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The map label for this gene is adhB [H]

Identifier: 150398899

GI number: 150398899

Start: 162977

End: 164140

Strand: Reverse

Name: adhB [H]

Synonym: Mevan_0143

Alternate gene names: 150398899

Gene position: 164140-162977 (Counterclockwise)

Preceding gene: 150398900

Following gene: 150398898

Centisome position: 9.54

GC content: 33.16

Gene sequence:

>1164_bases
ATGAAAAAATCCTATAATTTCTTACGAAAAATAGTTATACCTGAATTTGTGTATGGAATTGGTGCAATATCTTTAGTTGG
GCACTACGCTAAAAATTTTGGTGCAAAAAAAGCCCTTATTGTAACGGATTTAGGCGTTTTAAAGGCAGGAATTTTAAAAA
ATGTAACGTTATCTTTAGAGTCGGAAAAAATTAGTTATATAATCTTTAGCGATGTTTCAGAAAACCCAAGGATTTATGAA
GTTGAAAAGGGTGCCAGTGTTTACGAAAAAAACAATTGCGATATAATAATTGCCGTAGGGGGCGGAAGTCCGATTGATTG
TGCAAAAACCATAGGAATAACATATACTAATAAAAAAAACCCGCTTGAATTTATCGGGGTAGATGAAGTAGATATTCCTG
GGCCCCCTTTAATCTGTATCCCTACTACATCAGGATCATCAGCAGACGTTTCTCAGTTTGCAATATTGAATGACAATTCT
AAAAATGTAAAACTTGCAATTATAAGTAAATCTGTAGTTTCAGATGTTTCTATAATTGACCCTAAAACAACAATTACAAT
GACTGAAAGATTAACTGCCGCAACTGGAATGGATGCACTTTCACACGCTGTTGAAGCTTATGTATCTAATGCAAGTTCAA
GTATTACTGATTTACATGCATTAGCTGCAATGCCTTTAATTGTAAATAATATAATGCCTGCAATAAAAGACCCTGAAAAT
TTGGAATATCGTAGTAACATGATGCTTGGAAGTTTATATGCAGGAATTGCCTTTTCAAATGCAAGTTTAGGGCTTACACA
TGCAATGGCCCATAGCCTTGGCGGTTTACTGGATTTACCCCATGGAATTTGTAATTCTCTTCTTCTTGAACATGTAGTTG
ACTTTAATTATTACTATGCAACCGAAAAATACAAGGATATTGGAAATATTTTTGGATTAAATCTTGAAAATTACTCGGAT
GAAGAGTGTAAATATAAAATAGTATCCTTTTTATCAGATTTAAGAAAATCTATTGGAATTACCGGCACAATTGGAACTTT
AGGGGTTACTAAAAAGGAAATTCCATCACTTTCAATAAATGCCTTTAATGACCCGTGTATTGTAACTAATCCTAGAACTG
CTACTTTAAATGATATTGAAATGGTGTATAAAAATGCACTCTGA

Upstream 100 bases:

>100_bases
GAAAGATTTGAAAGGGTAGTTATAGAAAGGGAATTAAAAATGATTGAATTAAAAGAAAAAATCAGTAAACTTGAAAAGAA
ATTAAAAGAGGCTGGTTTTA

Downstream 100 bases:

>100_bases
TAACGAAATATCACTTCGAGATAAAATTATTGGATTAGGAGAACGTTCAGCTAAAAAAAGCTACTATCCTCAGTTACAGG
AAAAATTAAAGTACCTTGAA

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase II; ADH II [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKKSYNFLRKIVIPEFVYGIGAISLVGHYAKNFGAKKALIVTDLGVLKAGILKNVTLSLESEKISYIIFSDVSENPRIYE
VEKGASVYEKNNCDIIIAVGGGSPIDCAKTIGITYTNKKNPLEFIGVDEVDIPGPPLICIPTTSGSSADVSQFAILNDNS
KNVKLAIISKSVVSDVSIIDPKTTITMTERLTAATGMDALSHAVEAYVSNASSSITDLHALAAMPLIVNNIMPAIKDPEN
LEYRSNMMLGSLYAGIAFSNASLGLTHAMAHSLGGLLDLPHGICNSLLLEHVVDFNYYYATEKYKDIGNIFGLNLENYSD
EECKYKIVSFLSDLRKSIGITGTIGTLGVTKKEIPSLSINAFNDPCIVTNPRTATLNDIEMVYKNAL

Sequences:

>Translated_387_residues
MKKSYNFLRKIVIPEFVYGIGAISLVGHYAKNFGAKKALIVTDLGVLKAGILKNVTLSLESEKISYIIFSDVSENPRIYE
VEKGASVYEKNNCDIIIAVGGGSPIDCAKTIGITYTNKKNPLEFIGVDEVDIPGPPLICIPTTSGSSADVSQFAILNDNS
KNVKLAIISKSVVSDVSIIDPKTTITMTERLTAATGMDALSHAVEAYVSNASSSITDLHALAAMPLIVNNIMPAIKDPEN
LEYRSNMMLGSLYAGIAFSNASLGLTHAMAHSLGGLLDLPHGICNSLLLEHVVDFNYYYATEKYKDIGNIFGLNLENYSD
EECKYKIVSFLSDLRKSIGITGTIGTLGVTKKEIPSLSINAFNDPCIVTNPRTATLNDIEMVYKNAL
>Mature_387_residues
MKKSYNFLRKIVIPEFVYGIGAISLVGHYAKNFGAKKALIVTDLGVLKAGILKNVTLSLESEKISYIIFSDVSENPRIYE
VEKGASVYEKNNCDIIIAVGGGSPIDCAKTIGITYTNKKNPLEFIGVDEVDIPGPPLICIPTTSGSSADVSQFAILNDNS
KNVKLAIISKSVVSDVSIIDPKTTITMTERLTAATGMDALSHAVEAYVSNASSSITDLHALAAMPLIVNNIMPAIKDPEN
LEYRSNMMLGSLYAGIAFSNASLGLTHAMAHSLGGLLDLPHGICNSLLLEHVVDFNYYYATEKYKDIGNIFGLNLENYSD
EECKYKIVSFLSDLRKSIGITGTIGTLGVTKKEIPSLSINAFNDPCIVTNPRTATLNDIEMVYKNAL

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=393, Percent_Identity=25.1908396946565, Blast_Score=135, Evalue=6e-32,
Organism=Escherichia coli, GI48994951, Length=370, Percent_Identity=38.9189189189189, Blast_Score=267, Evalue=7e-73,
Organism=Escherichia coli, GI1789163, Length=381, Percent_Identity=34.3832020997375, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI87082107, Length=375, Percent_Identity=32.8, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1787493, Length=381, Percent_Identity=30.1837270341207, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789386, Length=320, Percent_Identity=23.125, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17537053, Length=427, Percent_Identity=24.824355971897, Blast_Score=135, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6321181, Length=376, Percent_Identity=37.2340425531915, Blast_Score=233, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24657991, Length=410, Percent_Identity=23.4146341463415, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 41779; Mature: 41779

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSYNFLRKIVIPEFVYGIGAISLVGHYAKNFGAKKALIVTDLGVLKAGILKNVTLSLE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHEEEEEE
SEKISYIIFSDVSENPRIYEVEKGASVYEKNNCDIIIAVGGGSPIDCAKTIGITYTNKKN
CCEEEEEEEECCCCCCCEEEEECCCCEEECCCCEEEEEECCCCCCCHHHEEEEEECCCCC
PLEFIGVDEVDIPGPPLICIPTTSGSSADVSQFAILNDNSKNVKLAIISKSVVSDVSIID
CEEEECCCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCEEEEEEEEHHHHCCCEEEC
PKTTITMTERLTAATGMDALSHAVEAYVSNASSSITDLHALAAMPLIVNNIMPAIKDPEN
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
LEYRSNMMLGSLYAGIAFSNASLGLTHAMAHSLGGLLDLPHGICNSLLLEHVVDFNYYYA
CHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHCCCEEEE
TEKYKDIGNIFGLNLENYSDEECKYKIVSFLSDLRKSIGITGTIGTLGVTKKEIPSLSIN
HHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHCCCEEEE
AFNDPCIVTNPRTATLNDIEMVYKNAL
CCCCCEEEECCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKKSYNFLRKIVIPEFVYGIGAISLVGHYAKNFGAKKALIVTDLGVLKAGILKNVTLSLE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHEEEEEE
SEKISYIIFSDVSENPRIYEVEKGASVYEKNNCDIIIAVGGGSPIDCAKTIGITYTNKKN
CCEEEEEEEECCCCCCCEEEEECCCCEEECCCCEEEEEECCCCCCCHHHEEEEEECCCCC
PLEFIGVDEVDIPGPPLICIPTTSGSSADVSQFAILNDNSKNVKLAIISKSVVSDVSIID
CEEEECCCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCEEEEEEEEHHHHCCCEEEC
PKTTITMTERLTAATGMDALSHAVEAYVSNASSSITDLHALAAMPLIVNNIMPAIKDPEN
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
LEYRSNMMLGSLYAGIAFSNASLGLTHAMAHSLGGLLDLPHGICNSLLLEHVVDFNYYYA
CHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHCCCEEEE
TEKYKDIGNIFGLNLENYSDEECKYKIVSFLSDLRKSIGITGTIGTLGVTKKEIPSLSIN
HHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHCCCEEEE
AFNDPCIVTNPRTATLNDIEMVYKNAL
CCCCCEEEECCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3584063; 2308827; 2935393 [H]