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The map label for this gene is trxA [H]

Identifier: 150398239

GI number: 150398239

Start: 3194321

End: 3195313

Strand: Direct

Name: trxA [H]

Synonym: Smed_3045

Alternate gene names: 150398239

Gene position: 3194321-3195313 (Clockwise)

Preceding gene: 150398238

Following gene: 150398240

Centisome position: 84.46

GC content: 64.95

Gene sequence:

>993_bases
ATGAGCGGTAGCGACAATCCCTATCAAGGTTCCTTCGGCAGCCAGATGACGGGCTCGGCTTCCTTCGGTGTACGGCCGGA
AAGCGCCGCGGGCGGTCCGAACGGCTTGATCCCGGACGACCTGATCAGGGAGACGACGACCGCCGCCTTCAGTCGCGACG
TGCTCGAGGCATCCCGCCAGCAGCCGGTTCTCGTCGATTTCTGGGCGCCTTGGTGTGGTCCATGCAAGCAACTGACCCCG
GTCATCGAAAAGGTGGTGAAGGAAGCCGCCGGCCGGGTGAAGCTCGTCAAGATGAACATCGACGATCATCCCTCGATTGC
GGGCCAGCTCGGTATTCAGTCCATTCCCGCAGTGATCGCCTTCGTCGACGGCCGACCGGTTGATGGTTTCATGGGGGCCG
TGCCCGAAAGCCAGATCAAGGAGTTCATCGACCGCATCGCCGGCCCGGGCACAGACGACGCAACGGCCGAGATCGAGAAT
GTGCTTGGGGAAGCCAGGGCGCTGCTCGATGCAGGCGACGCGCAGAACGCCGCCGGCCTCTACGGTGCGGTCCTGCAGGC
GGATCCGGAGAATGCCACGGCAGTAGCCGGGATGATCGAATGCATGATCGCGCTCGGGCAGCTCGCCGAGGCACGCCAGG
CGCTTTCCGGCTTGCCGGAGGCGCTCGCCAATGAAGCGTCCGTCGCTGCCGTCTCGAAAAAGCTCGACCAGATCGAGGAG
GCCCGCAAGCTCGGTGACCCGACGGCGCTCGAGCGTCAGCTCGCGCTCGATCCGGATGACCACGGCGCACGGCTCAAGCT
TGCCAAGATCCGCAATGTGGAGGGCGACCGGGCCGCCGCCGCCGAACACCTCCTGACCATCATGAAGCGCGACCGCAGCT
TCGAGGACGACGGCGCCCGGCGCGAACTGCTGTCGTTCTTCGAGGTATGGGGGCCGAAGGATCCGGCAACGATCGCGGCA
CGGCGCAAGCTGTCGTCGATTCTCTTTTCGTAA

Upstream 100 bases:

>100_bases
GACAGGACACGAGCCGCTTGTCTTGAAAGTAACGGCCTGACATACGATCTTTGGCGCGAATGCATGAAAACCGGACGCCC
GAGTCCGCGAGGAGAGAAGA

Downstream 100 bases:

>100_bases
CGGCTGCGCGGCAATTTTTTCAGCCGCAGCCGATCGATTCCGGTGCACTCCTTCTTGAGAATTCGGAGTACCGCACCATT
TTTTGGTCCTACAGCGCCGC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MSGSDNPYQGSFGSQMTGSASFGVRPESAAGGPNGLIPDDLIRETTTAAFSRDVLEASRQQPVLVDFWAPWCGPCKQLTP
VIEKVVKEAAGRVKLVKMNIDDHPSIAGQLGIQSIPAVIAFVDGRPVDGFMGAVPESQIKEFIDRIAGPGTDDATAEIEN
VLGEARALLDAGDAQNAAGLYGAVLQADPENATAVAGMIECMIALGQLAEARQALSGLPEALANEASVAAVSKKLDQIEE
ARKLGDPTALERQLALDPDDHGARLKLAKIRNVEGDRAAAAEHLLTIMKRDRSFEDDGARRELLSFFEVWGPKDPATIAA
RRKLSSILFS

Sequences:

>Translated_330_residues
MSGSDNPYQGSFGSQMTGSASFGVRPESAAGGPNGLIPDDLIRETTTAAFSRDVLEASRQQPVLVDFWAPWCGPCKQLTP
VIEKVVKEAAGRVKLVKMNIDDHPSIAGQLGIQSIPAVIAFVDGRPVDGFMGAVPESQIKEFIDRIAGPGTDDATAEIEN
VLGEARALLDAGDAQNAAGLYGAVLQADPENATAVAGMIECMIALGQLAEARQALSGLPEALANEASVAAVSKKLDQIEE
ARKLGDPTALERQLALDPDDHGARLKLAKIRNVEGDRAAAAEHLLTIMKRDRSFEDDGARRELLSFFEVWGPKDPATIAA
RRKLSSILFS
>Mature_329_residues
SGSDNPYQGSFGSQMTGSASFGVRPESAAGGPNGLIPDDLIRETTTAAFSRDVLEASRQQPVLVDFWAPWCGPCKQLTPV
IEKVVKEAAGRVKLVKMNIDDHPSIAGQLGIQSIPAVIAFVDGRPVDGFMGAVPESQIKEFIDRIAGPGTDDATAEIENV
LGEARALLDAGDAQNAAGLYGAVLQADPENATAVAGMIECMIALGQLAEARQALSGLPEALANEASVAAVSKKLDQIEEA
RKLGDPTALERQLALDPDDHGARLKLAKIRNVEGDRAAAAEHLLTIMKRDRSFEDDGARRELLSFFEVWGPKDPATIAAR
RKLSSILFS

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG3118

COG function: function code O; Thioredoxin domain-containing protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=40.2173913043478, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI87081747, Length=278, Percent_Identity=26.6187050359712, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87082331, Length=105, Percent_Identity=40, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788936, Length=123, Percent_Identity=34.1463414634146, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=39.1752577319588, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17554386, Length=130, Percent_Identity=28.4615384615385, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28573567, Length=110, Percent_Identity=32.7272727272727, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358065, Length=84, Percent_Identity=41.6666666666667, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24639826, Length=108, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 34997; Mature: 34866

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGSDNPYQGSFGSQMTGSASFGVRPESAAGGPNGLIPDDLIRETTTAAFSRDVLEASRQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
QPVLVDFWAPWCGPCKQLTPVIEKVVKEAAGRVKLVKMNIDDHPSIAGQLGIQSIPAVIA
CCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHE
FVDGRPVDGFMGAVPESQIKEFIDRIAGPGTDDATAEIENVLGEARALLDAGDAQNAAGL
EECCCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHH
YGAVLQADPENATAVAGMIECMIALGQLAEARQALSGLPEALANEASVAAVSKKLDQIEE
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ARKLGDPTALERQLALDPDDHGARLKLAKIRNVEGDRAAAAEHLLTIMKRDRSFEDDGAR
HHHCCCHHHHHHHHCCCCCCCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
RELLSFFEVWGPKDPATIAARRKLSSILFS
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGSDNPYQGSFGSQMTGSASFGVRPESAAGGPNGLIPDDLIRETTTAAFSRDVLEASRQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
QPVLVDFWAPWCGPCKQLTPVIEKVVKEAAGRVKLVKMNIDDHPSIAGQLGIQSIPAVIA
CCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHE
FVDGRPVDGFMGAVPESQIKEFIDRIAGPGTDDATAEIENVLGEARALLDAGDAQNAAGL
EECCCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHH
YGAVLQADPENATAVAGMIECMIALGQLAEARQALSGLPEALANEASVAAVSKKLDQIEE
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ARKLGDPTALERQLALDPDDHGARLKLAKIRNVEGDRAAAAEHLLTIMKRDRSFEDDGAR
HHHCCCHHHHHHHHCCCCCCCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
RELLSFFEVWGPKDPATIAARRKLSSILFS
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2492995 [H]