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The map label for this gene is cpxA [H]

Identifier: 150397446

GI number: 150397446

Start: 2323543

End: 2324961

Strand: Direct

Name: cpxA [H]

Synonym: Smed_2246

Alternate gene names: 150397446

Gene position: 2323543-2324961 (Clockwise)

Preceding gene: 150397445

Following gene: 150397452

Centisome position: 61.44

GC content: 61.52

Gene sequence:

>1419_bases
ATGATGAGCTCAGAATCAAGGACCGGATCAAGGGGCATGGCAAGCTTTGACGGTTTGAAGCGCGAAGGATCGGCACCGAC
GGAGGGTGCCTGGAAGCGCCTCGTCCGATGGCTGCGGCGCCGGCTCCCGATGGGCCTTTACGCGCGTTCGCTGCTGATCG
TCGTTATCCCGATGGTGCTGCTGCAGTCGGTGGTCGCCTTCGTGTTTATGGAGCGGCACTGGCAGCTTGTCACCCAACGC
CTGTCTTCCGCGGTGACCAGCGACATCGCCGCCATCGTCGACCTGATAACGACGTTTCCGCGGGAGGGCGATATCGACCA
GATCGTCCGCATCGCTCGCGATCAACTCGATCTGAACATAACCGTCGAACCGGGTGGCGAACTGCCGCCGCCGCGTCCCA
AGCCCTTCTTCGAAATCCTTGACCAGATTCTCAGCGAGGAGATTTCAAGCCAGATCCGGCGCCCCTTCTGGATCGACACT
GTCGGCAATTCGAAGATCGTGGAAATCCGCATCAAGCTTGAAGACGACCGTATTCTCAGGGTCTATGCCCGGCGCAACCA
GGCCTATGCTTCCAACACGCACATCTTCCTCGTGTGGATGGTCGGCGCGTCGCTCGTCTTGCTGACGATTGCGATCCTCT
TCCTGCGCGGTCAGATCCGGCCGATCCTTGCGCTGGCAAGCGCTGCCGAGAGCTTCGGTAAAGGTCAGAAGATCGACGAT
TTCGCCCCGCGGGGCGCCGACGAAATCCGGCGCGCCGGTCTCGCCTTCATCCTGATGCGCGAACGGATTGAACGCCAGAT
CGAACAGCGCACCGCGATGCTGACTGGCGTCAGCCACGATTTGAGGACGATTCTGACCCGCTTCAAGCTGCAGCTTGCAC
TTGTCGGCAACAATCCGGACCTGGAGAGCCTCAATCAGGACGTGGAGGACATGCAGAACATGCTGGAAGGCTATCTCGCC
TTCGCTCGAGGAGAGGCGGAAGAGGACGTCGGCCGGTTGAAGCTGAGCGAGCTGATGGCCCGGCTTGCGGCGGAGGCGGA
GCTGTACGGCAAGATACTGACCACTGCCATTCAGGGCGAGGACGAAATCCACGTCAGGCCGAACGCCTTCACCCGGCTGA
TCTCCAATCTCGCATCCAATGCGTATCGCTATGCGCGCACCGTGCATATCGAAGCGCGCCAGAGCGCGAAATGGTTGATC
ATCACGGTCGATGACGATGGTCCCGGCATTCCGGAACGCTCGCGCGAAGACGTGTTCAAACCCTTTTTCCGCCTCGACGA
AGCCCGCAATCTCGACAGCTCCGGCACCGGCCTCGGCCTTGCAGTCGCACGTGACATCGCCCGCAGCCATGGGGGCAACG
TCACGCTCGCAGACAGCCCGCTTGGCGGCCTGCGCGCAACCGTGCGCGTCCCGACGTGA

Upstream 100 bases:

>100_bases
TGCAGATAAACCGCCTGAGGCGCAAGATCGAGGACGATCCTTCCAACCCAGTCTGGCTGCAGACCGTTCGCGGAATCGGC
TACCGGCTGAGCGTTGACTG

Downstream 100 bases:

>100_bases
AATTCGGAAGCGATCACGTTCATGTTTTTAGGTCGATCCGACCTGAAACATCGTGATCTGGGAGCCCTCCCCCGCCGGAC
TGGAGCGGCCGGTAGCGCAG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MMSSESRTGSRGMASFDGLKREGSAPTEGAWKRLVRWLRRRLPMGLYARSLLIVVIPMVLLQSVVAFVFMERHWQLVTQR
LSSAVTSDIAAIVDLITTFPREGDIDQIVRIARDQLDLNITVEPGGELPPPRPKPFFEILDQILSEEISSQIRRPFWIDT
VGNSKIVEIRIKLEDDRILRVYARRNQAYASNTHIFLVWMVGASLVLLTIAILFLRGQIRPILALASAAESFGKGQKIDD
FAPRGADEIRRAGLAFILMRERIERQIEQRTAMLTGVSHDLRTILTRFKLQLALVGNNPDLESLNQDVEDMQNMLEGYLA
FARGEAEEDVGRLKLSELMARLAAEAELYGKILTTAIQGEDEIHVRPNAFTRLISNLASNAYRYARTVHIEARQSAKWLI
ITVDDDGPGIPERSREDVFKPFFRLDEARNLDSSGTGLGLAVARDIARSHGGNVTLADSPLGGLRATVRVPT

Sequences:

>Translated_472_residues
MMSSESRTGSRGMASFDGLKREGSAPTEGAWKRLVRWLRRRLPMGLYARSLLIVVIPMVLLQSVVAFVFMERHWQLVTQR
LSSAVTSDIAAIVDLITTFPREGDIDQIVRIARDQLDLNITVEPGGELPPPRPKPFFEILDQILSEEISSQIRRPFWIDT
VGNSKIVEIRIKLEDDRILRVYARRNQAYASNTHIFLVWMVGASLVLLTIAILFLRGQIRPILALASAAESFGKGQKIDD
FAPRGADEIRRAGLAFILMRERIERQIEQRTAMLTGVSHDLRTILTRFKLQLALVGNNPDLESLNQDVEDMQNMLEGYLA
FARGEAEEDVGRLKLSELMARLAAEAELYGKILTTAIQGEDEIHVRPNAFTRLISNLASNAYRYARTVHIEARQSAKWLI
ITVDDDGPGIPERSREDVFKPFFRLDEARNLDSSGTGLGLAVARDIARSHGGNVTLADSPLGGLRATVRVPT
>Mature_472_residues
MMSSESRTGSRGMASFDGLKREGSAPTEGAWKRLVRWLRRRLPMGLYARSLLIVVIPMVLLQSVVAFVFMERHWQLVTQR
LSSAVTSDIAAIVDLITTFPREGDIDQIVRIARDQLDLNITVEPGGELPPPRPKPFFEILDQILSEEISSQIRRPFWIDT
VGNSKIVEIRIKLEDDRILRVYARRNQAYASNTHIFLVWMVGASLVLLTIAILFLRGQIRPILALASAAESFGKGQKIDD
FAPRGADEIRRAGLAFILMRERIERQIEQRTAMLTGVSHDLRTILTRFKLQLALVGNNPDLESLNQDVEDMQNMLEGYLA
FARGEAEEDVGRLKLSELMARLAAEAELYGKILTTAIQGEDEIHVRPNAFTRLISNLASNAYRYARTVHIEARQSAKWLI
ITVDDDGPGIPERSREDVFKPFFRLDEARNLDSSGTGLGLAVARDIARSHGGNVTLADSPLGGLRATVRVPT

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=34.7169811320755, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789808, Length=276, Percent_Identity=34.0579710144928, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787894, Length=271, Percent_Identity=31.7343173431734, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=25.6317689530686, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI87082128, Length=273, Percent_Identity=25.6410256410256, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787374, Length=102, Percent_Identity=42.156862745098, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786912, Length=244, Percent_Identity=30.327868852459, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI145693157, Length=237, Percent_Identity=26.5822784810127, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789149, Length=226, Percent_Identity=25.6637168141593, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790861, Length=289, Percent_Identity=26.643598615917, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=25.4310344827586, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52863; Mature: 52863

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN ; PS50008 PIPLC_Y_DOMAIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSSESRTGSRGMASFDGLKREGSAPTEGAWKRLVRWLRRRLPMGLYARSLLIVVIPMVL
CCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LQSVVAFVFMERHWQLVTQRLSSAVTSDIAAIVDLITTFPREGDIDQIVRIARDQLDLNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEE
TVEPGGELPPPRPKPFFEILDQILSEEISSQIRRPFWIDTVGNSKIVEIRIKLEDDRILR
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEEEECCCHHHH
VYARRNQAYASNTHIFLVWMVGASLVLLTIAILFLRGQIRPILALASAAESFGKGQKIDD
HHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC
FAPRGADEIRRAGLAFILMRERIERQIEQRTAMLTGVSHDLRTILTRFKLQLALVGNNPD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEECCCCC
LESLNQDVEDMQNMLEGYLAFARGEAEEDVGRLKLSELMARLAAEAELYGKILTTAIQGE
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEIHVRPNAFTRLISNLASNAYRYARTVHIEARQSAKWLIITVDDDGPGIPERSREDVFK
CCEEECCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCCCCCCCHHHHHH
PFFRLDEARNLDSSGTGLGLAVARDIARSHGGNVTLADSPLGGLRATVRVPT
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCC
>Mature Secondary Structure
MMSSESRTGSRGMASFDGLKREGSAPTEGAWKRLVRWLRRRLPMGLYARSLLIVVIPMVL
CCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LQSVVAFVFMERHWQLVTQRLSSAVTSDIAAIVDLITTFPREGDIDQIVRIARDQLDLNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEE
TVEPGGELPPPRPKPFFEILDQILSEEISSQIRRPFWIDTVGNSKIVEIRIKLEDDRILR
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEEEECCCHHHH
VYARRNQAYASNTHIFLVWMVGASLVLLTIAILFLRGQIRPILALASAAESFGKGQKIDD
HHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC
FAPRGADEIRRAGLAFILMRERIERQIEQRTAMLTGVSHDLRTILTRFKLQLALVGNNPD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEECCCCC
LESLNQDVEDMQNMLEGYLAFARGEAEEDVGRLKLSELMARLAAEAELYGKILTTAIQGE
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEIHVRPNAFTRLISNLASNAYRYARTVHIEARQSAKWLIITVDDDGPGIPERSREDVFK
CCEEECCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCCCCCCCHHHHHH
PFFRLDEARNLDSSGTGLGLAVARDIARSHGGNVTLADSPLGGLRATVRVPT
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]