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The map label for this gene is hmd [H]

Identifier: 150399877

GI number: 150399877

Start: 1142842

End: 1143906

Strand: Reverse

Name: hmd [H]

Synonym: Mevan_1132

Alternate gene names: 150399877

Gene position: 1143906-1142842 (Counterclockwise)

Preceding gene: 150399878

Following gene: 150399876

Centisome position: 66.5

GC content: 40.19

Gene sequence:

>1065_bases
ATGAAAGTGGCAATATTAGGGGCAGGGTGCTACAGAACACACGCTGCATCAGGAATTACTAATTTTTCAAGAGCTGCACA
AGTTGCAAAAGAAGTAGGGATCCCAGAAATTACAATGACTCACTCAACAATCACAATGGGTGCAGAATTATTACATTTAA
TTCCAGAAGTTACTGAGGTCGTTGTTTCAGACCCATGTTTTGCTGAAGAGCCGGGAATTGTAGTTTTAGACCAGTTTGAC
TATGGGGCAGTAATGGAAGCACACTTAGCAGGGGATGCGGAAAAAGTAATGCCTGAAATCAGAGCTGCTGTAAAAGCTAA
AGCAAAAGAAACACCTAAACCACCTAAAGGATGTATCCACTTTGTACACCCTGAAAAAGTAGGTTTAAAAGTAACTTCAA
ACGACGTTGAAGCAGTTAAAGATGCTGATATCGTAATTACTTGGTTACCAAAAGGTGGTAGCCAACCTGCAATCATTGAA
AAATTCGCTAGCGAAATCAAAAAAGGTGCAGTTGTAACCCACGCTTGTACAATCCCAACACCTAAATTCGCTAAAATATT
CAAAGACTTAGGAAGAGACGACTTAAACATTATTTCATTCCACCCTGGAGCAGTTCCTGAAATGAAAGGCCAAGCATTCC
TTTCAGAAGGTTTAGCTGACGCAGAAAAAGTGGAAGAATTCTACTGCATTGCAAAAGCTGCAAGAGGAGAAGCATTCAAA
ATGCCTGCAAACTTAATCAGCCCGGTATGTGACATGGGTTCAGCAGTTACTGCGCCAGTTTACGCAGCTATTTTAGCTTA
TAGGGATGCTGTAACACAGATTTTAGGTGCGCCTGCAGACTTTGCTCAAATGATGGCTGATGAAGCTATTTCACAGATGT
TAGATTTAATGAGAAAAGAAGGGATTAAAAACATGGAAGAAAAATTAAGCCCTAAGGCATTAACAGGTACTGCTGACAGT
ATGTGTTTTGGCCCTTTAGCGGAAATCCTTCCTGCTTCATTAAAAGTACTTGAAAAGCATGCAAAAGAAAACAAATGCGA
ATGCGGTTGTTCAATCAAACCATAA

Upstream 100 bases:

>100_bases
TTACTTACCTTAATAACCAATATTTATATATGTATTATCACCTAATAATTTTCGTGTTATCTATAATATATATTTTTCAA
TACAAATTGAGGTGTAATAA

Downstream 100 bases:

>100_bases
TTCATAATTACCTCTTTTTTTAATATAACTTTAATTTACATTTCCGGTGGTCTTAATGATATTTTCAAAGGTAAAAAGCA
ATTTTCAAGCGCTAAAGGAT

Product: H(2)-dependent methylenetetrahydromethanopterin dehydrogenase

Products: NA

Alternate protein names: H(2)-dependent methylene-H(4)MPT dehydrogenase; H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase; N(5),N(10)-methenyltetrahydromethanopterin hydrogenase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MKVAILGAGCYRTHAASGITNFSRAAQVAKEVGIPEITMTHSTITMGAELLHLIPEVTEVVVSDPCFAEEPGIVVLDQFD
YGAVMEAHLAGDAEKVMPEIRAAVKAKAKETPKPPKGCIHFVHPEKVGLKVTSNDVEAVKDADIVITWLPKGGSQPAIIE
KFASEIKKGAVVTHACTIPTPKFAKIFKDLGRDDLNIISFHPGAVPEMKGQAFLSEGLADAEKVEEFYCIAKAARGEAFK
MPANLISPVCDMGSAVTAPVYAAILAYRDAVTQILGAPADFAQMMADEAISQMLDLMRKEGIKNMEEKLSPKALTGTADS
MCFGPLAEILPASLKVLEKHAKENKCECGCSIKP

Sequences:

>Translated_354_residues
MKVAILGAGCYRTHAASGITNFSRAAQVAKEVGIPEITMTHSTITMGAELLHLIPEVTEVVVSDPCFAEEPGIVVLDQFD
YGAVMEAHLAGDAEKVMPEIRAAVKAKAKETPKPPKGCIHFVHPEKVGLKVTSNDVEAVKDADIVITWLPKGGSQPAIIE
KFASEIKKGAVVTHACTIPTPKFAKIFKDLGRDDLNIISFHPGAVPEMKGQAFLSEGLADAEKVEEFYCIAKAARGEAFK
MPANLISPVCDMGSAVTAPVYAAILAYRDAVTQILGAPADFAQMMADEAISQMLDLMRKEGIKNMEEKLSPKALTGTADS
MCFGPLAEILPASLKVLEKHAKENKCECGCSIKP
>Mature_354_residues
MKVAILGAGCYRTHAASGITNFSRAAQVAKEVGIPEITMTHSTITMGAELLHLIPEVTEVVVSDPCFAEEPGIVVLDQFD
YGAVMEAHLAGDAEKVMPEIRAAVKAKAKETPKPPKGCIHFVHPEKVGLKVTSNDVEAVKDADIVITWLPKGGSQPAIIE
KFASEIKKGAVVTHACTIPTPKFAKIFKDLGRDDLNIISFHPGAVPEMKGQAFLSEGLADAEKVEEFYCIAKAARGEAFK
MPANLISPVCDMGSAVTAPVYAAILAYRDAVTQILGAPADFAQMMADEAISQMLDLMRKEGIKNMEEKLSPKALTGTADS
MCFGPLAEILPASLKVLEKHAKENKCECGCSIKP

Specific function: Catalyzes the reversible reduction of methenyl- H(4)MPT(+) to methylene-H(4)MPT [H]

COG id: COG4074

COG function: function code C; H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMD family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004889
- InterPro:   IPR010062
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03201 HMD [H]

EC number: =1.12.98.2 [H]

Molecular weight: Translated: 37804; Mature: 37804

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAILGAGCYRTHAASGITNFSRAAQVAKEVGIPEITMTHSTITMGAELLHLIPEVTEV
CEEEEEECCHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHH
VVSDPCFAEEPGIVVLDQFDYGAVMEAHLAGDAEKVMPEIRAAVKAKAKETPKPPKGCIH
HHCCCCCCCCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEE
FVHPEKVGLKVTSNDVEAVKDADIVITWLPKGGSQPAIIEKFASEIKKGAVVTHACTIPT
EECCCCCCEEEECCHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCC
PKFAKIFKDLGRDDLNIISFHPGAVPEMKGQAFLSEGLADAEKVEEFYCIAKAARGEAFK
HHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCEE
MPANLISPVCDMGSAVTAPVYAAILAYRDAVTQILGAPADFAQMMADEAISQMLDLMRKE
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GIKNMEEKLSPKALTGTADSMCFGPLAEILPASLKVLEKHAKENKCECGCSIKP
CHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKVAILGAGCYRTHAASGITNFSRAAQVAKEVGIPEITMTHSTITMGAELLHLIPEVTEV
CEEEEEECCHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHH
VVSDPCFAEEPGIVVLDQFDYGAVMEAHLAGDAEKVMPEIRAAVKAKAKETPKPPKGCIH
HHCCCCCCCCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEE
FVHPEKVGLKVTSNDVEAVKDADIVITWLPKGGSQPAIIEKFASEIKKGAVVTHACTIPT
EECCCCCCEEEECCHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCC
PKFAKIFKDLGRDDLNIISFHPGAVPEMKGQAFLSEGLADAEKVEEFYCIAKAARGEAFK
HHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCEE
MPANLISPVCDMGSAVTAPVYAAILAYRDAVTQILGAPADFAQMMADEAISQMLDLMRKE
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GIKNMEEKLSPKALTGTADSMCFGPLAEILPASLKVLEKHAKENKCECGCSIKP
CHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA