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The map label for this gene is uvrA [H]

Identifier: 153936378

GI number: 153936378

Start: 790707

End: 792944

Strand: Direct

Name: uvrA [H]

Synonym: CLC_0765

Alternate gene names: 153936378

Gene position: 790707-792944 (Clockwise)

Preceding gene: 153937129

Following gene: 153935697

Centisome position: 21.03

GC content: 31.77

Gene sequence:

>2238_bases
ATGGAGCAGGAATTTATAGTTTTAAAAGGATGTAAGGAAAATAATTTAAAAGATATTTCATTAAATATACCTAAGAGAAA
AATAACAATATTTACAGGGGTATCTGGTTCAGGGAAGTCATCAATTGTTTTTGAGACAGTAGCAAAGGAAGCTCAACGTC
AATTGAATGAGACCTTCACTGCCTTCATAAGAAATTTTTTACCTAAGTATGGTGAGGTTAAAGCTGATCACATAGAAAAT
TTATCAACGCCAATTATTATTGACCAAAGTAGGCTCGGTGGTAATTCAAGATCAACTTTAGGTACTATTACAGATATAAA
TTCATTCCTTAGAGCGCTATATTCAAGGTTTGGAAGTAATTATATCGGTAAGGCTAATATGTTTTCCTTTAATGATATTA
ATGGTATGTGTCCGGAATGTCAGGGTCTTGGTAAAAAGTTGGTTCCAAATATGGAGGAGATATTTGATAAAAGTAAATCC
CTAAATGAGGGAGCTATTTTACTTTCAGGTTTTGGAGTAGGTTCCTGGCATTGGAAAATATTTGCCCAGTCAGGATACTT
TGATAATGATAAGAAAATATGTGATTATTCAGAAGAAGAATTAGATAAGTTTTTATATGGTGGGCCAGATAAAATTAAGA
TAGATGAAACAGGTGGAATGAACATAACCTATGAAGGCTTATTGGTTAAGTTTAATAGGCTATATTTAAAGAAAGAAGGA
GAAACCTCTGAAGCTGCAAAGAAAAAACTAAATAAACTACTTATAGAGGACCAGTGCCCTGCTTGCGGGGGAAAAAGGCT
TCACCAAAGAGTATATGGATCTTTAATTAATGGTTATAATATAGCAGATTTAACTAGTATGCAAATTGATGAATTAGTTG
AGGTAGTTAAAGAAATAAATGATCCAGAAGCAGAACCTTTAGTTAAAGGTATAATAGAAAAGCTAAATAATATTATAGAT
ATAGGTCTTGGATATTTGACTTTAGATAGAGAAACTTCATCATTATCTGGTGGAGAATCTCAACGTATAAAGATGGTAAA
GCATTTAAATAGTAACCTTGTAGATTTAATGTATATCTTTGATGAGCCTAGTATAGGTCTTCATCCAAGAGATGTCCATA
AATTAAACAATCTATTAAAAAAGCTACGTGATAAAGGCAATACTGTAATAGTTGTTGAGCATGACCCTGATGTTATTAAA
ATTGCAGACCATATTATAGATGTAGGCCCAAAGGCAGGTAAGTATGGTGGTGAAATTGTATATGAGGGAACCTATGAAAA
TTTACTTAAATCAGGAACCTTAACTGGAAATGCCTTAAATAAAAGTCTTTCTATTAAAGAAAAGGTAAGAGATCATAAGG
GATATTTAAAGGTTGTAAATTGTAATAAAAATAATTTAAAAAATATATCTGTGACAATACCTAAGGGTGTATTAACAGTA
GTAACAGGAGTTGCAGGTTCAGGTAAAAGTACATTAATTAAACATGAGTTCTTAAAACAAAATAAAAATGCTGTATTAAT
AGATCAAAGTCCTGTGTCAGCTAATTCTAGGTCCAGCTTAGCCACCTATAGCGGAATTATGGATAATATAAGAAAAGCTT
TTGCTAAGGCAAATGGAGTTAATGCGTCATTATTTAGTTCAAATTCAAAAGGAGCCTGCGAAAATTGTAATGGAAGCGGA
ATAATAGAAACAAATCTTGCATTTATGGAAAACATAAAAAGTACTTGCGATGTTTGTGAAGGTAAAAAGTATAAAAAAGA
AGTTTTAGATTATAAATTACATGGGGAAAACATAATAGAAGTTCTTGAAATGTCAGTTTCAGATGCAATTGAATTTTTCA
ACTTAAGGTCAGTTAAGGCAAAACTGCAGTCTATAGAAGATATGGGCATTGGATATTTAACCTTAGGGCAAACTCTCGAT
ACCTTATCTGGCGGAGAATGTCAAAGATTAAAGCTTGCCAGTGAATTGCATAATGAAAGTTCTATATATATATTGGATGA
GCCTACAACAGGTCTTCATATAGCTGATATTGAAAAATTTATCAACATAGTTGAAAATATTGTGGATAGTGGCAATACAG
TTATAATAATTGAACATAATGTAGATATAATTAAAAGAGCAGATTGGATTATTGATATGGGGCCTGATGGTGGAACAAAA
GGTGGAGAGATAATATTTGAAGGGACTCCCAAACAATTACATAATTGCCAAGTATCATTAACAGCTAAGTATATTTAG

Upstream 100 bases:

>100_bases
TAAGAACTATAGAACATCAGAGATTAATAAATAGTAAATTTGTGTCAGTTCAAGGAGAAGATATAAATTAAAAACAAAGG
AGTGCCAAGGAGGAATATAG

Downstream 100 bases:

>100_bases
TTTATAACTAAGGAGAATTCTATTTGTAGAACTCTCCCTCACTTTAATTATAACATATGTAAAGCGTGAAATATAGACTA
CTAAATTTTGAATCTAACTG

Product: putative drug resistance ABC transporter, ATP-binding protein

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 745; Mature: 745

Protein sequence:

>745_residues
MEQEFIVLKGCKENNLKDISLNIPKRKITIFTGVSGSGKSSIVFETVAKEAQRQLNETFTAFIRNFLPKYGEVKADHIEN
LSTPIIIDQSRLGGNSRSTLGTITDINSFLRALYSRFGSNYIGKANMFSFNDINGMCPECQGLGKKLVPNMEEIFDKSKS
LNEGAILLSGFGVGSWHWKIFAQSGYFDNDKKICDYSEEELDKFLYGGPDKIKIDETGGMNITYEGLLVKFNRLYLKKEG
ETSEAAKKKLNKLLIEDQCPACGGKRLHQRVYGSLINGYNIADLTSMQIDELVEVVKEINDPEAEPLVKGIIEKLNNIID
IGLGYLTLDRETSSLSGGESQRIKMVKHLNSNLVDLMYIFDEPSIGLHPRDVHKLNNLLKKLRDKGNTVIVVEHDPDVIK
IADHIIDVGPKAGKYGGEIVYEGTYENLLKSGTLTGNALNKSLSIKEKVRDHKGYLKVVNCNKNNLKNISVTIPKGVLTV
VTGVAGSGKSTLIKHEFLKQNKNAVLIDQSPVSANSRSSLATYSGIMDNIRKAFAKANGVNASLFSSNSKGACENCNGSG
IIETNLAFMENIKSTCDVCEGKKYKKEVLDYKLHGENIIEVLEMSVSDAIEFFNLRSVKAKLQSIEDMGIGYLTLGQTLD
TLSGGECQRLKLASELHNESSIYILDEPTTGLHIADIEKFINIVENIVDSGNTVIIIEHNVDIIKRADWIIDMGPDGGTK
GGEIIFEGTPKQLHNCQVSLTAKYI

Sequences:

