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The map label for this gene is ugd [C]

Identifier: 150399166

GI number: 150399166

Start: 466177

End: 467499

Strand: Reverse

Name: ugd [C]

Synonym: Mevan_0413

Alternate gene names: 150399166

Gene position: 467499-466177 (Counterclockwise)

Preceding gene: 150399167

Following gene: 150399165

Centisome position: 27.18

GC content: 26.38

Gene sequence:

>1323_bases
ATGAAAATTTCAGTAATTGGGACAGGTTATGTTGGATTAATTCAAGCAGTGGGCTTAGCAAATTTTGGTTTTAAAGTTAT
AGGGATAGATATTGATGATTCAAAAGTTAAAATGTTAAATAATGGAATTTGTCCATTATATGAAGAAGGTTTGGAAGAAC
TTTTAAAAAAACACACAGGAAAAAATTTAGAATTTACAACATCCTATGAAAAAATAAAAGATTCTGAAGTTATTTTTTTG
TGTGTTGGAACGCCACAAGACAATAATGGAAATACTGATTTAAAATATATTTTTTCAGCAGTTGATAACTTAAAAAAACA
TATTTCGGGTAAAAAATATTTAGTTGTAAAATCAACTGTTCCAATTGGGACAAACCAGCTTTTAAAAGAACGTTTAAATG
GATATAATATTGAAATCATATCAAATCCAGAATTTTTAAGGGAAGGAATGGCTTTAAAAGATTTTTTAAATCCTGAAAGA
ATAATTTTAGGTTTTGATGAAAATGATTTATCTTCAAAGGAAATTTTGAAATACATTTATCAATATTTTATTGAAAAAAA
TATACCCTTGATATTAACAAATTACGAAACTGCAGAAATGATAAAATATGCTTCAAATGCATTTTTAGCAACAAAAATTT
CATTTATAAATGAGCTTTCTAAATTAGCAGACAAAACAAATGCGGACATAAAAACCGTATCTTATGCAATGGGACTTGAT
GATAGAATTGGGAAAAAATTTTTAAATGCGGGAATTGGATATGGAGGGTCATGTTTTCCAAAAGATGTAAAGTCTTTAAC
AAAACAGTTTGAATCTAAAGGTATCGATCCAAAACTTATGACTGCAACAGATAGCGTAAATGAAAACCAAGTAAAATGGT
TTTTTGAAAAAATTAAAAATTATTATGGGGATATTTCAGGTAAAACTTTTGCAGTTTTAGGTTTAGCTTTCAAACCCGAT
ACTGATGATTTAAGGGAAAGTGCTAGTATAAAACTAATTGATTTGCTACTAAAAGAAGATGCAATTATAAAAGGTTTTGA
TAATGTTAAAAGAGCAAGAGAAAATGCATATAATATGTATACATTAGATAAATCAAAAGCATTTTATGGATATAATTTAT
ATATTTTAGATAGTTTGGTAGAAGCAGTTACCGGGGTTGATGGAATAATTTTTGCTGTTGAAGATACTAAATTTAATACT
ATTGACTTTGAAAATATTTTTAATATGGTTAATGAAAAAGTCATATTTGATGGCAGAAATATAATTGATAATGAAAAAAT
TAAAAAAATCGAGTTTGAGTATATTGGAGTTGGATTAAGATGA

Upstream 100 bases:

>100_bases
TATTCGGCATAGTCTATTTAATTGTGTATTTTTTGAGCATAATTTTACTAAATATTATTAAGATATCTGAATTAAAAACT
TTTAAATTCTGGTGACTTAA

Downstream 100 bases:

>100_bases
AAATTTTAGTTACTGGTGCAGCTGGGTTTATAGGGTTTAGTTTTTCTGAAAATATTTTAAAAAATACTGAAATTCAAATA
ATTGGGATTGATAATTTAAA

Product: UDP-glucose 6-dehydrogenase

Products: UDP-glucuronate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MKISVIGTGYVGLIQAVGLANFGFKVIGIDIDDSKVKMLNNGICPLYEEGLEELLKKHTGKNLEFTTSYEKIKDSEVIFL
CVGTPQDNNGNTDLKYIFSAVDNLKKHISGKKYLVVKSTVPIGTNQLLKERLNGYNIEIISNPEFLREGMALKDFLNPER
IILGFDENDLSSKEILKYIYQYFIEKNIPLILTNYETAEMIKYASNAFLATKISFINELSKLADKTNADIKTVSYAMGLD
DRIGKKFLNAGIGYGGSCFPKDVKSLTKQFESKGIDPKLMTATDSVNENQVKWFFEKIKNYYGDISGKTFAVLGLAFKPD
TDDLRESASIKLIDLLLKEDAIIKGFDNVKRARENAYNMYTLDKSKAFYGYNLYILDSLVEAVTGVDGIIFAVEDTKFNT
IDFENIFNMVNEKVIFDGRNIIDNEKIKKIEFEYIGVGLR

Sequences:

>Translated_440_residues
MKISVIGTGYVGLIQAVGLANFGFKVIGIDIDDSKVKMLNNGICPLYEEGLEELLKKHTGKNLEFTTSYEKIKDSEVIFL
CVGTPQDNNGNTDLKYIFSAVDNLKKHISGKKYLVVKSTVPIGTNQLLKERLNGYNIEIISNPEFLREGMALKDFLNPER
IILGFDENDLSSKEILKYIYQYFIEKNIPLILTNYETAEMIKYASNAFLATKISFINELSKLADKTNADIKTVSYAMGLD
DRIGKKFLNAGIGYGGSCFPKDVKSLTKQFESKGIDPKLMTATDSVNENQVKWFFEKIKNYYGDISGKTFAVLGLAFKPD
TDDLRESASIKLIDLLLKEDAIIKGFDNVKRARENAYNMYTLDKSKAFYGYNLYILDSLVEAVTGVDGIIFAVEDTKFNT
IDFENIFNMVNEKVIFDGRNIIDNEKIKKIEFEYIGVGLR
>Mature_440_residues
MKISVIGTGYVGLIQAVGLANFGFKVIGIDIDDSKVKMLNNGICPLYEEGLEELLKKHTGKNLEFTTSYEKIKDSEVIFL
CVGTPQDNNGNTDLKYIFSAVDNLKKHISGKKYLVVKSTVPIGTNQLLKERLNGYNIEIISNPEFLREGMALKDFLNPER
IILGFDENDLSSKEILKYIYQYFIEKNIPLILTNYETAEMIKYASNAFLATKISFINELSKLADKTNADIKTVSYAMGLD
DRIGKKFLNAGIGYGGSCFPKDVKSLTKQFESKGIDPKLMTATDSVNENQVKWFFEKIKNYYGDISGKTFAVLGLAFKPD
TDDLRESASIKLIDLLLKEDAIIKGFDNVKRARENAYNMYTLDKSKAFYGYNLYILDSLVEAVTGVDGIIFAVEDTKFNT
IDFENIFNMVNEKVIFDGRNIIDNEKIKKIEFEYIGVGLR

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DOD-type homing endonuclease domain [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=465, Percent_Identity=33.1182795698925, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI296040438, Length=367, Percent_Identity=33.2425068119891, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI296040443, Length=317, Percent_Identity=34.7003154574132, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI1788340, Length=334, Percent_Identity=30.8383233532934, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI48994968, Length=445, Percent_Identity=24.4943820224719, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17560350, Length=460, Percent_Identity=32.8260869565217, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI17136908, Length=460, Percent_Identity=34.3478260869565, Blast_Score=246, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR003586
- InterPro:   IPR003587
- InterPro:   IPR006142
- InterPro:   IPR004042
- InterPro:   IPR006141
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.22

Molecular weight: Translated: 49639; Mature: 49639

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISVIGTGYVGLIQAVGLANFGFKVIGIDIDDSKVKMLNNGICPLYEEGLEELLKKHTG
CEEEEEECCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHCC
KNLEFTTSYEKIKDSEVIFLCVGTPQDNNGNTDLKYIFSAVDNLKKHISGKKYLVVKSTV
CCCEEEECHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECC
PIGTNQLLKERLNGYNIEIISNPEFLREGMALKDFLNPERIILGFDENDLSSKEILKYIY
CCCHHHHHHHHHCCCEEEEECCHHHHHCCCHHHHHCCCCEEEEECCCCCCCHHHHHHHHH
QYFIEKNIPLILTNYETAEMIKYASNAFLATKISFINELSKLADKTNADIKTVSYAMGLD
HHHHHCCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHCCCC
DRIGKKFLNAGIGYGGSCFPKDVKSLTKQFESKGIDPKLMTATDSVNENQVKWFFEKIKN
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
YYGDISGKTFAVLGLAFKPDTDDLRESASIKLIDLLLKEDAIIKGFDNVKRARENAYNMY
HHCCCCCCEEEEEEEEECCCHHHHHHCCCHHHHHHHHHCCHHHCCHHHHHHHHHCCCEEE
TLDKSKAFYGYNLYILDSLVEAVTGVDGIIFAVEDTKFNTIDFENIFNMVNEKVIFDGRN
EEECCCEEEEEEHHHHHHHHHHHCCCCEEEEEEECCCCCEECHHHHHHHHCCEEEECCCC
IIDNEKIKKIEFEYIGVGLR
CCCCCCCEEEEEEEEECCCC
>Mature Secondary Structure
MKISVIGTGYVGLIQAVGLANFGFKVIGIDIDDSKVKMLNNGICPLYEEGLEELLKKHTG
CEEEEEECCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHCC
KNLEFTTSYEKIKDSEVIFLCVGTPQDNNGNTDLKYIFSAVDNLKKHISGKKYLVVKSTV
CCCEEEECHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECC
PIGTNQLLKERLNGYNIEIISNPEFLREGMALKDFLNPERIILGFDENDLSSKEILKYIY
CCCHHHHHHHHHCCCEEEEECCHHHHHCCCHHHHHCCCCEEEEECCCCCCCHHHHHHHHH
QYFIEKNIPLILTNYETAEMIKYASNAFLATKISFINELSKLADKTNADIKTVSYAMGLD
HHHHHCCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHCCCC
DRIGKKFLNAGIGYGGSCFPKDVKSLTKQFESKGIDPKLMTATDSVNENQVKWFFEKIKN
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
YYGDISGKTFAVLGLAFKPDTDDLRESASIKLIDLLLKEDAIIKGFDNVKRARENAYNMY
HHCCCCCCEEEEEEEEECCCHHHHHHCCCHHHHHHHHHCCHHHCCHHHHHHHHHCCCEEE
TLDKSKAFYGYNLYILDSLVEAVTGVDGIIFAVEDTKFNTIDFENIFNMVNEKVIFDGRN
EEECCCEEEEEEHHHHHHHHHHHCCCCEEEEEEECCCCCEECHHHHHHHHCCEEEECCCC
IIDNEKIKKIEFEYIGVGLR
CCCCCCCEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: 3-Acetylpyridine adenine dinucleotide; 3-Pyridinealdehyde adenine dinucleotide; Deamino adenine dinucleotide; Thionicotinamide adenine dinucleotide [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {NAD+}} 1 {UDPglucose}} [C]

Substrates: UDP-glucose; NAD+; H2O

Specific reaction: UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH + 2 H+

General reaction: Redox reaction [C]

Inhibitor: NADH; UDPglucuronate; UDPxyl ose [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]