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The map label for this gene is ispA [C]

Identifier: 152976582

GI number: 152976582

Start: 2946240

End: 2947133

Strand: Reverse

Name: ispA [C]

Synonym: Bcer98_2871

Alternate gene names: 152976582

Gene position: 2947133-2946240 (Counterclockwise)

Preceding gene: 152976583

Following gene: 152976581

Centisome position: 72.11

GC content: 40.49

Gene sequence:

>894_bases
GTGGCATATGGAGATTTCGATGCTTTTGTAATAGAAAGCAAAATGTTTATAGAAAAAGAACTTGCGCGTTACGCGAATGA
ATTGCAATGTCCAAACGTGCTTCGCGATGCGATGACATATTCATTAGAAGCGGGTGGAAAACGTCTCCGCCCGTTACTTT
TATTTGCAACTTTACATGCGTTTGGGAAAGAACGAGAACTTGGGATAGGTGCAGCTTGTGCACTTGAAATGATTCATACA
TACTCTTTAATTCATGATGATTTGCCATGTATGGATGATGATGACTTAAGACGCGGGAAGCCAACCAATCATAAAGTATT
TGGAGAGGCGATGGCTGTTTTAGCCGGCGATGGTTTGCTCACCTATGCGTTTCAAGTAGTTTCAGCGTATAATTATGAAG
GGATTTCTAGTGAAATAAAGTTAAGGCTGGCACTTGAGCTTGCCAAAGCCGCGGGGCCAGAAGGAATGGTAGCTGGACAA
GTAGCGGATATGGAAGCGGAAGGGAAGCACCTTACACTGAATGAATTAGAGTATATTCATAAGCATAAAACAGGAAGATT
ATTAGAGTTTGCTGTACTTGCTGGTGCTATACTTGCTGGTGCAACAAAAGAAGAAGAGGAAAAGCTACTTGCCTTTGCAA
AATATGTTGGCCTTGCCTTTCAAATTAGAGATGATATTTTAGATGTGGAAGGAACGGAAGAAGAAATTGGAAAGCCAATT
GGCAGCGATGCTTCTAATGAAAAGAGTACATATACGACATTATTTGCGATAGACGAAGCAAAAAGTATATTAGAAGAAAC
GATTGCCAAAGCAAAGGATGCAATTATGTCCCTGCAATTACAAGATACATACTTGCTCTCTGTTTGTGATCTTATCGCAA
AGCGTAACAACTAG

Upstream 100 bases:

>100_bases
TGTGTGATGAGAAATTGAAAGATGTACAAGAACAAATGGCAGTAATCCTTGGAGAAGATGGACAGCTTGAGCCATTTACA
GCTTTAGGAGATGAAGCATA

Downstream 100 bases:

>100_bases
TATAACAGCGTTTTCATTTGTTGAGTCATTTATCATTTTGTGGTATAAATGTAGAAAAAGGTTTTTCTTTTCTTTTTATT
GGCAAAAATATATTTAGATT

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MAYGDFDAFVIESKMFIEKELARYANELQCPNVLRDAMTYSLEAGGKRLRPLLLFATLHAFGKERELGIGAACALEMIHT
YSLIHDDLPCMDDDDLRRGKPTNHKVFGEAMAVLAGDGLLTYAFQVVSAYNYEGISSEIKLRLALELAKAAGPEGMVAGQ
VADMEAEGKHLTLNELEYIHKHKTGRLLEFAVLAGAILAGATKEEEEKLLAFAKYVGLAFQIRDDILDVEGTEEEIGKPI
GSDASNEKSTYTTLFAIDEAKSILEETIAKAKDAIMSLQLQDTYLLSVCDLIAKRNN

Sequences:

>Translated_297_residues
MAYGDFDAFVIESKMFIEKELARYANELQCPNVLRDAMTYSLEAGGKRLRPLLLFATLHAFGKERELGIGAACALEMIHT
YSLIHDDLPCMDDDDLRRGKPTNHKVFGEAMAVLAGDGLLTYAFQVVSAYNYEGISSEIKLRLALELAKAAGPEGMVAGQ
VADMEAEGKHLTLNELEYIHKHKTGRLLEFAVLAGAILAGATKEEEEKLLAFAKYVGLAFQIRDDILDVEGTEEEIGKPI
GSDASNEKSTYTTLFAIDEAKSILEETIAKAKDAIMSLQLQDTYLLSVCDLIAKRNN
>Mature_296_residues
AYGDFDAFVIESKMFIEKELARYANELQCPNVLRDAMTYSLEAGGKRLRPLLLFATLHAFGKERELGIGAACALEMIHTY
SLIHDDLPCMDDDDLRRGKPTNHKVFGEAMAVLAGDGLLTYAFQVVSAYNYEGISSEIKLRLALELAKAAGPEGMVAGQV
ADMEAEGKHLTLNELEYIHKHKTGRLLEFAVLAGAILAGATKEEEEKLLAFAKYVGLAFQIRDDILDVEGTEEEIGKPIG
SDASNEKSTYTTLFAIDEAKSILEETIAKAKDAIMSLQLQDTYLLSVCDLIAKRNN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=236, Percent_Identity=30.5084745762712, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI1786623, Length=285, Percent_Identity=43.5087719298246, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1789578, Length=218, Percent_Identity=35.3211009174312, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17505681, Length=251, Percent_Identity=29.4820717131474, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24651612, Length=235, Percent_Identity=28.0851063829787, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32648; Mature: 32517

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYGDFDAFVIESKMFIEKELARYANELQCPNVLRDAMTYSLEAGGKRLRPLLLFATLHA
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
FGKERELGIGAACALEMIHTYSLIHDDLPCMDDDDLRRGKPTNHKVFGEAMAVLAGDGLL
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHCCHHH
TYAFQVVSAYNYEGISSEIKLRLALELAKAAGPEGMVAGQVADMEAEGKHLTLNELEYIH
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEECCEECCCCCCCEEEHHHHHHHH
KHKTGRLLEFAVLAGAILAGATKEEEEKLLAFAKYVGLAFQIRDDILDVEGTEEEIGKPI
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEHHHHCCCCCCHHHHCCCC
GSDASNEKSTYTTLFAIDEAKSILEETIAKAKDAIMSLQLQDTYLLSVCDLIAKRNN
CCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AYGDFDAFVIESKMFIEKELARYANELQCPNVLRDAMTYSLEAGGKRLRPLLLFATLHA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
FGKERELGIGAACALEMIHTYSLIHDDLPCMDDDDLRRGKPTNHKVFGEAMAVLAGDGLL
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHCCHHH
TYAFQVVSAYNYEGISSEIKLRLALELAKAAGPEGMVAGQVADMEAEGKHLTLNELEYIH
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEECCEECCCCCCCEEEHHHHHHHH
KHKTGRLLEFAVLAGAILAGATKEEEEKLLAFAKYVGLAFQIRDDILDVEGTEEEIGKPI
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEHHHHCCCCCCHHHHCCCC
GSDASNEKSTYTTLFAIDEAKSILEETIAKAKDAIMSLQLQDTYLLSVCDLIAKRNN
CCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]