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The map label for this gene is pyrG [H]

Identifier: 150398788

GI number: 150398788

Start: 24675

End: 26279

Strand: Reverse

Name: pyrG [H]

Synonym: Mevan_0028

Alternate gene names: 150398788

Gene position: 26279-24675 (Counterclockwise)

Preceding gene: 150398789

Following gene: 150398787

Centisome position: 1.53

GC content: 33.96

Gene sequence:

>1605_bases
ATGAAGTATATATTTGTTACAGGTGGTGTCGTTTCCTCATTAGGAAAAGGAATAACTGCTTCATCTCTTGGAAGACTTTT
AAAAGCACGTGGTTTTAACGTAAATATGGTTAAAATAGACCCTTATTTACAAATCGATGCTGGAACAATGTCGCCTTATG
AACACGGCGAAGTCTTTGTAACTGATGATGGGGGAGAAACTGACCTTGACCTTGGAAACTACGAAAGATTTATAGATATT
AGTTTAAAAGCGAAAAATAATATTACAACTGGTAAAATCTACTGGAACGTTCTTTCAAAAGAAAGAAAGGGCGATTACTT
GGGAAAAACTGTTCAAGTAATTCCACACATCACAAATGAAATAAAAGAATGGATAAAAGAACTTGGAAGCGAAAGCGATA
TTACAATTGTGGAAATTGGAGGAACTGTTGGAGATATTGAAAGTTTACCTTTTTTAGAAGCAATAAGGCAGTTTAAAAAA
GACGTTGGAAAAGAAAATGTTTTATATATTCATGTTTCGCTTTTACCATATATTAGAAGTGCAGGCGAATTAAAAACAAA
ACCAACACAACATTCAGTAAAAGAACTTAAAGGTATCGGAATTCAGCCCGATATACTAGTTTGTAGAACTGAAATTCCAA
TAAATGAAAAATTAAGGGAAAAATTAGCACTTTTCTGTGACGTTGAAAAGGAAGCCGTAATTGAAGGAAAAGATGCTAAA
ACCATATATGAAGTTCCATTAAATCTTGAAAAAGAAGGTTTAGGGGCCCTCGTTATCAAAAAACTTAATTTACGGGATTC
CGCCCCAAATCTTTCTGAATGGAGGGCGAACGTTGATAGAATAATAAACCCATTAAATTCTGTTTCAATTGGCGTTGTTG
GAAAGTACGTTGAATTAAAAGATGCGTATGCTAGTATTTTAGAAGCTCTTGGACATGCCGGTGCTAAAAATGACACTAAG
GTAAACGTAACATGGATTAATGCAGAAGAACTTGAAAACAAAAATTATAGAGAAATTCTCGATAAAATGCGTGAAGATGA
AAAAATCGATGGAATATTGGTACCCGGAGGTTTTGGAGATAGGGGAATAGATGGAAAAATAAATGCAGTATGCTATGCAC
GAGAAAATAACATTCCATTTTTAGGAATATGCCTTGGAATGCAGTGTGCAGTAATTGAATTTTCAAGAAATGTATGCGGA
TTAAATGGTGCAGATTCAACAGAATTTAACGAAAAAACCGAGCACCCTGTAATTGACTATATTCCTGAACAGCGTGATGT
TACCGAAAAAGGTGGCACTATGAGACTTGGGGCATATACTGCATTTTTAGAAAATGGTTCACTAGTAAATACACTCTATA
ATTCAATTGAAGTATCTGAAAGACATAGACATCGGTATGAAGTAAACCCAGAATACCATGAAATTTTAAGAAAAAACGGT
TTGAAAATTTCTGGAATTTCGCCAGATGGAAAACTTGCAGAATTTGTTGAACTTGAAAGCCACAAGTATTTTATAGCAAC
ACAAGGTCATCCAGAATTTAAATCAAGGCCAAATAATCCACATCCATTGTTTAATGGATTAATAAAAGCTTCACTTAAAA
AATAA

Upstream 100 bases:

>100_bases
CATTTATATTCAATTGAAGAAAATGTTTAAAATTATTATTTCATTTTGAAAATTAATTCATTTCAAAATTTAAATTTTTA
CTATTTATCGAGGGATTACT

Downstream 100 bases:

>100_bases
ACGTACAAATAAGCATACTATATAATTTTGGAGGTAATTCCATGTTTGATGCTAAATCATTTATTGAAGAGTCAGTTGAA
GATATTAAAAAACAGATCAA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MKYIFVTGGVVSSLGKGITASSLGRLLKARGFNVNMVKIDPYLQIDAGTMSPYEHGEVFVTDDGGETDLDLGNYERFIDI
SLKAKNNITTGKIYWNVLSKERKGDYLGKTVQVIPHITNEIKEWIKELGSESDITIVEIGGTVGDIESLPFLEAIRQFKK
DVGKENVLYIHVSLLPYIRSAGELKTKPTQHSVKELKGIGIQPDILVCRTEIPINEKLREKLALFCDVEKEAVIEGKDAK
TIYEVPLNLEKEGLGALVIKKLNLRDSAPNLSEWRANVDRIINPLNSVSIGVVGKYVELKDAYASILEALGHAGAKNDTK
VNVTWINAEELENKNYREILDKMREDEKIDGILVPGGFGDRGIDGKINAVCYARENNIPFLGICLGMQCAVIEFSRNVCG
LNGADSTEFNEKTEHPVIDYIPEQRDVTEKGGTMRLGAYTAFLENGSLVNTLYNSIEVSERHRHRYEVNPEYHEILRKNG
LKISGISPDGKLAEFVELESHKYFIATQGHPEFKSRPNNPHPLFNGLIKASLKK

Sequences:

>Translated_534_residues
MKYIFVTGGVVSSLGKGITASSLGRLLKARGFNVNMVKIDPYLQIDAGTMSPYEHGEVFVTDDGGETDLDLGNYERFIDI
SLKAKNNITTGKIYWNVLSKERKGDYLGKTVQVIPHITNEIKEWIKELGSESDITIVEIGGTVGDIESLPFLEAIRQFKK
DVGKENVLYIHVSLLPYIRSAGELKTKPTQHSVKELKGIGIQPDILVCRTEIPINEKLREKLALFCDVEKEAVIEGKDAK
TIYEVPLNLEKEGLGALVIKKLNLRDSAPNLSEWRANVDRIINPLNSVSIGVVGKYVELKDAYASILEALGHAGAKNDTK
VNVTWINAEELENKNYREILDKMREDEKIDGILVPGGFGDRGIDGKINAVCYARENNIPFLGICLGMQCAVIEFSRNVCG
LNGADSTEFNEKTEHPVIDYIPEQRDVTEKGGTMRLGAYTAFLENGSLVNTLYNSIEVSERHRHRYEVNPEYHEILRKNG
LKISGISPDGKLAEFVELESHKYFIATQGHPEFKSRPNNPHPLFNGLIKASLKK
>Mature_534_residues
MKYIFVTGGVVSSLGKGITASSLGRLLKARGFNVNMVKIDPYLQIDAGTMSPYEHGEVFVTDDGGETDLDLGNYERFIDI
SLKAKNNITTGKIYWNVLSKERKGDYLGKTVQVIPHITNEIKEWIKELGSESDITIVEIGGTVGDIESLPFLEAIRQFKK
DVGKENVLYIHVSLLPYIRSAGELKTKPTQHSVKELKGIGIQPDILVCRTEIPINEKLREKLALFCDVEKEAVIEGKDAK
TIYEVPLNLEKEGLGALVIKKLNLRDSAPNLSEWRANVDRIINPLNSVSIGVVGKYVELKDAYASILEALGHAGAKNDTK
VNVTWINAEELENKNYREILDKMREDEKIDGILVPGGFGDRGIDGKINAVCYARENNIPFLGICLGMQCAVIEFSRNVCG
LNGADSTEFNEKTEHPVIDYIPEQRDVTEKGGTMRLGAYTAFLENGSLVNTLYNSIEVSERHRHRYEVNPEYHEILRKNG
LKISGISPDGKLAEFVELESHKYFIATQGHPEFKSRPNNPHPLFNGLIKASLKK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=551, Percent_Identity=50.6352087114338, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI28559085, Length=548, Percent_Identity=49.4525547445255, Blast_Score=522, Evalue=1e-148,
Organism=Homo sapiens, GI28559083, Length=548, Percent_Identity=49.4525547445255, Blast_Score=522, Evalue=1e-148,
Organism=Homo sapiens, GI221316689, Length=548, Percent_Identity=49.4525547445255, Blast_Score=522, Evalue=1e-148,
Organism=Escherichia coli, GI1789142, Length=541, Percent_Identity=53.7892791127542, Blast_Score=570, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI25148299, Length=607, Percent_Identity=42.339373970346, Blast_Score=471, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6319432, Length=561, Percent_Identity=46.8805704099822, Blast_Score=496, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6322563, Length=561, Percent_Identity=46.3458110516934, Blast_Score=483, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24664469, Length=551, Percent_Identity=49.3647912885662, Blast_Score=520, Evalue=1e-147,
Organism=Drosophila melanogaster, GI21357815, Length=495, Percent_Identity=47.2727272727273, Blast_Score=439, Evalue=1e-123,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59517; Mature: 59517

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYIFVTGGVVSSLGKGITASSLGRLLKARGFNVNMVKIDPYLQIDAGTMSPYEHGEVFV
CEEEEEECHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCEEEEECCCCCCCCCCEEEE
TDDGGETDLDLGNYERFIDISLKAKNNITTGKIYWNVLSKERKGDYLGKTVQVIPHITNE
ECCCCCCCCCCCCCEEEEEEEEEECCCCEECEEEEEECCCCCCCCCCCCHHHHHHHHHHH
IKEWIKELGSESDITIVEIGGTVGDIESLPFLEAIRQFKKDVGKENVLYIHVSLLPYIRS
HHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHC
AGELKTKPTQHSVKELKGIGIQPDILVCRTEIPINEKLREKLALFCDVEKEAVIEGKDAK
CCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCHHHEECCCCCC
TIYEVPLNLEKEGLGALVIKKLNLRDSAPNLSEWRANVDRIINPLNSVSIGVVGKYVELK
EEEECCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEHHHHH
DAYASILEALGHAGAKNDTKVNVTWINAEELENKNYREILDKMREDEKIDGILVPGGFGD
HHHHHHHHHHHCCCCCCCCEEEEEEEEHHHHCCCCHHHHHHHHHCCCCCCEEEECCCCCC
RGIDGKINAVCYARENNIPFLGICLGMQCAVIEFSRNVCGLNGADSTEFNEKTEHPVIDY
CCCCCCEEEEEEEECCCCCEEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
IPEQRDVTEKGGTMRLGAYTAFLENGSLVNTLYNSIEVSERHRHRYEVNPEYHEILRKNG
CCCCCCHHHCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCC
LKISGISPDGKLAEFVELESHKYFIATQGHPEFKSRPNNPHPLFNGLIKASLKK
CEEECCCCCCCHHHHEEECCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKYIFVTGGVVSSLGKGITASSLGRLLKARGFNVNMVKIDPYLQIDAGTMSPYEHGEVFV
CEEEEEECHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCEEEEECCCCCCCCCCEEEE
TDDGGETDLDLGNYERFIDISLKAKNNITTGKIYWNVLSKERKGDYLGKTVQVIPHITNE
ECCCCCCCCCCCCCEEEEEEEEEECCCCEECEEEEEECCCCCCCCCCCCHHHHHHHHHHH
IKEWIKELGSESDITIVEIGGTVGDIESLPFLEAIRQFKKDVGKENVLYIHVSLLPYIRS
HHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHC
AGELKTKPTQHSVKELKGIGIQPDILVCRTEIPINEKLREKLALFCDVEKEAVIEGKDAK
CCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCHHHEECCCCCC
TIYEVPLNLEKEGLGALVIKKLNLRDSAPNLSEWRANVDRIINPLNSVSIGVVGKYVELK
EEEECCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEHHHHH
DAYASILEALGHAGAKNDTKVNVTWINAEELENKNYREILDKMREDEKIDGILVPGGFGD
HHHHHHHHHHHCCCCCCCCEEEEEEEEHHHHCCCCHHHHHHHHHCCCCCCEEEECCCCCC
RGIDGKINAVCYARENNIPFLGICLGMQCAVIEFSRNVCGLNGADSTEFNEKTEHPVIDY
CCCCCCEEEEEEEECCCCCEEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
IPEQRDVTEKGGTMRLGAYTAFLENGSLVNTLYNSIEVSERHRHRYEVNPEYHEILRKNG
CCCCCCHHHCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCC
LKISGISPDGKLAEFVELESHKYFIATQGHPEFKSRPNNPHPLFNGLIKASLKK
CEEECCCCCCCHHHHEEECCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA