Click here to switch to the map view.

The map label for this gene is holB [H]

Identifier: 152973879

GI number: 152973879

Start: 36855

End: 37838

Strand: Direct

Name: holB [H]

Synonym: Bcer98_0026

Alternate gene names: 152973879

Gene position: 36855-37838 (Clockwise)

Preceding gene: 152973878

Following gene: 152973880

Centisome position: 0.9

GC content: 36.69

Gene sequence:

>984_bases
ATGACGAAGACGTGGGAGCAGCTTTCTGCTATACAACCCATCGGTGTAAAGATGTTAATCAATAGTATTGCAAAAGAGCG
TATATCCCATGCTTATTTGTTAGAAGGCGCGAAAGGAACTGGAAAGTTTGCAACGGCAATTCAAATGGCAAAAAGTTTTC
TTTGTATGCAAAGAAGTGGTGTAGAACCATGTCATACATGTATCAATTGTCGTCGGATTGATTCGGGGAATCATCCTAAT
TTACATCTTGTAAAGCCAGATGGACTTTCTATTAAAAAACAACAAATCCATGACTTACAAGAAGAGTTTTCAAAAACAGG
TTTAGAAGCAAATAAGAAGATATATATTATTGAGCATGCAGACCGAATGACAGCCAATGCTGCCAATACTCTATTAAAGT
TTTTAGAAGAACCAAGTAGTGATACGACTGCAATTTTGCTTACGGAACAAAGTCATCAAATATTAAATACAATCTTATCT
CGCTGCCAAGTAGTGACTTTTCGGTCACTTCCTACAGCATCTTTAATTAAGAGATTACAGGATGAAGGAATAACGGTTTC
CTTATCTACTCTTGCAGCTCAAATTACGAATAGTTTTGAAGAAGCATTATCTCTGTGCAATGATGAATGGTTTGCACAAG
CACGAACTTTAGTGATAAAATTATGTGAAGCGCTCGAAAAAGATAAAACCTCTCTTTTTTTTGTACAAGAAAAATGGGGG
AAACACTTTGGAGAGAAGGAACAATTACAACTAGGTTTAGATATGCTACTCCTTATTTATAAGGATTTATTATATGTTCA
GCTAGGAGAGGAAGATCGTCTCGTTTTTCAAGAGCAGAAGGAGATGTTTGCAACTTTCTCTTATGCTCAGAAGCGCATTG
TATCAGCCCTTTTATATATATTAGAGGCAAAAAATAGAATCAACGCTAATGTAAATGCGCAGCTTGTGTTCGAGCAGTTA
GTGTTGCGGTTACAGGAGGGATGA

Upstream 100 bases:

>100_bases
CAGATCAGCCAATGGAGAATGTAGTAGAAGAAGTTATTCAGCTTATAGAAAGTAAATTGTTATAATAGAAGGAAAGTATA
GGATAAGTGAGGTATGCATT

Downstream 100 bases:

>100_bases
CCGTTTTGTATGATGTAGTAGGTGTTCGCTTTAAGAAGGCCGGAAAGGTATATTACTTTGATCCCAATCAATTCGATATT
TCGGAAAATGAGTTTGTAAT

Product: DNA polymerase III subunit delta'

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTKTWEQLSAIQPIGVKMLINSIAKERISHAYLLEGAKGTGKFATAIQMAKSFLCMQRSGVEPCHTCINCRRIDSGNHPN
LHLVKPDGLSIKKQQIHDLQEEFSKTGLEANKKIYIIEHADRMTANAANTLLKFLEEPSSDTTAILLTEQSHQILNTILS
RCQVVTFRSLPTASLIKRLQDEGITVSLSTLAAQITNSFEEALSLCNDEWFAQARTLVIKLCEALEKDKTSLFFVQEKWG
KHFGEKEQLQLGLDMLLLIYKDLLYVQLGEEDRLVFQEQKEMFATFSYAQKRIVSALLYILEAKNRINANVNAQLVFEQL
VLRLQEG

Sequences:

>Translated_327_residues
MTKTWEQLSAIQPIGVKMLINSIAKERISHAYLLEGAKGTGKFATAIQMAKSFLCMQRSGVEPCHTCINCRRIDSGNHPN
LHLVKPDGLSIKKQQIHDLQEEFSKTGLEANKKIYIIEHADRMTANAANTLLKFLEEPSSDTTAILLTEQSHQILNTILS
RCQVVTFRSLPTASLIKRLQDEGITVSLSTLAAQITNSFEEALSLCNDEWFAQARTLVIKLCEALEKDKTSLFFVQEKWG
KHFGEKEQLQLGLDMLLLIYKDLLYVQLGEEDRLVFQEQKEMFATFSYAQKRIVSALLYILEAKNRINANVNAQLVFEQL
VLRLQEG
>Mature_326_residues
TKTWEQLSAIQPIGVKMLINSIAKERISHAYLLEGAKGTGKFATAIQMAKSFLCMQRSGVEPCHTCINCRRIDSGNHPNL
HLVKPDGLSIKKQQIHDLQEEFSKTGLEANKKIYIIEHADRMTANAANTLLKFLEEPSSDTTAILLTEQSHQILNTILSR
CQVVTFRSLPTASLIKRLQDEGITVSLSTLAAQITNSFEEALSLCNDEWFAQARTLVIKLCEALEKDKTSLFFVQEKWGK
HFGEKEQLQLGLDMLLLIYKDLLYVQLGEEDRLVFQEQKEMFATFSYAQKRIVSALLYILEAKNRINANVNAQLVFEQLV
LRLQEG

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG0470

COG function: function code L; ATPase involved in DNA replication

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=197, Percent_Identity=30.9644670050761, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787341, Length=213, Percent_Identity=28.6384976525822, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004622 [H]

Pfam domain/function: NA

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 37033; Mature: 36902

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTWEQLSAIQPIGVKMLINSIAKERISHAYLLEGAKGTGKFATAIQMAKSFLCMQRSG
CCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHCC
VEPCHTCINCRRIDSGNHPNLHLVKPDGLSIKKQQIHDLQEEFSKTGLEANKKIYIIEHA
CCHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECC
DRMTANAANTLLKFLEEPSSDTTAILLTEQSHQILNTILSRCQVVTFRSLPTASLIKRLQ
CHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DEGITVSLSTLAAQITNSFEEALSLCNDEWFAQARTLVIKLCEALEKDKTSLFFVQEKWG
HCCCEEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHH
KHFGEKEQLQLGLDMLLLIYKDLLYVQLGEEDRLVFQEQKEMFATFSYAQKRIVSALLYI
HHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEAKNRINANVNAQLVFEQLVLRLQEG
HHHHHHCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKTWEQLSAIQPIGVKMLINSIAKERISHAYLLEGAKGTGKFATAIQMAKSFLCMQRSG
CCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHCC
VEPCHTCINCRRIDSGNHPNLHLVKPDGLSIKKQQIHDLQEEFSKTGLEANKKIYIIEHA
CCHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECC
DRMTANAANTLLKFLEEPSSDTTAILLTEQSHQILNTILSRCQVVTFRSLPTASLIKRLQ
CHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DEGITVSLSTLAAQITNSFEEALSLCNDEWFAQARTLVIKLCEALEKDKTSLFFVQEKWG
HCCCEEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHH
KHFGEKEQLQLGLDMLLLIYKDLLYVQLGEEDRLVFQEQKEMFATFSYAQKRIVSALLYI
HHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEAKNRINANVNAQLVFEQLVLRLQEG
HHHHHHCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]