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The map label for this gene is cobA [H]

Identifier: 150401289

GI number: 150401289

Start: 888668

End: 889402

Strand: Reverse

Name: cobA [H]

Synonym: Maeo_0861

Alternate gene names: 150401289

Gene position: 889402-888668 (Counterclockwise)

Preceding gene: 150401293

Following gene: 150401288

Centisome position: 56.67

GC content: 32.65

Gene sequence:

>735_bases
ATGAATGTATTTTTAGTAGGCGCAGGTCCCGGAGATGAAGGGCTAATTACTGTAAAAGGACTGGATTTAATAAAGAAAGC
AGATATAATAATATATGATGATTTAGTTGGTAAAAATTTATTAAAATACAGTAAAGAAGATGCAGAATTAATTTATGTTG
GAAAAAGAAAGGGAAAACACTCCCACAAACAAGAAGAAATAAACAATATATTGGTTGAAAAGGCAAAAGATGCCATTGCC
AACAATAAAATTGTTGTTAGGTTAAAAGGCGGTGATTCCTTTATATTTGGTAGAGGCGGTGAAGAGGTATTGGAATTAAA
AAAACACAATATAGATTATGAAATGGTTCCTGGAATTACCTCTTCAATAGCTGTTCCGGAGGTTTCAGACATACCACTTA
CACATAGAAAAGTTGCCACTTCATTTACTGTTGTAACAGGACATGAAGCAGAGGATAAAAAGGAAAACGAAAAACAGGTT
AAATTAAGTGAGTTAAATGCCAACACAATTGTAATTCTTATGGGAATAACTAATTTAGAAAATCATGTAATGGAGCTCCT
AAAAAATCAAAATAGAACCGTTGATACGCCTGTTGCCATAATAATGAATGGAACACGACCAGACCAGAAAATTATAAAAG
GAAATCTTGGAAATATTGTAAATATTGCAAAGGAAAACAACATTGCACCGCCTGGAATTATTGTGGTAGGGGATGTTGTT
AATGTTTTAGAATAA

Upstream 100 bases:

>100_bases
TTTTAATGTAGTAGTTTATATAATATATTATATGGATTATATTATAAATTGTATATGTTATTATTAATATTATTATTACT
ATTATTTGACTGGTGATATA

Downstream 100 bases:

>100_bases
TAATTCATATAAATAAGGGCAATATGAGATTATGGGGTATATAACAACCTATCTATCGATTTACTAAACAAAAAGAAAAT
GGTGAATATATGAAAGAGGA

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MNVFLVGAGPGDEGLITVKGLDLIKKADIIIYDDLVGKNLLKYSKEDAELIYVGKRKGKHSHKQEEINNILVEKAKDAIA
NNKIVVRLKGGDSFIFGRGGEEVLELKKHNIDYEMVPGITSSIAVPEVSDIPLTHRKVATSFTVVTGHEAEDKKENEKQV
KLSELNANTIVILMGITNLENHVMELLKNQNRTVDTPVAIIMNGTRPDQKIIKGNLGNIVNIAKENNIAPPGIIVVGDVV
NVLE

Sequences:

>Translated_244_residues
MNVFLVGAGPGDEGLITVKGLDLIKKADIIIYDDLVGKNLLKYSKEDAELIYVGKRKGKHSHKQEEINNILVEKAKDAIA
NNKIVVRLKGGDSFIFGRGGEEVLELKKHNIDYEMVPGITSSIAVPEVSDIPLTHRKVATSFTVVTGHEAEDKKENEKQV
KLSELNANTIVILMGITNLENHVMELLKNQNRTVDTPVAIIMNGTRPDQKIIKGNLGNIVNIAKENNIAPPGIIVVGDVV
NVLE
>Mature_244_residues
MNVFLVGAGPGDEGLITVKGLDLIKKADIIIYDDLVGKNLLKYSKEDAELIYVGKRKGKHSHKQEEINNILVEKAKDAIA
NNKIVVRLKGGDSFIFGRGGEEVLELKKHNIDYEMVPGITSSIAVPEVSDIPLTHRKVATSFTVVTGHEAEDKKENEKQV
KLSELNANTIVILMGITNLENHVMELLKNQNRTVDTPVAIIMNGTRPDQKIIKGNLGNIVNIAKENNIAPPGIIVVGDVV
NVLE

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=246, Percent_Identity=42.6829268292683, Blast_Score=179, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322922, Length=239, Percent_Identity=34.3096234309623, Blast_Score=126, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 26699; Mature: 26699

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVFLVGAGPGDEGLITVKGLDLIKKADIIIYDDLVGKNLLKYSKEDAELIYVGKRKGKH
CEEEEEECCCCCCCEEEEECCCHHHHCCEEEEECHHCCHHHHCCCCCCEEEEEECCCCCC
SHKQEEINNILVEKAKDAIANNKIVVRLKGGDSFIFGRGGEEVLELKKHNIDYEMVPGIT
CHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCCHHHHHHHHHCCCEEECCCCC
SSIAVPEVSDIPLTHRKVATSFTVVTGHEAEDKKENEKQVKLSELNANTIVILMGITNLE
CCCCCCCCCCCCCCHHHHEEEEEEEECCCCCCCCCCHHEEEEEECCCCEEEEEEECCCHH
NHVMELLKNQNRTVDTPVAIIMNGTRPDQKIIKGNLGNIVNIAKENNIAPPGIIVVGDVV
HHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHCCCCCCEEEEECCCCCCCCCEEEECCHH
NVLE
HHCC
>Mature Secondary Structure
MNVFLVGAGPGDEGLITVKGLDLIKKADIIIYDDLVGKNLLKYSKEDAELIYVGKRKGKH
CEEEEEECCCCCCCEEEEECCCHHHHCCEEEEECHHCCHHHHCCCCCCEEEEEECCCCCC
SHKQEEINNILVEKAKDAIANNKIVVRLKGGDSFIFGRGGEEVLELKKHNIDYEMVPGIT
CHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCCHHHHHHHHHCCCEEECCCCC
SSIAVPEVSDIPLTHRKVATSFTVVTGHEAEDKKENEKQVKLSELNANTIVILMGITNLE
CCCCCCCCCCCCCCHHHHEEEEEEEECCCCCCCCCCHHEEEEEECCCCEEEEEEECCCHH
NHVMELLKNQNRTVDTPVAIIMNGTRPDQKIIKGNLGNIVNIAKENNIAPPGIIVVGDVV
HHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHCCCCCCEEEEECCCCCCCCCEEEECCHH
NVLE
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]