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The map label for this gene is slrP [H]

Identifier: 153948043

GI number: 153948043

Start: 798823

End: 799779

Strand: Reverse

Name: slrP [H]

Synonym: YpsIP31758_0675

Alternate gene names: 153948043

Gene position: 799779-798823 (Counterclockwise)

Preceding gene: 153948203

Following gene: 153949590

Centisome position: 16.93

GC content: 45.04

Gene sequence:

>957_bases
ATGAATCTATCAAATATAACCTCGAACACACCAATGCCGAACATAGGGCCAGACCGTGAAATCCATTCTGACCGGGCAGC
AGCAACAGCCTTAACTCAGGCTGACTATTATGCAATATGGGAAAAGTGGGAAAATGATCCAAGAACTGTTGCTGGTGAAC
AACGGGGCCAGGCCGTAGCGAGAATGAAAGAGTGTTTGGATAACAATGCCGATAGACTCAATCTGCATCACCTTGATTTG
ACGTCATTGCCAGATACCCTACCACCGTGTAACGAACTGTACATATCGAACAATAACATCACTGAGTTGCCTACTTTGCC
AAACAACCTGCAAAGGTTGATGGCAATCTGTAATCAACTGCGTATATTACCCGATACATTACCTGAACATCTATTATCTC
TATATGTGACCTCGAATAAACTCGAACGGCTCCCCGAGAACCTGCCAGAGAGTCTCGAGACATTAAATGTTTGCGATAAT
CCGTCACTGCAATTCCCAAACAACTGGCCTTCGAATCTGAAGTATCTTAACATTGCAGACTGTGAATTAACTGAACTGCC
TACACTGCCGAACACCTTGACAGAACTGTATGCGGATTATAATCAACTGCGCACATTGCCCGATACATTGCCGACATCAC
TATTAACGCTAAGTGTGACCAGTAATCAATTCACACAACTCCCTGAGACATTGCCTGCCTCTCTGTCATTTTTAATGGTA
TTGTGCAATAGCCTCACCGCACTACCGGAAAATTTACCTCGTAGCTTAAGCTGTATCAGCGCTGAATATAATCAATTTTC
CCAACTTCCCGACCTAGCACGTCTGCCCCAAAACTGCGAACTTCTCTTGGAAGGTAACCCTCTTTCTGCCGGAGCACTGC
AGGAACTACAGCATATCCAAACTGACCCGCATTATCAGGGTCCACAGATTTACTACCCCGCATCAAAACAGGGATAG

Upstream 100 bases:

>100_bases
CAGTAAGCTAAAAATACCAGTAGTAGACCTTATGTATCCCCTGTTATTTATCCGCCAAAATAACGCCTCTAAGACTTATT
AAGGGAGCTGTTTTAATACA

Downstream 100 bases:

>100_bases
TAAGATGACGGGCGATGAAGATGCCAACCGTATTGTCGGCAAACGAATCATAGATGAGCTCATGGGGGAGATCGATATGG
CCCTGACTCATGAGGTTCTC

Product: outer membrane protein

Products: NA

Alternate protein names: Secreted effector protein slrP [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MNLSNITSNTPMPNIGPDREIHSDRAAATALTQADYYAIWEKWENDPRTVAGEQRGQAVARMKECLDNNADRLNLHHLDL
TSLPDTLPPCNELYISNNNITELPTLPNNLQRLMAICNQLRILPDTLPEHLLSLYVTSNKLERLPENLPESLETLNVCDN
PSLQFPNNWPSNLKYLNIADCELTELPTLPNTLTELYADYNQLRTLPDTLPTSLLTLSVTSNQFTQLPETLPASLSFLMV
LCNSLTALPENLPRSLSCISAEYNQFSQLPDLARLPQNCELLLEGNPLSAGALQELQHIQTDPHYQGPQIYYPASKQG

Sequences:

>Translated_318_residues
MNLSNITSNTPMPNIGPDREIHSDRAAATALTQADYYAIWEKWENDPRTVAGEQRGQAVARMKECLDNNADRLNLHHLDL
TSLPDTLPPCNELYISNNNITELPTLPNNLQRLMAICNQLRILPDTLPEHLLSLYVTSNKLERLPENLPESLETLNVCDN
PSLQFPNNWPSNLKYLNIADCELTELPTLPNTLTELYADYNQLRTLPDTLPTSLLTLSVTSNQFTQLPETLPASLSFLMV
LCNSLTALPENLPRSLSCISAEYNQFSQLPDLARLPQNCELLLEGNPLSAGALQELQHIQTDPHYQGPQIYYPASKQG
>Mature_318_residues
MNLSNITSNTPMPNIGPDREIHSDRAAATALTQADYYAIWEKWENDPRTVAGEQRGQAVARMKECLDNNADRLNLHHLDL
TSLPDTLPPCNELYISNNNITELPTLPNNLQRLMAICNQLRILPDTLPEHLLSLYVTSNKLERLPENLPESLETLNVCDN
PSLQFPNNWPSNLKYLNIADCELTELPTLPNTLTELYADYNQLRTLPDTLPTSLLTLSVTSNQFTQLPETLPASLSFLMV
LCNSLTALPENLPRSLSCISAEYNQFSQLPDLARLPQNCELLLEGNPLSAGALQELQHIQTDPHYQGPQIYYPASKQG

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (Thioredoxin).

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 TTSS), and delivered into the host cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 10 LRR (leucine-rich) repeats [H]

Homologues:

Organism=Caenorhabditis elegans, GI71985928, Length=260, Percent_Identity=28.4615384615385, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 35642; Mature: 35642

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSNITSNTPMPNIGPDREIHSDRAAATALTQADYYAIWEKWENDPRTVAGEQRGQAVA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
RMKECLDNNADRLNLHHLDLTSLPDTLPPCNELYISNNNITELPTLPNNLQRLMAICNQL
HHHHHHCCCCCEEEEEECCHHCCCCCCCCCCEEEECCCCCEECCCCHHHHHHHHHHHHHH
RILPDTLPEHLLSLYVTSNKLERLPENLPESLETLNVCDNPSLQFPNNWPSNLKYLNIAD
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECC
CELTELPTLPNTLTELYADYNQLRTLPDTLPTSLLTLSVTSNQFTQLPETLPASLSFLMV
CCHHCCCCCHHHHHHHHHHHHHHHCCHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
LCNSLTALPENLPRSLSCISAEYNQFSQLPDLARLPQNCELLLEGNPLSAGALQELQHIQ
HHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHC
TDPHYQGPQIYYPASKQG
CCCCCCCCEEECCCCCCC
>Mature Secondary Structure
MNLSNITSNTPMPNIGPDREIHSDRAAATALTQADYYAIWEKWENDPRTVAGEQRGQAVA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
RMKECLDNNADRLNLHHLDLTSLPDTLPPCNELYISNNNITELPTLPNNLQRLMAICNQL
HHHHHHCCCCCEEEEEECCHHCCCCCCCCCCEEEECCCCCEECCCCHHHHHHHHHHHHHH
RILPDTLPEHLLSLYVTSNKLERLPENLPESLETLNVCDNPSLQFPNNWPSNLKYLNIAD
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECC
CELTELPTLPNTLTELYADYNQLRTLPDTLPTSLLTLSVTSNQFTQLPETLPASLSFLMV
CCHHCCCCCHHHHHHHHHHHHHHHCCHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
LCNSLTALPENLPRSLSCISAEYNQFSQLPDLARLPQNCELLLEGNPLSAGALQELQHIQ
HHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHC
TDPHYQGPQIYYPASKQG
CCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10861017 [H]