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The map label for this gene is bfmBAA [H]

Identifier: 152976567

GI number: 152976567

Start: 2928372

End: 2929373

Strand: Reverse

Name: bfmBAA [H]

Synonym: Bcer98_2856

Alternate gene names: 152976567

Gene position: 2929373-2928372 (Counterclockwise)

Preceding gene: 152976568

Following gene: 152976566

Centisome position: 71.67

GC content: 40.42

Gene sequence:

>1002_bases
ATGGCAGAAGTAAAAGAAAAACGCCATGAAGCGCTTGGCTTAAGTGATGAGCAAGTATTAGAAATGTACCGTACGATGTT
ACTTGCACGTAAAATTGATGAACGCATGTGGTTATTAAACCGTGCGGGTAAAATTCCATTCGTAATTTCTTGTCAAGGAC
AAGAAGCGGCGCAAGTAGGAGCAGCGTTTGCACTCGATCGTGAAAAAGATTATGTATTACCTTACTATCGTGATATGGGC
GTAGTATTAACATTTGGTATGACAGCAAAAGAACTGATGTTATCTGGATTTGCAAAAGCGGAAGATCCAAACTCAGGTGG
TCGTCAAATGCCTGGTCACTTTGGACAGAAGAAAAATCGTATTGTAACAGGATCGTCTCCGGTTACAACGCAAGTACCAC
ATGCCGTTGGGATTGCTTTAGCGGGAAAAATGGAGAAAAAAGATTTAGTAACGTTTGTAACATTTGGTGAAGGTTCTTCT
AACCAAGGTGATTTCCACGAAGGTGCGAACTTTGCTGGTGTACATAAGCTACCTGTCATCTTTATGTGTGAAAATAACAA
ATATGCCATTTCAGTACCACTTGAAAAGCAATTAGCGTGTAAAAATGTATCAGATCGTGCGATTGGATATGGTATGCCAG
GATATACGGTAGACGGAAATGACCCACTTGCAGTATATCAAGCTGTAAAAGAGGCGGCAGAACGCGGCAGACGCGGGGAA
GGCCCAACGTTAATTGAGACTGTATCATATCGTTTAACAGCACATTCAAGTGATGATGACGATCGTGTATATCGCGATAA
AGAAGAGGTGGAAGAAGCGAAGAAGAAAGATTCAATCTTTACATTTGCTGCTTATTTAAAAGAAGTAGGTTTATTGACAG
AAGAATCCGAAAAACAAATGTTAGATGAAATTATGCATATCGTAAATGAAGCAACAGAATATGCAGAAAATGCTCCGTAT
GCAGCACCTGAAGATGCATTGAAGCACGTATACGCAGAATAG

Upstream 100 bases:

>100_bases
TCCGCATCCATCATTATCAGAAGCGATTGGTGAAGCAGCACTAGCTGTAGATGGAAAAGCGTTACACGCATAAAAATGTG
GATTTAGGAGGTTATGAAAA

Downstream 100 bases:

>100_bases
GGGGGGAACGTTTCATGGCTGTAATGTCTTATATTGACGCGATTACATTGGCAATGCGTGAAGAAATGGAACGCGATGAG
AAAGTATTTGTATTAGGAGA

Product: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MAEVKEKRHEALGLSDEQVLEMYRTMLLARKIDERMWLLNRAGKIPFVISCQGQEAAQVGAAFALDREKDYVLPYYRDMG
VVLTFGMTAKELMLSGFAKAEDPNSGGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGKMEKKDLVTFVTFGEGSS
NQGDFHEGANFAGVHKLPVIFMCENNKYAISVPLEKQLACKNVSDRAIGYGMPGYTVDGNDPLAVYQAVKEAAERGRRGE
GPTLIETVSYRLTAHSSDDDDRVYRDKEEVEEAKKKDSIFTFAAYLKEVGLLTEESEKQMLDEIMHIVNEATEYAENAPY
AAPEDALKHVYAE

Sequences:

>Translated_333_residues
MAEVKEKRHEALGLSDEQVLEMYRTMLLARKIDERMWLLNRAGKIPFVISCQGQEAAQVGAAFALDREKDYVLPYYRDMG
VVLTFGMTAKELMLSGFAKAEDPNSGGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGKMEKKDLVTFVTFGEGSS
NQGDFHEGANFAGVHKLPVIFMCENNKYAISVPLEKQLACKNVSDRAIGYGMPGYTVDGNDPLAVYQAVKEAAERGRRGE
GPTLIETVSYRLTAHSSDDDDRVYRDKEEVEEAKKKDSIFTFAAYLKEVGLLTEESEKQMLDEIMHIVNEATEYAENAPY
AAPEDALKHVYAE
>Mature_332_residues
AEVKEKRHEALGLSDEQVLEMYRTMLLARKIDERMWLLNRAGKIPFVISCQGQEAAQVGAAFALDREKDYVLPYYRDMGV
VLTFGMTAKELMLSGFAKAEDPNSGGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGKMEKKDLVTFVTFGEGSSN
QGDFHEGANFAGVHKLPVIFMCENNKYAISVPLEKQLACKNVSDRAIGYGMPGYTVDGNDPLAVYQAVKEAAERGRRGEG
PTLIETVSYRLTAHSSDDDDRVYRDKEEVEEAKKKDSIFTFAAYLKEVGLLTEESEKQMLDEIMHIVNEATEYAENAPYA
APEDALKHVYAE

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCKDHA family [H]

Homologues:

Organism=Homo sapiens, GI11386135, Length=321, Percent_Identity=39.2523364485981, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI258645172, Length=321, Percent_Identity=39.2523364485981, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI4885543, Length=323, Percent_Identity=32.5077399380805, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI291084742, Length=321, Percent_Identity=32.398753894081, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4505685, Length=321, Percent_Identity=32.398753894081, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI291084744, Length=328, Percent_Identity=31.7073170731707, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI291084757, Length=172, Percent_Identity=34.3023255813954, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI86563355, Length=321, Percent_Identity=40.1869158878505, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI86563357, Length=321, Percent_Identity=40.1869158878505, Blast_Score=210, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17536047, Length=327, Percent_Identity=32.7217125382263, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI32564172, Length=325, Percent_Identity=32.9230769230769, Blast_Score=141, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6321026, Length=324, Percent_Identity=32.4074074074074, Blast_Score=143, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21355903, Length=323, Percent_Identity=33.1269349845201, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24639744, Length=311, Percent_Identity=32.1543408360129, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI28571106, Length=311, Percent_Identity=32.1543408360129, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24639740, Length=311, Percent_Identity=32.1543408360129, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24639746, Length=272, Percent_Identity=33.4558823529412, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24639748, Length=304, Percent_Identity=31.9078947368421, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 36932; Mature: 36801

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVKEKRHEALGLSDEQVLEMYRTMLLARKIDERMWLLNRAGKIPFVISCQGQEAAQVG
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHH
AAFALDREKDYVLPYYRDMGVVLTFGMTAKELMLSGFAKAEDPNSGGRQMPGHFGQKKNR
HHHEECCCCCCCCCHHHCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCE
IVTGSSPVTTQVPHAVGIALAGKMEKKDLVTFVTFGEGSSNQGDFHEGANFAGVHKLPVI
EEECCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHCCCCCCCEECCCEE
FMCENNKYAISVPLEKQLACKNVSDRAIGYGMPGYTVDGNDPLAVYQAVKEAAERGRRGE
EEECCCCEEEECCHHHHHHHCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCC
GPTLIETVSYRLTAHSSDDDDRVYRDKEEVEEAKKKDSIFTFAAYLKEVGLLTEESEKQM
CCHHHHHHEEEEEECCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHH
LDEIMHIVNEATEYAENAPYAAPEDALKHVYAE
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
AEVKEKRHEALGLSDEQVLEMYRTMLLARKIDERMWLLNRAGKIPFVISCQGQEAAQVG
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHH
AAFALDREKDYVLPYYRDMGVVLTFGMTAKELMLSGFAKAEDPNSGGRQMPGHFGQKKNR
HHHEECCCCCCCCCHHHCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCE
IVTGSSPVTTQVPHAVGIALAGKMEKKDLVTFVTFGEGSSNQGDFHEGANFAGVHKLPVI
EEECCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHCCCCCCCEECCCEE
FMCENNKYAISVPLEKQLACKNVSDRAIGYGMPGYTVDGNDPLAVYQAVKEAAERGRRGE
EEECCCCEEEECCHHHHHHHCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCC
GPTLIETVSYRLTAHSSDDDDRVYRDKEEVEEAKKKDSIFTFAAYLKEVGLLTEESEKQM
CCHHHHHHEEEEEECCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHH
LDEIMHIVNEATEYAENAPYAAPEDALKHVYAE
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]