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The map label for this gene is yopM [H]

Identifier: 153948203

GI number: 153948203

Start: 800106

End: 800960

Strand: Reverse

Name: yopM [H]

Synonym: YpsIP31758_0676

Alternate gene names: 153948203

Gene position: 800960-800106 (Counterclockwise)

Preceding gene: 153949086

Following gene: 153948043

Centisome position: 16.96

GC content: 46.32

Gene sequence:

>855_bases
ATGAATCTATCAAATATAACCTCGCACATGTCAATGTCGAACATAGGACCAGACCGTGAAATCCATTCTGACCGGGCAGC
AGCAACAGCCTTAACTTCGGCTGACTATCATGCAATATGGGAAAAGTGGGCAAGCGAGGCGATAACGGGTGCTGATGAAC
AGCGGGGCCTGGCAGTGGCGAGAATGAAAGAGTGCCTGGAAAACAGTGCCGATAACCTCGAACTCTATGGGCTTGATTTG
ACCTCATTACCAGACATTCTGCCGCCGTGTAACGAGCTGGATCTCATGGGCAATAATTTAACTGAGTTGTCAGCAACACT
GCCAGACAACCTGCAAAAACTGAATGCTTCTTTTAATCAACTGCGTACATTACCGAATACATTACCGGCCTCGCTGTTAT
CTCTAAATGTGTACAGAAATGAACTGGAACGGCTCCCTGAGCCGCTACCTGAAGGGCTGAAAGAATTAGACGTTGGTAAT
AATGAGTCACTGCAACTCCCAAACCGCTGGCCCTCGGTTCTGGAGTCTCTTGGTATTGCAAACTGTAACTTAGCTGAACT
GCCTACACTGCCGAACAGTTTGAAAAAACTGGAGGCGTATGGTAATCAACTGCGCACATTGCCCGAGACATTGCCAATAT
CGCTGTTAAGTTTAAATGTAACCGCTAATCAACTCACACAACTCCCCGAAACATTGCCCGCCCTTCTGTCATCTTTACTG
ATATCGAACAATAGGCTCACAGCACTACCGGAAAATTTACCTCGTAGCTTAAGGTGTATCAGCGCTGAATATAATCAATT
ACCCCAACTTTCCGACCTGGCCCGTCTGCACCCAAATTGTGAAATTATCTTATAA

Upstream 100 bases:

>100_bases
TAAATTAGCTGAAAATACCAGTAGTAGACCTTATCCACCCCCTGTTATTTATCAGCCAAAATAACGCCTCTAAGACTTAT
TAAGGGAGCGGTTTAATACA

Downstream 100 bases:

>100_bases
GGTAATTCTCTTTGCAAAAAGCAGTCATGAATCATGGGGGAGATCGATATGGCTCTGACTCATGAGGTTCTCTCTGCCAA
AGGAGCCTCCTCCTTATTAG

Product: outer membrane protein YopM

Products: NA

Alternate protein names: Secreted effector protein slrP [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNLSNITSHMSMSNIGPDREIHSDRAAATALTSADYHAIWEKWASEAITGADEQRGLAVARMKECLENSADNLELYGLDL
TSLPDILPPCNELDLMGNNLTELSATLPDNLQKLNASFNQLRTLPNTLPASLLSLNVYRNELERLPEPLPEGLKELDVGN
NESLQLPNRWPSVLESLGIANCNLAELPTLPNSLKKLEAYGNQLRTLPETLPISLLSLNVTANQLTQLPETLPALLSSLL
ISNNRLTALPENLPRSLRCISAEYNQLPQLSDLARLHPNCEIIL

Sequences:

>Translated_284_residues
MNLSNITSHMSMSNIGPDREIHSDRAAATALTSADYHAIWEKWASEAITGADEQRGLAVARMKECLENSADNLELYGLDL
TSLPDILPPCNELDLMGNNLTELSATLPDNLQKLNASFNQLRTLPNTLPASLLSLNVYRNELERLPEPLPEGLKELDVGN
NESLQLPNRWPSVLESLGIANCNLAELPTLPNSLKKLEAYGNQLRTLPETLPISLLSLNVTANQLTQLPETLPALLSSLL
ISNNRLTALPENLPRSLRCISAEYNQLPQLSDLARLHPNCEIIL
>Mature_284_residues
MNLSNITSHMSMSNIGPDREIHSDRAAATALTSADYHAIWEKWASEAITGADEQRGLAVARMKECLENSADNLELYGLDL
TSLPDILPPCNELDLMGNNLTELSATLPDNLQKLNASFNQLRTLPNTLPASLLSLNVYRNELERLPEPLPEGLKELDVGN
NESLQLPNRWPSVLESLGIANCNLAELPTLPNSLKKLEAYGNQLRTLPETLPISLLSLNVTANQLTQLPETLPALLSSLL
ISNNRLTALPENLPRSLRCISAEYNQLPQLSDLARLHPNCEIIL

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (Thioredoxin).

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 TTSS), and delivered into the host cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 10 LRR (leucine-rich) repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 31253; Mature: 31253

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSNITSHMSMSNIGPDREIHSDRAAATALTSADYHAIWEKWASEAITGADEQRGLAVA
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RMKECLENSADNLELYGLDLTSLPDILPPCNELDLMGNNLTELSATLPDNLQKLNASFNQ
HHHHHHHCCCCCEEEEECCHHHCCCCCCCCCCHHHCCCCHHHHHHHCHHHHHHHHHHHHH
LRTLPNTLPASLLSLNVYRNELERLPEPLPEGLKELDVGNNESLQLPNRWPSVLESLGIA
HHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEECCCHHHHHHHHCCCC
NCNLAELPTLPNSLKKLEAYGNQLRTLPETLPISLLSLNVTANQLTQLPETLPALLSSLL
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCEEHEEECCCHHHHHHHHHHHHHHHHHHH
ISNNRLTALPENLPRSLRCISAEYNQLPQLSDLARLHPNCEIIL
HCCCCCEECCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEC
>Mature Secondary Structure
MNLSNITSHMSMSNIGPDREIHSDRAAATALTSADYHAIWEKWASEAITGADEQRGLAVA
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RMKECLENSADNLELYGLDLTSLPDILPPCNELDLMGNNLTELSATLPDNLQKLNASFNQ
HHHHHHHCCCCCEEEEECCHHHCCCCCCCCCCHHHCCCCHHHHHHHCHHHHHHHHHHHHH
LRTLPNTLPASLLSLNVYRNELERLPEPLPEGLKELDVGNNESLQLPNRWPSVLESLGIA
HHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEECCCHHHHHHHHCCCC
NCNLAELPTLPNSLKKLEAYGNQLRTLPETLPISLLSLNVTANQLTQLPETLPALLSSLL
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCEEHEEECCCHHHHHHHHHHHHHHHHHHH
ISNNRLTALPENLPRSLRCISAEYNQLPQLSDLARLHPNCEIIL
HCCCCCEECCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10861017 [H]