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The map label for this gene is yeaE [H]

Identifier: 150397207

GI number: 150397207

Start: 2055970

End: 2056815

Strand: Direct

Name: yeaE [H]

Synonym: Smed_2006

Alternate gene names: 150397207

Gene position: 2055970-2056815 (Clockwise)

Preceding gene: 150397204

Following gene: 150397210

Centisome position: 54.36

GC content: 64.3

Gene sequence:

>846_bases
ATGCACGATCCGATCCCGACCATCACTTTTCCGGACGGCCGCAAGGTTCCCGTGCTCGGCCAAGGCACTTGGCGAATGGG
CGAAAACCGTGCCGGAGCCGCCGACGAGGTCCGCAGCCTGCAAGCGGGGCTCGATCTCGGCATGACGCTGATCGACACGG
CGGAGATGTATGGCGACGGCGCCGCCGAACGCATCGTCGGAGAAGCGATCAAGGGTCGGCGGGGGGACGCCTTCCTGGTC
AGCAAGGTACTGCCCTCCAATGCCAGCCGGACGGGCACGCTTGCCGCCTGCGAACGCAGCCTGCGCAATATCGGGACCGA
TTGCCTCGATCTATACCTTCTGCATTGGCGTGGCGGCCATCCGCTCACCGAGACTGTGGCCGCCTTCGAAGAGCTGAAGC
AGGCTGGTAAGATCCGCGCCTGGGGCGTCTCGAATTTTGACGTCGACGACATGGAGGAGCTTGCGGCCGTACCCGACGGC
GGCAATGTCGCGGCCAACCAGGTGCTCTACAATCTCGCGCGCCGCGGCGTCGAATTCGACCTTCTGCCCTGGTGCCGCGG
CCGCGGCGTTCCGATCATGGCCTATTCGCCGCTCGACGAGGGCCGCCTGCTCAATGATGCCGACCTTATCCACATCGCCA
AGGCGCATCAGGCGACGCCCGCCCAGGTGGCGCTCGCATTTTTGAAGACGCGCTCCGGCGTCATATCGATTCCGAAGACC
GGTTCCGCCGGACGCGCCCGCGAAAACCGCGACGCAATGGATATCCATCTGACGGCGGAAAATCTCGCCGAACTGGATCG
TCATTTCCCGCCGCCAAAGAGGAAGACGCGGCTGGAAGTGATCTGA

Upstream 100 bases:

>100_bases
ACGGAGCGTCCCGGGCCGGCCATGTTTGCGATTGCCTTATGGACTTTCAGCCAGCGGGCTTTAAATCTCGGCACTGACGC
AACCTGCAGGACCATTACCG

Downstream 100 bases:

>100_bases
GAAGCGACCACAGCGGCGCAGGCTCGGTGGCCCGCCTTGCCGACTGCGCTCATCCACGTCCCTATCGCGGTTGAGAGAAC
CGCCTCACATCCCCTGCGGG

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MHDPIPTITFPDGRKVPVLGQGTWRMGENRAGAADEVRSLQAGLDLGMTLIDTAEMYGDGAAERIVGEAIKGRRGDAFLV
SKVLPSNASRTGTLAACERSLRNIGTDCLDLYLLHWRGGHPLTETVAAFEELKQAGKIRAWGVSNFDVDDMEELAAVPDG
GNVAANQVLYNLARRGVEFDLLPWCRGRGVPIMAYSPLDEGRLLNDADLIHIAKAHQATPAQVALAFLKTRSGVISIPKT
GSAGRARENRDAMDIHLTAENLAELDRHFPPPKRKTRLEVI

Sequences:

>Translated_281_residues
MHDPIPTITFPDGRKVPVLGQGTWRMGENRAGAADEVRSLQAGLDLGMTLIDTAEMYGDGAAERIVGEAIKGRRGDAFLV
SKVLPSNASRTGTLAACERSLRNIGTDCLDLYLLHWRGGHPLTETVAAFEELKQAGKIRAWGVSNFDVDDMEELAAVPDG
GNVAANQVLYNLARRGVEFDLLPWCRGRGVPIMAYSPLDEGRLLNDADLIHIAKAHQATPAQVALAFLKTRSGVISIPKT
GSAGRARENRDAMDIHLTAENLAELDRHFPPPKRKTRLEVI
>Mature_281_residues
MHDPIPTITFPDGRKVPVLGQGTWRMGENRAGAADEVRSLQAGLDLGMTLIDTAEMYGDGAAERIVGEAIKGRRGDAFLV
SKVLPSNASRTGTLAACERSLRNIGTDCLDLYLLHWRGGHPLTETVAAFEELKQAGKIRAWGVSNFDVDDMEELAAVPDG
GNVAANQVLYNLARRGVEFDLLPWCRGRGVPIMAYSPLDEGRLLNDADLIHIAKAHQATPAQVALAFLKTRSGVISIPKT
GSAGRARENRDAMDIHLTAENLAELDRHFPPPKRKTRLEVI

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI223468663, Length=288, Percent_Identity=29.5138888888889, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI310109922, Length=290, Percent_Identity=31.7241379310345, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI310109920, Length=310, Percent_Identity=30.3225806451613, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI5453543, Length=309, Percent_Identity=29.126213592233, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI45446745, Length=310, Percent_Identity=30, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4503285, Length=310, Percent_Identity=30, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI24497577, Length=296, Percent_Identity=28.3783783783784, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI5174391, Length=296, Percent_Identity=28.3783783783784, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI5174695, Length=298, Percent_Identity=29.5302013422819, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI24497585, Length=294, Percent_Identity=29.5918367346939, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI24497583, Length=303, Percent_Identity=29.042904290429, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI291291012, Length=266, Percent_Identity=28.5714285714286, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI4502049, Length=292, Percent_Identity=29.7945205479452, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI300116273, Length=281, Percent_Identity=29.8932384341637, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1788081, Length=279, Percent_Identity=50.179211469534, Blast_Score=284, Evalue=6e-78,
Organism=Escherichia coli, GI1786400, Length=262, Percent_Identity=31.6793893129771, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87081735, Length=275, Percent_Identity=31.6363636363636, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788070, Length=298, Percent_Identity=30.2013422818792, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082198, Length=269, Percent_Identity=29.368029739777, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787674, Length=248, Percent_Identity=28.6290322580645, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789199, Length=325, Percent_Identity=28.9230769230769, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI48994888, Length=216, Percent_Identity=32.4074074074074, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561298, Length=281, Percent_Identity=32.0284697508897, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71998625, Length=286, Percent_Identity=29.020979020979, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17564128, Length=309, Percent_Identity=30.7443365695793, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17537077, Length=301, Percent_Identity=26.578073089701, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17537075, Length=300, Percent_Identity=25.6666666666667, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17552492, Length=271, Percent_Identity=27.6752767527675, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17550248, Length=303, Percent_Identity=24.0924092409241, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17561300, Length=291, Percent_Identity=26.8041237113402, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17538386, Length=282, Percent_Identity=28.3687943262411, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17537079, Length=306, Percent_Identity=25.4901960784314, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17566692, Length=305, Percent_Identity=24.5901639344262, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6324694, Length=287, Percent_Identity=28.2229965156794, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6320576, Length=264, Percent_Identity=29.9242424242424, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6322556, Length=269, Percent_Identity=26.0223048327138, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320079, Length=283, Percent_Identity=25.0883392226148, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24663317, Length=299, Percent_Identity=30.7692307692308, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45553081, Length=292, Percent_Identity=27.0547945205479, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24662789, Length=304, Percent_Identity=27.6315789473684, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24657054, Length=295, Percent_Identity=28.4745762711864, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI20129731, Length=299, Percent_Identity=27.7591973244147, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI281366140, Length=252, Percent_Identity=26.5873015873016, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356425, Length=304, Percent_Identity=26.3157894736842, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24662781, Length=296, Percent_Identity=26.6891891891892, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24662785, Length=295, Percent_Identity=26.1016949152542, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 30536; Mature: 30536

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDPIPTITFPDGRKVPVLGQGTWRMGENRAGAADEVRSLQAGLDLGMTLIDTAEMYGDG
CCCCCCCEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCC
AAERIVGEAIKGRRGDAFLVSKVLPSNASRTGTLAACERSLRNIGTDCLDLYLLHWRGGH
HHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHEECCCC
PLTETVAAFEELKQAGKIRAWGVSNFDVDDMEELAAVPDGGNVAANQVLYNLARRGVEFD
CHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEE
LLPWCRGRGVPIMAYSPLDEGRLLNDADLIHIAKAHQATPAQVALAFLKTRSGVISIPKT
ECCCCCCCCCEEEEECCCCCCCCCCCCCEEEEHHHCCCCHHHHHHHHHHHCCCEEECCCC
GSAGRARENRDAMDIHLTAENLAELDRHFPPPKRKTRLEVI
CCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MHDPIPTITFPDGRKVPVLGQGTWRMGENRAGAADEVRSLQAGLDLGMTLIDTAEMYGDG
CCCCCCCEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCC
AAERIVGEAIKGRRGDAFLVSKVLPSNASRTGTLAACERSLRNIGTDCLDLYLLHWRGGH
HHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHEECCCC
PLTETVAAFEELKQAGKIRAWGVSNFDVDDMEELAAVPDGGNVAANQVLYNLARRGVEFD
CHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEE
LLPWCRGRGVPIMAYSPLDEGRLLNDADLIHIAKAHQATPAQVALAFLKTRSGVISIPKT
ECCCCCCCCCEEEEECCCCCCCCCCCCCEEEEHHHCCCCHHHHHHHHHHHCCCEEECCCC
GSAGRARENRDAMDIHLTAENLAELDRHFPPPKRKTRLEVI
CCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]