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The map label for this gene is atoC [H]

Identifier: 150397881

GI number: 150397881

Start: 2785161

End: 2786810

Strand: Reverse

Name: atoC [H]

Synonym: Smed_2683

Alternate gene names: 150397881

Gene position: 2786810-2785161 (Counterclockwise)

Preceding gene: 150397885

Following gene: 150397880

Centisome position: 73.69

GC content: 62.61

Gene sequence:

>1650_bases
ATGCAAGCATTTCTCAAAACAGGATGTTCAGCCGTTTGTGGGACGAATGGCTCGCATGATTTGGCACATGAGGTTTGCCA
ACAGTACCCCGCATGTCCCAGGCAGGAGGCTTTCGTGACAGCTCATATTCTTGTCATCGACGACGATCCGGTGCAGCGGC
GGCTGCTGACGAACATGATCGAGCGGCTCGGCCATGTCGCGCATCTCGCCGACAACGGGCGCAGCGGGCTGGAGCTCATG
CAGCGCAAGGGTGGCATCATCAATGTCATTCTGCTCGATCTCCTGATGCCGGGAATGAACGGCCACAGCTTTCTGGAAGC
GCTCGCCGAGCGAGGCGTCGACACCCCCGTCATCGTACAGACGGGGCAGGGGGGGATCGAAACAGTGGTTCAGGCGATGC
AGGCCGGCGCCTTCGATTTCCTCGTCAAGCCCGTTTCGCCGGAGCGGCTGTCGATCGCCCTGGGTAACGCGCTGAAGATG
GCGAGCCGAGACGGCAAGGTCAAAACCGCCCGGCGTCCACGCGGCGGGTCCGTCGGTTTCGACGATATCGTTTCGGCAAG
CCCGGCGATGATCCGTGTCATCGATCTCGCACGCCGCGCCGCGCAGTCGAACATCCCGGTCGTGCTCGAAGGCGAATCGG
GCGTCGGCAAGGAAATGGTCGCCCGCGCAATCCAGGCGGCCAGCGATCGGGCGACGAAACCGTTCGTCACCGTGAACTGC
GGGGCCATCCCCGGCAATCTCGTCGAGAGCATTCTCTTCGGCCATGAGAAGGGCGCGTTTACCGGCGCAAGCGAAAAGCA
CAGCGGCAAGTTCGTCGACGCCGATGGCGGCACGTTGTTTCTCGACGAGATCGGCGACCTCCCGCTCGAGGTCCAGGTCA
AGCTGTTGCGCGCCGTCCAACAGGGCGAGATCGAAACGGTCGGGGCTCGTCAGCCGCAGAAGGTGAATGTGCGGCTTATC
TCGGCCACCAACAAGGACCTCATCAACGAGGTACGCGAGGGCCGGTTTCGCGAAGACCTCTACTATCGGCTGAACGTCTT
CCCGATCACCATACCGGCGCTGCGCCGGCGCAAGGAGGACATCCCCGTTCTGGTCCGAGCCTTCGTCGAGCGCTTCGCCG
CAGAGCAGAGGCTCGACCAGCGGCTGACGGTCTCGAACGGTGCAATGGCGCTGCTGACATCCTATGACTGGCCGGGTAAT
ATCCGGCAGCTCGAAAATGCGATCTTCCGCGCCGTCGTTCTCGCCGAAGGTCACGAACTCACCGTCAGGGATTTTCCGCA
GGTCGCCACCCAGATACCGGGATATATCGTTGCCGACCGGACCGGTCTCTCCTGGGGTGACGGCGGTCCGGAAGGCCGCA
CCGCGCCCGATCGGCCGGCCGCCGTGACGGCCGATGCCGGGGCACTGGAAACCGCACCTACCGATCAACGGGACGAACGC
ATTGAGAACGCAATAGCCAGCCTGAGCGAGGGCGGCGAGGTCAGGAAGCTCGCGGAGGTCGAGGAGGAGCTGATTCGCTT
TGCCTTGAAATTCTACCGCGGCCAGATGAGCCAGGTTGCCCGCAAACTGGGAATCGGTCGATCGACCCTTTACCGCAAAC
TCAAGGATTACGGCATCGATCCCGACAATCCCTTGCGCGAGGCGGCATAA

Upstream 100 bases:

>100_bases
GCGAAGCGAATTTCATTGTCGGTTCTCTCGTTTTGGACAGGCCCAACCCTGAAGCGAGGCAACGGCATGGCTCCCATTGC
TACCGCCGGCGATGGATAAA

Downstream 100 bases:

>100_bases
AATCGACGCATTCACACCTCATTTCCCGTGCAAATCGTTTGCCGCCGTTTAGACCTTGTTAGCAAACTGTTCACTATATT
ATAAGGGGCGGTGAACACTG

Product: two component sigma54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MQAFLKTGCSAVCGTNGSHDLAHEVCQQYPACPRQEAFVTAHILVIDDDPVQRRLLTNMIERLGHVAHLADNGRSGLELM
QRKGGIINVILLDLLMPGMNGHSFLEALAERGVDTPVIVQTGQGGIETVVQAMQAGAFDFLVKPVSPERLSIALGNALKM
ASRDGKVKTARRPRGGSVGFDDIVSASPAMIRVIDLARRAAQSNIPVVLEGESGVGKEMVARAIQAASDRATKPFVTVNC
GAIPGNLVESILFGHEKGAFTGASEKHSGKFVDADGGTLFLDEIGDLPLEVQVKLLRAVQQGEIETVGARQPQKVNVRLI
SATNKDLINEVREGRFREDLYYRLNVFPITIPALRRRKEDIPVLVRAFVERFAAEQRLDQRLTVSNGAMALLTSYDWPGN
IRQLENAIFRAVVLAEGHELTVRDFPQVATQIPGYIVADRTGLSWGDGGPEGRTAPDRPAAVTADAGALETAPTDQRDER
IENAIASLSEGGEVRKLAEVEEELIRFALKFYRGQMSQVARKLGIGRSTLYRKLKDYGIDPDNPLREAA

Sequences:

>Translated_549_residues
MQAFLKTGCSAVCGTNGSHDLAHEVCQQYPACPRQEAFVTAHILVIDDDPVQRRLLTNMIERLGHVAHLADNGRSGLELM
QRKGGIINVILLDLLMPGMNGHSFLEALAERGVDTPVIVQTGQGGIETVVQAMQAGAFDFLVKPVSPERLSIALGNALKM
ASRDGKVKTARRPRGGSVGFDDIVSASPAMIRVIDLARRAAQSNIPVVLEGESGVGKEMVARAIQAASDRATKPFVTVNC
GAIPGNLVESILFGHEKGAFTGASEKHSGKFVDADGGTLFLDEIGDLPLEVQVKLLRAVQQGEIETVGARQPQKVNVRLI
SATNKDLINEVREGRFREDLYYRLNVFPITIPALRRRKEDIPVLVRAFVERFAAEQRLDQRLTVSNGAMALLTSYDWPGN
IRQLENAIFRAVVLAEGHELTVRDFPQVATQIPGYIVADRTGLSWGDGGPEGRTAPDRPAAVTADAGALETAPTDQRDER
IENAIASLSEGGEVRKLAEVEEELIRFALKFYRGQMSQVARKLGIGRSTLYRKLKDYGIDPDNPLREAA
>Mature_549_residues
MQAFLKTGCSAVCGTNGSHDLAHEVCQQYPACPRQEAFVTAHILVIDDDPVQRRLLTNMIERLGHVAHLADNGRSGLELM
QRKGGIINVILLDLLMPGMNGHSFLEALAERGVDTPVIVQTGQGGIETVVQAMQAGAFDFLVKPVSPERLSIALGNALKM
ASRDGKVKTARRPRGGSVGFDDIVSASPAMIRVIDLARRAAQSNIPVVLEGESGVGKEMVARAIQAASDRATKPFVTVNC
GAIPGNLVESILFGHEKGAFTGASEKHSGKFVDADGGTLFLDEIGDLPLEVQVKLLRAVQQGEIETVGARQPQKVNVRLI
SATNKDLINEVREGRFREDLYYRLNVFPITIPALRRRKEDIPVLVRAFVERFAAEQRLDQRLTVSNGAMALLTSYDWPGN
IRQLENAIFRAVVLAEGHELTVRDFPQVATQIPGYIVADRTGLSWGDGGPEGRTAPDRPAAVTADAGALETAPTDQRDER
IENAIASLSEGGEVRKLAEVEEELIRFALKFYRGQMSQVARKLGIGRSTLYRKLKDYGIDPDNPLREAA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=499, Percent_Identity=38.4769539078156, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI1790437, Length=493, Percent_Identity=40.1622718052738, Blast_Score=328, Evalue=5e-91,
Organism=Escherichia coli, GI1790299, Length=501, Percent_Identity=37.9241516966068, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1788905, Length=374, Percent_Identity=42.5133689839572, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI87082117, Length=284, Percent_Identity=46.4788732394366, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1789087, Length=405, Percent_Identity=37.7777777777778, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI87082152, Length=259, Percent_Identity=47.8764478764479, Blast_Score=227, Evalue=2e-60,
Organism=Escherichia coli, GI1789233, Length=361, Percent_Identity=40.1662049861496, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI1787583, Length=363, Percent_Identity=34.7107438016529, Blast_Score=202, Evalue=6e-53,
Organism=Escherichia coli, GI87081872, Length=359, Percent_Identity=34.8189415041783, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1786524, Length=263, Percent_Identity=40.6844106463878, Blast_Score=184, Evalue=9e-48,
Organism=Escherichia coli, GI87081858, Length=407, Percent_Identity=30.4668304668305, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI1789828, Length=336, Percent_Identity=34.2261904761905, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1787487, Length=111, Percent_Identity=35.1351351351351, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 59691; Mature: 59691

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAFLKTGCSAVCGTNGSHDLAHEVCQQYPACPRQEAFVTAHILVIDDDPVQRRLLTNMI
CCCHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHH
ERLGHVAHLADNGRSGLELMQRKGGIINVILLDLLMPGMNGHSFLEALAERGVDTPVIVQ
HHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEE
TGQGGIETVVQAMQAGAFDFLVKPVSPERLSIALGNALKMASRDGKVKTARRPRGGSVGF
CCCCHHHHHHHHHHCCCHHEEECCCCCCCEEEEHHHHHHHHCCCCCCEECCCCCCCCCCH
DDIVSASPAMIRVIDLARRAAQSNIPVVLEGESGVGKEMVARAIQAASDRATKPFVTVNC
HHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEC
GAIPGNLVESILFGHEKGAFTGASEKHSGKFVDADGGTLFLDEIGDLPLEVQVKLLRAVQ
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEHHHHCCCCHHHHHHHHHHHH
QGEIETVGARQPQKVNVRLISATNKDLINEVREGRFREDLYYRLNVFPITIPALRRRKED
CCCCEECCCCCCCEEEEEEEECCCHHHHHHHHCCCHHHCCEEEEEEEEEEHHHHHCCCCC
IPVLVRAFVERFAAEQRLDQRLTVSNGAMALLTSYDWPGNIRQLENAIFRAVVLAEGHEL
CHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEE
TVRDFPQVATQIPGYIVADRTGLSWGDGGPEGRTAPDRPAAVTADAGALETAPTDQRDER
EHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHH
IENAIASLSEGGEVRKLAEVEEELIRFALKFYRGQMSQVARKLGIGRSTLYRKLKDYGID
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
PDNPLREAA
CCCCHHCCC
>Mature Secondary Structure
MQAFLKTGCSAVCGTNGSHDLAHEVCQQYPACPRQEAFVTAHILVIDDDPVQRRLLTNMI
CCCHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHH
ERLGHVAHLADNGRSGLELMQRKGGIINVILLDLLMPGMNGHSFLEALAERGVDTPVIVQ
HHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEE
TGQGGIETVVQAMQAGAFDFLVKPVSPERLSIALGNALKMASRDGKVKTARRPRGGSVGF
CCCCHHHHHHHHHHCCCHHEEECCCCCCCEEEEHHHHHHHHCCCCCCEECCCCCCCCCCH
DDIVSASPAMIRVIDLARRAAQSNIPVVLEGESGVGKEMVARAIQAASDRATKPFVTVNC
HHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEC
GAIPGNLVESILFGHEKGAFTGASEKHSGKFVDADGGTLFLDEIGDLPLEVQVKLLRAVQ
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEHHHHCCCCHHHHHHHHHHHH
QGEIETVGARQPQKVNVRLISATNKDLINEVREGRFREDLYYRLNVFPITIPALRRRKED
CCCCEECCCCCCCEEEEEEEECCCHHHHHHHHCCCHHHCCEEEEEEEEEEHHHHHCCCCC
IPVLVRAFVERFAAEQRLDQRLTVSNGAMALLTSYDWPGNIRQLENAIFRAVVLAEGHEL
CHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEE
TVRDFPQVATQIPGYIVADRTGLSWGDGGPEGRTAPDRPAAVTADAGALETAPTDQRDER
EHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHH
IENAIASLSEGGEVRKLAEVEEELIRFALKFYRGQMSQVARKLGIGRSTLYRKLKDYGID
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
PDNPLREAA
CCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]