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The map label for this gene is aroD

Identifier: 150399456

GI number: 150399456

Start: 754475

End: 755131

Strand: Reverse

Name: aroD

Synonym: Mevan_0705

Alternate gene names: 150399456

Gene position: 755131-754475 (Counterclockwise)

Preceding gene: 150399457

Following gene: 150399454

Centisome position: 43.9

GC content: 28.46

Gene sequence:

>657_bases
ATGATATGCATACCAATAATTGATAATACGGTAGAAAAAGCGTTAATTTCAGCAAAAGAAGCTTTAAAATATGGTGATAT
TGTTGAATTTCGGCTTGATTTACTTGATAACTTAACTAAATTTGACATTGAAAAATTTGCAAAAATTCCTTCGATTATTA
CAATAAGGGCAAATTGGGAAGGCGGCGCTTGGAAAGAGTCAAATAATAAGAGAATTGAATTTTTAAAACATGCAATAAAA
CATGGTGCAAAGTTTATTGATGTTGAATTAAAAGAAGAAAAAAATTTAGAACTCGTTACATATCGGAATGAAATTGGTTC
AAAAACAAAAATTATAGTTTCATACCATGATTTTGAAAAAACACCAGAAATAAATGAATTAATTGATGTAGTTGAAAAAG
AACTAAAAATTGGAGATATTGCAAAATTTGCAACGTTTTCAAATTCAAAAAAAGATGTCTTAAAAATTTTAGAGGTAATG
AACAAGTATCCAGGAGATATAATTGCAATAGGCATGGGCGAATCAGGAAAACTTACTAGGATTTTAGGGCTTAGATTTGG
CTCAATTTTAACCTTTGCATCAATGAAAGGAAAATCATCTGCACCAGGCCAGATTGATGTTACGAAATTAAAAGAAATTT
TAAATTTGATTGAATAA

Upstream 100 bases:

>100_bases
CCGCAGTTGAAGGGATTGGAAAAATTACGGCTAAAAAAATACGTGAAGTAGTTACTAAAACTTATAACGAAAAAAATACA
ATGAAAAATGAGGATTTATT

Downstream 100 bases:

>100_bases
ATAAAATTATTCTAAAATAATTTTAAATTTTAAATCTGCTCCTTTTTTTAATTTTTCAATAATTTCTCGATTTATATCTT
TTGAAGCTTTATCTGAATTA

Product: 3-dehydroquinate dehydratase, type I

Products: NA

Alternate protein names: 3-dehydroquinase; Type I DHQase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MICIPIIDNTVEKALISAKEALKYGDIVEFRLDLLDNLTKFDIEKFAKIPSIITIRANWEGGAWKESNNKRIEFLKHAIK
HGAKFIDVELKEEKNLELVTYRNEIGSKTKIIVSYHDFEKTPEINELIDVVEKELKIGDIAKFATFSNSKKDVLKILEVM
NKYPGDIIAIGMGESGKLTRILGLRFGSILTFASMKGKSSAPGQIDVTKLKEILNLIE

Sequences:

>Translated_218_residues
MICIPIIDNTVEKALISAKEALKYGDIVEFRLDLLDNLTKFDIEKFAKIPSIITIRANWEGGAWKESNNKRIEFLKHAIK
HGAKFIDVELKEEKNLELVTYRNEIGSKTKIIVSYHDFEKTPEINELIDVVEKELKIGDIAKFATFSNSKKDVLKILEVM
NKYPGDIIAIGMGESGKLTRILGLRFGSILTFASMKGKSSAPGQIDVTKLKEILNLIE
>Mature_218_residues
MICIPIIDNTVEKALISAKEALKYGDIVEFRLDLLDNLTKFDIEKFAKIPSIITIRANWEGGAWKESNNKRIEFLKHAIK
HGAKFIDVELKEEKNLELVTYRNEIGSKTKIIVSYHDFEKTPEINELIDVVEKELKIGDIAKFATFSNSKKDVLKILEVM
NKYPGDIIAIGMGESGKLTRILGLRFGSILTFASMKGKSSAPGQIDVTKLKEILNLIE

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; third step. [C]

COG id: COG0710

COG function: function code E; 3-dehydroquinate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-I 3-dehydroquinase family

Homologues:

Organism=Escherichia coli, GI1787984, Length=236, Percent_Identity=34.3220338983051, Blast_Score=94, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROD_METVS (A6UQ39)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001323223.1
- ProteinModelPortal:   A6UQ39
- SMR:   A6UQ39
- STRING:   A6UQ39
- GeneID:   5326178
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_0705
- eggNOG:   arNOG12575
- HOGENOM:   HBG732926
- OMA:   NHDFDKT
- ProtClustDB:   CLSK876583
- HAMAP:   MF_00214
- InterPro:   IPR018508
- InterPro:   IPR013785
- InterPro:   IPR001381
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01093

Pfam domain/function: PF01487 DHquinase_I

EC number: =4.2.1.10

Molecular weight: Translated: 24583; Mature: 24583

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS01028 DEHYDROQUINASE_I

Important sites: ACT_SITE 116-116 ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MICIPIIDNTVEKALISAKEALKYGDIVEFRLDLLDNLTKFDIEKFAKIPSIITIRANWE
CEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
GGAWKESNNKRIEFLKHAIKHGAKFIDVELKEEKNLELVTYRNEIGSKTKIIVSYHDFEK
CCCEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCCCCEEEEEEEECCCC
TPEINELIDVVEKELKIGDIAKFATFSNSKKDVLKILEVMNKYPGDIIAIGMGESGKLTR
CCCHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHH
ILGLRFGSILTFASMKGKSSAPGQIDVTKLKEILNLIE
HHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHC
>Mature Secondary Structure
MICIPIIDNTVEKALISAKEALKYGDIVEFRLDLLDNLTKFDIEKFAKIPSIITIRANWE
CEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
GGAWKESNNKRIEFLKHAIKHGAKFIDVELKEEKNLELVTYRNEIGSKTKIIVSYHDFEK
CCCEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCCCCEEEEEEEECCCC
TPEINELIDVVEKELKIGDIAKFATFSNSKKDVLKILEVMNKYPGDIIAIGMGESGKLTR
CCCHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHH
ILGLRFGSILTFASMKGKSSAPGQIDVTKLKEILNLIE
HHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA