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The map label for this gene is guaAB

Identifier: 150398787

GI number: 150398787

Start: 23701

End: 24633

Strand: Reverse

Name: guaAB

Synonym: Mevan_0027

Alternate gene names: 150398787

Gene position: 24633-23701 (Counterclockwise)

Preceding gene: 150398788

Following gene: 150398786

Centisome position: 1.43

GC content: 36.66

Gene sequence:

>933_bases
ATGTTTGATGCTAAATCATTTATTGAAGAGTCAGTTGAAGATATTAAAAAACAGATCAATGGTAGAAAAACAATAATCGC
ATTAAGTGGCGGAGTAGATAGTTCCGTTGCAGCAGTTCTTACGGGAAAAGCTATTGGAGACCAGTTGCTTGCAGTTTACG
TCGATACGGGGCTAATGCGAAAAAATGAATCCAATGAAATATGGAATATTTTTAAGGAACAGATGGGACTTAATCTAAAA
ATAGTCGAAGCAAAAGACTTATTTTTAAGCGAATTAGCAGGAATAGATGACCCCGAACAAAAAAGGAAAATAATTGGCAG
AATATTTATTGAAGTATTTGAAAAAGTTGCTAAAGAGCAAGGTGAGGAAATTCTTGTACAAGGCACAATTGCACCAGACT
GGATAGAGAGTGAAGGCCAGATTAAAACTCACCATAATATTGCACTTCCTAGTGGAATGGTTTTAGAAGTTGTTGAACCA
CTAAGAGACCTATATAAAGATGAAGTAAGGAAGTTAGCAACTGAACTTGGATTACCTGAAAAAATCGCACATAGGCAGCC
GTTCCCAGGACCAGGGCTTGCTGTTAGAATACTTGGGGAAATTACTGAAGAAAAATTAGAAATATGTAAGGAAGCAAACT
TTATTGTTTCAGAAGAAATTGAAAAAACAGGACTTCAAAAAGAGTTGTGGCAGTATTTTGCAGCGGTACTCGATACAAAG
GCCACTGGCGTTAAAGGAGATATTAGGGACTACAACTGGGTTGTTGCATTGAGGTTCGTAAAATCACTTGATGCAATGAC
TGCCCACACACCAGAAATCCCTTTTGACCTTATAAAAAGAATCAGTAAAAGAATAACATCTGAAATTCCAAACGTTACAC
GTGTTGTTTTAGATGTAACGGATAAACCTCCCGCAACAATTGAATTTGAATAA

Upstream 100 bases:

>100_bases
GGCCAAATAATCCACATCCATTGTTTAATGGATTAATAAAAGCTTCACTTAAAAAATAAACGTACAAATAAGCATACTAT
ATAATTTTGGAGGTAATTCC

Downstream 100 bases:

>100_bases
ATTTGAATAACTCAAATAATTTTTAAATAATAATTATTTAAAATCAAATATTTTGCTTTTTAATTTATTTTTTGCGTTTT
AGAATTATTTTAAATATAGC

Product: GMP synthase subunit B

Products: NA

Alternate protein names: GMP synthetase

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MFDAKSFIEESVEDIKKQINGRKTIIALSGGVDSSVAAVLTGKAIGDQLLAVYVDTGLMRKNESNEIWNIFKEQMGLNLK
IVEAKDLFLSELAGIDDPEQKRKIIGRIFIEVFEKVAKEQGEEILVQGTIAPDWIESEGQIKTHHNIALPSGMVLEVVEP
LRDLYKDEVRKLATELGLPEKIAHRQPFPGPGLAVRILGEITEEKLEICKEANFIVSEEIEKTGLQKELWQYFAAVLDTK
ATGVKGDIRDYNWVVALRFVKSLDAMTAHTPEIPFDLIKRISKRITSEIPNVTRVVLDVTDKPPATIEFE

Sequences:

>Translated_310_residues
MFDAKSFIEESVEDIKKQINGRKTIIALSGGVDSSVAAVLTGKAIGDQLLAVYVDTGLMRKNESNEIWNIFKEQMGLNLK
IVEAKDLFLSELAGIDDPEQKRKIIGRIFIEVFEKVAKEQGEEILVQGTIAPDWIESEGQIKTHHNIALPSGMVLEVVEP
LRDLYKDEVRKLATELGLPEKIAHRQPFPGPGLAVRILGEITEEKLEICKEANFIVSEEIEKTGLQKELWQYFAAVLDTK
ATGVKGDIRDYNWVVALRFVKSLDAMTAHTPEIPFDLIKRISKRITSEIPNVTRVVLDVTDKPPATIEFE
>Mature_310_residues
MFDAKSFIEESVEDIKKQINGRKTIIALSGGVDSSVAAVLTGKAIGDQLLAVYVDTGLMRKNESNEIWNIFKEQMGLNLK
IVEAKDLFLSELAGIDDPEQKRKIIGRIFIEVFEKVAKEQGEEILVQGTIAPDWIESEGQIKTHHNIALPSGMVLEVVEP
LRDLYKDEVRKLATELGLPEKIAHRQPFPGPGLAVRILGEITEEKLEICKEANFIVSEEIEKTGLQKELWQYFAAVLDTK
ATGVKGDIRDYNWVVALRFVKSLDAMTAHTPEIPFDLIKRISKRITSEIPNVTRVVLDVTDKPPATIEFE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=312, Percent_Identity=34.2948717948718, Blast_Score=153, Evalue=2e-37,
Organism=Escherichia coli, GI1788854, Length=312, Percent_Identity=48.3974358974359, Blast_Score=299, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI71992710, Length=369, Percent_Identity=31.7073170731707, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71992717, Length=369, Percent_Identity=31.7073170731707, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI133901714, Length=369, Percent_Identity=31.7073170731707, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323873, Length=320, Percent_Identity=45.625, Blast_Score=271, Evalue=8e-74,
Organism=Drosophila melanogaster, GI281365319, Length=317, Percent_Identity=35.0157728706625, Blast_Score=149, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAAB_METVS (A6UN70)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001322554.1
- ProteinModelPortal:   A6UN70
- SMR:   A6UN70
- STRING:   A6UN70
- GeneID:   5325732
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_0027
- eggNOG:   arNOG04539
- HOGENOM:   HBG391775
- OMA:   QGTIAPD
- ProtClustDB:   PRK00919
- HAMAP:   MF_00345
- InterPro:   IPR001674
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00884

Pfam domain/function: PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 34736; Mature: 34736

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDAKSFIEESVEDIKKQINGRKTIIALSGGVDSSVAAVLTGKAIGDQLLAVYVDTGLMR
CCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
KNESNEIWNIFKEQMGLNLKIVEAKDLFLSELAGIDDPEQKRKIIGRIFIEVFEKVAKEQ
CCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GEEILVQGTIAPDWIESEGQIKTHHNIALPSGMVLEVVEPLRDLYKDEVRKLATELGLPE
CCEEEEECCCCCHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCH
KIAHRQPFPGPGLAVRILGEITEEKLEICKEANFIVSEEIEKTGLQKELWQYFAAVLDTK
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCC
ATGVKGDIRDYNWVVALRFVKSLDAMTAHTPEIPFDLIKRISKRITSEIPNVTRVVLDVT
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEC
DKPPATIEFE
CCCCCEEECC
>Mature Secondary Structure
MFDAKSFIEESVEDIKKQINGRKTIIALSGGVDSSVAAVLTGKAIGDQLLAVYVDTGLMR
CCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
KNESNEIWNIFKEQMGLNLKIVEAKDLFLSELAGIDDPEQKRKIIGRIFIEVFEKVAKEQ
CCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GEEILVQGTIAPDWIESEGQIKTHHNIALPSGMVLEVVEPLRDLYKDEVRKLATELGLPE
CCEEEEECCCCCHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCH
KIAHRQPFPGPGLAVRILGEITEEKLEICKEANFIVSEEIEKTGLQKELWQYFAAVLDTK
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCC
ATGVKGDIRDYNWVVALRFVKSLDAMTAHTPEIPFDLIKRISKRITSEIPNVTRVVLDVT
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEC
DKPPATIEFE
CCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA