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The map label for this gene is srp54 [H]

Identifier: 150399615

GI number: 150399615

Start: 888754

End: 890106

Strand: Reverse

Name: srp54 [H]

Synonym: Mevan_0865

Alternate gene names: 150399615

Gene position: 890106-888754 (Counterclockwise)

Preceding gene: 150399616

Following gene: 150399612

Centisome position: 51.75

GC content: 34.15

Gene sequence:

>1353_bases
ATGCTTGATAAGTTAGGGCAAAACCTGTCTGAAGCACTGAATAAGATAAAAAATGCTACGTTTGTCGATAAAAAACTCGT
AAAAGAAGTAATTAAGGATATTCAAAAAGCTTTAATCCAGTCTGACGTTAATGTAAAGTTAGTATTCAACATGAGTAAAG
AAATTGAGAGAAAGGCAATAGAAGAAGCTCCTCCAAAAGGATTTTCTAAAAAAGAACATATTATAAAAATTGTTTATGAT
GAACTTGTAAAATTACTTGGGGAAAATCCTCAAAAGCTTGAACTTGACCCTTCAAAAAAGTCAGTAATATTACTTGTTGG
AATTCAAGGAAGTGGTAAAACAACAAGTTCAGCAAAACTTGCAAGGTACATTCAGAAAAAAGGAATGAAACCTGCTTTAA
TTGCAGCGGATATTTACAGGCCGGCAGCATACCAACAGTTAAAACAGTTATCCGAGAAAATAAATGTTCCTCTTTTTGGT
GATGAAACAAAAACAAAAACTCCAGTAGAAATTGTAAAGGAAGGCATTGAAAAATTAAAAAAATCCGATGTTTTGATTAT
AGATACAGCTGGAAGACACAAAGAAGAAGAAAGTCTTTTAGAAGAAATGAAGCAGATGAAAGAAATTACAAATCCAAATG
AAATAATCCTTGTAATTGATGGTACCTTAGGCCAACAGGCTAAAAATCAGGCAAAAGCATTCAAAGACGCAGTTTCAGAA
ATTGGTAGTATATTGGTTACAAAACTTGATGGTTCTGCAAAAGGCGGCGGTGCATTAAGTGCTGTTGCAGAAATCAATGC
ACCTATTAAATTTATTGGAACTGGTGAAGGTGTTGATAACTTAGAAACATTTGACCCAAAAAAATTTATTTCAAGGCTTC
TTGGAATGGGGGATTTAGATTCCCTTTTAGAGAAAACTGAAGATGTAATGGACGAATCAACGGAAGAAAGTATCGATTCA
ATATTGAAAGGAAAATTTACCCTAGTGGAACTTTATGCACAACTTGAAACAATTTCAAAAATGGGTCCTATGAAGCAGAT
AATGGGAATGATTCCGGGGTTTGGCGGAAATATGCCAAAAGAAGCTGCACAACTTACGGAACAGAAATTGAAACGATATA
AAATTATGATGGACTCGATGACGATGGAAGAAAAAGAAAATCCTGAGTTAATCAAGACATCTAGGCTTCAAAGAATTGCA
AAGGGCGCAGGTGTAAAACAAGATGAGATAAAAGACCTCTTAAAGTATTACGCAACAACTAAAAACGCATTTGGTAATTT
AAAAAGAGGAAAAATGCCGAAAATGGGCGGTAAAATGGGCCAAATAATGAGGCAATTAATGTATAAGGAGTAA

Upstream 100 bases:

>100_bases
TAAATTTTGTTGTTGGCCGGATACTTGATAATTTGGGTGTTGAAAATAACATATTTAAGAGATGGGGAGAATAATTATCT
GCTAATAATTTGGTGAAAAC

Downstream 100 bases:

>100_bases
AAATATATTAAAGGTTTAATCCAGTAATTTGGATACCTGCTCCTTTTAATTTGTATTTTATATTTAATTGGATTAATAAT
GGCGTAATCTGCTCAATAAA

Product: signal recognition particle protein Srp54

Products: NA

Alternate protein names: SRP54 [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MLDKLGQNLSEALNKIKNATFVDKKLVKEVIKDIQKALIQSDVNVKLVFNMSKEIERKAIEEAPPKGFSKKEHIIKIVYD
ELVKLLGENPQKLELDPSKKSVILLVGIQGSGKTTSSAKLARYIQKKGMKPALIAADIYRPAAYQQLKQLSEKINVPLFG
DETKTKTPVEIVKEGIEKLKKSDVLIIDTAGRHKEEESLLEEMKQMKEITNPNEIILVIDGTLGQQAKNQAKAFKDAVSE
IGSILVTKLDGSAKGGGALSAVAEINAPIKFIGTGEGVDNLETFDPKKFISRLLGMGDLDSLLEKTEDVMDESTEESIDS
ILKGKFTLVELYAQLETISKMGPMKQIMGMIPGFGGNMPKEAAQLTEQKLKRYKIMMDSMTMEEKENPELIKTSRLQRIA
KGAGVKQDEIKDLLKYYATTKNAFGNLKRGKMPKMGGKMGQIMRQLMYKE

Sequences:

>Translated_450_residues
MLDKLGQNLSEALNKIKNATFVDKKLVKEVIKDIQKALIQSDVNVKLVFNMSKEIERKAIEEAPPKGFSKKEHIIKIVYD
ELVKLLGENPQKLELDPSKKSVILLVGIQGSGKTTSSAKLARYIQKKGMKPALIAADIYRPAAYQQLKQLSEKINVPLFG
DETKTKTPVEIVKEGIEKLKKSDVLIIDTAGRHKEEESLLEEMKQMKEITNPNEIILVIDGTLGQQAKNQAKAFKDAVSE
IGSILVTKLDGSAKGGGALSAVAEINAPIKFIGTGEGVDNLETFDPKKFISRLLGMGDLDSLLEKTEDVMDESTEESIDS
ILKGKFTLVELYAQLETISKMGPMKQIMGMIPGFGGNMPKEAAQLTEQKLKRYKIMMDSMTMEEKENPELIKTSRLQRIA
KGAGVKQDEIKDLLKYYATTKNAFGNLKRGKMPKMGGKMGQIMRQLMYKE
>Mature_450_residues
MLDKLGQNLSEALNKIKNATFVDKKLVKEVIKDIQKALIQSDVNVKLVFNMSKEIERKAIEEAPPKGFSKKEHIIKIVYD
ELVKLLGENPQKLELDPSKKSVILLVGIQGSGKTTSSAKLARYIQKKGMKPALIAADIYRPAAYQQLKQLSEKINVPLFG
DETKTKTPVEIVKEGIEKLKKSDVLIIDTAGRHKEEESLLEEMKQMKEITNPNEIILVIDGTLGQQAKNQAKAFKDAVSE
IGSILVTKLDGSAKGGGALSAVAEINAPIKFIGTGEGVDNLETFDPKKFISRLLGMGDLDSLLEKTEDVMDESTEESIDS
ILKGKFTLVELYAQLETISKMGPMKQIMGMIPGFGGNMPKEAAQLTEQKLKRYKIMMDSMTMEEKENPELIKTSRLQRIA
KGAGVKQDEIKDLLKYYATTKNAFGNLKRGKMPKMGGKMGQIMRQLMYKE

Specific function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=425, Percent_Identity=42.3529411764706, Blast_Score=344, Evalue=8e-95,
Organism=Homo sapiens, GI226371618, Length=372, Percent_Identity=44.6236559139785, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI89061728, Length=159, Percent_Identity=49.685534591195, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI295424842, Length=290, Percent_Identity=22.7586206896552, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI23308697, Length=290, Percent_Identity=22.7586206896552, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1788963, Length=422, Percent_Identity=38.6255924170616, Blast_Score=281, Evalue=4e-77,
Organism=Escherichia coli, GI1789874, Length=270, Percent_Identity=34.4444444444444, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17539958, Length=427, Percent_Identity=40.5152224824356, Blast_Score=333, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI193206261, Length=211, Percent_Identity=26.0663507109005, Blast_Score=79, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6325345, Length=428, Percent_Identity=41.3551401869159, Blast_Score=311, Evalue=9e-86,
Organism=Saccharomyces cerevisiae, GI6320498, Length=224, Percent_Identity=25.4464285714286, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17647949, Length=425, Percent_Identity=41.1764705882353, Blast_Score=321, Evalue=8e-88,
Organism=Drosophila melanogaster, GI24641198, Length=216, Percent_Identity=24.0740740740741, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004125
- InterPro:   IPR022941 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49982; Mature: 49982

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKLGQNLSEALNKIKNATFVDKKLVKEVIKDIQKALIQSDVNVKLVFNMSKEIERKAI
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHH
EEAPPKGFSKKEHIIKIVYDELVKLLGENPQKLELDPSKKSVILLVGIQGSGKTTSSAKL
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEEEEECCCCCCCHHHHH
ARYIQKKGMKPALIAADIYRPAAYQQLKQLSEKINVPLFGDETKTKTPVEIVKEGIEKLK
HHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHH
KSDVLIIDTAGRHKEEESLLEEMKQMKEITNPNEIILVIDGTLGQQAKNQAKAFKDAVSE
HCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
IGSILVTKLDGSAKGGGALSAVAEINAPIKFIGTGEGVDNLETFDPKKFISRLLGMGDLD
HHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCHH
SLLEKTEDVMDESTEESIDSILKGKFTLVELYAQLETISKMGPMKQIMGMIPGFGGNMPK
HHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCH
EAAQLTEQKLKRYKIMMDSMTMEEKENPELIKTSRLQRIAKGAGVKQDEIKDLLKYYATT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
KNAFGNLKRGKMPKMGGKMGQIMRQLMYKE
HHHHCCCCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MLDKLGQNLSEALNKIKNATFVDKKLVKEVIKDIQKALIQSDVNVKLVFNMSKEIERKAI
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHH
EEAPPKGFSKKEHIIKIVYDELVKLLGENPQKLELDPSKKSVILLVGIQGSGKTTSSAKL
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEEEEECCCCCCCHHHHH
ARYIQKKGMKPALIAADIYRPAAYQQLKQLSEKINVPLFGDETKTKTPVEIVKEGIEKLK
HHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHH
KSDVLIIDTAGRHKEEESLLEEMKQMKEITNPNEIILVIDGTLGQQAKNQAKAFKDAVSE
HCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
IGSILVTKLDGSAKGGGALSAVAEINAPIKFIGTGEGVDNLETFDPKKFISRLLGMGDLD
HHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCHH
SLLEKTEDVMDESTEESIDSILKGKFTLVELYAQLETISKMGPMKQIMGMIPGFGGNMPK
HHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCH
EAAQLTEQKLKRYKIMMDSMTMEEKENPELIKTSRLQRIAKGAGVKQDEIKDLLKYYATT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
KNAFGNLKRGKMPKMGGKMGQIMRQLMYKE
HHHHCCCCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA