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The map label for this gene is dxs [H]

Identifier: 152976581

GI number: 152976581

Start: 2944063

End: 2945955

Strand: Reverse

Name: dxs [H]

Synonym: Bcer98_2870

Alternate gene names: 152976581

Gene position: 2945955-2944063 (Counterclockwise)

Preceding gene: 152976582

Following gene: 152976580

Centisome position: 72.08

GC content: 38.83

Gene sequence:

>1893_bases
GTGGATCTAACGCAAATTCAAAACCCTAGTTTTTTGAAAGATATGTCTATCAGCGAACTAGAGGAATTGAGTGAGGATAT
TCGTAAGTTTTTAATTGAAGAGCTCTCTCAAACAGGTGGACATATTGCTCCTAACTTAGGTGTAGTAGAACTCACAATTG
CGCTGCATACATTATTTGATAGTCCGAAAGATAAATTTTTATGGGATGTCGGACATCAATCTTATGTTCATAAAATTTTA
ACAGGGCGTGCAAAAGAGTTTCGTACATTAAGGCAGTATAAAGGATTGTGTGGTTTTCCAAAACGATGTGAAAGTGAACA
TGATGTGTGGGAAACTGGTCATAGTTCAACATCATTATCTGCTGCGATGGGAATGGCTTTAGCGCGTGATTTAAAGAAAA
CAGATGAATATGTTATACCGATTATCGGAGATGGTGCTTTAACTGGAGGAATGGCTCTAGAAGCGCTGAATCATATCGGA
CATGAAAAGACAGATATGATTGTGATACTTAACGATAATGAAATGTCAATCGCACCGAATGTTGGAGCACTTCATAATGT
ACTTGGTCGTTTGCGTACAGCTGGTAAATATCAATGGGTAAAAGATGAACTGGAGTATATTCTTAAAAAGATTCCAGCAG
TTGGTGGGAAAGTTGCAGCGACGGCTGAAAAGATTAAAGATAGCTTGAAATATTTATTAGTATCTGGTGTTTTTTTTGAG
GAATTAGGTTTTACATATTTAGGTCCAGTTGATGGACATGATTATGAAAAACTATTTGAAACACTGCAATATGCGAAGAA
AACAAAAGGTCCAGTACTTGTTCATGTGATTACAAAGAAAGGGAAAGGATATAAACCTGCTGAAAGCGATGTAATCGGTA
CTTGGCATGGCACTGGCCCATATAAGATTGAATCGGGAGACTTTGTGAAACCGAAGGAAGTTGCTCCAGCATGGAGCGCT
GTTGTTAGTGAAACGGTTCGTAAACTGGCAAGAGTGGATGAGCGTATCGTAGCGATTACGCCGGCGATGCCTGTTGGATC
TAAACTTGAGAAGTTTCATCAAGAATTTCCAAATCGTATGATTGATGTAGGAATTGCCGAGCAACATGCAACAACGATGG
CAGCTGGAATGGCAACACAAGGAATGAAACCATTCTTAGCAATCTATTCGACGTTTTTACAAAGAGCATATGATCAAGTT
GTTCATGATATATGTCGTCAAAACTTAAATGTTTTCATCGGTATTGATCGTTCTGGATTAGTTGGTGCAGATGGAGAAAC
GCATCAAGGAGTATTTGATATTGCGTTTTTACGCCACTTACCCAATATCGTCCTTATGATGCCGAAAGATGAGAATGAAG
GACAACATTTAGTATATACAGCAATGCAATATGAAGATGGACCGATTGCACTTCGATATCCGCGTGGAAATGGACTTGGT
GTTCCAATGGATGATGAATTCAAGGTAATTCCAATTGGCACATGGGAAACATTAAGAGAAGGTACGCAAGCAGCTATTGT
AACATTTGGGACAACAATTCCAATGGCTATGGAAGCAGCCGAGCGTCTTGGAAAAGCTGGTGTTTCTGTAAAGGTGGTAA
ATGCTCGTTTTATTAAGCCAATGGATGAAGCATACTTACATGATCTTTTAGGAAAGAATATACCGATTTTAACAATTGAA
GAAGCTTGTTTAATCGGCGGGTTTGGTTCAGGAGTTATGGAGTTTGCTGCTGAACATGGATATCATAGTGCATTGATTGA
ACGAATGGGAATTCCAGATTATTTTATCGAGCACGGTAGTGTGACGAAATTATTAGAAGAAATTGGGTTAACAACAGATG
CGGTTGTAGATCGCATCCATACAATGATTCCATCAAAACAAAAAAGGGCGTAA

Upstream 100 bases:

>100_bases
AAAATGTAGTAGGAAAAGCTAAGAACTTCTTGTATTGTGTAAAGTTTTTTTATAATATTTGACATGTTGACAGATTATGA
AATGAAAGTGAGTGATCCAT

Downstream 100 bases:

>100_bases
CAAATGAGTGTAAAAAAAGAAAGAGTAGATGTATTAGTAGTAGAACGCGGGTTGATTGAAACACGTGAAAAAGCAAAGCG
CGCCATTATGGCTGGGCTTG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 630; Mature: 630

Protein sequence:

>630_residues
MDLTQIQNPSFLKDMSISELEELSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHTLFDSPKDKFLWDVGHQSYVHKIL
TGRAKEFRTLRQYKGLCGFPKRCESEHDVWETGHSSTSLSAAMGMALARDLKKTDEYVIPIIGDGALTGGMALEALNHIG
HEKTDMIVILNDNEMSIAPNVGALHNVLGRLRTAGKYQWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGVFFE
ELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHGTGPYKIESGDFVKPKEVAPAWSA
VVSETVRKLARVDERIVAITPAMPVGSKLEKFHQEFPNRMIDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAYDQV
VHDICRQNLNVFIGIDRSGLVGADGETHQGVFDIAFLRHLPNIVLMMPKDENEGQHLVYTAMQYEDGPIALRYPRGNGLG
VPMDDEFKVIPIGTWETLREGTQAAIVTFGTTIPMAMEAAERLGKAGVSVKVVNARFIKPMDEAYLHDLLGKNIPILTIE
EACLIGGFGSGVMEFAAEHGYHSALIERMGIPDYFIEHGSVTKLLEEIGLTTDAVVDRIHTMIPSKQKRA

Sequences:

>Translated_630_residues
MDLTQIQNPSFLKDMSISELEELSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHTLFDSPKDKFLWDVGHQSYVHKIL
TGRAKEFRTLRQYKGLCGFPKRCESEHDVWETGHSSTSLSAAMGMALARDLKKTDEYVIPIIGDGALTGGMALEALNHIG
HEKTDMIVILNDNEMSIAPNVGALHNVLGRLRTAGKYQWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGVFFE
ELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHGTGPYKIESGDFVKPKEVAPAWSA
VVSETVRKLARVDERIVAITPAMPVGSKLEKFHQEFPNRMIDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAYDQV
VHDICRQNLNVFIGIDRSGLVGADGETHQGVFDIAFLRHLPNIVLMMPKDENEGQHLVYTAMQYEDGPIALRYPRGNGLG
VPMDDEFKVIPIGTWETLREGTQAAIVTFGTTIPMAMEAAERLGKAGVSVKVVNARFIKPMDEAYLHDLLGKNIPILTIE
EACLIGGFGSGVMEFAAEHGYHSALIERMGIPDYFIEHGSVTKLLEEIGLTTDAVVDRIHTMIPSKQKRA
>Mature_630_residues
MDLTQIQNPSFLKDMSISELEELSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHTLFDSPKDKFLWDVGHQSYVHKIL
TGRAKEFRTLRQYKGLCGFPKRCESEHDVWETGHSSTSLSAAMGMALARDLKKTDEYVIPIIGDGALTGGMALEALNHIG
HEKTDMIVILNDNEMSIAPNVGALHNVLGRLRTAGKYQWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGVFFE
ELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHGTGPYKIESGDFVKPKEVAPAWSA
VVSETVRKLARVDERIVAITPAMPVGSKLEKFHQEFPNRMIDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAYDQV
VHDICRQNLNVFIGIDRSGLVGADGETHQGVFDIAFLRHLPNIVLMMPKDENEGQHLVYTAMQYEDGPIALRYPRGNGLG
VPMDDEFKVIPIGTWETLREGTQAAIVTFGTTIPMAMEAAERLGKAGVSVKVVNARFIKPMDEAYLHDLLGKNIPILTIE
EACLIGGFGSGVMEFAAEHGYHSALIERMGIPDYFIEHGSVTKLLEEIGLTTDAVVDRIHTMIPSKQKRA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=674, Percent_Identity=23.2937685459941, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI4507521, Length=674, Percent_Identity=23.2937685459941, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI133778974, Length=427, Percent_Identity=26.6978922716628, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI225637461, Length=432, Percent_Identity=24.7685185185185, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI225637463, Length=432, Percent_Identity=24.7685185185185, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI225637459, Length=432, Percent_Identity=24.7685185185185, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1786622, Length=608, Percent_Identity=44.7368421052632, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1788808, Length=271, Percent_Identity=25.4612546125461, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17539652, Length=409, Percent_Identity=23.2273838630807, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17538422, Length=287, Percent_Identity=24.0418118466899, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24666278, Length=538, Percent_Identity=25.092936802974, Blast_Score=108, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45551847, Length=672, Percent_Identity=23.5119047619048, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI45550715, Length=672, Percent_Identity=23.5119047619048, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24645119, Length=628, Percent_Identity=23.7261146496815, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21358145, Length=227, Percent_Identity=23.7885462555066, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24650940, Length=227, Percent_Identity=23.7885462555066, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 69601; Mature: 69601

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTQIQNPSFLKDMSISELEELSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHTLFD
CCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
SPKDKFLWDVGHQSYVHKILTGRAKEFRTLRQYKGLCGFPKRCESEHDVWETGHSSTSLS
CCCHHHEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHCCCCCHHHHCCCCCCHHH
AAMGMALARDLKKTDEYVIPIIGDGALTGGMALEALNHIGHEKTDMIVILNDNEMSIAPN
HHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCC
VGALHNVLGRLRTAGKYQWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGVFFE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHGTGP
HCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCC
YKIESGDFVKPKEVAPAWSAVVSETVRKLARVDERIVAITPAMPVGSKLEKFHQEFPNRM
EEECCCCCCCCHHHCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCE
IDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAYDQVVHDICRQNLNVFIGIDRSGL
EECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
VGADGETHQGVFDIAFLRHLPNIVLMMPKDENEGQHLVYTAMQYEDGPIALRYPRGNGLG
CCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEEEECCCCEEEEECCCCCCC
VPMDDEFKVIPIGTWETLREGTQAAIVTFGTTIPMAMEAAERLGKAGVSVKVVNARFIKP
CCCCCCEEEEECCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEECHHHCCC
MDEAYLHDLLGKNIPILTIEEACLIGGFGSGVMEFAAEHGYHSALIERMGIPDYFIEHGS
HHHHHHHHHHCCCCCEEEECCHHEECCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHCCCH
VTKLLEEIGLTTDAVVDRIHTMIPSKQKRA
HHHHHHHHCCCHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MDLTQIQNPSFLKDMSISELEELSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHTLFD
CCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
SPKDKFLWDVGHQSYVHKILTGRAKEFRTLRQYKGLCGFPKRCESEHDVWETGHSSTSLS
CCCHHHEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHCCCCCHHHHCCCCCCHHH
AAMGMALARDLKKTDEYVIPIIGDGALTGGMALEALNHIGHEKTDMIVILNDNEMSIAPN
HHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCC
VGALHNVLGRLRTAGKYQWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGVFFE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHGTGP
HCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCC
YKIESGDFVKPKEVAPAWSAVVSETVRKLARVDERIVAITPAMPVGSKLEKFHQEFPNRM
EEECCCCCCCCHHHCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCE
IDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAYDQVVHDICRQNLNVFIGIDRSGL
EECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
VGADGETHQGVFDIAFLRHLPNIVLMMPKDENEGQHLVYTAMQYEDGPIALRYPRGNGLG
CCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEEEECCCCEEEEECCCCCCC
VPMDDEFKVIPIGTWETLREGTQAAIVTFGTTIPMAMEAAERLGKAGVSVKVVNARFIKP
CCCCCCEEEEECCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEECHHHCCC
MDEAYLHDLLGKNIPILTIEEACLIGGFGSGVMEFAAEHGYHSALIERMGIPDYFIEHGS
HHHHHHHHHHCCCCCEEEECCHHEECCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHCCCH
VTKLLEEIGLTTDAVVDRIHTMIPSKQKRA
HHHHHHHHCCCHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA