILSEI
>Mature_364_residues
MKTFLVCALEPSANLHLKEVLKAYKKDFSKFELHGIYDESLCKEFDLNSKPLYSSHEFSAMGFIEVLPLIFKAKKAIKEL
VNLSFTQKMDGILCIDSPAFNIPFAKALKKAGSKIPRIYYILPQVWAWKKGRIPIIESHFDILASILPFDNQFFNKSTYV
GHPLLDELKEFKNQEDINNTLLKKDDEKTIAFLPGSRRSEITRLMPIFKELSQKFKGEKILCVPPFNLEKLEIYGDISEF
KIENNTPKVLKKADFAFICSGTATLEAALVGTPFVLAYKAKAIDIFIAKLFVKLKHIGLANIFCDFAKKEALNPEFLQDK
VNVLNLYEAYNKYDYKAFFAKVDFLKEYLQFGSAKNLAKILSEI

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=333, Percent_Identity=27.3273273273273, Blast_Score=118, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 41653; Mature: 41653

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTFLVCALEPSANLHLKEVLKAYKKDFSKFELHGIYDESLCKEFDLNSKPLYSSHEFSA
CCEEEEEEECCCCCCCHHHHHHHHHHHHHHEEEECCCHHHHHHHCCCCCCCCCCCCCCHH
MGFIEVLPLIFKAKKAIKELVNLSFTQKMDGILCIDSPAFNIPFAKALKKAGSKIPRIYY
HHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCCCEEEE
ILPQVWAWKKGRIPIIESHFDILASILPFDNQFFNKSTYVGHPLLDELKEFKNQEDINNT
ECCHHHCCCCCCCCEEHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHCCHHHHHHH
LLKKDDEKTIAFLPGSRRSEITRLMPIFKELSQKFKGEKILCVPPFNLEKLEIYGDISEF
HHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECHHHE
KIENNTPKVLKKADFAFICSGTATLEAALVGTPFVLAYKAKAIDIFIAKLFVKLKHIGLA
EECCCCHHHHHHCCEEEEECCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCHH
NIFCDFAKKEALNPEFLQDKVNVLNLYEAYNKYDYKAFFAKVDFLKEYLQFGSAKNLAKI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
LSEI
HHCC
>Mature Secondary Structure
MKTFLVCALEPSANLHLKEVLKAYKKDFSKFELHGIYDESLCKEFDLNSKPLYSSHEFSA
CCEEEEEEECCCCCCCHHHHHHHHHHHHHHEEEECCCHHHHHHHCCCCCCCCCCCCCCHH
MGFIEVLPLIFKAKKAIKELVNLSFTQKMDGILCIDSPAFNIPFAKALKKAGSKIPRIYY
HHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCCCEEEE
ILPQVWAWKKGRIPIIESHFDILASILPFDNQFFNKSTYVGHPLLDELKEFKNQEDINNT
ECCHHHCCCCCCCCEEHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHCCHHHHHHH
LLKKDDEKTIAFLPGSRRSEITRLMPIFKELSQKFKGEKILCVPPFNLEKLEIYGDISEF
HHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECHHHE
KIENNTPKVLKKADFAFICSGTATLEAALVGTPFVLAYKAKAIDIFIAKLFVKLKHIGLA
EECCCCHHHHHHCCEEEEECCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCHH
NIFCDFAKKEALNPEFLQDKVNVLNLYEAYNKYDYKAFFAKVDFLKEYLQFGSAKNLAKI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
LSEI
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA