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The map label for this gene is purM

Identifier: 152974116

GI number: 152974116

Start: 316685

End: 317728

Strand: Direct

Name: purM

Synonym: Bcer98_0275

Alternate gene names: 152974116

Gene position: 316685-317728 (Clockwise)

Preceding gene: 152974115

Following gene: 152974117

Centisome position: 7.75

GC content: 38.31

Gene sequence:

>1044_bases
ATGGCGAATGCGTATAAGCAAGCAGGAGTAGATATTGAAGCTGGATATGAAGCGGTATCTCGCATGAAAAAACACGTACA
AACAACAATGAGAAAAGAAGTGCTAGGCGGTCTAGGTGGTTTTGGGGGTATGTTTGATTTATCAAAATTGCCATTAGAAG
AACCTGTATTAGTATCAGGAACAGATGGTGTAGGTACAAAGTTAATGCTTGCTTTCATGGCAGATAAACATGACACAATT
GGCATCGATGCAGTAGCAATGTGTGTAAATGATATCGTTGTTCAAGGAGCAGAACCATTATTTTTCCTTGACTATATTGC
TTGTGGTAAAGCTGATCCAAGTAAAATTGAGCACATCGTCAAAGGGATAGCGGAAGGTTGTCGGCAAGCTGGATGCTCAC
TAATTGGAGGGGAAACAGCAGAAATGCCAGGTATGTATTCCAAGGAAGAGTATGATTTAGCAGGATTTACTGTTGGGATT
GTTGATAAAAAGAAAATTATAACAGGTCATTCGCTTGATGAGGGGCATGTGTTAATTGGTTTAGCTTCTAGTGGGATTCA
TAGTAACGGTTATTCTTTAGTTCGCAAAGTATTATTAGAAGACGGACAGATGTCTTTAGACCGTATATATGGACGGTTAG
AACTACCTCTTGGTGAAGAGTTATTAAAGCCGACGAAAATTTATGTCAAACCTATTTTAGAACTATTGAAGAAATATGAA
GTGTATGGCATGGCACATATTACAGGTGGTGGTTTTATTGAAAATATTCCACGTATGTTACCGAAAGGAATTGGAGCAGA
AATTGACCTTGGCTCTTGGAACATTCAACCGATTTTTAGCCTAATTCAAGAGGTTGGAAAGATAGAAGAGAAGGAAATGT
TCAATATTTTTAACATGGGTATTGGTATGGTAGTAGCGGTGAAAGAAGAAAATGCAAAAGCGGTTGTTCGTCTTCTTGAA
GAACAAGGAGAAAAAGCGTATATCATTGGACGCACTGTAAAAGGATCAGGTGTTGCTTTTAATGGAGGAATAGATCATGA
ATAG

Upstream 100 bases:

>100_bases
AAGAAAAGAAGCTTCTACTTCTTTCTATGTAGAAGCTAGCTTCTTTCTGAAAACGGTCGCCCTAGATGGGGAGAAATTAA
AAGACGAGGTGTGAAAAACA

Downstream 100 bases:

>100_bases
ATTGGCAATCTTTGCCTCTGGAAGCGGATCTAACTTTCAAGCATTCGTTAACGCAGTAGAAGAAAATAGATTACATGCTG
AAATTAGTTTGCTAGTATGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKLPLEEPVLVSGTDGVGTKLMLAFMADKHDTI
GIDAVAMCVNDIVVQGAEPLFFLDYIACGKADPSKIEHIVKGIAEGCRQAGCSLIGGETAEMPGMYSKEEYDLAGFTVGI
VDKKKIITGHSLDEGHVLIGLASSGIHSNGYSLVRKVLLEDGQMSLDRIYGRLELPLGEELLKPTKIYVKPILELLKKYE
VYGMAHITGGGFIENIPRMLPKGIGAEIDLGSWNIQPIFSLIQEVGKIEEKEMFNIFNMGIGMVVAVKEENAKAVVRLLE
EQGEKAYIIGRTVKGSGVAFNGGIDHE

Sequences:

>Translated_347_residues
MANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKLPLEEPVLVSGTDGVGTKLMLAFMADKHDTI
GIDAVAMCVNDIVVQGAEPLFFLDYIACGKADPSKIEHIVKGIAEGCRQAGCSLIGGETAEMPGMYSKEEYDLAGFTVGI
VDKKKIITGHSLDEGHVLIGLASSGIHSNGYSLVRKVLLEDGQMSLDRIYGRLELPLGEELLKPTKIYVKPILELLKKYE
VYGMAHITGGGFIENIPRMLPKGIGAEIDLGSWNIQPIFSLIQEVGKIEEKEMFNIFNMGIGMVVAVKEENAKAVVRLLE
EQGEKAYIIGRTVKGSGVAFNGGIDHE
>Mature_346_residues
ANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKLPLEEPVLVSGTDGVGTKLMLAFMADKHDTIG
IDAVAMCVNDIVVQGAEPLFFLDYIACGKADPSKIEHIVKGIAEGCRQAGCSLIGGETAEMPGMYSKEEYDLAGFTVGIV
DKKKIITGHSLDEGHVLIGLASSGIHSNGYSLVRKVLLEDGQMSLDRIYGRLELPLGEELLKPTKIYVKPILELLKKYEV
YGMAHITGGGFIENIPRMLPKGIGAEIDLGSWNIQPIFSLIQEVGKIEEKEMFNIFNMGIGMVVAVKEENAKAVVRLLEE
QGEKAYIIGRTVKGSGVAFNGGIDHE

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=331, Percent_Identity=48.9425981873112, Blast_Score=324, Evalue=7e-89,
Organism=Homo sapiens, GI209869995, Length=331, Percent_Identity=48.9425981873112, Blast_Score=324, Evalue=7e-89,
Organism=Homo sapiens, GI209869993, Length=331, Percent_Identity=48.9425981873112, Blast_Score=324, Evalue=7e-89,
Organism=Escherichia coli, GI1788845, Length=328, Percent_Identity=55.4878048780488, Blast_Score=355, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17567511, Length=332, Percent_Identity=41.2650602409639, Blast_Score=241, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6321203, Length=339, Percent_Identity=45.4277286135693, Blast_Score=290, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24582400, Length=294, Percent_Identity=42.1768707482993, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_BACCN (A7GKI0)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001373633.1
- ProteinModelPortal:   A7GKI0
- SMR:   A7GKI0
- STRING:   A7GKI0
- EnsemblBacteria:   EBBACT00000037806
- GeneID:   5344704
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_0275
- eggNOG:   COG0150
- GeneTree:   EBGT00050000002660
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- ProtClustDB:   PRK05385
- BioCyc:   BCER315749:BCER98_0275-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 37481; Mature: 37350

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKLPLEEPVLVSG
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEC
TDGVGTKLMLAFMADKHDTIGIDAVAMCVNDIVVQGAEPLFFLDYIACGKADPSKIEHIV
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCHHHHHHHH
KGIAEGCRQAGCSLIGGETAEMPGMYSKEEYDLAGFTVGIVDKKKIITGHSLDEGHVLIG
HHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCEEEE
LASSGIHSNGYSLVRKVLLEDGQMSLDRIYGRLELPLGEELLKPTKIYVKPILELLKKYE
EECCCCCCCHHHHHHHHHHHCCCCCHHHHHCEECCCCCHHHHCHHHHHHHHHHHHHHHHH
VYGMAHITGGGFIENIPRMLPKGIGAEIDLGSWNIQPIFSLIQEVGKIEEKEMFNIFNMG
HHEEEEECCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHCC
IGMVVAVKEENAKAVVRLLEEQGEKAYIIGRTVKGSGVAFNGGIDHE
CEEEEEEECCCHHHHHHHHHHCCCEEEEEEEEECCCCEEECCCCCCC
>Mature Secondary Structure 
ANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKLPLEEPVLVSG
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEC
TDGVGTKLMLAFMADKHDTIGIDAVAMCVNDIVVQGAEPLFFLDYIACGKADPSKIEHIV
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCHHHHHHHH
KGIAEGCRQAGCSLIGGETAEMPGMYSKEEYDLAGFTVGIVDKKKIITGHSLDEGHVLIG
HHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCEEEE
LASSGIHSNGYSLVRKVLLEDGQMSLDRIYGRLELPLGEELLKPTKIYVKPILELLKKYE
EECCCCCCCHHHHHHHHHHHCCCCCHHHHHCEECCCCCHHHHCHHHHHHHHHHHHHHHHH
VYGMAHITGGGFIENIPRMLPKGIGAEIDLGSWNIQPIFSLIQEVGKIEEKEMFNIFNMG
HHEEEEECCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHCC
IGMVVAVKEENAKAVVRLLEEQGEKAYIIGRTVKGSGVAFNGGIDHE
CEEEEEEECCCHHHHHHHHHHCCCEEEEEEEEECCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA