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The map label for this gene is tmk

Identifier: 152973878

GI number: 152973878

Start: 36193

End: 36819

Strand: Direct

Name: tmk

Synonym: Bcer98_0025

Alternate gene names: 152973878

Gene position: 36193-36819 (Clockwise)

Preceding gene: 152973877

Following gene: 152973879

Centisome position: 0.89

GC content: 35.73

Gene sequence:

>627_bases
ATGAAGGGATTATTTGTAACAATTGAAGGACCAGAAGGGTCAGGAAAATCAACATTAATTACAAAGTTATTACCATATTT
TGAAAATAAGGGACAGAAAGTAATTGCAACAAGAGAACCAGGTGGAATTGCTATTTCAGAAGAAATTCGAACGATTTTAC
ATAAAAAAGAGTATACAACGATGGAAGCTCGTACAGAGGCTTTATTATATGCAGCAGCAAGGAGGCAACATTTAGTAGAA
AAAGTTATGCCAGCATTAGAGGCAGATCAGCTTGTATTGTGTGATCGTTTTATTGACAGCTCTCTTGCTTATCAAGGATA
TGCAAGAGGATTAGGGATTGATAAAGTATATGAAATGAATCGCTTTGCTACAGAAGACTGTATGCCGAGCTTAACAATTT
ATTTAGATATTGCGCCAGAAGTTGGTTTGGCACGTATTGAAAAAGATGCTGCAAGAGAAGTGAATCGTTTAGATATGGAA
AGTATTGCATTTCATCGTCTTGTACGTGAGGGCTATCTACAAATTGTAGAACGGTTCAAAGATCGCATTGTAGTAGTGAA
TGCAGATCAGCCAATGGAGAATGTAGTAGAAGAAGTTATTCAGCTTATAGAAAGTAAATTGTTATAA

Upstream 100 bases:

>100_bases
ATATAAGAGAGATGGCCCATTTAGAAAGAACTGGAGCTCGTTTTCAAGGGAATCCAGCGTATATAAAGGTATATGTTATA
GAGAGAAAGTAGGTTTTAGG

Downstream 100 bases:

>100_bases
TAGAAGGAAAGTATAGGATAAGTGAGGTATGCATTATGACGAAGACGTGGGAGCAGCTTTCTGCTATACAACCCATCGGT
GTAAAGATGTTAATCAATAG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKGLFVTIEGPEGSGKSTLITKLLPYFENKGQKVIATREPGGIAISEEIRTILHKKEYTTMEARTEALLYAAARRQHLVE
KVMPALEADQLVLCDRFIDSSLAYQGYARGLGIDKVYEMNRFATEDCMPSLTIYLDIAPEVGLARIEKDAAREVNRLDME
SIAFHRLVREGYLQIVERFKDRIVVVNADQPMENVVEEVIQLIESKLL

Sequences:

>Translated_208_residues
MKGLFVTIEGPEGSGKSTLITKLLPYFENKGQKVIATREPGGIAISEEIRTILHKKEYTTMEARTEALLYAAARRQHLVE
KVMPALEADQLVLCDRFIDSSLAYQGYARGLGIDKVYEMNRFATEDCMPSLTIYLDIAPEVGLARIEKDAAREVNRLDME
SIAFHRLVREGYLQIVERFKDRIVVVNADQPMENVVEEVIQLIESKLL
>Mature_208_residues
MKGLFVTIEGPEGSGKSTLITKLLPYFENKGQKVIATREPGGIAISEEIRTILHKKEYTTMEARTEALLYAAARRQHLVE
KVMPALEADQLVLCDRFIDSSLAYQGYARGLGIDKVYEMNRFATEDCMPSLTIYLDIAPEVGLARIEKDAAREVNRLDME
SIAFHRLVREGYLQIVERFKDRIVVVNADQPMENVVEEVIQLIESKLL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=204, Percent_Identity=35.2941176470588, Blast_Score=105, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_BACCN (A7GJU2)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001373395.1
- ProteinModelPortal:   A7GJU2
- SMR:   A7GJU2
- STRING:   A7GJU2
- EnsemblBacteria:   EBBACT00000038480
- GeneID:   5345045
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_0025
- eggNOG:   COG0125
- GeneTree:   EBGT00050000002345
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK00698
- BioCyc:   BCER315749:BCER98_0025-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23563; Mature: 23563

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLFVTIEGPEGSGKSTLITKLLPYFENKGQKVIATREPGGIAISEEIRTILHKKEYTT
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHH
MEARTEALLYAAARRQHLVEKVMPALEADQLVLCDRFIDSSLAYQGYARGLGIDKVYEMN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RFATEDCMPSLTIYLDIAPEVGLARIEKDAAREVNRLDMESIAFHRLVREGYLQIVERFK
HHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
DRIVVVNADQPMENVVEEVIQLIESKLL
CCEEEEECCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKGLFVTIEGPEGSGKSTLITKLLPYFENKGQKVIATREPGGIAISEEIRTILHKKEYTT
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHH
MEARTEALLYAAARRQHLVEKVMPALEADQLVLCDRFIDSSLAYQGYARGLGIDKVYEMN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RFATEDCMPSLTIYLDIAPEVGLARIEKDAAREVNRLDMESIAFHRLVREGYLQIVERFK
HHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
DRIVVVNADQPMENVVEEVIQLIESKLL
CCEEEEECCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA