Click here to switch to the map view.

The map label for this gene is tyrA [C]

Identifier: 150401448

GI number: 150401448

Start: 1051363

End: 1052706

Strand: Reverse

Name: tyrA [C]

Synonym: Maeo_1024

Alternate gene names: 150401448

Gene position: 1052706-1051363 (Counterclockwise)

Preceding gene: 150401453

Following gene: 150401444

Centisome position: 67.07

GC content: 29.69

Gene sequence:

>1344_bases
ATGATAATATCAATAATAGGCGGAACAGATGGATTAGGGAAATGGTTTGCAAAATATTTAAGCAGTAAAGGATATTCTGT
AATAGTTAGTGGTAGAGATAAAGAAAAAGGAGAAGCAGTTGAAAAAGAATTGGGGGTAATATATACGCAGGACAATATTG
AAGCCACAAAAAAAGGAGATATTGTAATTTTGGCAGTTCCTATAAATATTACTGAATGGATGATTAAAGAGTTGGCACCC
CATGTAAGGGAAAATTGTGTTTTAATGGATATTACCTCTATAAAAGAAATTCCAACAAAGGCCATGTTAAAATATGCAAA
AAAAGATACATTTATAATGCCCACCCATCCAATGTTTGGACCTTCTACGCCATCTTTAAGAAGGCAGGTTGTTATATTAA
CACCACCTACCAAGGAACATGAAAATAACCCCTGGTTTATTAAAATAAAAAACTTTTTTGAAGAAGAGGGGGCCCGGGTA
ATTATAATTCCACCAGAAAAACATGATAAAATTATGGGCGTTGTTCAGGGACTAACTCATTATTCATATATAGTTCTTGG
TTCGACATTAAGGGAGTTGAATATAGATATAAAAGAATCGCGAAAATACGCCTCCCCAATATATGAATTAATGATAAATA
TTATAGCAAGAATTATTGGGCAAAATCCTTATTTGTATGCCGATATACAGATGCACAATCCACAAATAAATGATATTCAT
CAAACATTTATAAATGAGTGCGAAAAAATAAAGGAAATAGTTGAAAACAACGACAGAGAAGCATTTGCAAAACTAATGAA
AGAATCCTCAAAACACTTTGGAAATGAAACTATAAAAGGAATGAATTATTCTGATAAAGCCGTAGGGGCAATAACTCGGG
AAGTAGATAAGCTAAAAAAATCAATTGGTAAAGAGGCTGGTTTAAAACATGCCTACTCCAATAAAGTTCATTTTGGAATT
GTGAAAGATGTAGTTGATGATTTTATAATATTGGATAAACAAGGCAAGGATTTAAAATTAAGCATTGCAAATACCAATTT
AATGACAAAAGAAGAATTAAAACAATGGAAGGAGGCAAATTTAAAAAAATATTATAATGATATTTCATTTTTATTTAAAG
ATAATATAGACATTGATATAATACTAGAATTATTAAAAAGTAAATATAATATTGAAATAATTGATGTTTATAAAGGAGCT
CCCATACAGGAAGGATATAAAAGTATCACATTTAGAATATATTCATTTAAAAAACAAGATTTAGAAAATTTGAGGAGCTC
CCTTATAAGAACTGTGGAAAATATTGGAGGAATTAAACGATACAATACAGATATTTTAAATTAA

Upstream 100 bases:

>100_bases
CCTAATTTATCTGTCGATTCACTATATATATAATAAATTATCTAATATATCATATCATTATTTATACAATATAATAAAAA
ATAATAAAAAAAGGAATATT

Downstream 100 bases:

>100_bases
TATATTTTGATAACAACAGATAATGTCTATTATTTATTATCTATTATTTTTACTTATTCTATTATTTTTATTTATTTATC
TATTGCTTATTTATATATTA

Product: prephenate dehydrogenase

Products: 4-hydroxyphenylpyruvate; CO2; NADH

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MIISIIGGTDGLGKWFAKYLSSKGYSVIVSGRDKEKGEAVEKELGVIYTQDNIEATKKGDIVILAVPINITEWMIKELAP
HVRENCVLMDITSIKEIPTKAMLKYAKKDTFIMPTHPMFGPSTPSLRRQVVILTPPTKEHENNPWFIKIKNFFEEEGARV
IIIPPEKHDKIMGVVQGLTHYSYIVLGSTLRELNIDIKESRKYASPIYELMINIIARIIGQNPYLYADIQMHNPQINDIH
QTFINECEKIKEIVENNDREAFAKLMKESSKHFGNETIKGMNYSDKAVGAITREVDKLKKSIGKEAGLKHAYSNKVHFGI
VKDVVDDFIILDKQGKDLKLSIANTNLMTKEELKQWKEANLKKYYNDISFLFKDNIDIDIILELLKSKYNIEIIDVYKGA
PIQEGYKSITFRIYSFKKQDLENLRSSLIRTVENIGGIKRYNTDILN

Sequences:

>Translated_447_residues
MIISIIGGTDGLGKWFAKYLSSKGYSVIVSGRDKEKGEAVEKELGVIYTQDNIEATKKGDIVILAVPINITEWMIKELAP
HVRENCVLMDITSIKEIPTKAMLKYAKKDTFIMPTHPMFGPSTPSLRRQVVILTPPTKEHENNPWFIKIKNFFEEEGARV
IIIPPEKHDKIMGVVQGLTHYSYIVLGSTLRELNIDIKESRKYASPIYELMINIIARIIGQNPYLYADIQMHNPQINDIH
QTFINECEKIKEIVENNDREAFAKLMKESSKHFGNETIKGMNYSDKAVGAITREVDKLKKSIGKEAGLKHAYSNKVHFGI
VKDVVDDFIILDKQGKDLKLSIANTNLMTKEELKQWKEANLKKYYNDISFLFKDNIDIDIILELLKSKYNIEIIDVYKGA
PIQEGYKSITFRIYSFKKQDLENLRSSLIRTVENIGGIKRYNTDILN
>Mature_447_residues
MIISIIGGTDGLGKWFAKYLSSKGYSVIVSGRDKEKGEAVEKELGVIYTQDNIEATKKGDIVILAVPINITEWMIKELAP
HVRENCVLMDITSIKEIPTKAMLKYAKKDTFIMPTHPMFGPSTPSLRRQVVILTPPTKEHENNPWFIKIKNFFEEEGARV
IIIPPEKHDKIMGVVQGLTHYSYIVLGSTLRELNIDIKESRKYASPIYELMINIIARIIGQNPYLYADIQMHNPQINDIH
QTFINECEKIKEIVENNDREAFAKLMKESSKHFGNETIKGMNYSDKAVGAITREVDKLKKSIGKEAGLKHAYSNKVHFGI
VKDVVDDFIILDKQGKDLKLSIANTNLMTKEELKQWKEANLKKYYNDISFLFKDNIDIDIILELLKSKYNIEIIDVYKGA
PIQEGYKSITFRIYSFKKQDLENLRSSLIRTVENIGGIKRYNTDILN

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=274, Percent_Identity=30.2919708029197, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6319643, Length=286, Percent_Identity=23.7762237762238, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR005121
- InterPro:   IPR008299
- InterPro:   IPR003099 [H]

Pfam domain/function: PF03147 FDX-ACB; PF02153 PDH [H]

EC number: 1.3.1.12

Molecular weight: Translated: 51196; Mature: 51196

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISIIGGTDGLGKWFAKYLSSKGYSVIVSGRDKEKGEAVEKELGVIYTQDNIEATKKGD
CEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCEEEECCCCCCCCCCC
IVILAVPINITEWMIKELAPHVRENCVLMDITSIKEIPTKAMLKYAKKDTFIMPTHPMFG
EEEEEECCCHHHHHHHHHHHHHHCCEEEEEEHHHHHCCHHHHHHHHCCCCEEECCCCCCC
PSTPSLRRQVVILTPPTKEHENNPWFIKIKNFFEEEGARVIIIPPEKHDKIMGVVQGLTH
CCCCCCCCEEEEECCCCCCCCCCCEEEEEEHHHHHCCCEEEEECCCCCHHHHHHHHHHHH
YSYIVLGSTLRELNIDIKESRKYASPIYELMINIIARIIGQNPYLYADIQMHNPQINDIH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHH
QTFINECEKIKEIVENNDREAFAKLMKESSKHFGNETIKGMNYSDKAVGAITREVDKLKK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHH
SIGKEAGLKHAYSNKVHFGIVKDVVDDFIILDKQGKDLKLSIANTNLMTKEELKQWKEAN
HHCHHHCCCHHHCCCEEEHHHHHHHHHEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHH
LKKYYNDISFLFKDNIDIDIILELLKSKYNIEIIDVYKGAPIQEGYKSITFRIYSFKKQD
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHEEEEEEEHHHHH
LENLRSSLIRTVENIGGIKRYNTDILN
HHHHHHHHHHHHHHCCCCEECCCCCCC
>Mature Secondary Structure
MIISIIGGTDGLGKWFAKYLSSKGYSVIVSGRDKEKGEAVEKELGVIYTQDNIEATKKGD
CEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCEEEECCCCCCCCCCC
IVILAVPINITEWMIKELAPHVRENCVLMDITSIKEIPTKAMLKYAKKDTFIMPTHPMFG
EEEEEECCCHHHHHHHHHHHHHHCCEEEEEEHHHHHCCHHHHHHHHCCCCEEECCCCCCC
PSTPSLRRQVVILTPPTKEHENNPWFIKIKNFFEEEGARVIIIPPEKHDKIMGVVQGLTH
CCCCCCCCEEEEECCCCCCCCCCCEEEEEEHHHHHCCCEEEEECCCCCHHHHHHHHHHHH
YSYIVLGSTLRELNIDIKESRKYASPIYELMINIIARIIGQNPYLYADIQMHNPQINDIH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHH
QTFINECEKIKEIVENNDREAFAKLMKESSKHFGNETIKGMNYSDKAVGAITREVDKLKK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHH
SIGKEAGLKHAYSNKVHFGIVKDVVDDFIILDKQGKDLKLSIANTNLMTKEELKQWKEAN
HHCHHHCCCHHHCCCEEEHHHHHHHHHEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHH
LKKYYNDISFLFKDNIDIDIILELLKSKYNIEIIDVYKGAPIQEGYKSITFRIYSFKKQD
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHEEEEEEEHHHHH
LENLRSSLIRTVENIGGIKRYNTDILN
HHHHHHHHHHHHHHCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: prephenate; NAD+

Specific reaction: prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]