Click here to switch to the map view.

The map label for this gene is cycW [H]

Identifier: 150398279

GI number: 150398279

Start: 3233311

End: 3233970

Strand: Direct

Name: cycW [H]

Synonym: Smed_3085

Alternate gene names: 150398279

Gene position: 3233311-3233970 (Clockwise)

Preceding gene: 150398278

Following gene: 150398280

Centisome position: 85.49

GC content: 64.55

Gene sequence:

>660_bases
TTGACCGCCCTCTTTCTCCGGGATCTCAAGCTTTCGGTGCGCGCCGGCGGCGGCGCGATGATCGGCGTACTTTTCTTCAT
GACCGTGGTCGCGGTCATCCCCTTCGGTGTCGGGCCGGACCTCAACCTGCTCGCTCGGATCGGTCCGGCAATCCTCTGGA
TCGGAGCGCTGCTCGCATCGCTGCTCGGACTCGACCGGCTCTTCCAGGCAGAACGCGAAGACGGCTCGCTCGACCTCATC
ATGATGCAGGAGACGCCGTTGCTCCTCACCGTTCTCGTCAAATGCGCCGCTCATTGGACCGCCACCGGTCTGCCGCTGGT
GGTCGCCTCGCCCTTCCTCGGTCTCTTCATGAACATGGACGAACGCGCGATCGGCGCCACGATGCTGACGCTGCTTGCAG
GAACCCCGGCGATCACCCTGATCGGAGCGGTCGGCGCAGCGGTAGCGGTGGCGCTTCCGCGCGGCGGCCTGCTGGTATCG
ATCCTGGTGCTTCCGCTCGCCATACCGGTTCTGATCTTCGGGGTCAGCGCCGTCTATGCGGCTATCGAGGATCCCGCCCC
GTTTCTGCCGCCTTTCATGATATTGATGGCGATAACCCTGTTCTTTGCGGTGATCGGACCCGTGGCGGCCGCCTCAGCCC
TCAGGCATTCGGCCGACTGA

Upstream 100 bases:

>100_bases
TGGCGCGCCATCTCGAACGCGGCGGGATCGTCATCGCCGCCACGCACCAGGCTCTGGGGTTCACCGGGGTTAAAAGCCTC
GAAATGACGGGGTTCTTCCA

Downstream 100 bases:

>100_bases
GACACGGCACTTTAGGATCGATTGCGGAAGGGGTGCTTCCGCGTTAAAGAGCCAATATGAGCGAAAACAGCCTGGCCATA
CGCAAGTTCAGCGATCTCGC

Product: heme exporter protein CcmB

Products: NA

Alternate protein names: Cytochrome c-type biogenesis protein CycW [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MTALFLRDLKLSVRAGGGAMIGVLFFMTVVAVIPFGVGPDLNLLARIGPAILWIGALLASLLGLDRLFQAEREDGSLDLI
MMQETPLLLTVLVKCAAHWTATGLPLVVASPFLGLFMNMDERAIGATMLTLLAGTPAITLIGAVGAAVAVALPRGGLLVS
ILVLPLAIPVLIFGVSAVYAAIEDPAPFLPPFMILMAITLFFAVIGPVAAASALRHSAD

Sequences:

>Translated_219_residues
MTALFLRDLKLSVRAGGGAMIGVLFFMTVVAVIPFGVGPDLNLLARIGPAILWIGALLASLLGLDRLFQAEREDGSLDLI
MMQETPLLLTVLVKCAAHWTATGLPLVVASPFLGLFMNMDERAIGATMLTLLAGTPAITLIGAVGAAVAVALPRGGLLVS
ILVLPLAIPVLIFGVSAVYAAIEDPAPFLPPFMILMAITLFFAVIGPVAAASALRHSAD
>Mature_218_residues
TALFLRDLKLSVRAGGGAMIGVLFFMTVVAVIPFGVGPDLNLLARIGPAILWIGALLASLLGLDRLFQAEREDGSLDLIM
MQETPLLLTVLVKCAAHWTATGLPLVVASPFLGLFMNMDERAIGATMLTLLAGTPAITLIGAVGAAVAVALPRGGLLVSI
LVLPLAIPVLIFGVSAVYAAIEDPAPFLPPFMILMAITLFFAVIGPVAAASALRHSAD

Specific function: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes [H]

COG id: COG2386

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmB/CycW/HelB family [H]

Homologues:

Organism=Escherichia coli, GI1788528, Length=214, Percent_Identity=43.4579439252336, Blast_Score=115, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003544 [H]

Pfam domain/function: PF03379 CcmB [H]

EC number: NA

Molecular weight: Translated: 22709; Mature: 22578

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALFLRDLKLSVRAGGGAMIGVLFFMTVVAVIPFGVGPDLNLLARIGPAILWIGALLAS
CCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LLGLDRLFQAEREDGSLDLIMMQETPLLLTVLVKCAAHWTATGLPLVVASPFLGLFMNMD
HHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
ERAIGATMLTLLAGTPAITLIGAVGAAVAVALPRGGLLVSILVLPLAIPVLIFGVSAVYA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AIEDPAPFLPPFMILMAITLFFAVIGPVAAASALRHSAD
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TALFLRDLKLSVRAGGGAMIGVLFFMTVVAVIPFGVGPDLNLLARIGPAILWIGALLAS
CCHHHHHHHHHEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LLGLDRLFQAEREDGSLDLIMMQETPLLLTVLVKCAAHWTATGLPLVVASPFLGLFMNMD
HHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
ERAIGATMLTLLAGTPAITLIGAVGAAVAVALPRGGLLVSILVLPLAIPVLIFGVSAVYA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AIEDPAPFLPPFMILMAITLFFAVIGPVAAASALRHSAD
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1850420; 12597275 [H]