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The map label for this gene is apt [H]

Identifier: 150397470

GI number: 150397470

Start: 2346736

End: 2347278

Strand: Reverse

Name: apt [H]

Synonym: Smed_2270

Alternate gene names: 150397470

Gene position: 2347278-2346736 (Counterclockwise)

Preceding gene: 150397472

Following gene: 150397467

Centisome position: 62.07

GC content: 60.22

Gene sequence:

>543_bases
ATGACCGCTCTTCAATCGGACCTGATTTCCGCCATTCGAAGCATTCCGGACTATCCGAAACCGGGCGTCATGTTCCGCGA
CATCACGACCCTGCTCGGCAACCCCAGGGCTTTCCGACGTGCCATTGACGAACTCGTCCACCCTTATGCCGGCACCAAGG
TCGACAAGGTCGCGGGCATCGAGGCGCGAGGTTTTATCCTGGGCGGTGCGATCGCGCACCAGCTTTCAGCGGGTTTCATA
CCCATTCGCAAAAGAGGAAAGCTTCCGCACGACACGGTGCGTATCGCCTATAGCCTTGAGTACGGCGTGGACGAAATGGA
AATGCACCGGGATGCGGTCGTTCCCGGTGACAAGGTGATCCTCGTCGATGACCTGATTGCCACCGGCGGCACTGCCGAAG
GCGCCGCCAAGCTTCTGCAGCAGATGGGCGCGGAGATCGTCGCTGCCTGCTTCATCATCGACCTGCCTGAGCTCGGCGGA
CGCAGGAAGCTCGAGGCGCTGGGCGTCAATGTGCGTACGCTGATCGAATTCGAAGGGCATTGA

Upstream 100 bases:

>100_bases
TTGTTCCCCCGGATCCCGTGCGAAGAAAATCCTGTAAACCGGTGCTTTGTTGGTGCTATGCCTGTGGCGATCGAAGATCC
AGCAAAGGCCGCATTCAGAT

Downstream 100 bases:

>100_bases
ACGCCTGCAGCGCCGTGCCTTTCAAGCAAATTCAATGACCTTGCTCTCGAAGCGGATAACCGGCTCGCCATGCTGGTTCT
CGCCCTCGCAGAGGATAGTG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MTALQSDLISAIRSIPDYPKPGVMFRDITTLLGNPRAFRRAIDELVHPYAGTKVDKVAGIEARGFILGGAIAHQLSAGFI
PIRKRGKLPHDTVRIAYSLEYGVDEMEMHRDAVVPGDKVILVDDLIATGGTAEGAAKLLQQMGAEIVAACFIIDLPELGG
RRKLEALGVNVRTLIEFEGH

Sequences:

>Translated_180_residues
MTALQSDLISAIRSIPDYPKPGVMFRDITTLLGNPRAFRRAIDELVHPYAGTKVDKVAGIEARGFILGGAIAHQLSAGFI
PIRKRGKLPHDTVRIAYSLEYGVDEMEMHRDAVVPGDKVILVDDLIATGGTAEGAAKLLQQMGAEIVAACFIIDLPELGG
RRKLEALGVNVRTLIEFEGH
>Mature_179_residues
TALQSDLISAIRSIPDYPKPGVMFRDITTLLGNPRAFRRAIDELVHPYAGTKVDKVAGIEARGFILGGAIAHQLSAGFIP
IRKRGKLPHDTVRIAYSLEYGVDEMEMHRDAVVPGDKVILVDDLIATGGTAEGAAKLLQQMGAEIVAACFIIDLPELGGR
RKLEALGVNVRTLIEFEGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=170, Percent_Identity=44.7058823529412, Blast_Score=150, Evalue=4e-37,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=49.5867768595041, Blast_Score=124, Evalue=3e-29,
Organism=Escherichia coli, GI1786675, Length=173, Percent_Identity=50.8670520231214, Blast_Score=192, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=43.2748538011696, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=170, Percent_Identity=37.0588235294118, Blast_Score=118, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=164, Percent_Identity=36.5853658536585, Blast_Score=99, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17136334, Length=170, Percent_Identity=37.6470588235294, Blast_Score=121, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19470; Mature: 19339

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALQSDLISAIRSIPDYPKPGVMFRDITTLLGNPRAFRRAIDELVHPYAGTKVDKVAGI
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHCCC
EARGFILGGAIAHQLSAGFIPIRKRGKLPHDTVRIAYSLEYGVDEMEMHRDAVVPGDKVI
CCCCEEEHHHHHHHHHCCCEEHHCCCCCCCHHEEEEEEECCCCCHHHHHHHCCCCCCCEE
LVDDLIATGGTAEGAAKLLQQMGAEIVAACFIIDLPELGGRRKLEALGVNVRTLIEFEGH
EEECHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEEEEECCC
>Mature Secondary Structure 
TALQSDLISAIRSIPDYPKPGVMFRDITTLLGNPRAFRRAIDELVHPYAGTKVDKVAGI
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHCCC
EARGFILGGAIAHQLSAGFIPIRKRGKLPHDTVRIAYSLEYGVDEMEMHRDAVVPGDKVI
CCCCEEEHHHHHHHHHCCCEEHHCCCCCCCHHEEEEEEECCCCCHHHHHHHCCCCCCCEE
LVDDLIATGGTAEGAAKLLQQMGAEIVAACFIIDLPELGGRRKLEALGVNVRTLIEFEGH
EEECHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]