>Translated_745_residues
MEQEFIVLKGCKENNLKDISLNIPKRKITIFTGVSGSGKSSIVFETVAKEAQRQLNETFTAFIRNFLPKYGEVKADHIEN
LSTPIIIDQSRLGGNSRSTLGTITDINSFLRALYSRFGSNYIGKANMFSFNDINGMCPECQGLGKKLVPNMEEIFDKSKS
LNEGAILLSGFGVGSWHWKIFAQSGYFDNDKKICDYSEEELDKFLYGGPDKIKIDETGGMNITYEGLLVKFNRLYLKKEG
ETSEAAKKKLNKLLIEDQCPACGGKRLHQRVYGSLINGYNIADLTSMQIDELVEVVKEINDPEAEPLVKGIIEKLNNIID
IGLGYLTLDRETSSLSGGESQRIKMVKHLNSNLVDLMYIFDEPSIGLHPRDVHKLNNLLKKLRDKGNTVIVVEHDPDVIK
IADHIIDVGPKAGKYGGEIVYEGTYENLLKSGTLTGNALNKSLSIKEKVRDHKGYLKVVNCNKNNLKNISVTIPKGVLTV
VTGVAGSGKSTLIKHEFLKQNKNAVLIDQSPVSANSRSSLATYSGIMDNIRKAFAKANGVNASLFSSNSKGACENCNGSG
IIETNLAFMENIKSTCDVCEGKKYKKEVLDYKLHGENIIEVLEMSVSDAIEFFNLRSVKAKLQSIEDMGIGYLTLGQTLD
TLSGGECQRLKLASELHNESSIYILDEPTTGLHIADIEKFINIVENIVDSGNTVIIIEHNVDIIKRADWIIDMGPDGGTK
GGEIIFEGTPKQLHNCQVSLTAKYI
>Mature_745_residues
MEQEFIVLKGCKENNLKDISLNIPKRKITIFTGVSGSGKSSIVFETVAKEAQRQLNETFTAFIRNFLPKYGEVKADHIEN
LSTPIIIDQSRLGGNSRSTLGTITDINSFLRALYSRFGSNYIGKANMFSFNDINGMCPECQGLGKKLVPNMEEIFDKSKS
LNEGAILLSGFGVGSWHWKIFAQSGYFDNDKKICDYSEEELDKFLYGGPDKIKIDETGGMNITYEGLLVKFNRLYLKKEG
ETSEAAKKKLNKLLIEDQCPACGGKRLHQRVYGSLINGYNIADLTSMQIDELVEVVKEINDPEAEPLVKGIIEKLNNIID
IGLGYLTLDRETSSLSGGESQRIKMVKHLNSNLVDLMYIFDEPSIGLHPRDVHKLNNLLKKLRDKGNTVIVVEHDPDVIK
IADHIIDVGPKAGKYGGEIVYEGTYENLLKSGTLTGNALNKSLSIKEKVRDHKGYLKVVNCNKNNLKNISVTIPKGVLTV
VTGVAGSGKSTLIKHEFLKQNKNAVLIDQSPVSANSRSSLATYSGIMDNIRKAFAKANGVNASLFSSNSKGACENCNGSG
IIETNLAFMENIKSTCDVCEGKKYKKEVLDYKLHGENIIEVLEMSVSDAIEFFNLRSVKAKLQSIEDMGIGYLTLGQTLD
TLSGGECQRLKLASELHNESSIYILDEPTTGLHIADIEKFINIVENIVDSGNTVIIIEHNVDIIKRADWIIDMGPDGGTK
GGEIIFEGTPKQLHNCQVSLTAKYI

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=685, Percent_Identity=37.5182481751825, Blast_Score=434, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 82251; Mature: 82251

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQEFIVLKGCKENNLKDISLNIPKRKITIFTGVSGSGKSSIVFETVAKEAQRQLNETFT
CCCCEEEEECCCCCCCEEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
AFIRNFLPKYGEVKADHIENLSTPIIIDQSRLGGNSRSTLGTITDINSFLRALYSRFGSN
HHHHHHCCCCCCCCHHHHHCCCCCEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
YIGKANMFSFNDINGMCPECQGLGKKLVPNMEEIFDKSKSLNEGAILLSGFGVGSWHWKI
CCCCCCCEEECCCCCCCCHHHCCCHHCCCCHHHHHHHCCCCCCCEEEEEECCCCCEEEEE
FAQSGYFDNDKKICDYSEEELDKFLYGGPDKIKIDETGGMNITYEGLLVKFNRLYLKKEG
EEECCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCEEEECCEEEEEEEEEEECCC
ETSEAAKKKLNKLLIEDQCPACGGKRLHQRVYGSLINGYNIADLTSMQIDELVEVVKEIN
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
DPEAEPLVKGIIEKLNNIIDIGLGYLTLDRETSSLSGGESQRIKMVKHLNSNLVDLMYIF
CCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEE
DEPSIGLHPRDVHKLNNLLKKLRDKGNTVIVVEHDPDVIKIADHIIDVGPKAGKYGGEIV
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEE
YEGTYENLLKSGTLTGNALNKSLSIKEKVRDHKGYLKVVNCNKNNLKNISVTIPKGVLTV
ECCCHHHHHHCCCCCCHHHCCCCHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCHHHH
VTGVAGSGKSTLIKHEFLKQNKNAVLIDQSPVSANSRSSLATYSGIMDNIRKAFAKANGV
HHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
NASLFSSNSKGACENCNGSGIIETNLAFMENIKSTCDVCEGKKYKKEVLDYKLHGENIIE
CEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHCEEECCHHHHH
VLEMSVSDAIEFFNLRSVKAKLQSIEDMGIGYLTLGQTLDTLSGGECQRLKLASELHNES
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHCCCCCCHHHHHHHHHHCCCC
SIYILDEPTTGLHIADIEKFINIVENIVDSGNTVIIIEHNVDIIKRADWIIDMGPDGGTK
EEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCEEEEECCCCCCC
GGEIIFEGTPKQLHNCQVSLTAKYI
CCEEEEECCCHHHHCCEEEEEEECC
>Mature Secondary Structure
MEQEFIVLKGCKENNLKDISLNIPKRKITIFTGVSGSGKSSIVFETVAKEAQRQLNETFT
CCCCEEEEECCCCCCCEEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
AFIRNFLPKYGEVKADHIENLSTPIIIDQSRLGGNSRSTLGTITDINSFLRALYSRFGSN
HHHHHHCCCCCCCCHHHHHCCCCCEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
YIGKANMFSFNDINGMCPECQGLGKKLVPNMEEIFDKSKSLNEGAILLSGFGVGSWHWKI
CCCCCCCEEECCCCCCCCHHHCCCHHCCCCHHHHHHHCCCCCCCEEEEEECCCCCEEEEE
FAQSGYFDNDKKICDYSEEELDKFLYGGPDKIKIDETGGMNITYEGLLVKFNRLYLKKEG
EEECCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCEEEECCEEEEEEEEEEECCC
ETSEAAKKKLNKLLIEDQCPACGGKRLHQRVYGSLINGYNIADLTSMQIDELVEVVKEIN
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
DPEAEPLVKGIIEKLNNIIDIGLGYLTLDRETSSLSGGESQRIKMVKHLNSNLVDLMYIF
CCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEE
DEPSIGLHPRDVHKLNNLLKKLRDKGNTVIVVEHDPDVIKIADHIIDVGPKAGKYGGEIV
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEE
YEGTYENLLKSGTLTGNALNKSLSIKEKVRDHKGYLKVVNCNKNNLKNISVTIPKGVLTV
ECCCHHHHHHCCCCCCHHHCCCCHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCHHHH
VTGVAGSGKSTLIKHEFLKQNKNAVLIDQSPVSANSRSSLATYSGIMDNIRKAFAKANGV
HHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
NASLFSSNSKGACENCNGSGIIETNLAFMENIKSTCDVCEGKKYKKEVLDYKLHGENIIE
CEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHCEEECCHHHHH
VLEMSVSDAIEFFNLRSVKAKLQSIEDMGIGYLTLGQTLDTLSGGECQRLKLASELHNES
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHCCCCCCHHHHHHHHHHCCCC
SIYILDEPTTGLHIADIEKFINIVENIVDSGNTVIIIEHNVDIIKRADWIIDMGPDGGTK
EEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCEEEEECCCCCCC
GGEIIFEGTPKQLHNCQVSLTAKYI
CCEEEEECCCHHHHCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]