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The map label for this gene is hmgA [H]

Identifier: 150401147

GI number: 150401147

Start: 737724

End: 738980

Strand: Direct

Name: hmgA [H]

Synonym: Maeo_0718

Alternate gene names: 150401147

Gene position: 737724-738980 (Clockwise)

Preceding gene: 150401146

Following gene: 150401148

Centisome position: 47.0

GC content: 35.8

Gene sequence:

>1257_bases
GTGGAAGATAATAATAATAATAATAATAATAATAATAATATAGATATATCCGAAATTATAAATAAATTAAAAAATAAAGA
AATAAAGCCATATCAATTAGATGAATTATTTAATTCAGAAGAAGCCGTAAAAATAAGAAGAAAATATATTGAAGATATGG
TAAATATGGAGCTCCCTCAAATTTCAAATTATACAATTGACGAAAAAGAGGCTTCCAAAAAAAATATAGAAAATATGATA
GGGGCAATACAAATACCGCTCGGCTATGCTGGACCATTAAAAGTAAATGGAAAACATGCCAATAAAGAATATTTCGTTCC
ACTTGCTACCACAGAGGGGGCATTGGTTGCTTCTGTAAATCGAGGTTGTAGTATAATCTCAAAATGTGGGGGTTGCACAG
TTAGAGTAATAGGAGACAAAATGACAAGAGCTCCCGTATTTACTACAAAATCCATAGTCGATGCAATGGAATTAAAAGAA
TGGATTGAAGCCAATTTCCAAAAAATAAAAGAAATTGCAGAAACCACCACCCGTCATGGGAAATTAAAGAGTATTAGTCC
CATATTAATAGTTGGAAGATTCGTATATCCAAGATTTACATACAGCACAGGCGATGCTATGGGTATGAATATGGTAACCA
TTGCCACAGAAAAAGCCTGTGAGTTCATAACCAGCCAAATCAGAGAGGAAAAAAATATAATCGTTCATATGGCGGCACTA
AGTGGAAATGTTTGCACAGACAAAAAACCAGCAGGAATAAACCTCATAGAGGGAAGGGGAAAAACAGTCATAGCAGAGGT
TTATTTAACCAATGAGGAAATAAAAAAATACTTAAAAACCACGGCAAAAGCAATTGAACAAGTGAATATGTATAAAAATT
TAATTGGTTCAGCCATAAGTAACTCCATGGGATTTAATGCCCATTATGCCAATATTGTAGGGGCTTTATTTCTTGCTACG
GGGCAGGATGAAGCCCATATTGTAGAAGGGAGTTTAGGAATAACTGTTGCAGAAAGTGATGAAAACGGACTATATTTCTC
AGTTACACTCCCAGATTTGCCGGTTGGAACAGTTGGAGGCGGAACAAGAATTGAAACCCAGAATGAATGTTTAAAAATTA
TTGATTGCAACGGGGGAGGTAATGCCTTGAAGTTTGCTGAAATAGTCGGGGCTACTGTTCTTGCCGGTGAGTTATCGTTG
ATGGGAGCTCTGGCATCAGGACATTTGGCAAAGGCGCATTCTGAATTAGGCAGATAA

Upstream 100 bases:

>100_bases
CCATATAAAAGATAGCATAAATAAATACAATAAAGAAAATGATATTAAAAAAGATACTAAGGTATTAAATATAGTATCTC
TACTTGATAAGGTGATTTAA

Downstream 100 bases:

>100_bases
AAAAATAAAATAATTATAATAATTATAATAATAAGGAATACAATATTATAAAAATAGAATAAGATAGAATAAACCAATAT
AATAATAAAGGGATATTATG

Product: 3-hydroxy-3-methylglutaryl coenzyme A reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MEDNNNNNNNNNNIDISEIINKLKNKEIKPYQLDELFNSEEAVKIRRKYIEDMVNMELPQISNYTIDEKEASKKNIENMI
GAIQIPLGYAGPLKVNGKHANKEYFVPLATTEGALVASVNRGCSIISKCGGCTVRVIGDKMTRAPVFTTKSIVDAMELKE
WIEANFQKIKEIAETTTRHGKLKSISPILIVGRFVYPRFTYSTGDAMGMNMVTIATEKACEFITSQIREEKNIIVHMAAL
SGNVCTDKKPAGINLIEGRGKTVIAEVYLTNEEIKKYLKTTAKAIEQVNMYKNLIGSAISNSMGFNAHYANIVGALFLAT
GQDEAHIVEGSLGITVAESDENGLYFSVTLPDLPVGTVGGGTRIETQNECLKIIDCNGGGNALKFAEIVGATVLAGELSL
MGALASGHLAKAHSELGR

Sequences:

>Translated_418_residues
MEDNNNNNNNNNNIDISEIINKLKNKEIKPYQLDELFNSEEAVKIRRKYIEDMVNMELPQISNYTIDEKEASKKNIENMI
GAIQIPLGYAGPLKVNGKHANKEYFVPLATTEGALVASVNRGCSIISKCGGCTVRVIGDKMTRAPVFTTKSIVDAMELKE
WIEANFQKIKEIAETTTRHGKLKSISPILIVGRFVYPRFTYSTGDAMGMNMVTIATEKACEFITSQIREEKNIIVHMAAL
SGNVCTDKKPAGINLIEGRGKTVIAEVYLTNEEIKKYLKTTAKAIEQVNMYKNLIGSAISNSMGFNAHYANIVGALFLAT
GQDEAHIVEGSLGITVAESDENGLYFSVTLPDLPVGTVGGGTRIETQNECLKIIDCNGGGNALKFAEIVGATVLAGELSL
MGALASGHLAKAHSELGR
>Mature_418_residues
MEDNNNNNNNNNNIDISEIINKLKNKEIKPYQLDELFNSEEAVKIRRKYIEDMVNMELPQISNYTIDEKEASKKNIENMI
GAIQIPLGYAGPLKVNGKHANKEYFVPLATTEGALVASVNRGCSIISKCGGCTVRVIGDKMTRAPVFTTKSIVDAMELKE
WIEANFQKIKEIAETTTRHGKLKSISPILIVGRFVYPRFTYSTGDAMGMNMVTIATEKACEFITSQIREEKNIIVHMAAL
SGNVCTDKKPAGINLIEGRGKTVIAEVYLTNEEIKKYLKTTAKAIEQVNMYKNLIGSAISNSMGFNAHYANIVGALFLAT
GQDEAHIVEGSLGITVAESDENGLYFSVTLPDLPVGTVGGGTRIETQNECLKIIDCNGGGNALKFAEIVGATVLAGELSL
MGALASGHLAKAHSELGR

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=416, Percent_Identity=43.2692307692308, Blast_Score=298, Evalue=8e-81,
Organism=Homo sapiens, GI196049380, Length=296, Percent_Identity=45.2702702702703, Blast_Score=238, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI25144592, Length=418, Percent_Identity=40.9090909090909, Blast_Score=285, Evalue=4e-77,
Organism=Saccharomyces cerevisiae, GI6323483, Length=430, Percent_Identity=40.4651162790698, Blast_Score=274, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6323565, Length=417, Percent_Identity=40.0479616306954, Blast_Score=267, Evalue=3e-72,
Organism=Drosophila melanogaster, GI281362379, Length=400, Percent_Identity=43, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI45553469, Length=400, Percent_Identity=43, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24649399, Length=400, Percent_Identity=43, Blast_Score=253, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 45488; Mature: 45488

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS00318 HMG_COA_REDUCTASE_2 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDNNNNNNNNNNIDISEIINKLKNKEIKPYQLDELFNSEEAVKIRRKYIEDMVNMELPQ
CCCCCCCCCCCCCEEHHHHHHHHHCCCCCCEEHHHHHCCHHHHHHHHHHHHHHHCCCCCC
ISNYTIDEKEASKKNIENMIGAIQIPLGYAGPLKVNGKHANKEYFVPLATTEGALVASVN
CCCCCCCHHHHHHHHHHHHHCEEEECCCCCCCEEECCCCCCCEEEEEEECCCCCEEEECC
RGCSIISKCGGCTVRVIGDKMTRAPVFTTKSIVDAMELKEWIEANFQKIKEIAETTTRHG
CCHHHHHHCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KLKSISPILIVGRFVYPRFTYSTGDAMGMNMVTIATEKACEFITSQIREEKNIIVHMAAL
CCCCCCCEEEEEHHHCCEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEEEC
SGNVCTDKKPAGINLIEGRGKTVIAEVYLTNEEIKKYLKTTAKAIEQVNMYKNLIGSAIS
CCCCCCCCCCCCCEEEECCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSMGFNAHYANIVGALFLATGQDEAHIVEGSLGITVAESDENGLYFSVTLPDLPVGTVGG
CCCCCCCHHHHHHHHHHEECCCCCCEEEECCCEEEEEECCCCCEEEEEECCCCCCCCCCC
GTRIETQNECLKIIDCNGGGNALKFAEIVGATVLAGELSLMGALASGHLAKAHSELGR
CCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MEDNNNNNNNNNNIDISEIINKLKNKEIKPYQLDELFNSEEAVKIRRKYIEDMVNMELPQ
CCCCCCCCCCCCCEEHHHHHHHHHCCCCCCEEHHHHHCCHHHHHHHHHHHHHHHCCCCCC
ISNYTIDEKEASKKNIENMIGAIQIPLGYAGPLKVNGKHANKEYFVPLATTEGALVASVN
CCCCCCCHHHHHHHHHHHHHCEEEECCCCCCCEEECCCCCCCEEEEEEECCCCCEEEECC
RGCSIISKCGGCTVRVIGDKMTRAPVFTTKSIVDAMELKEWIEANFQKIKEIAETTTRHG
CCHHHHHHCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KLKSISPILIVGRFVYPRFTYSTGDAMGMNMVTIATEKACEFITSQIREEKNIIVHMAAL
CCCCCCCEEEEEHHHCCEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEEEC
SGNVCTDKKPAGINLIEGRGKTVIAEVYLTNEEIKKYLKTTAKAIEQVNMYKNLIGSAIS
CCCCCCCCCCCCCEEEECCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSMGFNAHYANIVGALFLATGQDEAHIVEGSLGITVAESDENGLYFSVTLPDLPVGTVGG
CCCCCCCHHHHHHHHHHEECCCCCCEEEECCCEEEEEECCCCCEEEEEECCCCCCCCCCC
GTRIETQNECLKIIDCNGGGNALKFAEIVGATVLAGELSLMGALASGHLAKAHSELGR
CCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]