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The map label for this gene is bfmBAB [H]

Identifier: 152976566

GI number: 152976566

Start: 2927374

End: 2928357

Strand: Reverse

Name: bfmBAB [H]

Synonym: Bcer98_2855

Alternate gene names: 152976566

Gene position: 2928357-2927374 (Counterclockwise)

Preceding gene: 152976567

Following gene: 152976565

Centisome position: 71.65

GC content: 39.53

Gene sequence:

>984_bases
ATGGCTGTAATGTCTTATATTGACGCGATTACATTGGCAATGCGTGAAGAAATGGAACGCGATGAGAAAGTATTTGTATT
AGGAGAGGACGTTGGTAAAAAAGGTGGCGTATTTAAAGCGACAACTGGATTGTATGATCAATTCGGCGAAGAGCGTGCGC
TCGATACACCGCTTGCAGAATCTGCAATTGCAGGAGTAGCAATCGGAGCGGCAATGTATGGTATGCGTCCGATTGCGGAA
ATGCAATTTGCTGATTTTATTATGCCAGCGGTGAACCAAATTGTGTCTGAAGCAGCAAGAATTCGCTATCGTTCTAATAA
CGACTGGACTTGTCCATTAACGATACGTGCACCATTTGGTGGCGGTGTTCATGGTGCTTTGTATCATTCACAATCCGTAG
AAGCATTATTTGCAAACCAACCAGGTTTAAAAATAGTAATTCCTTCTACACCATATGATGCAAAAGGATTATTAAAAGCG
GCGATTCGTGATGAAGATCCAGTATTATTCTTTGAACATAAACGTGCATATCGTTTAATTAAAGGCGAAGTACCAGAAGA
TGACTACGTATTACCGATTGGAAAAGCAGATGTAAAACGTGAAGGCGATGATATTACTGTTATCACATATGGATTATGTG
TTCATTTTGCTCTTCAAGCTGCTGAAAAGTTAGCAAAAGATGGCATTTCTGCACATATTCTTGACTTGCGTACTGTATAT
CCATTAGATAAGGAAGCAATTATTGAAGCTGCTTCAAAAACAGGTAAAGTTCTTCTTGTAACGGAAGATAATAAAGAAGG
AAGTATTATGAGCGAAGTATCCGCGATTATCGCTGAAAATTGTCTGTTTGATTTAGATGCACCAATTGCACGTCTTGCAG
GTCCAGACGTTCCGGCGATGCCATATGCACCAACAATGGAAAAATTCTTTATGGTAAATCCAGATAAAGTTGAAAAAGCA
ATGCGTGAACTTGCGGAATTTTAA

Upstream 100 bases:

>100_bases
ATATCGTAAATGAAGCAACAGAATATGCAGAAAATGCTCCGTATGCAGCACCTGAAGATGCATTGAAGCACGTATACGCA
GAATAGGGGGGGAACGTTTC

Downstream 100 bases:

>100_bases
TCGGGGGGACTATACATGGCTGTAGAAAATATTACAATGCCTCAGCTCGGGGAGAGCGTAACAGAAGGTACAATTAGCAA
ATGGCTTGTAAATGTTGGGG

Product: transketolase central region

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MAVMSYIDAITLAMREEMERDEKVFVLGEDVGKKGGVFKATTGLYDQFGEERALDTPLAESAIAGVAIGAAMYGMRPIAE
MQFADFIMPAVNQIVSEAARIRYRSNNDWTCPLTIRAPFGGGVHGALYHSQSVEALFANQPGLKIVIPSTPYDAKGLLKA
AIRDEDPVLFFEHKRAYRLIKGEVPEDDYVLPIGKADVKREGDDITVITYGLCVHFALQAAEKLAKDGISAHILDLRTVY
PLDKEAIIEAASKTGKVLLVTEDNKEGSIMSEVSAIIAENCLFDLDAPIARLAGPDVPAMPYAPTMEKFFMVNPDKVEKA
MRELAEF

Sequences:

>Translated_327_residues
MAVMSYIDAITLAMREEMERDEKVFVLGEDVGKKGGVFKATTGLYDQFGEERALDTPLAESAIAGVAIGAAMYGMRPIAE
MQFADFIMPAVNQIVSEAARIRYRSNNDWTCPLTIRAPFGGGVHGALYHSQSVEALFANQPGLKIVIPSTPYDAKGLLKA
AIRDEDPVLFFEHKRAYRLIKGEVPEDDYVLPIGKADVKREGDDITVITYGLCVHFALQAAEKLAKDGISAHILDLRTVY
PLDKEAIIEAASKTGKVLLVTEDNKEGSIMSEVSAIIAENCLFDLDAPIARLAGPDVPAMPYAPTMEKFFMVNPDKVEKA
MRELAEF
>Mature_326_residues
AVMSYIDAITLAMREEMERDEKVFVLGEDVGKKGGVFKATTGLYDQFGEERALDTPLAESAIAGVAIGAAMYGMRPIAEM
QFADFIMPAVNQIVSEAARIRYRSNNDWTCPLTIRAPFGGGVHGALYHSQSVEALFANQPGLKIVIPSTPYDAKGLLKAA
IRDEDPVLFFEHKRAYRLIKGEVPEDDYVLPIGKADVKREGDDITVITYGLCVHFALQAAEKLAKDGISAHILDLRTVYP
LDKEAIIEAASKTGKVLLVTEDNKEGSIMSEVSAIIAENCLFDLDAPIARLAGPDVPAMPYAPTMEKFFMVNPDKVEKAM
RELAEF

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=327, Percent_Identity=42.5076452599388, Blast_Score=275, Evalue=5e-74,
Organism=Homo sapiens, GI34101272, Length=327, Percent_Identity=42.5076452599388, Blast_Score=275, Evalue=5e-74,
Organism=Homo sapiens, GI156564403, Length=304, Percent_Identity=40.4605263157895, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI291084858, Length=304, Percent_Identity=39.8026315789474, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI133778974, Length=173, Percent_Identity=30.635838150289, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI205277463, Length=284, Percent_Identity=26.056338028169, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI4507521, Length=284, Percent_Identity=26.056338028169, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17538422, Length=326, Percent_Identity=41.1042944785276, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17506935, Length=327, Percent_Identity=42.2018348623853, Blast_Score=247, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6319698, Length=327, Percent_Identity=40.0611620795107, Blast_Score=244, Evalue=1e-65,
Organism=Drosophila melanogaster, GI160714832, Length=327, Percent_Identity=42.5076452599388, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI160714828, Length=327, Percent_Identity=42.5076452599388, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI21358145, Length=308, Percent_Identity=40.9090909090909, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24650940, Length=308, Percent_Identity=40.9090909090909, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24650943, Length=90, Percent_Identity=41.1111111111111, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24650945, Length=90, Percent_Identity=41.1111111111111, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 35810; Mature: 35678

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVMSYIDAITLAMREEMERDEKVFVLGEDVGKKGGVFKATTGLYDQFGEERALDTPLAE
CHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEHHHHHHHHCCCCCCCCCHHH
SAIAGVAIGAAMYGMRPIAEMQFADFIMPAVNQIVSEAARIRYRSNNDWTCPLTIRAPFG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEEECCCC
GGVHGALYHSQSVEALFANQPGLKIVIPSTPYDAKGLLKAAIRDEDPVLFFEHKRAYRLI
CCCCHHHCCCCCHHEEECCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHH
KGEVPEDDYVLPIGKADVKREGDDITVITYGLCVHFALQAAEKLAKDGISAHILDLRTVY
CCCCCCCCEEEECCCCHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCC
PLDKEAIIEAASKTGKVLLVTEDNKEGSIMSEVSAIIAENCLFDLDAPIARLAGPDVPAM
CCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCC
PYAPTMEKFFMVNPDKVEKAMRELAEF
CCCCCCHHEEEECHHHHHHHHHHHHCC
>Mature Secondary Structure 
AVMSYIDAITLAMREEMERDEKVFVLGEDVGKKGGVFKATTGLYDQFGEERALDTPLAE
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEHHHHHHHHCCCCCCCCCHHH
SAIAGVAIGAAMYGMRPIAEMQFADFIMPAVNQIVSEAARIRYRSNNDWTCPLTIRAPFG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEEECCCC
GGVHGALYHSQSVEALFANQPGLKIVIPSTPYDAKGLLKAAIRDEDPVLFFEHKRAYRLI
CCCCHHHCCCCCHHEEECCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHH
KGEVPEDDYVLPIGKADVKREGDDITVITYGLCVHFALQAAEKLAKDGISAHILDLRTVY
CCCCCCCCEEEECCCCHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCC
PLDKEAIIEAASKTGKVLLVTEDNKEGSIMSEVSAIIAENCLFDLDAPIARLAGPDVPAM
CCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCC
PYAPTMEKFFMVNPDKVEKAMRELAEF
CCCCCCHHEEEECHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]