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The map label for this gene is ndhD1 [H]

Identifier: 152977478

GI number: 152977478

Start: 3871147

End: 3872649

Strand: Reverse

Name: ndhD1 [H]

Synonym: Bcer98_3810

Alternate gene names: 152977478

Gene position: 3872649-3871147 (Counterclockwise)

Preceding gene: 152977479

Following gene: 152977477

Centisome position: 94.75

GC content: 41.32

Gene sequence:

>1503_bases
ATGAGTGCTTTCTTATTATCTTTCTTCATTTTCTCCCCACTTCTTAGTATCTTCTTACTTCTATTTACACCAAAAACAAA
GGTACGTGCGGTGCGCGGGATTGGCTTGTTTGGCACGATGCTTCCGCTTGGAACAGCGATTCTTTTAGCGTGCGCATATG
CTTCTGGGAAGAATTTAGCCATTTTTTCAGAAAGGGTAAAATGGATTCAATTTGGCAACTTTCCTGAATTAGACAAAAGC
TTATTTATCATTGACTATGAACTTGGAATGGATGGTTTTTCCCTAGTAATGATGATGTTAGCTTCACTTTTAGTCATGCT
TGCGGCGCTGACGGCTTTTTCCATTCAGCATCAGGTGAAGGCTTTTTATATGCTGTTATTAATGCTTGAAATTGGAGTGC
TTGGCGTTTTCGCGGCAGAAAACTTATTTTTATTCTTTATTTTCTTCGAGATTACATTACCGCCGATGTTTTTGCTAATT
GGAAAATGGGGGAAGTTGTCGAGCGAACAGGCAGCGTATAGCTATTTAATATATAACGGAATTGGTTCAGCGATTTTACT
TATTATTTTCTCCATTTTGTTTGCTAAAACGGGCACAACAAATTTTGAAGAGTTGAAGACGATTTTGGCAGGGACGGATT
CATCATTTTTTAATGGGATGTCTCATTCGCTCCAGCTCAGCATATTTATCGCACTGATGCTTGCGTTTAGTATTAAGTTA
CCGTTGTTTCCGCTACATCGATGGATGGTGAATGTACATGTGGAAGCACATCCGGCAGTTGTGATGATACATGCGGGTGT
GCTACTAAAAATTGGGGCGTACGGTATGATTCGTTTTGGAAAAGGACTATTCCCGGAGCAATTTCAAAGCTTTGCTACCA
TCTTGGCTATTTTAGGTGTAGTAAATTTTTTATACGGTGCTTTCCTTGCTTTCATTCAAACCGACTTCCGAAAGGTGCTG
GCCTATTCTAGTATTTCGCATATGGGAATTGTGCTAATTGGACTTGCAGCACTGAATGCAGCAGGTGTACAAGGGGCGCT
CTTTCAAGTCGTGTCGCACGGTTTAATTGCCGCGCTACTCTTTTTCCTACTTGGCGTAATTGAAGAACGATTTGGTACGT
CGCACATTACGAAGCTTGGAGGCCTTGCAAAACAAGTTCCAATACTTAGTGCATGTTTATTGGCAGGAAGCATGGCTTCG
CTTGGATTGCCGGGAATGTCTGGATTTGTAAGCGAATTTCTTGCTTTTCTCGGTCTATTCCAAGAGAAGCCAATTGTAGC
CGCAGTTGGAGTGCTTGGCATTATATTAACAGCTGCATATGTTTTAAGAGCAACTTTACAAGTAACGTTTGGGAAGCGGG
AATTAGAAGGAAAGCCAGATATGCGTGGTTGGGAGTACATTCCGGTTCTTTTGCTACTTGCATGTATCATAACAATCGGT
GTGTTGCCGGATTTATTAGGAGAACCACTTCAAGATACACTAAAAACATTGGGGGTGAGATAG

Upstream 100 bases:

>100_bases
CAAAACTTCAAAACGGTAATGTACAAGTGTACGGAACGGTGACTGCTATTTCTTTGGCAGCATTGGTTGTCATTTTGTTA
TATACAGGGGGGGATTGGCA

Downstream 100 bases:

>100_bases
GATGGATATGGAGGTATTGTTTCGGTTACCGTGGCATCTTATGGTTCCGGAGTTTATTCTTCTTGGCGGAGCCATTCTTC
TCTCGCTTCTTGATTTGTTT

Product: NADH dehydrogenase subunit M

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MSAFLLSFFIFSPLLSIFLLLFTPKTKVRAVRGIGLFGTMLPLGTAILLACAYASGKNLAIFSERVKWIQFGNFPELDKS
LFIIDYELGMDGFSLVMMMLASLLVMLAALTAFSIQHQVKAFYMLLLMLEIGVLGVFAAENLFLFFIFFEITLPPMFLLI
GKWGKLSSEQAAYSYLIYNGIGSAILLIIFSILFAKTGTTNFEELKTILAGTDSSFFNGMSHSLQLSIFIALMLAFSIKL
PLFPLHRWMVNVHVEAHPAVVMIHAGVLLKIGAYGMIRFGKGLFPEQFQSFATILAILGVVNFLYGAFLAFIQTDFRKVL
AYSSISHMGIVLIGLAALNAAGVQGALFQVVSHGLIAALLFFLLGVIEERFGTSHITKLGGLAKQVPILSACLLAGSMAS
LGLPGMSGFVSEFLAFLGLFQEKPIVAAVGVLGIILTAAYVLRATLQVTFGKRELEGKPDMRGWEYIPVLLLLACIITIG
VLPDLLGEPLQDTLKTLGVR

Sequences:

>Translated_500_residues
MSAFLLSFFIFSPLLSIFLLLFTPKTKVRAVRGIGLFGTMLPLGTAILLACAYASGKNLAIFSERVKWIQFGNFPELDKS
LFIIDYELGMDGFSLVMMMLASLLVMLAALTAFSIQHQVKAFYMLLLMLEIGVLGVFAAENLFLFFIFFEITLPPMFLLI
GKWGKLSSEQAAYSYLIYNGIGSAILLIIFSILFAKTGTTNFEELKTILAGTDSSFFNGMSHSLQLSIFIALMLAFSIKL
PLFPLHRWMVNVHVEAHPAVVMIHAGVLLKIGAYGMIRFGKGLFPEQFQSFATILAILGVVNFLYGAFLAFIQTDFRKVL
AYSSISHMGIVLIGLAALNAAGVQGALFQVVSHGLIAALLFFLLGVIEERFGTSHITKLGGLAKQVPILSACLLAGSMAS
LGLPGMSGFVSEFLAFLGLFQEKPIVAAVGVLGIILTAAYVLRATLQVTFGKRELEGKPDMRGWEYIPVLLLLACIITIG
VLPDLLGEPLQDTLKTLGVR
>Mature_499_residues
SAFLLSFFIFSPLLSIFLLLFTPKTKVRAVRGIGLFGTMLPLGTAILLACAYASGKNLAIFSERVKWIQFGNFPELDKSL
FIIDYELGMDGFSLVMMMLASLLVMLAALTAFSIQHQVKAFYMLLLMLEIGVLGVFAAENLFLFFIFFEITLPPMFLLIG
KWGKLSSEQAAYSYLIYNGIGSAILLIIFSILFAKTGTTNFEELKTILAGTDSSFFNGMSHSLQLSIFIALMLAFSIKLP
LFPLHRWMVNVHVEAHPAVVMIHAGVLLKIGAYGMIRFGKGLFPEQFQSFATILAILGVVNFLYGAFLAFIQTDFRKVLA
YSSISHMGIVLIGLAALNAAGVQGALFQVVSHGLIAALLFFLLGVIEERFGTSHITKLGGLAKQVPILSACLLAGSMASL
GLPGMSGFVSEFLAFLGLFQEKPIVAAVGVLGIILTAAYVLRATLQVTFGKRELEGKPDMRGWEYIPVLLLLACIITIGV
LPDLLGEPLQDTLKTLGVR

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=324, Percent_Identity=31.1728395061728, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI251831117, Length=393, Percent_Identity=25.6997455470738, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1788613, Length=466, Percent_Identity=35.1931330472103, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1788827, Length=358, Percent_Identity=26.8156424581006, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788614, Length=506, Percent_Identity=26.4822134387352, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1788831, Length=348, Percent_Identity=26.4367816091954, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI145693160, Length=417, Percent_Identity=25.8992805755396, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI2367154, Length=364, Percent_Identity=23.9010989010989, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788829, Length=303, Percent_Identity=22.7722772277228, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 54434; Mature: 54303

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFLLSFFIFSPLLSIFLLLFTPKTKVRAVRGIGLFGTMLPLGTAILLACAYASGKNLA
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCH
IFSERVKWIQFGNFPELDKSLFIIDYELGMDGFSLVMMMLASLLVMLAALTAFSIQHQVK
HHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFYMLLLMLEIGVLGVFAAENLFLFFIFFEITLPPMFLLIGKWGKLSSEQAAYSYLIYNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
IGSAILLIIFSILFAKTGTTNFEELKTILAGTDSSFFNGMSHSLQLSIFIALMLAFSIKL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHCC
PLFPLHRWMVNVHVEAHPAVVMIHAGVLLKIGAYGMIRFGKGLFPEQFQSFATILAILGV
CHHHHHHHHEEEEEECCCEEEEEECCHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHH
VNFLYGAFLAFIQTDFRKVLAYSSISHMGIVLIGLAALNAAGVQGALFQVVSHGLIAALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FFLLGVIEERFGTSHITKLGGLAKQVPILSACLLAGSMASLGLPGMSGFVSEFLAFLGLF
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
QEKPIVAAVGVLGIILTAAYVLRATLQVTFGKRELEGKPDMRGWEYIPVLLLLACIITIG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHH
VLPDLLGEPLQDTLKTLGVR
HHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure 
SAFLLSFFIFSPLLSIFLLLFTPKTKVRAVRGIGLFGTMLPLGTAILLACAYASGKNLA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCH
IFSERVKWIQFGNFPELDKSLFIIDYELGMDGFSLVMMMLASLLVMLAALTAFSIQHQVK
HHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFYMLLLMLEIGVLGVFAAENLFLFFIFFEITLPPMFLLIGKWGKLSSEQAAYSYLIYNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
IGSAILLIIFSILFAKTGTTNFEELKTILAGTDSSFFNGMSHSLQLSIFIALMLAFSIKL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHCC
PLFPLHRWMVNVHVEAHPAVVMIHAGVLLKIGAYGMIRFGKGLFPEQFQSFATILAILGV
CHHHHHHHHEEEEEECCCEEEEEECCHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHH
VNFLYGAFLAFIQTDFRKVLAYSSISHMGIVLIGLAALNAAGVQGALFQVVSHGLIAALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FFLLGVIEERFGTSHITKLGGLAKQVPILSACLLAGSMASLGLPGMSGFVSEFLAFLGLF
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
QEKPIVAAVGVLGIILTAAYVLRATLQVTFGKRELEGKPDMRGWEYIPVLLLLACIITIG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHH
VLPDLLGEPLQDTLKTLGVR
HHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]